{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:24:48Z","timestamp":1772184288562,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.toxlet.2015.11.020","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T07:01:59Z","timestamp":1448348519000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan ( Oxyuranus scutellatus ) by F(ab\u2032) 2 and whole IgG antivenoms"],"prefix":"10.1016","volume":"241","author":[{"given":"Mar\u00eda","family":"Herrera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-1603","authenticated-orcid":false,"given":"Rita","family":"de C\u00e1ssia de O. Colla\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauren","family":"Villalta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e1ngela","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-040X","authenticated-orcid":false,"given":"Christine E.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen K.","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teatulohi","family":"Matainaho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon D.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-4632","authenticated-orcid":false,"given":"David J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Rodrigues-Simioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2015.11.020_bib0005","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0041-0101(95)00126-3","article-title":"Antibody-mediated neutralization and binding-reversal studies on alpha-neurotoxins from Micrurus nigrocinctus nigrocinctus (coral snake) venom","volume":"34","author":"Alape-Gir\u00f3n","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0010","first-page":"38","article-title":"Observations on the isolated phrenic nerve diaphragm preparation of the rat","volume":"1","author":"B\u00fclbring","year":"1946","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0015","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.toxlet.2012.02.001","article-title":"Solving the \u2018Brown snake paradox\u2019: in vitro characterisation of Australasian snake presynaptic neurotoxin activity","volume":"210","author":"Barber","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0020","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1126\/science.7100919","article-title":"Neurotoxin-specific immunoglobulins accelerate dissociation of the neurotoxin-acetylcholine receptor complex","volume":"217","author":"Boulain","year":"1982","journal-title":"Sience"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0025","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/0041-0101(79)90245-9","article-title":"The lethality in mice of dangerous Australian and other snake venom","volume":"17","author":"Broad","year":"1979","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0030","doi-asserted-by":"crossref","first-page":"735","DOI":"10.5694\/j.1326-5377.1967.tb21596.x","article-title":"The Taipan (Oxyuranus scutellatus) and the effect of its bite","volume":"1","author":"Campbell","year":"1967","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0035","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0041-0101(99)00118-X","article-title":"The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni","volume":"37","author":"Crachi","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0040","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/S0041-0101(99)00114-2","article-title":"A pharmacological examination of venom from the Papuan taipan (Oxyuranus scutellatus canni)","volume":"37","author":"Crachi","year":"1999","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0045","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1016\/0306-4522(76)90074-9","article-title":"The effects of Taipoxin and Notexin on the function and fine structure of the murine neuromuscular junction","volume":"1","author":"Cull-Candy","year":"1976","journal-title":"Neuroscience"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0050","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.toxicon.2013.04.016","article-title":"The effect of temperature on the effects of the phospholipase A2 neurotoxins \u03b2-bungarotoxin and taipoxin at the neuromuscular junction","volume":"70","author":"Fathi","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0055","series-title":"Probit Analysis","author":"Finney","year":"1971"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0060","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1432-1033.1976.tb10833.x","article-title":"Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the Australian snake taipan (Oxyuranus s. scutellatus)","volume":"68","author":"Fohlman","year":"1976","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0065","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1432-1033.1988.tb13822.x","article-title":"Reversal of snake neurotoxin binding to mammalian acetylcholine receptor by specific antiserum","volume":"171","author":"Gatineau","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0070","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/0041-0101(94)00178-B","article-title":"The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom","volume":"5","author":"Goularte","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0075","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2165\/00003088-200342080-00002","article-title":"Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation","volume":"42","author":"Guti\u00e9rrez","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0080","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1006\/exnr.1999.7275","article-title":"Neurotoxicity of the venom phospholipases A2 notexin and taipoxin","volume":"161","author":"Harris","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0085","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.jprot.2012.01.006","article-title":"Comparative proteomic analysis of the venom of the snake taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity","volume":"75","author":"Herrera","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0090","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.neuropharm.2007.01.002","article-title":"The neuromuscular activity of paradoxin: a presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)","volume":"52","author":"Hodgson","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0095","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/sj.bjp.0702286","article-title":"The effects of specific antibody fragments on the \u2018irreversible' neurotoxicity induced by Brown snake (Pseudonaja) venom","volume":"126","author":"Jones","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0100","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.neuro.2009.12.009","article-title":"Variations in the pharmacological profile of post-synaptic neurotoxins isolated from the venoms of the Papuan (Oxyuranus scutellatus canni) and coastal (Oxyuranus scutellatus scutellatus) taipans","volume":"31","author":"Kornhauser","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0105","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1124\/jpet.105.093641","article-title":"Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni)","volume":"315","author":"Kuruppu","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0110","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4269\/ajtmh.1995.52.525","article-title":"Snakebites by the Papuan taipan (Oxyuranus scutellatus canni): paralysis, hemostatic and electrocardiographic abnormalities, and effects of antivenom","volume":"52","author":"Lalloo","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0115","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/00001721-199502000-00011","article-title":"Coagulopathy following bites by the Papuan taipan (Oxyuranus scutellatus canni)","volume":"6","author":"Lalloo","year":"1995","journal-title":"Blood Coagul Fibrinol."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0120","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0035-9203(97)90394-1","article-title":"Electrocardiographic abnormalities in patients bitten by taipans (Oxyuranus scutellatus canni) and other elapid snakes in Papua New Guinea","volume":"91","author":"Lalloo","year":"1997","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0125","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1016\/S0021-9258(18)60492-2","article-title":"Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom","volume":"264","author":"Lambeau","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0130","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.expneurol.2009.07.017","article-title":"Ultrastructural evidence for the uptake of a neurotoxic snake venom phospholipase A2 into mammalian motor nerve terminals","volume":"219","author":"Logonder","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0135","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/S0968-0004(00)01556-5","article-title":"How do presynaptic PLA2 neurotoxins block nerve terminals?","volume":"25","author":"Montecucco","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0140","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1007\/s00018-008-8113-3","article-title":"Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action","volume":"65","author":"Montecucco","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0145","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/j.1471-4159.2009.06365.x","article-title":"Mass spectrometry analysis of the phospholipase A2 activity of snake pre-synaptic neurotoxins in cultured neurons","volume":"111","author":"Paoli","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0150","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.neuropharm.2004.04.012","article-title":"\u03b2-Bungarotoxin-induced depletion of synaptic vesicles at the mammalian neuromuscular junction","volume":"47","author":"Prasarnpun","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0155","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1126\/science.1120640","article-title":"Equivalent effects of snake PLA2 neurotoxins and lysophospholipids-fatty acid mixtures","volume":"310","author":"Rigoni","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0160","doi-asserted-by":"publisher","first-page":"11238","DOI":"10.1074\/jbc.M610176200","article-title":"Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products","volume":"282","author":"Rigoni","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0165","doi-asserted-by":"publisher","first-page":"34013","DOI":"10.1074\/jbc.M803243200","article-title":"Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores","volume":"283","author":"Rigoni","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0170","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0041-0101(93)90352-J","article-title":"Identification of the site at which phospholipase A2 neurotoxins localize to produce their neuromuscular blocking effects","volume":"31","author":"Simpson","year":"1993","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0175","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/0041-0101(84)90003-5","article-title":"Presynaptic effects of snake venom toxins which have phospholipase A2 activity (\u03b2-bungarotoxin, taipoxin, crotoxin)","volume":"22","author":"Su","year":"1984","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0180","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.toxicon.2014.06.019","article-title":"Understanding the molecular mechanism underlying the presynaptic toxicity of secreted phospholipases A2: an update","volume":"89","author":"\u0160ribar","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0185","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/0167-4838(87)90302-5","article-title":"Studies on the subunit structure of textilotoxin, a potent neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis)","volume":"915","author":"Tyler","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0190","doi-asserted-by":"publisher","first-page":"e1144","DOI":"10.1371\/journal.pntd.0001144","article-title":"Preclinical evaluation of a caprylic acid-fractionated whole IgG antivenom for the treatment of Papuan taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea and Indonesian Papua","volume":"5","author":"Vargas","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.toxlet.2015.11.020_bib0195","series-title":"Handbook of Clinical Toxicology of Animal Venoms and Poisons","first-page":"595","article-title":"Clinical toxicology of snakebite in Australia and New Guinea","author":"White","year":"1995"},{"key":"10.1016\/j.toxlet.2015.11.020_bib0200","series-title":"Venomous Bites and Stings in Papua New Guinea: a Treatment Guide for Health Workers and Doctors","first-page":"5","article-title":"Snakebite in Papua New Guinea","author":"Williams","year":"2005"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427415301168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427415301168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T23:26:50Z","timestamp":1653607610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427415301168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":40,"alternative-id":["S0378427415301168"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2015.11.020","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab\u2032)2 and whole IgG antivenoms","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2015.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}