{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:51:17Z","timestamp":1783515077369,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["31502035"],"award-info":[{"award-number":["31502035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.toxlet.2018.07.019","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T12:39:18Z","timestamp":1532522358000},"page":"114-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Melamine causes testicular toxicity by destroying blood-testis barrier in piglets"],"prefix":"10.1016","volume":"296","author":[{"given":"Lingling","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2018.07.019_bib0005","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1021\/jf800295z","article-title":"Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry","volume":"56","author":"Andersen","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0010","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.fct.2011.03.046","article-title":"Gestational and lactational transfer of melamine following gavage administration of a single dose to rats","volume":"49","author":"Chan","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2014.02.008","article-title":"Acute testicular toxicity induced by melamine alone or a mixture of melamine and cyanuric acid in mice","volume":"46","author":"Chang","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.etap.2017.01.009","article-title":"In vitro toxicity evaluation of melamine on mouse TM4 Sertoli cells","volume":"50","author":"Chang","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2018.07.019_bib0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/pr.110.002790","article-title":"The blood-testis barrier and its implications for male contraception","volume":"64","author":"Cheng","year":"2012","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.toxlet.2018.07.019_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/spmg.1.2.15745","article-title":"Regulation of blood-testis barrier dynamics by desmosome, gap junction, hemidesmosome and polarity proteins: an, hemidesmosome and polarity proteins: an unexpected turn of events","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.toxlet.2018.07.019_bib0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrneph.2011.24","article-title":"Melamine-related kidney stones and renal toxicity","volume":"7","author":"Dalal","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/toxsci\/kfn160","article-title":"Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs","volume":"106","author":"Dobson","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0045","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/biolreprod\/3.3.308","article-title":"The blood-testis barrier in the rat and the physiological compartmentation of the seminiferous epithelium","volume":"3","author":"Dym","year":"1970","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.toxlet.2018.07.019_bib0050","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-15-0366","article-title":"Blood-testis barrier and Sertoli cell function: lessons from SCCx43KO mice","volume":"151","author":"Gerber","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2018.07.019_bib0055","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1056\/NEJMoa0809550","article-title":"Melamine-contaminated powdered formula and urolithiasis in young children","volume":"360","author":"Guan","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1681\/ASN.2008101065","article-title":"Melamine toxicity and the kidney","volume":"20","author":"Hau","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0065","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0273-2300(85)90044-3","article-title":"The induction of bladder stones by terephthalic acid, dimethyl terephthalate, and melamine (2,4,6-triamino-s-triazine) and its relevance to risk assessment","volume":"5","author":"Heck","year":"1985","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0070","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00441-007-0489-0","article-title":"Identification of cellular isoform of oviduct-specific glycoprotein: role in oviduct tissue remodeling?","volume":"330","author":"Kadam","year":"2007","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0075","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.etap.2017.01.018","article-title":"Melamine and\/or formaldehyde exposures affect steroidogenesis via alteration of StAR protein and testosterone synthetic enzyme expression in male mice","volume":"50","author":"Khalil","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0080","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0895-3988(09)60030-1","article-title":"Study on migration of melamine from food packaging materials on markets","volume":"22","author":"Lu","year":"2009","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0085","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00204-015-1492-y","article-title":"Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNFalpha\/p38 MAPK signaling pathway in vivo and in vitro","volume":"90","author":"Lu","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0090","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1210\/en.2002-0211","article-title":"TGF-beta3 regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study","volume":"144","author":"Lui","year":"2003","journal-title":"Endocrinology"},{"issue":"February (2)","key":"10.1016\/j.toxlet.2018.07.019_bib0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0041-008X(84)90314-4","article-title":"Urolithiasis and bladder carcinogenicity of melamine in rodents","volume":"72","author":"Melnick","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0100","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/B978-0-12-407704-1.00006-3","article-title":"Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the Yin and Yang effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2","volume":"301","author":"Mok","year":"2013","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"1546","key":"10.1016\/j.toxlet.2018.07.019_bib0105","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1098\/rstb.2010.0025","article-title":"Claudin and occludin expression and function in the seminiferous epithelium Philos","volume":"365","author":"Morrow","year":"2010","journal-title":"Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0110","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","article-title":"Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis","volume":"25","author":"Mruk","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0115","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1093\/carcin\/16.11.2773","article-title":"Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation","volume":"16","author":"Ogasawara","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.toxlet.2018.07.019_bib0120","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/978-0-387-09597-4_12","article-title":"Blood-testis barrier, junctional and transport proteins and spermatogenesis","volume":"636","author":"Setchell","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.toxlet.2018.07.019_bib0125","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1095\/biolreprod.106.059212","article-title":"Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice","volume":"76","author":"Sridharan","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0130","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.fct.2014.02.029","article-title":"Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid","volume":"68","author":"Stine","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0135","first-page":"810","article-title":"Melamine related urinary calculus and acute renal failure in infants","volume":"46","author":"Sun","year":"2008","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.toxlet.2018.07.019_bib0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.rvsc.2016.10.007","article-title":"Melamine negatively affects testosterone synthesis in mice","volume":"109","author":"Sun","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1354\/vp.45-3-417","article-title":"Characterization of melamine-containing and calcium oxalate crystals in three dogs with suspected pet food-induced nephrotoxicosis","volume":"45","author":"Thompson","year":"2008","journal-title":"Vet. Pathol."},{"issue":"Suppl 8","key":"10.1016\/j.toxlet.2018.07.019_bib0150","first-page":"20","article-title":"Melamine toxicity in rat foetuses and infants","volume":"19","author":"Wang","year":"2013","journal-title":"Hong Kong Med. J."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0155","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","article-title":"Impacts of environmental toxicants on male reproductive dysfunction","volume":"32","author":"Wong","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0160","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.rvsc.2012.11.010","article-title":"The reproductive toxicity of melamine in the absence and presence of cyanuric acid in male mice","volume":"94","author":"Yin","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0165","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1477-7827-8-97","article-title":"Cadmium suppresses the proliferation of piglet Sertoli cells and causes their DNA damage, cell apoptosis and aberrant ultrastructure","volume":"8","author":"Zhang","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.toxlet.2018.07.019_bib0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2011.03.004","article-title":"Melamine induces sperm DNA damage and abnormality, but not genetic toxicity","volume":"60","author":"Zhang","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418315066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418315066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T10:14:18Z","timestamp":1535192058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427418315066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":34,"alternative-id":["S0378427418315066"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.07.019","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melamine causes testicular toxicity by destroying blood-testis barrier in piglets","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}