{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:19:57Z","timestamp":1782933597430,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.toxlet.2017.06.001","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T13:00:54Z","timestamp":1498482054000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["A comparative assessment of e-cigarette aerosols and cigarette smoke on in vitro endothelial cell migration"],"prefix":"10.1016","volume":"277","author":[{"given":"Mark","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Jaunky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Breheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frazer","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Gaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2017.06.001_bib0005","article-title":"A review of in vitro cigarette smoke exposure systems","volume":"65","author":"Adamson","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"issue":"May(10)","key":"10.1016\/j.toxlet.2017.06.001_bib0010","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking and cardiovascular disease: an update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"July(6)","key":"10.1016\/j.toxlet.2017.06.001_bib0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/15376516.2016.1217112","article-title":"Electronic cigarette aerosol induces significantly less cytotoxicity than tobacco smoke","volume":"26","author":"Azzopardi","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"issue":"June(6)","key":"10.1016\/j.toxlet.2017.06.001_bib0020","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1371\/journal.pmed.0020160","article-title":"Smoking Cessation and Cardiovascular Disease Risk Factors: Results from the Third National Health and Nutrition Examination Survey","volume":"2","author":"Bakhru","year":"2005","journal-title":"PLoS Med."},{"issue":"October(11)","key":"10.1016\/j.toxlet.2017.06.001_bib0025","doi-asserted-by":"crossref","first-page":"11192","DOI":"10.3390\/ijerph111111192","article-title":"Carbonyl compounds generated from electronic cigarettes","volume":"11","author":"Bekki","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"December(15)","key":"10.1016\/j.toxlet.2017.06.001_bib0030","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1096\/fj.03-0312fje","article-title":"Disruption of vascular endothelial homeostasis by tobacco smoke: impact on atherosclerosis","volume":"17","author":"Bernhard","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0035","series-title":"Hypertension: Pathophysiology, Diagnosis and Management","first-page":"2621","article-title":"Smoking and cardiovascular disease","author":"Black","year":"1995"},{"issue":"Suppl 2","key":"10.1016\/j.toxlet.2017.06.001_bib0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/tobaccocontrol-2013-051470","article-title":"Electronic cigarettes: human health effects","volume":"23","author":"Callahan-Lyon","year":"2014","journal-title":"Tob. Control"},{"issue":"Suppl 2","key":"10.1016\/j.toxlet.2017.06.001_bib0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/tobaccocontrol-2013-051482","article-title":"Chemical evaluation of e-cigarettes","volume":"23","author":"Cheng","year":"2014","journal-title":"Tob. Control"},{"issue":"April(4)","key":"10.1016\/j.toxlet.2017.06.001_bib0050","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.3390\/ijerph110404356","article-title":"Characteristics, perceived side-effects and benefits of electronic cigarette use: a worldwide survey of more than 19,000 consumers","volume":"11","author":"Farsalinos","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"August(8)","key":"10.1016\/j.toxlet.2017.06.001_bib0055","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/add.12942","article-title":"E-cigarettes generate high levels of aldehydes only in \u2018dry puff\u2019 conditions","volume":"110","author":"Farsalinos","year":"2015","journal-title":"Addiction"},{"issue":"Suppl 1","key":"10.1016\/j.toxlet.2017.06.001_bib0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/13547500902965047","article-title":"The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke","volume":"14","author":"Faux","year":"2009","journal-title":"Biomarkers"},{"issue":"November\u2013December(6)","key":"10.1016\/j.toxlet.2017.06.001_bib0065","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/1091581812461810","article-title":"Modification of smoke toxicant yields alters the effects of cigarette smoke extracts on endothelial migration: an in vitro study using a cardiovascular disease model","volume":"31","author":"Fearon","year":"2012","journal-title":"Int. J. Toxicol."},{"issue":"February(1)","key":"10.1016\/j.toxlet.2017.06.001_bib0070","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tiv.2012.08.018","article-title":"In vitro models for assessing the potential cardiovascular disease risk associated with cigarette smoking","volume":"27","author":"Fearon","year":"2013","journal-title":"Toxicol. In Vitro"},{"issue":"2","key":"10.1016\/j.toxlet.2017.06.001_bib0075","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/tobaccocontrol-2012-050859","article-title":"Levels of selected carcinogens and toxicants in vapour from electronic cigarettes","volume":"23","author":"Goniewicz","year":"2014","journal-title":"Tob. Control"},{"issue":"November(11)","key":"10.1016\/j.toxlet.2017.06.001_bib0080","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/add.12659","article-title":"Electronic cigarettes: review of use, content, safety, effects on smokers and potential for harm and benefit","volume":"109","author":"Hajek","year":"2014","journal-title":"Addiction"},{"key":"10.1016\/j.toxlet.2017.06.001_bib0085","series-title":"Tobacco and Tobacco Products \u2013 Atmosphere for Conditioning and Testing","author":"International Organization for Standardization. ISO 3402","year":"1999"},{"issue":"January(4)","key":"10.1016\/j.toxlet.2017.06.001_bib0090","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1056\/NEJMc1413069","article-title":"Hidden formaldehyde in e-cigarette aerosols","volume":"372","author":"Jensen","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","article-title":"Oxidative stress and apoptosis. Oxidative stress and apoptosis","volume":"7","author":"Kannan","year":"2016","journal-title":"Pathophysiology"},{"issue":"October(10)","key":"10.1016\/j.toxlet.2017.06.001_bib0100","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/ntr\/ntu078","article-title":"Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage","volume":"16","author":"Kosmider","year":"2014","journal-title":"Nicotine Tob. Res."},{"issue":"2","key":"10.1016\/j.toxlet.2017.06.001_bib0105","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"issue":"March(2)","key":"10.1016\/j.toxlet.2017.06.001_bib0110","first-page":"108","article-title":"A double-edged sword in atherosclerotic disease","volume":"30","author":"Liu","year":"2014","journal-title":"Acta Cardiol. Sin."},{"issue":"October(10)","key":"10.1016\/j.toxlet.2017.06.001_bib0115","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.chemrestox.6b00188","article-title":"Chemical composition of an e-cigarette aerosol: a quantitative comparison with cigarette smoke","volume":"29","author":"Margham","year":"2016","journal-title":"Chem. Res. Toxicol."},{"issue":"August(5)","key":"10.1016\/j.toxlet.2017.06.001_bib0120","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.tiv.2015.03.008","article-title":"Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models","volume":"29","author":"McQuillan","year":"2015","journal-title":"Toxicol. In Vitro"},{"issue":"September(9)","key":"10.1016\/j.toxlet.2017.06.001_bib0125","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/1940-6207.CAPR-15-0058","article-title":"Effects of switching to electronic cigarettes with and without concurrent smoking on exposure to nicotine, carbon monoxide, and acrolein","volume":"8","author":"McRobbie","year":"2015","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"March(3)","key":"10.1016\/j.toxlet.2017.06.001_bib0130","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.toxlet.2017.06.001_bib0135","doi-asserted-by":"crossref","first-page":"e424","DOI":"10.1038\/cddis.2012.162","article-title":"Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death","volume":"3","author":"Messner","year":"2012","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0140","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1161\/01.CIR.99.11.1411","article-title":"Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction","volume":"99","author":"Newby","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.toxlet.2017.06.001_bib0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000360220","article-title":"Estimating the harms of nicotine-containing products using the MCDA approach","volume":"20","author":"Nutt","year":"2014","journal-title":"Eur. Addict. Res."},{"issue":"1","key":"10.1016\/j.toxlet.2017.06.001_bib0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.vph.2008.05.001","article-title":"Effect of nicotine on human umbilical vein endothelial cells (HUVECs) migration and angiogenesis","volume":"49","author":"Park","year":"2008","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0155","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/tobaccocontrol-2013-051122","article-title":"Electronic nicotine delivery system (electronic cigarette) awareness, use, reactions and beliefs: a systematic review","volume":"23","author":"Pepper","year":"2014","journal-title":"Tob. Control"},{"issue":"Suppl 4","key":"10.1016\/j.toxlet.2017.06.001_bib0160","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1289\/ehp.97105s4875","article-title":"Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity","volume":"105","author":"Pryor","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0165","unstructured":"Public Health England, E-cigarettes: an evidence update: a report commissioned by Public Health England, 2017; Available from: https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/457102\/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England_FINAL.pdf."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0170","series-title":"The Chemical Components of Tobacco and Tobacco Smoke","author":"Rodgman","year":"2013"},{"key":"10.1016\/j.toxlet.2017.06.001_bib0175","series-title":"Nicotine Without Smoke, Tobacco Harm Reduction, a Report by the Tobacco Advisory Group of the Royal College of Physicians","author":"Royal College of Physicians","year":"2017"},{"issue":"March(1)","key":"10.1016\/j.toxlet.2017.06.001_bib0180","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/jsre.2000.6055","article-title":"Inhibition of endothelial cell migration by cigarette smoke condensate","volume":"96","author":"Snajdar","year":"2001","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.toxlet.2017.06.001_bib0185","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/toxsci\/kfh210","article-title":"Effect of aqueous tobacco smoke extract and shear stress on PECAM-1 expression and cell motility in human uterine endothelial cells","volume":"81","author":"Soghomonians","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"July(6)","key":"10.1016\/j.toxlet.2017.06.001_bib0190","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/15376516.2016.1222473","article-title":"Oluwatobiloba Oke, et al. E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke","volume":"26","author":"Taylor","year":"2016","journal-title":"Toxicol Mech Methods."},{"key":"10.1016\/j.toxlet.2017.06.001_bib0195","series-title":"Cardiovascular Diseases. Information Bulletin","author":"World Health Organization","year":"2015"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417302266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417302266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T07:53:53Z","timestamp":1535702033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427417302266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":39,"alternative-id":["S0378427417302266"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.06.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative assessment of e-cigarette aerosols and cigarette smoke on in vitro endothelial cell migration","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}