{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:03:35Z","timestamp":1789790615880,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Saud University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.toxlet.2016.04.011","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T16:47:08Z","timestamp":1460479628000},"page":"50-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress"],"prefix":"10.1016","volume":"252","author":[{"given":"Hesham M.","family":"Korashy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibraheem M.","family":"Attafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Assiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamah M.","family":"Belali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheik F.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"AL-Alallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz E.Al","family":"Anazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulqader A.","family":"Alhaider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2016.04.011_bib0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cbi.2011.03.014","article-title":"Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression","volume":"192","author":"Alhaider","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0010","doi-asserted-by":"crossref","first-page":"795602","DOI":"10.1155\/2015\/795602","article-title":"Chemotherapy-Induced cardiotoxicity: overview of the roles of oxidative stress","volume":"2015","author":"Angsutararux","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tox.2013.01.024","article-title":"The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model","volume":"306","author":"Ansari","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0020","first-page":"1789","article-title":"Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis","volume":"60","author":"Arola","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0025","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.biocel.2008.02.020","article-title":"Molecular regulation of cardiac hypertrophy","volume":"40","author":"Barry","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0030","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/clinchem\/24.5.828","article-title":"Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 degrees C","volume":"24","author":"Buhl","year":"1978","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/abbi.1999.1558","article-title":"Hydrogen peroxide dose dependent induction of cell death or hypertrophy in cardiomyocytes","volume":"373","author":"Chen","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0008-6363(99)00212-6","article-title":"The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions","volume":"44","author":"Cleutjens","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0045","unstructured":"FDA, 2005. label for Iressa (gefitinib)."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0050","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/01.RES.0000022879.57270.11","article-title":"Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments","volume":"90","author":"Herron","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0055","first-page":"4401","article-title":"Voluntary wheel running in rats receiving doxorubicin: effects on running activity and cardiac myosin heavy chain","volume":"29","author":"Hydock","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbrc.2007.05.027","article-title":"Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity","volume":"359","author":"Ichihara","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.carpath.2006.01.001","article-title":"Serum biomarkers for heart failure","volume":"15","author":"Jarolim","year":"2006","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0009-8981(78)90240-1","article-title":"An investigation into creatine kinase and other plasma enzymes in thyroid disorders","volume":"85","author":"Jenkins","year":"1978","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/978-1-4614-6176-0_18","article-title":"Small-cell lung cancer: an update on targeted therapies","volume":"779","author":"Joshi","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0014-4827(76)90447-X","article-title":"Properties of a clonal muscle cell line from rat heart","volume":"98","author":"Kimes","year":"1976","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tox.2004.04.011","article-title":"Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells","volume":"201","author":"Korashy","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tiv.2007.08.003","article-title":"Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line","volume":"22","author":"Korashy","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0095","doi-asserted-by":"crossref","first-page":"593195","DOI":"10.1155\/2012\/593195","article-title":"Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism","volume":"2012","author":"Korashy","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12012-014-9266-y","article-title":"Mitogen-activated protein kinases pathways mediate the sunitinib-induced hypertrophy in rat cardiomyocyte H9c2 cells","volume":"15","author":"Korashy","year":"2015","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4143\/crt.2008.40.3.121","article-title":"Clinical correlation between brain natriutetic peptide and anthracyclin-induced cardiac toxicity","volume":"40","author":"Lee","year":"2008","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0115","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJMoa012630","article-title":"Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents","volume":"346","author":"Lowes","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0120","first-page":"3","article-title":"Targeted therapies in small cell lung cancer","volume":"5","author":"Lu","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s11239-010-0539-4","article-title":"Recurrent myocardial infarction associated with gefitinib therapy","volume":"32","author":"Lynch","year":"2011","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0130","first-page":"725","article-title":"Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway","volume":"88","author":"Maayah","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0135","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s10495-007-0129-x","article-title":"Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of human myeloid leukemia HL-60 cells by a dietary compound withaferin A with concomitant protection by N-acetyl cysteine","volume":"12","author":"Malik","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0140","first-page":"239","article-title":"Gefitinib","volume":"39","author":"Rahman","year":"2014"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0145","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1124\/jpet.111.185892","article-title":"Oxidative stress and myocardial gene alterations associated with Doxorubicin-induced cardiotoxicity in rats persist for 2 months after treatment cessation","volume":"339","author":"Richard","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0150","series-title":"Molecular Cloning. A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0155","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.niox.2005.09.009","article-title":"A novel lignan composition from Cedrus deodara induces apoptosis and early nitric oxide generation in human leukemia Molt-4 and HL-60 cells","volume":"14","author":"Shashi","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.toxlet.2016.04.011_bib0160","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.5858\/2005-129-1044-MTRTTU","article-title":"Myocarditis temporally related to the use of gefitinib (Iressa)","volume":"129","author":"Truell","year":"2005","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0165","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro","volume":"47","author":"Watkins","year":"2011","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0170","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/clinchem\/28.10.2017","article-title":"Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals","volume":"28","author":"Wu","year":"1982","journal-title":"Clin. Chem."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vph.2008.07.004","article-title":"Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells","volume":"49","author":"Zordoky","year":"2008","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.toxlet.2016.04.011_bib0180","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1124\/dmd.108.023077","article-title":"Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats","volume":"36","author":"Zordoky","year":"2008","journal-title":"Drug Metab. Dispos."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427416300625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427416300625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T17:58:34Z","timestamp":1655488714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427416300625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":36,"alternative-id":["S0378427416300625"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2016.04.011","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2016.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}