{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:09:37Z","timestamp":1791360577409,"version":"4.3.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.toxlet.2014.09.025","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T19:48:51Z","timestamp":1412279331000},"page":"46-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Gestational exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pancreatic \u03b2-cell function in F1 rat offspring"],"prefix":"10.1016","volume":"232","author":[{"given":"P.","family":"Rajesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Balasubramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.09.025_bib0005","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.2337\/diabetes.51.5.1409","article-title":"Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter","volume":"51","author":"Ban","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0010","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1126\/science.278.5341.1288","article-title":"Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases","volume":"278","author":"Bennett","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0015","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.envint.2008.08.010","article-title":"Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study","volume":"35","author":"Berman","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0020","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/bdra.20685","article-title":"Epigenomic disruption: the effects of early developmental exposures. Birth defects research Part A","volume":"88","author":"Bernal","year":"2010","journal-title":"Clinic. Mol. Teratol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0025","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2337\/diabetes.52.6.1319","article-title":"Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes","volume":"52","author":"Bouzakri","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0030","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1074\/jbc.M111272200","article-title":"Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion","volume":"277","author":"Brissova","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1677\/JME-07-0134","article-title":"A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease","volume":"40","author":"Brun","year":"2008","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2013.09.014","article-title":"Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors","volume":"62","author":"Cantonwine","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12575-009-9021-0","article-title":"A practical guide to rodent islet isolation and assessment","volume":"11","author":"Carter","year":"2009","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine disruptors: from endocrine to metabolic disruption","volume":"73","author":"Casals-Casas","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0060","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.2337\/diabetes.50.6.1302","article-title":"Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action","volume":"50","author":"Chan","year":"2001","journal-title":"Diabetes"},{"issue":"Suppl. 1","key":"10.1016\/j.toxlet.2014.09.025_bib0065","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.2337\/diabetes.53.2007.S136","article-title":"Uncoupling protein 2 and islet function","volume":"53","author":"Chan","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0070","doi-asserted-by":"crossref","first-page":"e1004160","DOI":"10.1371\/journal.pgen.1004160","article-title":"Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion","volume":"10","author":"Dayeh","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0080","first-page":"E667","article-title":"A new procedure for the isolation of plasma membranes, T tubules, and internal membranes from skeletal muscle","volume":"270","author":"Dombrowski","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0085","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.2337\/db07-1614","article-title":"miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells","volume":"57","author":"El Ouaamari","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0090","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ijheh.2013.01.006","article-title":"Phthalate exposure in pregnant women and newborns - the urinary metabolite excretion pattern differs distinctly","volume":"216","author":"Enke","year":"2013","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0095","article-title":"Environmental phthalate exposure and preterm birth","author":"Ferguson","year":"2013","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/isl.2.1.10456","article-title":"Stress hypERactivation in the beta-cell","volume":"2","author":"Fonseca","year":"2010","journal-title":"Islets"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0105","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1210\/me.2011-1256","article-title":"Pax6 is crucial for beta-cell function, insulin biosynthesis, and glucose-induced insulin secretion","volume":"26","author":"Gosmain","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0021-9673(00)90124-9","article-title":"Rapid purification of glucokinase and glycerokinase from Bacillus stearothermophilus by hydrophobic interaction chromatography","volume":"369","author":"Goward","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1742-7843.2007.00114.x","article-title":"The faroes statement: human health effects of developmental exposure to chemicals in our environment","volume":"102","author":"Grandjean","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0120","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1172\/JCI200522365","article-title":"The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion","volume":"115","author":"Gupta","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0125","doi-asserted-by":"crossref","unstructured":"Hao C., Cheng, X., Guo J., Xia H., Ma, X., 2013. Perinatal exposure to diethyl-hexyl-phthalate induces obesity in mice. Front Biosci (Elite Ed) 5, 725\u2013733.","DOI":"10.2741\/E653"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-069X-7-27","article-title":"Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999\u20132002","volume":"7","author":"Hatch","year":"2008","journal-title":"Environ. Health"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0135","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/j.1460-2075.1993.tb05949.x","article-title":"Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport","volume":"12","author":"Heimberg","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0140","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2605.2007.00841.x","article-title":"Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans","volume":"31","author":"Janjua","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0145","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1210\/en.2010-1162","article-title":"Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats","volume":"152","author":"Jiang","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0150","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ncb2211","article-title":"Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism","volume":"13","author":"Jordan","year":"2011","journal-title":"Nat. Cell Bio."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1741-7007-2-23","article-title":"Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation","volume":"2","author":"Kaiser","year":"2004","journal-title":"BMC Bio."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0160","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.addr.2008.12.015","article-title":"Role of MafA in pancreatic beta-cells","volume":"61","author":"Kaneto","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1507\/endocrj.K07E-041","article-title":"PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function","volume":"55","author":"Kaneto","year":"2008","journal-title":"Endocr. J."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1507\/endocrj.KR-109","article-title":"Role of FoxO Proteins in Pancreatic beta Cells","volume":"54","author":"Kitamura","year":"2007","journal-title":"Endocr. J."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0175","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1172\/JCI200216857","article-title":"The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth","volume":"110","author":"Kitamura","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0180","doi-asserted-by":"crossref","first-page":"e6953","DOI":"10.1371\/journal.pone.0006953","article-title":"Insulin gene expression is regulated by DNA methylation","volume":"4","author":"Kuroda","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0185","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the isolation of intact islets of Langerhans from the rat pancreas","volume":"16","author":"Lacy","year":"1967","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1136\/jech.46.3.184","article-title":"Early growth and abdominal fatness in adult life","volume":"46","author":"Law","year":"1992","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.nutr.28.061807.155530","article-title":"Insulin signaling in the pancreatic beta-cell","volume":"28","author":"Leibiger","year":"2008","journal-title":"Annu. Rev. Nutrition"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0200","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1152\/ajpendo.00233.2011","article-title":"Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat","volume":"301","author":"Lin","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0205","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2337\/dc11-2396","article-title":"Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly","volume":"35","author":"Lind","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0210","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0215","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nature07617","article-title":"Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance","volume":"457","author":"Luan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0220","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1289\/ehp.8075","article-title":"Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age","volume":"114","author":"Main","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0225","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.taap.2012.10.027","article-title":"Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring","volume":"266","author":"Martinez-Arguelles","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0230","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10038-007-0231-5","article-title":"Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4087 Japanese subjects","volume":"53","author":"Miyake","year":"2008","journal-title":"J. Human Genet."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0235","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2337\/diab.14.10.669","article-title":"Immunoassay of pancreatic and plasma insulin following alloxan injection of rats","volume":"14","author":"Morgan","year":"1965","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0240","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1126\/science.1089769","article-title":"Control of pancreas and liver gene expression by HNF transcription factors","volume":"303","author":"Odom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0245","doi-asserted-by":"crossref","first-page":"8977","DOI":"10.1073\/pnas.0608703104","article-title":"Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance","volume":"104","author":"Okada","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0250","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1016175429877","article-title":"Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells","volume":"7","author":"Oyadomari","year":"2002","journal-title":"Apoptosis: An Int. J. Program. Cell Death"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0255","first-page":"1405","article-title":"Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components","volume":"50","author":"Pearson","year":"1993","journal-title":"Am. J. Hospital Pharm."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0260","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0265","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/0960327113506238","article-title":"Di(2-ethylhexyl) phthalate exposure impairs insulin receptor and glucose transporter 4 gene expression in L6 myotubes","volume":"33","author":"Rajesh","year":"2013","journal-title":"Human Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0270","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jcb.24399","article-title":"Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins","volume":"114","author":"Rajesh","year":"2013","journal-title":"J. Cellular Biochem."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0275","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tiv.2006.07.005","article-title":"Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells","volume":"21","author":"Rengarajan","year":"2007","journal-title":"Toxicol. in vitro"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0280","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2337\/db13-0246","article-title":"Direct autocrine action of insulin on beta-cells: does it make physiological sense?","volume":"62","author":"Rhodes","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0285","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1101\/gad.11.13.1662","article-title":"Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development","volume":"11","author":"Sander","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0290","article-title":"Phthalate exposure and reproductive hormone concentrations in pregnancy","author":"Sathyanarayana","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.50.1.1","article-title":"Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus","volume":"50","author":"Schuit","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0300","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1210\/en.2008-0015","article-title":"Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner","volume":"149","author":"Seo","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0305","unstructured":"Shelby, M.D., 2006. NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). Ntp Cerhr Mon v, vii-7, II-iii-xiii passim."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0310","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1016-8478(23)13114-1","article-title":"The gene Pax4 is an essential regulator of pancreatic beta-cell development","volume":"18","author":"Sosa-Pineda","year":"2004","journal-title":"Mol. Cells"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0315","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/386399a0","article-title":"The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas","volume":"386","author":"Sosa-Pineda","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0320","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.taap.2011.08.022","article-title":"Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat","volume":"257","author":"Srinivasan","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0325","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1289\/ehp.9882","article-title":"Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult US males","volume":"115","author":"Stahlhut","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0330","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1079\/PNS2005417","article-title":"Fetal origins of insulin resistance and obesity","volume":"64","author":"Stocker","year":"2005","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0335","doi-asserted-by":"crossref","first-page":"13209","DOI":"10.1073\/pnas.94.24.13209","article-title":"The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism","volume":"94","author":"Stoffel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0340","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.envres.2011.05.015","article-title":"Phthalate exposure associated with self-reported diabetes among Mexican women","volume":"111","author":"Svensson","year":"2011","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0345","article-title":"Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols","author":"Tefre de Renzy-Martin","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0350","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.envres.2013.07.007","article-title":"Phthalates and the diets of U. S. children and adolescents","volume":"126","author":"Trasande","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0355","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/emboj.2011.503","article-title":"DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients","volume":"31","author":"Volkmar","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0360","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00125-006-0490-2","article-title":"MAFA controls genes implicated in insulin biosynthesis and secretion","volume":"50","author":"Wang","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0365","doi-asserted-by":"crossref","first-page":"35953","DOI":"10.1074\/jbc.M006612200","article-title":"Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta-cell genes implicated in glucose metabolism and nutrient-induced insulin secretion","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2014.09.025_bib0370","first-page":"1243","article-title":"Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation","volume":"47","author":"Xu","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0375","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/384458a0","article-title":"Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)","volume":"384","author":"Yamagata","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0380","doi-asserted-by":"crossref","first-page":"e25167","DOI":"10.1371\/journal.pone.0025167","article-title":"Postnatal pancreatic islet beta cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation","volume":"6","author":"Yuan","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0385","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2337\/db11-1048","article-title":"Global DNA methylation is associated with insulin resistance: a monozygotic twin study","volume":"61","author":"Zhao","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2014.09.025_bib0390","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1677\/joe.1.05701","article-title":"Alterations in net glucose uptake and in the pancreatic B-cell GLUT2 transporter induced by diazoxide and by secretory stimuli","volume":"185","author":"Zhao","year":"2005","journal-title":"J. Endocrinol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414013599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414013599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T10:45:47Z","timestamp":1717411547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414013599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0378427414013599"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.09.025","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational exposure to di(2-ethylhexyl) phthalate (DEHP) impairs pancreatic \u03b2-cell function in F1 rat offspring","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.09.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}