{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:33:47Z","timestamp":1770834827218,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160063"],"award-info":[{"award-number":["81160063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"crossref","award":["2013GXNSFBA019167"],"award-info":[{"award-number":["2013GXNSFBA019167"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education","award":["GK2013-13-A-01-03"],"award-info":[{"award-number":["GK2013-13-A-01-03"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.toxlet.2014.11.009","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T16:04:31Z","timestamp":1416153871000},"page":"233-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats"],"prefix":"10.1016","volume":"232","author":[{"given":"Wen","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuerong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.11.009_bib0005","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1056\/NEJM200102083440610","article-title":"Is liver fibrosis reversible?","volume":"344","author":"Bonis","year":"2001","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0010","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/1319-3767.43274","article-title":"Serum hyaluronic acid as a noninvasive marker of hepatic fibrosis in chronic hepatitis B","volume":"14","author":"Geramizadeh","year":"2008","journal-title":"Saudi J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0015","doi-asserted-by":"crossref","first-page":"i48","DOI":"10.1136\/ard.2009.120196","article-title":"Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies","volume":"69","author":"Distler","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0020","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2004.05.004","article-title":"The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis","volume":"148","author":"Campo","year":"2004","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2002-26761","article-title":"Oxidative stress, plant-derived antioxidants and liver fibrosis","volume":"68","author":"Gebhardt","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4155\/fmc.11.169","article-title":"Advancing cancer drug discovery towards more agile development of targeted combination therapies","volume":"4","author":"Carragher","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0040","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2036.2008.03695.x","article-title":"Systematic review: combination therapies for treatment-na\u00efve chronic hepatitis B","volume":"27","author":"Kumar","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0045","first-page":"106","article-title":"Effects of taurine on proliferation and apoptosis of hepatic stellate cells in vitro","volume":"3","author":"Chen","year":"2004","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0050","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hepres.2004.04.006","article-title":"Transforming growth factor-\u03b2-induced stimulation of formation of collagen fiber network and anti fibrotic effect of taurine in an in vitro model of hepatic fibrosis","volume":"30","author":"Kato","year":"2004","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jhep.2005.01.033","article-title":"Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis","volume":"43","author":"Miyazaki","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0060","first-page":"677","article-title":"Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells","volume":"27","author":"Nakamuta","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0065","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.mehy.2008.07.045","article-title":"Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells","volume":"72","author":"McCarty","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0070","doi-asserted-by":"crossref","first-page":"20543","DOI":"10.3390\/ijms141020543","article-title":"Combined taurine, epigallocatechin gallate and genistein therapy reduces HSC-T6 cell proliferation and modulates the expression of fibrogenic factors","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0075","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1248\/bpb.b12-00548","article-title":"Combination therapy with taurine, epigallocatechin gallate and genistein for protection against hepatic fibrosis induced by alcohol in rat","volume":"35","author":"Zhuo","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0080","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3892\/ijmm_00000154","article-title":"Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang","volume":"23","author":"Lee","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1749-8546-7-23","article-title":"Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis","volume":"7","author":"Wang","year":"2012","journal-title":"Chin. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0090","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1002\/pmic.200900071","article-title":"iTRAQ-coupled 2-D LC\u2013MS\/MS analysis of protein profile associated with HBV-modulated DNA methylation","volume":"9","author":"Niu","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0095","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s10620-011-1745-4","article-title":"Novel biomarker candidates to predict hepatic fibrosis in hepatitis C identified by serum proteomics","volume":"56","author":"Yang","year":"2011","journal-title":"Digest. Dis. Sci."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/abbs\/gmq108","article-title":"Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease","volume":"43","author":"Zhang","year":"2011","journal-title":"Acta Biochim. Biophys. Sinica"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0110","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/pr1011476","article-title":"Coomassie staining as loading control in western blot analysis","volume":"10","author":"Charlotte","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0115","first-page":"989","article-title":"Expression of thioredoxin and thioredoxin-binding protein-2 in the liver of patients with chronic hepatitis C as a predictor of response to interferon therapy","volume":"17","author":"Hamano","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0120","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jprot.2008.12.003","article-title":"Proteome analysis of a human liver carcinoma cell line stably expressing hepatitis delta virus ribonucleoproteins","volume":"72","author":"Mota","year":"2009","journal-title":"J. Proteomics"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0125","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.fsi.2009.04.002","article-title":"Identification of immune responsible fibrinogen beta chain in the liver of large yellow croaker using a modified annealing control primer system","volume":"27","author":"Xie","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0130","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1097\/00001721-200004001-00018","article-title":"Measurement of the procoagulant activity of factor VII in patients with liver cirrhosis and normal prothrombin activity: evaluation of the bleeding risk","volume":"Suppl 1","author":"Manzano","year":"2000","journal-title":"Blood Coagul. Fibrin."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0135","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.clinbiochem.2011.09.008","article-title":"Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients","volume":"44","author":"Grattagliano","year":"2011","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0140","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0145","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jhep.2014.02.014","article-title":"A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease","volume":"60","author":"Nishikawa","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0150","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15216540601115960","article-title":"Triosephosphate isomerase deficiency: facts and doubts","volume":"58","author":"Orosz","year":"2006","journal-title":"IUBMB Life"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0155","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1002\/pmic.200500541","article-title":"Comparative proteomic studies on the pathogenesis of human ulcerative colitis","volume":"6","author":"Hsieh","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-230X-12-76","article-title":"Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profilein patients with ulcerative colitis","volume":"12","author":"Poulsen","year":"2012","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0165","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.4161\/cbt.7.12.7067","article-title":"Cancer cell killing via ROS: to increase or decrease, that is the question","volume":"7","author":"Wang","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0170","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.freeradbiomed.2013.07.011","article-title":"Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis","volume":"65","author":"Shearn","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1751-2980.2010.00422.x","article-title":"Dynamic expression of hepatic thioredoxin mRNA in rats with non-alcoholic fatty liver disease","volume":"11","author":"Duan","year":"2010","journal-title":"J. Digest. Dis."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jhep.2004.09.020","article-title":"Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice","volume":"42","author":"Okuyama","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/hep.23271","article-title":"Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease","volume":"51","author":"Bell","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-230X-10-79","article-title":"Mouse model of carbon tetrachloride-induced liver fibrosis: histopathological changes and expression of CD133 and epidermal growth factor","volume":"10","author":"Fujii","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0195","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/hep.20054","article-title":"PAR1 antagonism protects against experimental liver fibrosis: role of proteinase receptors in stellate cell activation","volume":"39","author":"Fiorucci","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0200","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1538-7836.2008.03015.x","article-title":"Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies","volume":"6","author":"Anstee","year":"2008","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.toxlet.2014.11.009_bib0205","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clinbiochem.2013.10.016","article-title":"The differential diagnostic model for serous peptidomics in HBV carriers established by MALDI-TOF-MS analysis","volume":"47","author":"Tian","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0210","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/jcp.29.11.971","article-title":"Factor VII as a marker of hepatocellular synthetic function in liver disease","volume":"29","author":"Green","year":"1976","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.toxlet.2014.11.009_bib0215","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MBC.0b013e32835975ed","article-title":"The coagulopathy of liver disease: does vitamin K help?","volume":"24","author":"Saja","year":"2013","journal-title":"Blood Coagul. Fibrin."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414014362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414014362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:14:24Z","timestamp":1759900464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414014362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0378427414014362"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.11.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}