{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:56:33Z","timestamp":1790078193155,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Program of the Presidium of Russian Academy of Sciences No. 1 \u201cNanostructures\u201d"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.toxlet.2015.11.018","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T17:55:11Z","timestamp":1448301311000},"page":"184-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects"],"prefix":"10.1016","volume":"241","author":[{"given":"Olga D.","family":"Hendrickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-9183","authenticated-orcid":false,"given":"Sergey G.","family":"Klochkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana V.","family":"Novikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Bravova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena F.","family":"Shevtsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina V.","family":"Safenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Zherdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey O.","family":"Bachurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris B.","family":"Dzantiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2015.11.018_bib0005","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/j.cca.2010.08.016","article-title":"Silver nanoparticle applications and human health","volume":"411","author":"Ahamed","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0010","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3109\/17435390.2013.815284","article-title":"Analytically monitored digestion of silver nanoparticles and their toxicity on human intestinal cells","volume":"8","author":"Bohmert","year":"2014","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0015","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2007.10.004","article-title":"Nanosilver: a nanoproduct in medical application","volume":"176","author":"Chen","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0020","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.fct.2013.07.071","article-title":"Dietary exposure to silver nanoparticles in Sprague-Dawley rats: effects on oxidative stress and inflammation","volume":"60","author":"Ebabe Elle","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0025","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.fct.2014.12.019","article-title":"Silver nanoparticles: their potential toxic effects after oral exposure and underlying mechanisms\u2014a review","volume":"77","author":"Gaillet","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0030","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yrtph.2013.11.002","article-title":"Oral toxicity of silver ions, silver nanoparticles and colloidal silver\u2014a review","volume":"68","author":"Hadrup","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0035","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00204-011-0759-1","article-title":"Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats","volume":"86","author":"Hadrup","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0040","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1080\/1536383X.2014.949695","article-title":"Study of distribution and biological effects of fullerene C60 after single and multiple intragastrical administrations to rats","volume":"23","author":"Hendrickson","year":"2014","journal-title":"Fuller. Nanotub. Carb. N"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0045","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/10408440903453074","article-title":"A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity","volume":"40","author":"Johnston","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0050","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/08958370701874663","article-title":"Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats","volume":"20","author":"Kim","year":"2008","journal-title":"Inhal. Toxicol."},{"issue":"20","key":"10.1016\/j.toxlet.2015.11.018_bib0055","article-title":"Subchronic oral toxicity of silver nanoparticles","volume":"7","author":"Kim","year":"2010","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0060","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3109\/17435390.2012.676099","article-title":"Genotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles","volume":"7","author":"Kim","year":"2013","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0065","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5487\/TR.2012.28.3.139","article-title":"A transfer of silver nanoparticles from pregnant rat to offspring","volume":"28","author":"Lee","year":"2012","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0070","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1743-8977-10-36","article-title":"Biopersistence of silver nanoparticles in tissues from Sprague\u2013Dawley rats","volume":"10","author":"Lee","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0075","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8977-8-18","article-title":"Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate","volume":"8","author":"Loeschner","year":"2011","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0080","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1292\/jvms.11-0038","article-title":"An evaluation of acute toxicity of colloidal silver nanoparticles","volume":"73","author":"Maneewattanapinyo","year":"2011","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0085","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jfda.2014.01.010","article-title":"Molecular toxicity mechanism of nanosilver","volume":"22","author":"McShan","year":"2013","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0090","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s10534-013-9645-z","article-title":"Antimicrobial silver: uses, toxicity and potential for resistance","volume":"26","author":"Mijnendonckx","year":"2013","journal-title":"Biometals"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0095","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nano.2013.06.010","article-title":"In vivo human time-exposure study of orally dosed commercial silver nanoparticles","volume":"10","author":"Munger","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0100","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.etap.2010.05.004","article-title":"Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles","volume":"30","author":"Park","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0105","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1080\/15287394.2013.849635","article-title":"Toxicokinetic differences and toxicities of silver nanoparticles and silver ions in rats after single oral administration","volume":"76","author":"Park","year":"2013","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2228-5326-2-32","article-title":"Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects","volume":"2","author":"Prabhu","year":"2012","journal-title":"Int. Nano Letters"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0115","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.3390\/ma6062295","article-title":"Mechanisms of silver nanoparticle release, transformation and toxicity: a critical review of current knowledge and recommendations for future studies and applications","volume":"6","author":"Reidy","year":"2013","journal-title":"Materials"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0120","doi-asserted-by":"publisher","first-page":"A220","DOI":"10.1289\/ehp.121-a220","article-title":"Nanosilver: weighing the risks and benefits","volume":"121","author":"Seltenrich","year":"2013","journal-title":"Environ. Health Perspect"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0125","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1021\/nn302649p","article-title":"Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure","volume":"6","author":"van der Zande","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0130","first-page":"81","article-title":"The biological effects and possible modes of action of nanosilver","volume":"223","author":"Volker","year":"2013","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0135","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.drudis.2014.11.014","article-title":"Silver nanoparticles: synthesis, properties, and therapeutic applications","volume":"20","author":"Wei","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0140","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1080\/17435390902725914","article-title":"Nano-silver\u2014a review of available data and knowledge gaps in human and environmental risk assessment","volume":"3","author":"Wijnhoven","year":"2009","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-94-017-8739-0_1","article-title":"Presence in, and release of, nanomaterials from consumer products","volume":"811","author":"Yang","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0150","doi-asserted-by":"publisher","first-page":"9193","DOI":"10.1007\/s11033-012-1792-8","article-title":"The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity","volume":"39","author":"You","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.toxlet.2015.11.018_bib0155","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3109\/17435390.2013.857734","article-title":"Effects of silver nanoparticles on pregnant dams and embryo\u2013fetal development in rats","volume":"8","author":"Yu","year":"2014","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.toxlet.2015.11.018_bib0160","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1002\/adma.201001811","article-title":"A new transparent conductor: silver nanowire film buried at the surface of a transparent polymer","volume":"22","author":"Zeng","year":"2010","journal-title":"Adv. Mater."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427415301132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427415301132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T09:28:29Z","timestamp":1537176509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427415301132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":32,"alternative-id":["S0378427415301132"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2015.11.018","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2015.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}