{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:23:13Z","timestamp":1791566593320,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CDTI and Technological Funds"},{"DOI":"10.13039\/501100001872","name":"CDTI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.toxlet.2016.04.001","type":"journal-article","created":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T18:15:25Z","timestamp":1459707325000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Cytotoxicity of goniodomin A and B in non contractile cells"],"prefix":"10.1016","volume":"250-251","author":[{"given":"Bego\u00f1a","family":"Espi\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Cagide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Louzao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Vilari\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes R.","family":"Vieytes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Botana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2016.04.001_bib0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/jcp.10040","article-title":"Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells","volume":"190","author":"Abe","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0010","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1074\/jbc.275.7.5163","article-title":"Effects of Jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations","volume":"275","author":"Bubb","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000099206","article-title":"Effects of a synthetic analog of polycavernoside A on human neuroblastoma cells","volume":"19","author":"Cagide","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0020","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1111\/j.1742-4658.2008.06714.x","article-title":"Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin","volume":"275","author":"Espi\u00f1a","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0025","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/bjp.2008.323","article-title":"Cytoskeletal toxicity of pectenotoxins in hepatic cells","volume":"155","author":"Espi\u00f1a","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0030","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1021\/tx9002337","article-title":"Impact of the pectenotoxin C-43 oxidation degree on its cytotoxic effect on rat hepatocytes","volume":"23","author":"Espi\u00f1a","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1476-5381.2009.00512.x","article-title":"The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes","volume":"159","author":"Espi\u00f1a","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1246\/bcsj.80.1173","article-title":"Synthesis and relative stereochemistry of the A- and F-rings of goniodomin a","author":"Fujiwara","year":"2007","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0045","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1246\/bcsj.80.1173","article-title":"Synthesis of and relative stereochemistry of the A- & and F-ring goniodomin","volume":"80","author":"Fujiwara","year":"2007","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0050","doi-asserted-by":"crossref","first-page":"26026","DOI":"10.1016\/S0021-9258(19)74488-3","article-title":"Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational change of actin","volume":"268","author":"Furukawa","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0055","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1021\/ol1031409","article-title":"A convergent synthesis of the C1-C16 segment of goniodomin A via palladium-catalyzed organostannane-thioester coupling","volume":"13","author":"Fuwa","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0060","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1021\/acs.joc.5b02650","article-title":"Progress toward the total synthesis of goniodomin A: stereocontrolled convergent synthesis of the C12-C36 fragment","volume":"81","author":"Fuwa","year":"2016","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2983\/035.028.0219","article-title":"Mortality of the veined rapa whelk, Rapana venosa, in relation to a bloom of Alexandrium monilatum in the York river, United States","volume":"28","author":"Harding","year":"2009","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.hal.2005.08.004","article-title":"Production of goniodomin A by the planktonic, chain-forming dinoflagellate Alexandrium monilatum (Howell) Balech isolated from the Gulf Coast of the United States","volume":"5","author":"Hsia","year":"2006","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0955-0674(98)80095-1","article-title":"Microtubules and actin filaments: dynamic targets for cancer chemotherapy","volume":"10","author":"Jordan","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0080","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tetlet.2007.11.084","article-title":"Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry","volume":"49","author":"Katagiri","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0085","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1016\/j.tetlet.2008.03.082","article-title":"Synthesis of the ABC-ring models of goniodomin A: preference for the unnatural configuration at C11 of the BC-ring in a non-macrocyclic model system","volume":"49","author":"Katagiri","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0090","first-page":"1","article-title":"Biological synopsis of phytoplankton new to the Bay of Fundy. II","volume":"2919","author":"Klein","year":"2010","journal-title":"Can. Manuscr. Rep. Fish. Aquat. Sci."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0095","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ydbio.2008.05.549","article-title":"Actin cytoskeleton modulates calcium signaling during maturation of starfish oocytes","volume":"320","author":"Kyozuka","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0100","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000094138","article-title":"The sodium channel of human excitable cells is a target for gambierol","volume":"17","author":"Louzao","year":"2006","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0105","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/tx050316q","article-title":"Changes in membrane potential: an early signal triggered by neurologically active phycotoxins","volume":"19","author":"Louzao","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0110","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0022-3565(24)35217-6","article-title":"Powerful activation of skeletal muscle actomyosin ATPase by goniodomin A is highly sensitive to troponin\/tropomyosin complex","volume":"291","author":"Matsunaga","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.hal.2009.11.005","article-title":"Effects of the toxic dinoflagellate Alexandrium monilatum on survival, grazing and behavioral response of three ecologically important bivalve molluscs","volume":"9","author":"May","year":"2010","journal-title":"Harmful Algae"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0120","doi-asserted-by":"crossref","first-page":"F1113","DOI":"10.1152\/ajprenal.00195.2006","article-title":"Interaction of epithelial ion channels with the actin-based cytoskeleton","volume":"291","author":"Mazzochi","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0125","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.2042-7158.1998.tb06899.x","article-title":"Goniodomin A, an antifungal polyether macrolide, increases the filamentous actin content of 1321N1 human astrocytoma cells","volume":"50","author":"Mizuno","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/ecss.2001.0767","article-title":"Phytoplankton blooms in black sea and mediterranean coastal ecosystems subjected to anthropogenic eutrophication: similarities and differences","volume":"53","author":"Moncheva","year":"2001","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0135","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0040-4039(00)86674-5","article-title":"Goniodomin a, a novel polyether macrolide from the dinoflagellate goniodoma pseudogoniaulax","volume":"29","author":"Murakami","year":"1988","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0031-9422(97)00756-5","article-title":"From the dinoflagellate Alexandrium hiranoi","volume":"48","author":"Murakami","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0145","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1246\/bcsj.20120152","article-title":"Stereoselective synthesis of the C1-C16 fragment of goniodomin A","volume":"85","author":"Nakajima","year":"2012","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0531-5565(87)90038-6","article-title":"Comparison of major cytoskeletons among normal human fibroblasts, immortal human fibroblasts transformed by exposure to Co-60 gamma rays, and the latter cells made tumorigenic by treatment with harvey murine sarcoma virus","volume":"22","author":"Namba","year":"1987","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0155","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/b700307m","article-title":"Synthesis of macrocyclic shellfish toxins containing spiroimine moieties","volume":"24","author":"O\u2019Connor","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0160","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1254\/jjp.73.263","article-title":"Application of physiologically active substances isolated from natural resources to pharmacological studies","volume":"73","author":"Ohizumi","year":"1997","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0165","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1021\/ol902217q","article-title":"Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: convergent synthesis of the C15-C36 segment","volume":"11","author":"Saito","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0170","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tet.2010.11.017","article-title":"Synthetic studies on goniodomin A: convergent assembly of the C15-C36 segment via palladium-catalyzed organostannane-thioester coupling","volume":"67","author":"Saito","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0175","doi-asserted-by":"crossref","first-page":"659","DOI":"10.7164\/antibiotics.21.659","article-title":"Goniodomin, a new antibiotic from a dinoflagellate","volume":"21","author":"Sharma","year":"1968","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0180","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0006-2952(96)00389-9","article-title":"Altered actin polymerization dynamics in various malignant cell types: evidence for differential sensitivity to cytochalasin B","volume":"52","author":"Stournaras","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0185","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1021\/ol8000377","article-title":"Assignment of the absolute configuration of goniodomin A by NMR spectroscopy and synthesis of model compounds","volume":"10","author":"Takeda","year":"2008","journal-title":"Org. Lett."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0190","series-title":"Stereochemical Assignment of Goniodomin A, an Actin-targeting Polyether Macrolide","author":"Takeda","year":"2008"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0195","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0041-0101(89)90141-4","article-title":"Histopathological studies on experimental marine toxin poisoning\u2014III Morphological changes in the liver and thymus of male ICR mice induced by goniodomin A, isolated from the dinoflagellate Goniodoma pseudogoniaulax","volume":"27","author":"Terao","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2016.04.001_bib0200","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.marpolbul.2014.05.014","article-title":"Distribution of resting cysts of the potentially toxic dinoflagellate Alexandrium pseudogonyaulax in recently-deposited sediment within Bizerte Lagoon (Mediterranean coast Tunisia)","volume":"84","author":"Triki","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jcbfm.2012.144","article-title":"The role of actin filament dynamics in the myogenic response of cerebral resistance arteries","volume":"33","author":"Walsh","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0210","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1046\/j.1471-4159.2002.01059.x","article-title":"Endoplasmic reticulum calcium release is modulated by actin polymerization","volume":"82","author":"Wang","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-2999(98)00164-2","article-title":"Modulation of actomyosin ATPase by goniodomin A differs in types of cardiac myosin","volume":"346","author":"Yasuda","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.001_bib0220","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxicon.2015.12.018","article-title":"First report of goniodomin A production by the dinoflagellate Alexandrium pseudogonyaulax developing in southern Mediterranean (Bizerte Lagoon Tunisia)","volume":"111","author":"Zmerli Triki","year":"2016","journal-title":"Toxicon"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427416300522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427416300522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:06:46Z","timestamp":1748833606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427416300522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":44,"alternative-id":["S0378427416300522"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2016.04.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxicity of goniodomin A and B in non contractile cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2016.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}