{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:37:25Z","timestamp":1780054645736,"version":"3.54.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico \u2013 CNPq","award":["473468\/2013-1"],"award-info":[{"award-number":["473468\/2013-1"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro \u2013 FAPERJ","award":["E-26110.604\/2014"],"award-info":[{"award-number":["E-26110.604\/2014"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.toxlet.2017.12.028","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T18:13:14Z","timestamp":1514916794000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Renal tubular damage caused by cylindrospermopsin (cyanotoxin) in mice"],"prefix":"10.1016","volume":"286","author":[{"given":"A.C.N.","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.F.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2017.12.028_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1993.73.1.1","article-title":"Interstitial lymphatic mechanisms in the control of extracellular fluid volume","volume":"73","author":"Auckland","year":"1993","journal-title":"Physiol. Rev."},{"issue":"April (4746)","key":"10.1016\/j.toxlet.2017.12.028_bib0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5694\/j.1326-5377.1980.tb131814.x","article-title":"Palm island mystery disease","volume":"2","author":"Byth","year":"1980","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0020","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2006.05.006","article-title":"Evaluation of renal enzymuria and cellular excretion as an marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats","volume":"373","author":"Da Silva Melo","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<151::AID-TOX19>3.0.CO;2-D","article-title":"Use of HPLC-MS\/MS to monitor cylindrospermopsin, a blue\u2013green algal toxin, for public health purposes","volume":"14","author":"Eagleshaw","year":"1999","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2017.12.028_bib0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<143::AID-TOX18>3.0.CO;2-H","article-title":"Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice","volume":"14","author":"Falconer","year":"1999","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/MNH.0b013e3283521cfa","article-title":"Renal interstitial fibrosis: mechanisms and evaluation","volume":"21","author":"Farris","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0040","first-page":"796","article-title":"Isolation and culture of toxic strains of Anabaena flos-aquae (Lyngb.) de Br\u00e9b","volume":"15","author":"Gorham","year":"1964","journal-title":"Verh. Int. Verein. Limnol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0278-6915(88)90039-7","article-title":"Dose-response and time-response biochemical and histological study of potassium dichromate-induced nephrotoxicity in the rat","volume":"26","author":"Gumbleton","year":"1988","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/B978-0-12-420117-0.00003-7","article-title":"Gamma-glutamyl transpeptidase: redox regulation and drug resistance","volume":"122","author":"Hanigan","year":"2014","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0041-0101(94)90023-X","article-title":"Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method","volume":"32","author":"Harada","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0060","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1128\/AEM.50.5.1292-1295.1985","article-title":"Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir","volume":"50","author":"Hawkins","year":"1985","journal-title":"Appl. Environ. Microbiol."},{"issue":"2","key":"10.1016\/j.toxlet.2017.12.028_bib0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/tox.10104","article-title":"Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male swiss albino mice: determination of No observed adverse effect level for deriving a drinking water guideline value","volume":"18","author":"Humpage","year":"2003","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0070","first-page":"H1329","article-title":"Leukocyte adhesion, edema, and development of postischemic capillary no-reflow","volume":"267","author":"Jerome","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"April (11)","key":"10.1016\/j.toxlet.2017.12.028_bib0075","first-page":"823","article-title":"Urinary enzymes in research and in clinical medicine. Report on a symposium of the Humboldt-Universitat Berlin and the Bezirkrankenhaus Frankfurt\/Oder in Frankfurt\/Oder, 22\u201325","volume":"25","author":"Jung","year":"1987","journal-title":"J. Clin. Chem. Biochem."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6941.2001.tb00782.x","article-title":"Ecological and molecular investigations of cyanotoxin production","volume":"35","author":"Kaebernick","year":"2001","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/bj1140197","article-title":"The excretion of lactate dehydrogenase in human urine after the ingestion of aspirine","volume":"114","author":"Leathwood","year":"1969","journal-title":"Biochem. J."},{"issue":"June (6)","key":"10.1016\/j.toxlet.2017.12.028_bib0090","first-page":"731","article-title":"Localization by in situ hybridization of gamma-glutamyl transpeptidase mRNA in the rat kidney using 35S-labeled RNA probes","volume":"62","author":"Lebargy","year":"1990","journal-title":"Lab. Invest."},{"issue":"6","key":"10.1016\/j.toxlet.2017.12.028_bib0095","first-page":"535","article-title":"Is serum gamma glutamyltransferase a marker of oxidative stress?","volume":"38","author":"Lee","year":"2004","journal-title":"Rev. Radic. Res."},{"issue":"15","key":"10.1016\/j.toxlet.2017.12.028_bib0100","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1073\/pnas.93.15.7923","article-title":"Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice","volume":"93","author":"Lieberman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.toxlet.2017.12.028_bib0105","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.toxicon.2012.02.003","article-title":"Single sublethal dose of microcystin-LR is responsible for different alterations in biochemical, histological and physiological renal parameters","volume":"59","author":"Lowe","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folinphenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0115","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0120","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/cbic.201000726","article-title":"The last step of the biosynthesis of the cyanotoxins cylindrospermopsin and 7-epi-cylindrospermopsin is catalysed by CyrI, a 2-oxoglutarate-dependent iron oxygenase","volume":"12","author":"Mazmouz","year":"2011","journal-title":"Chembiochem"},{"issue":"July (3)","key":"10.1016\/j.toxlet.2017.12.028_bib0125","first-page":"759","volume":"77","author":"Mukherjee","year":"1997","journal-title":"Endocytosis Phys. Rev."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0130","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/tox.10008","article-title":"Distribution of 14C cylindrospermopsin in vivo in the mouse","volume":"16","author":"Norris","year":"2001","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.molmed.2007.06.006","article-title":"Nephrin \u2013 a unique structural and signaling protein of the kidney filter","volume":"13","author":"Patrakka","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.toxicon.2005.10.013","article-title":"First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes","volume":"47","author":"Preussel","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2017.12.028_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/10.1.1","article-title":"The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death","volume":"10","author":"Putaala","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/bbrc.1994.1694","article-title":"Role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes","volume":"201","author":"Runnegar","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0155","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-2952(94)00466-8","article-title":"Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes","volume":"49","author":"Runnegar","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ki.1976.26","article-title":"Sites of enzyme activity along the nephron","volume":"9","author":"Schmidt","year":"1976","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0165","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<135::AID-TOX17>3.0.CO;2-L","article-title":"The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska)","volume":"14","author":"Seawright","year":"1999","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0272-0590(87)90056-X","article-title":"Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney","volume":"9","author":"Stonard","year":"1987","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0175","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0041-0101(94)90008-6","article-title":"Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans","volume":"32","author":"Terao","year":"1994","journal-title":"Toxicon"},{"issue":"October (4 pt. 2)","key":"10.1016\/j.toxlet.2017.12.028_bib0180","first-page":"F601","article-title":"Intrarenal handling of proteins in rats using fractional micropuncture technique","volume":"263","author":"Tojo","year":"1992","journal-title":"Am. J. Physiol."},{"issue":"528","key":"10.1016\/j.toxlet.2017.12.028_bib0185","first-page":"4347","article-title":"Comparison between calcium transport and adenosine triphosphatase activity in membrane vesicles derived from rabbit kidney proximal tubules","volume":"261","author":"Vieyra","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0190","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1016\/S0043-1354(02)00194-X","article-title":"HPLC-PDA detection of cylindrospermopsin \u2013 opportunities and limits","volume":"36","author":"Welker","year":"2002","journal-title":"Water Res."},{"key":"10.1016\/j.toxlet.2017.12.028_bib0195","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0076-6879(05)01028-1","article-title":"\u00a9-Glutamyl transpeptidase in glutathione biosynthesis","volume":"401","author":"Zhang","year":"2005","journal-title":"Methods Enzymol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417315382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427417315382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T18:11:22Z","timestamp":1660241482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427417315382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":39,"alternative-id":["S0378427417315382"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.12.028","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal tubular damage caused by cylindrospermopsin (cyanotoxin) in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2017.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}