{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:19:38Z","timestamp":1768792778202,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005393","name":"ARRS","doi-asserted-by":"publisher","award":["P1-0208"],"award-info":[{"award-number":["P1-0208"]}],"id":[{"id":"10.13039\/100005393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.toxlet.2014.12.013","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:07:58Z","timestamp":1419379678000},"page":"8-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics"],"prefix":"10.1016","volume":"233","author":[{"given":"Tijana","family":"Markovi\u010d","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Gobec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gurwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Mlinari\u010d-Ra\u0161\u010dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2014.12.013_bib0005","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3390\/ijerph10093834","article-title":"Optimal method to stimulate cytokine production and its use in immunotoxicity assessment","volume":"10","author":"Ai","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0010","first-page":"2214","article-title":"Verapamil inhibits B-cell proliferation and tumor necrosis factor release and induces a clinical response in B-cell chronic lymphocytic leukemia","volume":"8","author":"Berrebi","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2217\/pgs.13.213","article-title":"Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines","volume":"15","author":"Brown","year":"2014","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2006.09.003","article-title":"In vitro tests to evaluate immunotoxicity: a preliminary study","volume":"229","author":"Carfi","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2010.06.012","article-title":"Selective inhibition of B lymphocytes in TBTC-treated human bone marrow long-term culture","volume":"276","author":"Carfi","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0030","doi-asserted-by":"crossref","first-page":"e1000287","DOI":"10.1371\/journal.pgen.1000287","article-title":"Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines","volume":"4","author":"Choy","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.toxlet.2003.12.024","article-title":"Importance of immunotoxicity in safety assessment: a medical toxicologist\u2019s perspective","volume":"149","author":"Descotes","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0040","unstructured":"Eurepean Commission, 2006. Regulation (EC) of No 1907\/2006 of the European parliament and of the council 18 December 2006 concerning Registration, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemical Agency, amending Directive 1999\/45\/EC and repealing Council Regulation (EEC) No 793\/93 and Commission Regulation (EC) No 1488\/94 as well as Council Directive 76\/769\/EEC and Commission Directives 91\/155\/EEC, 93\/67\/EEC and 2002\/21\/EC."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0045","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1101\/gad.1688508","article-title":"Genomic predictors of interindividual differences in response to DNA damaging agents","volume":"22","author":"Fry","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/1547691X.2010.509848","article-title":"Present and future of in vitro immunotoxicology in drug development","volume":"7","author":"Galbiati","year":"2010","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0300-483X(03)00043-X","article-title":"Species differences in the structure and function of the immune system","volume":"188","author":"Haley","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.14573\/altex.2013.4.411","article-title":"Immunotoxicology: challenges in the 21st century and in vitro opportunities","volume":"30","author":"Hartung","year":"2013","journal-title":"ALTEX"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0065","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/TP.0b013e3181874a36","article-title":"Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin","volume":"86","author":"Heidt","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/meth.1999.0823","article-title":"Theory and practice of cytokine assessment in immunotoxicology","volume":"19","author":"House","year":"1999","journal-title":"Methods"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/1535-7163.MCT-06-0591","article-title":"Effect of population and gender on chemotherapeutic agent-induced cytotoxicity","volume":"6","author":"Huang","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0080","first-page":"75","article-title":"Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair","volume":"1","author":"Hussain","year":"2012","journal-title":"Int. J. Mol. Cell. Med."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/eji.1830160118","article-title":"Activation and proliferation signals in mouse B cells VIII. Induction of DNA synthesis in B cells by a combination of calcium ionophores and phorbol myristate acetate","volume":"16","author":"Klaus","year":"1986","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.fct.2008.10.025","article-title":"Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro","volume":"47","author":"Koeper","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0095","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.tiv.2010.07.007","article-title":"Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: implications for the prediction of general toxicity and immunotoxicity","volume":"24","author":"Kooijman","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0100","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1248\/bpb.b212017","article-title":"Molecular mechanisms of environmental organotin toxicity in mammals","volume":"35","author":"Kotake","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0887-2333(01)00028-5","article-title":"Whole blood cytokine response as a measure of immunotoxicity","volume":"15","author":"Langezaal","year":"2001","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1177\/026119290203000605","article-title":"Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release","volume":"30","author":"Langezaal","year":"2002","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0115","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/toxsci\/kfs023","article-title":"Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model","volume":"126","author":"Lock","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfp224","article-title":"Establishment of an immunoglobulin M antibody-forming cell response model for characterizing immunotoxicity in primary human B cells","volume":"112","author":"Lu","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2217\/pgs.10.27","article-title":"Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways","volume":"11","author":"Morag","year":"2010","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s12031-012-9852-z","article-title":"Sex differences in human lymphoblastoid cells sensitivities to antipsychotic drugs","volume":"49","author":"Morag","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0135","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/toxsci\/kfq322","article-title":"In vitro screening for population variability in chemical toxicity","volume":"119","author":"O\u2019Shea","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tox.2004.08.014","article-title":"Detection of immunotoxicity using T-cell based cytokine reporter cell lines (Cell Chip)","volume":"206","author":"Ringerike","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0145","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/jnr.22000","article-title":"Utility of lymphoblastoid cell lines","volume":"87","author":"Sie","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.toxlet.2014.12.013_bib0150","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.tiv.2010.11.021","article-title":"In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals","volume":"25","author":"Stolevik","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2014.12.013_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxlet.2005.10.017","article-title":"Fluorescent Cell Chip a new in vitro approach for immunotoxicity screening","volume":"162","author":"Wagner","year":"2006","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414015203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427414015203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T19:52:51Z","timestamp":1566157971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427414015203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0378427414015203"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.12.013","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2014.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}