{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:05:12Z","timestamp":1778670312522,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico \u2212 CNPq","award":["203440\/2014-5"],"award-info":[{"award-number":["203440\/2014-5"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad \u2212 MINECO","award":["AGL2012-32387"],"award-info":[{"award-number":["AGL2012-32387"]}]},{"name":"CSIC \u2212 Intramural","award":["201570I028"],"award-info":[{"award-number":["201570I028"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.toxlet.2017.10.001","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T13:01:01Z","timestamp":1507726861000},"page":"158-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase"],"prefix":"10.1016","volume":"281","author":[{"given":"Danize Aparecida","family":"Rizzetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Corrales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maylla Ronacher","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck Maciel","family":"Pe\u00e7anha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalton Valentim","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Alessandra","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2017.10.001_bib0005","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.fct.2015.10.013","article-title":"Changes in tissue oxidative stress, brain biogenic amines and acetylcholinesterase following co-exposure to lead, arsenic and mercury in rats","volume":"86","author":"Agrawal","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0010","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.taap.2013.01.030","article-title":"Mercury induces proliferation and reduces cell size in vascular smooth muscle cells through MAPK, oxidative stress and cyclooxygenase-2 pathways","volume":"268","author":"Aguado","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/0886022X.2016.1138832","article-title":"Inhalation of mercury vapor can cause the toxic effects on rat kidney","volume":"38","author":"Akgul","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0020","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/CS20110072","article-title":"Chronic HgCl(2) treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation","volume":"121","author":"Blanco-Rivero","year":"2011","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1475-2891-9-52","article-title":"IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial","volume":"9","author":"Boelsma","year":"2010","journal-title":"Nutr. J."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.HYP.0000174602.59935.d5","article-title":"Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive rats","volume":"46","author":"Bolterman","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0035","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.3390\/nu7075252","article-title":"Peptides-Derived from thai rice bran improves endothelial function in 2K-1C Renovascular hypertensive rats","volume":"7","author":"Boonla","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0040","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1080\/10473289.2003.10466300","article-title":"A new method to assess mercury emissions: a study of three coal-fired electric-generating power station configurations","volume":"53","author":"Boylan","year":"2003","journal-title":"J. Air Waste Manag. Assoc."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/jappl.1973.34.2.279","article-title":"Validation in awake rats of a tail-cuff method for measuring systolic pressure","volume":"34","author":"Bunag","year":"1973","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0050","first-page":"226","article-title":"Renal mechanisms in the cardiovascular effects of chronic exposure to inorganic mercury in rats","volume":"49","author":"Carmignani","year":"1992","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0055","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4315\/0362-028X-67.9.1939","article-title":"Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis","volume":"67","author":"Davalos","year":"2004","journal-title":"J. Food Prot."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12011-011-9242-3","article-title":"Effects of lycopene and proanthocyanidins on hepatotoxicity induced by mercuric chloride in rats","volume":"146","author":"Deng","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0065","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuint.2012.12.006","article-title":"Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury","volume":"62","author":"Farina","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0070","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1476-5381.2011.01276.x","article-title":"Endothelium-mediated control of vascular tone: COX-1 and COX-2 products","volume":"164","author":"Feletou","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1476-069X-5-29","article-title":"A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon","volume":"5","author":"Fillion","year":"2006","journal-title":"Environ. Health"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0080","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1111\/j.1476-5381.2011.01203.x","article-title":"Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species","volume":"162","author":"Furieri","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00217-015-2518-7","article-title":"Egg white hydrolysates with in vitro biological multiactivities to control complications associated with the metabolic syndrome","volume":"242","author":"Garc\u00e9s-Rim\u00f3n","year":"2016","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0090","doi-asserted-by":"crossref","first-page":"e0151193","DOI":"10.1371\/journal.pone.0151193","article-title":"Pepsin egg white hydrolysate ameliorates obesity-related oxidative stress, inflammation and steatosis in zucker fatty rats","volume":"11","author":"Garc\u00e9s-Rim\u00f3n","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0095","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2014.04.016","article-title":"Protective effect of curcumin against heavy metals-induced liver damage","volume":"69","author":"Garc\u00eda-Nino","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0100","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.foodchem.2014.08.116","article-title":"High-pressure improves enzymatic proteolysis and the release of peptides with angiotensin I converting enzyme inhibitory and antioxidant activities from lentil proteins","volume":"171","author":"Garcia-Mora","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0105","first-page":"1988","article-title":"Vascular effects of egg white-derived peptides in resistance arteries from rats: structure-activity relationships","volume":"90","author":"Garcia-Redondo","year":"2010","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0110","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00394-013-0625-4","article-title":"Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats","volume":"53","author":"Girgih","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0115","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.3390\/nu6125652","article-title":"A novel hemp seed meal protein hydrolysate reduces oxidative stress factors in spontaneously hypertensive rats","volume":"6","author":"Girgih","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0891-5849(94)90202-X","article-title":"The correlation between active oxygens scavenging and antioxidative effects of flavonoids","volume":"16","author":"Hanasaki","year":"1994","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0125","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1751-7176.2011.00489.x","article-title":"Role of mercury toxicity in hypertension, cardiovascular disease, and stroke","volume":"13","author":"Houston","year":"2011","journal-title":"J. Clin. Hypertens. (Greenwich.)"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0130","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1021\/jf102120c","article-title":"Egg-derived peptide IRW inhibits TNF-alpha-induced inflammatory response and oxidative stress in endothelial cells","volume":"58","author":"Huang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0135","first-page":"64","article-title":"A study of impact of mercury chloride on myocardium in experiment","author":"Kamynsky","year":"2016","journal-title":"Georgian. Med. News"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0140","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jhazmat.2015.11.031","article-title":"A review on the distribution of Hg in the environment and its human health impacts","volume":"306","author":"Kim","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0145","doi-asserted-by":"crossref","first-page":"e49005","DOI":"10.1371\/journal.pone.0049005","article-title":"Low mercury concentration produces vasoconstriction, decreases nitric oxide bioavailability and increases oxidative stress in rat conductance artery","volume":"7","author":"Lemos","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0150","doi-asserted-by":"crossref","first-page":"9854","DOI":"10.1021\/jf201911p","article-title":"Blood pressure lowering effect of a pea protein hydrolysate in hypertensive rats and humans","volume":"59","author":"Li","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.etap.2007.02.005","article-title":"Small doses of mercury increase arterial pressure reactivity to phenylephrine in rats","volume":"24","author":"Machado","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0160","doi-asserted-by":"crossref","first-page":"e82829","DOI":"10.1371\/journal.pone.0082829","article-title":"Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats","volume":"8","author":"Majumder","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.foodchem.2007.12.049","article-title":"Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats","volume":"109","author":"Manso","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0170","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/HJH.0b013e32834f043b","article-title":"Peroxisome proliferator-activated receptor-gamma activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress","volume":"30","author":"Martin","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/ars.2011.4335","article-title":"Reciprocal relationship between reactive oxygen species and cyclooxygenase-2 and vascular dysfunction in hypertension","volume":"18","author":"Martinez-Revelles","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0180","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.jclinepi.2011.02.001","article-title":"Total cardiovascular risk approach to improve efficiency of cardiovascular prevention in resource constrain settings","volume":"64","author":"Mendis","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0185","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.4315\/0362-028X-67.9.1914","article-title":"Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis","volume":"67","author":"Miguel","year":"2004","journal-title":"J. Food Prot."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1079\/BJN20051570","article-title":"Short-term effect of egg-white hydrolysate products on the arterial blood pressure of hypertensive rats","volume":"94","author":"Miguel","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0195","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1016\/j.lfs.2005.11.025","article-title":"Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats","volume":"78","author":"Miguel","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0200","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/mnfr.200700012","article-title":"Angiotensin-converting enzyme activity in plasma and tissues of spontaneously hypertensive rats after the short- and long-term intake of hydrolysed egg white","volume":"51","author":"Miguel","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0205","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cbi.2014.10.034","article-title":"Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation","volume":"224C","author":"Mohammadi-Bardbori","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"Suppl 1","key":"10.1016\/j.toxlet.2017.10.001_bib0210","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1097\/01.hjh.0000467595.42348.aa","article-title":"7A.08: Experimental study to evaluate the effect of a pepsin egg white hydrolysate on cardiometabolic complications in diet induced obese rats","volume":"33","author":"Moreno","year":"2015","journal-title":"J. Hypertens."},{"issue":"11","key":"10.1016\/j.toxlet.2017.10.001_bib0215","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/risa.12598","article-title":"Costs of health damage from atmospheric emissions of toxic metals: part 2-analysis for mercury and lead","volume":"36","author":"Nedellec","year":"2016","journal-title":"Risk Anal."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0220","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/1091581815589766","article-title":"Mercury exposure and endothelial dysfunction: an interplay between nitric oxide and oxidative stress","volume":"34","author":"Omanwar","year":"2015","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0225","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1021\/acs.jafc.5b02801","article-title":"Long-term regulation of the local renin-angiotensin system in the myocardium of spontaneously hypertensive rats by feeding bioactive peptides derived from spirulina platensis","volume":"63","author":"Pan","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0230","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1017\/S1368980013000219","article-title":"Dietary pattern and hypertension in Korean adults","volume":"17","author":"Park","year":"2014","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0235","first-page":"29","article-title":"The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration","volume":"61","author":"Pe\u00e7anha","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0240","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.3390\/ijerph120810020","article-title":"An investigation of organic and inorganic mercury exposure and blood pressure in a small-scale gold mining community in Ghana","volume":"12","author":"Rajaee","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0245","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.envres.2003.08.013","article-title":"The US EPA reference dose for methylmercury: sources of uncertainty","volume":"95","author":"Rice","year":"2004","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0250","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/01.CIR.102.22.2677","article-title":"Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study","volume":"102","author":"Rissanen","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0255","doi-asserted-by":"crossref","first-page":"e55806","DOI":"10.1371\/journal.pone.0055806","article-title":"Apocynin prevents vascular effects caused by chronic exposure to low concentrations of mercury","volume":"8","author":"Rizzetti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0260","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.envres.2017.02.022","article-title":"The cessation of the long-term exposure to low doses of mercury ameliorates the increase in systolic blood pressure and vascular damage in rats","volume":"155","author":"Rizzetti","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jff.2011.05.006","article-title":"Food-derived peptidic antioxidants: a review of their production, assessment, and potential applications","volume":"3","author":"Samaranayaka","year":"2011","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0270","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.peptides.2010.06.020","article-title":"Antioxidative peptides from food proteins: a review","volume":"31","author":"Sarmadi","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0275","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1749-6632.1976.tb47062.x","article-title":"Elevation of angiotensin-converting enzyme in granulomatous lymph nodes and serum in sarcoidosis: clinical and possible pathogenic significance","volume":"278","author":"Silverstein","year":"1976","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0280","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ahj.2014.07.007","article-title":"Metal pollutants and cardiovascular disease: mechanisms and consequences of exposure","volume":"168","author":"Solenkova","year":"2014","journal-title":"Am. Heart J."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0285","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1021\/es0482278","article-title":"Biogeographic provinces of total and methyl mercury in zooplankton and fish from the Beaufort and Chukchi seas: results from the SHEBA drift","volume":"39","author":"Stern","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0290","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1471-2458-12-378","article-title":"Blood pressure and particulate air pollution in schoolchildren of Lahore, Pakistan","volume":"12","author":"Sughis","year":"2012","journal-title":"BMC Public Health"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0295","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fct.2015.04.029","article-title":"The protective role of olive oil hydroxytyrosol against oxidative alterations induced by mercury in human erythrocytes","volume":"82","author":"Tagliafierro","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0300","first-page":"39","article-title":"Acute toxic actions of mercury on the cardiovascular system","volume":"67","author":"Vassallo","year":"1996","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0305","doi-asserted-by":"crossref","first-page":"H1033","DOI":"10.1152\/ajpheart.00430.2008","article-title":"Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries","volume":"295","author":"Wiggers","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0310","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.cbpc.2007.10.003","article-title":"Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats","volume":"147","author":"Wiggers","year":"2008","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0315","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuro.2016.02.010","article-title":"Cerebrovascular endothelial dysfunction induced by mercury exposure at low concentrations","volume":"53","author":"Wiggers","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.11.004","article-title":"The mechanisms associated with the development of hypertension after exposure to lead, mercury species or their mixtures differs with the metal and the mixture ratio","volume":"339","author":"Wildemann","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0325","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10534-006-9016-0","article-title":"Cadmium and mercury cause an oxidative stress-induced endothelial dysfunction","volume":"20","author":"Wolf","year":"2007","journal-title":"Biometals"},{"key":"10.1016\/j.toxlet.2017.10.001_bib0330","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jnutbio.2007.11.004","article-title":"Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with L-NAME-induced hypertension","volume":"19","author":"Yang","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.toxlet.2017.10.001_bib0335","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijbiomac.2013.04.047","article-title":"Protective role of Aralia elata polysaccharide on mercury(II)-induced cardiovascular oxidative injury in rats","volume":"59","author":"Zhang","year":"2013","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417313784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417313784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T03:34:56Z","timestamp":1535340896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427417313784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":67,"alternative-id":["S0378427417313784"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.10.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}