{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:18:55Z","timestamp":1782364735061,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000824","name":"UK Home Office","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.toxlet.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T16:42:43Z","timestamp":1407170563000},"page":"393-401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard"],"prefix":"10.1016","volume":"230","author":[{"given":"Paul A.","family":"Jowsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Blain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.08.001_bib0005","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1128\/MCB.01717-07","article-title":"Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote S-phase genome stability","volume":"28","author":"Bailis","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0010","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1177\/0960327110389501","article-title":"Delayed toxic effects of sulfur mustard on respiratory tract of Iranian veterans","volume":"30","author":"Balali-Mood","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1472-8206.2005.00325.x","article-title":"The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning","volume":"19","author":"Balali-Mood","year":"2005","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1742-7843.2006.pto_429.x","article-title":"Comparison of early and late toxic effects of sulfur mustard in Iranian veterans","volume":"99","author":"Balali-Mood","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0025","first-page":"239","article-title":"Deoxyribonucleic acid damage in Iranian veterans 25 years after wartime exposure to sulfur mustard","volume":"18","author":"Behravan","year":"2013","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0030","doi-asserted-by":"crossref","first-page":"a012807","DOI":"10.1101\/cshperspect.a012807","article-title":"The minichromosome maintenance replicative helicase","volume":"5","author":"Bell","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0035","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10565-014-9279-0","article-title":"Mustard gas surrogate, 2-chloroethyl ethylsulfide (2-cees), induces centrosome amplification and aneuploidy in human and mouse cells : 2-cees induces centrosome amplification and chromosome instability","volume":"4","author":"Bennett","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0040","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.taap.2010.04.001","article-title":"Role of map kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide","volume":"245","author":"Black","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0045","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1093\/emboj\/18.23.6845","article-title":"Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation","volume":"18","author":"Bulavin","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0050","doi-asserted-by":"crossref","first-page":"10078","DOI":"10.1073\/pnas.0403410101","article-title":"Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases","volume":"101","author":"Cortez","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/jpet.105.097014","article-title":"Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint","volume":"317","author":"Dillman","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/tx00038a013","article-title":"Synthesis, characterization, and quantitation of the major adducts formed between sulfur mustard and DNA of calf thymus and human blood","volume":"7","author":"Fidder","year":"1994","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0065","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2004.12.028","article-title":"Centrosome amplification, chromosome instability and cancer development","volume":"230","author":"Fukasawa","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0070","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/10408444.2010.541224","article-title":"Sulfur mustard toxicity: history, chemistry, pharmacokinetics, and pharmacodynamics","volume":"41","author":"Ghabili","year":"2011","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0075","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/15569527.2011.595751","article-title":"Long-term ocular consequences of sulfur mustard in lung-injured war veterans","volume":"31","author":"Ghasemi","year":"2012","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0080","first-page":"351","article-title":"MCM proteins as diagnostic and prognostic tumor markers in the clinical setting","volume":"25","author":"Giaginis","year":"2010","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0085","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/toxsci\/kfi306","article-title":"Characterization of the initial response of engineered human skin to sulfur mustard","volume":"90","author":"Greenberg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0090","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.taap.2011.10.010","article-title":"Sulfur mustard primes human neutrophils for increased degranulation and stimulates cytokine release via TRPM2\/p38 MAPK signaling","volume":"258","author":"Ham","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000078673","article-title":"MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications","volume":"71","author":"Hashimoto","year":"2004","journal-title":"Pathobiology"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0100","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/j.tiv.2009.07.021","article-title":"Microvesicating effects of sulfur mustard on an in vitro human skin model","volume":"23","author":"Hayden","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2009.05.022","article-title":"Mustard gas exposure and carcinogenesis of lung","volume":"678","author":"Hosseini-khalili","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/toxsci\/kfq032","article-title":"Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents","volume":"115","author":"Jiang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2008.12.001","article-title":"DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide","volume":"257","author":"Jowsey","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.toxlet.2010.04.020","article-title":"The role of homologous recombination in the cellular response to sulphur mustard","volume":"197","author":"Jowsey","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2011.11.009","article-title":"DNA damage responses in cells exposed to sulphur mustard","volume":"209","author":"Jowsey","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/01926230309801","article-title":"Sulfur mustard-induced apoptosis in hairless guinea pig skin","volume":"31","author":"Kan","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0135","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00204-007-0265-7","article-title":"Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (Sm)-induced cell death in HaCaT cells","volume":"82","author":"Kehe","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tox.2005.06.014","article-title":"Medical aspects of sulphur mustard poisoning","volume":"214","author":"Kehe","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0145","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/01.jom.0000094993.20914.d1","article-title":"Incidence of lung, eye and skin lesions as late complications in 34,000 Iranians with wartime exposure to mustard agent","volume":"45","author":"Khateri","year":"2003","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0150","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1749-6632.2010.05605.x","article-title":"Oxidants and antioxidants in sulfur mustard-induced injury","volume":"1203","author":"Laskin","year":"2010","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0155","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1750-3639.2009.00326.x","article-title":"Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates","volume":"20","author":"Martinez","year":"2010","journal-title":"Brain Pathol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0160","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/carcin\/22.4.661","article-title":"Repair of sulfur mustard-induced DNA damage in mammalian cells measured by a host cell reactivation assay","volume":"22","author":"Matijasevic","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0165","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0167-4889(98)00078-0","article-title":"Alterations in human lymphocyte dna caused by sulfur mustard can be mitigated by selective inhibitors of poly(ADP-ribose) polymerase","volume":"1404","author":"Meier","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0170","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.toxlet.2008.07.005","article-title":"Activation of MAPK\/AP-1 signaling pathway in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard gas analog","volume":"181","author":"Mukhopadhyay","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0175","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","article-title":"Centrioles, centrosomes, and cilia in health and disease","volume":"139","author":"Nigg","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0180","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.freeradbiomed.2010.01.039","article-title":"Treatment with the catalytic metalloporphyrin aeol 10,150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide","volume":"48","author":"O\u2019Neill","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0185","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.freeradbiomed.2009.09.011","article-title":"Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1hairless mice","volume":"47","author":"Pal","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0190","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/0272-0590(85)90123-X","article-title":"Molecular basis for mustard-induced vesication","volume":"5","author":"Papirmeister","year":"1985","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0195","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/toxsci\/kfp211","article-title":"Acute morphological and toxicological effects in a human bronchial coculture model after sulfur mustard exposure","volume":"112","author":"Pohl","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0200","first-page":"163","article-title":"Long-term effects of mustard gas on respiratory system of Iranian veterans after Iraq\u2013Iran war: a review","volume":"16","author":"Razavi","year":"2013","journal-title":"Chin. J. Traumatol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jbt.20043","article-title":"Microarray analysis of gene expression in murine skin exposed to sulfur mustard","volume":"18","author":"Rogers","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15569520802092054","article-title":"Transcriptional responses associated with sulfur mustard and thermal burns in porcine skin","volume":"27","author":"Rogers","year":"2008","journal-title":"Cutan. Ocul. Toxicol."},{"issue":"Suppl. 1","key":"10.1016\/j.toxlet.2014.08.001_bib0215","first-page":"S243","article-title":"Oxidative modification of brain proteins in Alzheimer\u2019s disease: perspective on future studies based on results of redox proteomics studies","volume":"33","author":"Sultana","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2407-1-6","article-title":"MCM2 \u2013 a promising marker for premalignant lesions of the lung: a cohort study","volume":"1","author":"Tan","year":"2001","journal-title":"BMC Cancer"},{"key":"10.1016\/j.toxlet.2014.08.001_bib0225","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/tx100038b","article-title":"Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in Jb6 and HaCaT cells: possible role of ataxia telangiectasia-mutated\/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway","volume":"23","author":"Tewari-Singh","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2014.08.001_bib0230","doi-asserted-by":"crossref","first-page":"53353","DOI":"10.1074\/jbc.M408026200","article-title":"MCM2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses","volume":"279","author":"Yoo","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414012041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414012041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T05:24:03Z","timestamp":1538371443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414012041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0378427414012041"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.08.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}