{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:52Z","timestamp":1790395132386,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"State Agency for the Development of Science and Technology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.toxlet.2018.08.018","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T15:43:49Z","timestamp":1535557429000},"page":"21-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Tributyltin impacts in metabolic syndrome development through disruption of angiotensin II receptor signaling pathways in white adipose tissue from adult female rats"],"prefix":"10.1016","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-6095","authenticated-orcid":false,"given":"Leandro","family":"Ceotto Freitas-Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Campos Zicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Maria","family":"Navia-Pelaez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriane","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"dos Santos Aggum Capettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Regina","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaliene","family":"Versiani Matos Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Henrique","family":"Sousa Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jones","family":"Bernardes Graceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2018.08.018_bib0005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00075197-200207000-00006","article-title":"Angiotensinogen, adipocyte differentiation and fat mass enlargement","volume":"5","author":"Ailhaud","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0010","series-title":"The IDF Consensus Worldwide Definition of the Metabolic Syndrome","author":"Alberti","year":"2006"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2009.03.003","article-title":"Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1","volume":"64","author":"Ara\u00fajo","year":"2010","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1677\/JOE-08-0363","article-title":"Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor- from 3T3-L1 preadipocytes","volume":"202","author":"Asamizu","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0025","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1189\/jlb.1104682","article-title":"Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1","volume":"78","author":"Barcelos","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0030","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.toxlet.2012.03.020","article-title":"State-of-the-science of endocrine disrupting chemicals, 2012","volume":"211","author":"Bergman","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0035","series-title":"Adipose Tissue and Lipid Metabolism. Biochem. Lipids, Lipoproteins Membr","first-page":"263","author":"Bernlohr","year":"2002"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxlet.2015.03.009","article-title":"Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas","volume":"235","author":"Bertuloso","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0045","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/oby.2001.63","article-title":"Metabolic and hemodynamic response of adipose tissue to angiotensin II","volume":"9","author":"Boschmann","year":"2001","journal-title":"Obes. Res."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.physbeh.2016.11.020","article-title":"The intricacies of the renin-angiotensin-system in metabolic regulation","volume":"178","author":"Bruce","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0055","series-title":"AMIA \u2026 Annu. Symp. Proceedings. AMIA Symp.","article-title":"Semantic MEDLINE for discovery browsing: using semantic predications and the literature-based discovery paradigm to elucidate a mechanism for the obesity paradox","author":"Cairelli","year":"2013"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0060","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.4049\/jimmunol.1400625","article-title":"Skin Wound Healing is accelerated and scarless in the absence of commensal microbiota","volume":"193","author":"Canesso","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0065","doi-asserted-by":"crossref","first-page":"T47","DOI":"10.1530\/JOE-13-0339","article-title":"Adipocytokines in obesity and metabolic disease","volume":"220","author":"Cao","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tcb.2017.01.006","article-title":"Inflammation and the metabolic syndrome: the tissue-specific functions of NF-\u03baB","volume":"27","author":"Catrysse","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0075","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/s41467-017-01944-z","article-title":"Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice","volume":"8","author":"Chamorro-Garcia","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.toxlet.2018.08.018_bib0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.HYP.0000168046.19884.6a","article-title":"PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin","volume":"46","author":"Clasen","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0085","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3132\/dvdr.2007.003","article-title":"Metabolic syndrome, or what you will: definitions and epidemiology","volume":"4","author":"Day","year":"2007","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0090","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1210\/en.2009-0065","article-title":"The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis","volume":"150","author":"de Kloet","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0095","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.physbeh.2010.03.018","article-title":"The renin angiotensin system and the metabolic syndrome","volume":"100","author":"De Kloet","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2015.00075","article-title":"Early pharmacological inhibition of angiotensin-I converting enzyme activity induces obesity in adulthood","volume":"6","author":"De Picoli Souza","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0105","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0110","doi-asserted-by":"crossref","unstructured":"Endlich, P.W., Claudio, E.R., Lima, L.C. F, R.J.R. Peluso, A.A. Stefanon, I. Bissoli, N.S. Lemos, V.S. Santos, R.A. Abreu, G.R., 2017. Exercise modulates the aortic renin-angiotensin system independently of estrogen therapy in ovariectomized hypertensive rats. https:\/\/doi.org\/10.1016\/j.peptides.2016.11.010.","DOI":"10.1016\/j.peptides.2016.11.010"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0115","series-title":"MicroRNA and Adipogenesis","author":"Engin","year":"2017"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0120","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tem.2014.02.004","article-title":"Role of interleukins in obesity: implications for metabolic disease","volume":"25","author":"Febbraio","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0125","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0130","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.jnutbio.2013.07.002","article-title":"The renin\u2013angiotensin system in adipose tissue and its metabolic consequences during obesity","volume":"24","author":"Frigolet","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0135","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004838","article-title":"Not just fat: the structure and function of the lipid droplet","volume":"3","author":"Fujimoto","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0140","doi-asserted-by":"crossref","first-page":"F1606","DOI":"10.1152\/ajprenal.00063.2012","article-title":"Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats","volume":"302","author":"Giani","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0145","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1210\/en.2005-1129","article-title":"Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling","volume":"147","author":"Gr\u00fcn","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0150","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1210\/me.2005-0367","article-title":"Endocrine-disrupting organotin compounds are potent inducers of Adipogenesis in vertebrates","volume":"20","author":"Gr\u00fcn","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0155","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/hy1101.092970","article-title":"Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats","volume":"38","author":"Henriksen","year":"2001","journal-title":"Hypertens. (Dallas, Tex. 1979)"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0160","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1096\/fj.01-0432com","article-title":"Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through Toll-like receptor 4-derived signaling pathways","volume":"15","author":"Hwang","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0165","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1073\/pnas.0802690105","article-title":"Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance","volume":"105","author":"Jayasooriya","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0170","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1210\/endo.138.4.5038","article-title":"Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells 1","volume":"138","author":"Jones","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0175","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/ijo.2008.102","article-title":"Global burden of obesity in 2005 and projections to 2030","volume":"32","author":"Kelly","year":"2008","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0180","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1210\/en.2005-0003","article-title":"Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor","volume":"146","author":"Kouyama","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12640-016-9606-8","article-title":"Association between microglia, inflammatory factors, and complement with loss of Hippocampal Mossy Fiber Synapses induced by Trimethyltin","volume":"30","author":"Kraft","year":"2016","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0190","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/sj.ki.5001810","article-title":"Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation","volume":"70","author":"Kurata","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0195","doi-asserted-by":"crossref","unstructured":"Leal, V. de O., Mafra, D., 2013. Adipokines in obesity. Clin. Chim. Acta 419, 87\u201394. https:\/\/doi.org\/10.1016\/j.cca.2013.02.003.","DOI":"10.1016\/j.cca.2013.02.003"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0200","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.brainresbull.2016.07.010","article-title":"Trimethyltin-induced hippocampal neurodegeneration: amechanism-based review","volume":"125","author":"Lee","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0205","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0210","series-title":"Mononuclear Cell Therapy Reverts Cuff-induced Thrombosis in Apolipoprotein E-deficient Mice","author":"Lima","year":"2012"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0215","first-page":"1","article-title":"Neurodegeneration Alters Metabolic Profile and Sirt 1 signaling in high-fat-induced obese mice","author":"Lima","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0220","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nut.2011.07.014","article-title":"Effects of high-fat diet on plasma lipids, adiposity, and inflammatory markers in ovariectomized C57BL\/6 mice","volume":"28","author":"Ludgero-Correia","year":"2012","journal-title":"Nutrition"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0225","first-page":"E523","article-title":"Deletion of nuclear factor-\u03baB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice","volume":"309","author":"Minegishi","year":"2015","journal-title":"Am. J. Physiol. Metab."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0230","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1758-5996-5-79","article-title":"Crosstalk between circulating peroxisome proliferator-activated receptor gamma, adipokines and metabolic syndrome in obese subjects","volume":"5","author":"Mirzaei","year":"2013","journal-title":"Diabetol. Metab. Syndr."},{"issue":"2","key":"10.1016\/j.toxlet.2018.08.018_bib0235","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/bbrc.1996.5964","article-title":"ob gene expression and secretion of leptin following differentiation of rat preadipocytes to adipocytes in primary culture","volume":"230","author":"Mitchell","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0240","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2013.05.011","article-title":"Tributyltin induces oxidative damage, inflammation and apoptosis via disturbance in blood-brain barrier and metal homeostasis in cerebral cortex of rat brain: an in vivo and in vitro study","volume":"310","author":"Mitra","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2010.02.001","article-title":"Angiotensin-(1-7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas","volume":"161","author":"Mu\u00f1oz","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0250","series-title":"Review of the Environmental Protection Agency\u2019s Draft IRIS Assessment of Tetrachloroethylene","author":"National Research Council (US) Committee to Review EPA\u2019s Toxicological Assessment of Tetrachloroethylene","year":"2010"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jdermsci.2007.05.001","article-title":"Effects of tributyltin on the emotional behavior of C57BL\/6 mice and the development of atopic dermatitis-like lesions in DS-Nh mice","volume":"47","author":"Ohtaki","year":"2007","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0260","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2011.05.017","article-title":"The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose","volume":"255","author":"Penza","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0270","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1740-0929.2011.00982.x","article-title":"Differences in adipose tissue inflammation and oxidative status in C57BL\/6 and ApoE-\/- mice fed high fat diet","volume":"83","author":"Pereira","year":"2012","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0275","doi-asserted-by":"crossref","first-page":"H1219","DOI":"10.1152\/ajpheart.00796.2011","article-title":"The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome","volume":"302","author":"Putnam","year":"2012","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0280","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cyto.2010.11.015","article-title":"Exposure to an organometal compound stimulates adipokine and cytokine expression in white adipose tissue","volume":"53","author":"Ravanan","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.peptides.2014.04.021","article-title":"Peptides angiotensin II and 1-7 during aging in metabolic syndrome rats. Expression of AT1, AT2 and Mas receptors in abdominal white adipose tissue","volume":"57","author":"Rubio-ru\u00edz","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0290","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2337\/db07-0953","article-title":"Mas deficiency in FVB\/N mice produces marked changes in lipid and glycemic metabolism","volume":"57","author":"Santos","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0295","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.taap.2017.01.021","article-title":"Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin\/leptin signaling in female rats","volume":"319","author":"Sena","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0300","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.RES.0000156273.30274.f7","article-title":"Glycogen-synthase Kinase3beta\/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells","volume":"96","author":"Skurk","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0305","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1515\/enr-2016-0025","article-title":"Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity","volume":"50","author":"Slamkova","year":"2016","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0310","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR\u03b32, a lipid-activated transcription factor","volume":"79","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2018.08.018_bib0315","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1172\/JCI200420964","article-title":"Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma","volume":"114","author":"Tsai","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0320","series-title":"Obesity and Overweight: Fact Sheet N\u00b0311 [WWW Document]","author":"WHO - World and Health Organization","year":"2016"},{"issue":"65","key":"10.1016\/j.toxlet.2018.08.018_bib0325","article-title":"Animal models of metabolic syndrome: a review","volume":"13","author":"Wong","year":"2016","journal-title":"Nutr. Metab. (Lond)."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0330","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nm.3616","article-title":"Obesity- and aging-induced excess of central transforming growth factor-\u03b2 potentiates diabetic development via an RNA stress response","volume":"20","author":"Yan","year":"2014","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.toxlet.2018.08.018_bib0335","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2010.391","article-title":"Role of adipose tissue renin-angiotensin system in metabolic and inflammatory diseases associated with obesity","volume":"79","author":"Yvan-Charvet","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0340","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1515\/hsz-2012-0290","article-title":"Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output","volume":"394","author":"Zhang","year":"2013","journal-title":"Biol. Chem."},{"key":"10.1016\/j.toxlet.2018.08.018_bib0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115148","article-title":"A model of metabolic syndrome and related diseases with intestinal endotoxemia in rats fed a high fat and high sucrose diet","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418318265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418318265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T12:59:03Z","timestamp":1540817943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427418318265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":69,"alternative-id":["S0378427418318265"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.08.018","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tributyltin impacts in metabolic syndrome development through disruption of angiotensin II receptor signaling pathways in white adipose tissue from adult female rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}