{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:40:42Z","timestamp":1792784442047,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["81370080"],"award-info":[{"award-number":["81370080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["81001261"],"award-info":[{"award-number":["81001261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Future Industry Special Project of Shenzhen","award":["ZDSYS20140509101335476"],"award-info":[{"award-number":["ZDSYS20140509101335476"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.toxlet.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T14:20:25Z","timestamp":1530800425000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Poly (ADP-ribose) glycohydrolase silencing-mediated maintenance of H2A and downregulation of H2AK9me protect human bronchial epithelial cells from benzo(a)pyrene-induced carcinogenesis"],"prefix":"10.1016","volume":"295","author":[{"given":"Zhuoying","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaofeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2019an","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.toxlet.2018.07.003_bib0005","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1182\/blood.V96.13.4328","article-title":"BAL is a novel risk-related gene in diffuse large B-cell lymphomas, that enhances cellular migration","volume":"96","author":"Aguiar","year":"2000","journal-title":"Blood"},{"issue":"7174","key":"10.1016\/j.toxlet.2018.07.003_bib0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature06420","article-title":"Poly(ADP-ribose)-binding zinc finger motifs in DNA repair\/checkpoint proteins","volume":"451","author":"Ahel","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.toxlet.2018.07.003_bib0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(03)00100-X","article-title":"The histone variant MacroH2A interferes with transcription factor binding and SWI\/SNF nucleosome remodeling","volume":"11","author":"Angelov","year":"2003","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.toxlet.2018.07.003_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-8-86","article-title":"Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer","volume":"8","author":"Castro","year":"2010","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.toxlet.2018.07.003_bib0025","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/hmg\/10.10.1101","article-title":"Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant","volume":"10","author":"Chadwick","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"6685","key":"10.1016\/j.toxlet.2018.07.003_bib0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/31275","article-title":"Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals","volume":"393","author":"Costanzi","year":"1998","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.toxlet.2018.07.003_bib0035","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1073\/pnas.0408918102","article-title":"Stable X chromosome inactivation involves the PRC1 polycomb complex and requires histone MACROH2A1 and the CULLIN3\/SPOP ubiquitin E3 ligase","volume":"102","author":"Hern\u00e1ndezmu\u00f1oz","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.toxlet.2018.07.003_bib0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/excr.2000.4951","article-title":"Histone macroH2A1.2 is concentrated in the XY-body by the early pachytene stage of spermatogenesis","volume":"258","author":"Hoyer-Fender","year":"2000","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.toxlet.2018.07.003_bib0045","first-page":"155","article-title":"Poly(ADP-ribose) glycohydrolase silencing down-regulates TCTP and cofilin-1 associated with metastasis in benzo(a)pyrene carcinogenesis","volume":"5","author":"Huang","year":"2014","journal-title":"Am. J. Cancer. Res."},{"issue":"5\u20136","key":"10.1016\/j.toxlet.2018.07.003_bib0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/bfgp\/elq024","article-title":"Chatting histone modifications in mammals","volume":"9","author":"Izzo","year":"2010","journal-title":"Briefings Funct. Genomics"},{"issue":"14","key":"10.1016\/j.toxlet.2018.07.003_bib0055","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1128\/MCB.02351-05","article-title":"BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate","volume":"26","author":"Juszczynski","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.toxlet.2018.07.003_bib0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-8935-6-20","article-title":"A quantitative atlas of histone modification signatures from human cancer cells","volume":"6","author":"Leroy","year":"2013","journal-title":"Epigenet. Chromatin"},{"issue":"3","key":"10.1016\/j.toxlet.2018.07.003_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151172","article-title":"Poly(ADP-ribose) glycohydrolase (PARG) silencing suppresses benzo(a)pyrene induced cell transformation","volume":"11","author":"Li","year":"2016","journal-title":"Plos One"},{"issue":"11","key":"10.1016\/j.toxlet.2018.07.003_bib0070","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.18632\/oncotarget.2007","article-title":"Expression and functionality of histone H2A variants in cancer","volume":"5","author":"Monteiro","year":"2014","journal-title":"Oncotarget"},{"issue":"20","key":"10.1016\/j.toxlet.2018.07.003_bib0075","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1128\/MCB.05244-11","article-title":"QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferation","volume":"31","author":"Novikov","year":"2011","journal-title":"Mol. Cell. Biol."},{"issue":"52","key":"10.1016\/j.toxlet.2018.07.003_bib0080","doi-asserted-by":"crossref","first-page":"40974","DOI":"10.1074\/jbc.M006520200","article-title":"Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins","volume":"275","author":"Pleschke","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.toxlet.2018.07.003_bib0085","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.toxlet.2018.07.003_bib0090","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1074\/jbc.275.13.9390","article-title":"Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139","volume":"275","author":"Rogakou","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2018.07.003_bib0095","first-page":"169","article-title":"Regulation of chromatin structure by poly(ADP-ribosyl)ation","volume":"3","author":"Sascha","year":"2012","journal-title":"Front. Genet."},{"issue":"6","key":"10.1016\/j.toxlet.2018.07.003_bib0100","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nprot.2007.202","article-title":"Extraction, purification and analysis of histones","volume":"2","author":"Shechter","year":"2007","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.toxlet.2018.07.003_bib0105","first-page":"1313","article-title":"Actin disruption agents induce phosphorylation of histone H2AX in human breast adenocarcinoma MCF-7 cells","volume":"25","author":"Shin","year":"2011","journal-title":"Oncol. Rep."},{"issue":"38","key":"10.1016\/j.toxlet.2018.07.003_bib0110","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1038\/onc.2009.26","article-title":"Histone macroH2A isoforms predict the risk of lung cancer recurrence","volume":"28","author":"Sporn","year":"2009","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.toxlet.2018.07.003_bib0115","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.dnarep.2006.05.040","article-title":"Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability","volume":"5","author":"Yu","year":"2006","journal-title":"Dna Repair"},{"issue":"1","key":"10.1016\/j.toxlet.2018.07.003_bib0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2004.10.019","article-title":"Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA","volume":"8","author":"Zhang","year":"2005","journal-title":"Dev. Cell"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418314875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418314875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T07:29:09Z","timestamp":1571556549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427418314875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":24,"alternative-id":["S0378427418314875"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.07.003","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly (ADP-ribose) glycohydrolase silencing-mediated maintenance of H2A and downregulation of H2AK9me protect human bronchial epithelial cells from benzo(a)pyrene-induced carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}