{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:29:14Z","timestamp":1789669754835,"version":"4.0.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003705","name":"Korea Institute of Toxicology","doi-asserted-by":"publisher","award":["KK-1707"],"award-info":[{"award-number":["KK-1707"]}],"id":[{"id":"10.13039\/501100003705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF- 2018R1D1A1A09035783"],"award-info":[{"award-number":["NRF- 2018R1D1A1A09035783"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.toxlet.2018.12.007","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T21:10:06Z","timestamp":1545340206000},"page":"55-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"special_numbering":"C","title":["Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells"],"prefix":"10.1016","volume":"303","author":[{"given":"Eun-Jung","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuhong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolho","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0005","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/ajrccm\/143.1.144","article-title":"Bronchiolar inflammation and fibrosis associated with smoking. A morphologic cross-sectional population analysis","volume":"143","author":"Adesina","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"issue":"4","key":"10.1016\/j.toxlet.2018.12.007_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/aje\/kwt335","article-title":"The 2014 Surgeon General\u2019s report: commemorating the 50th Anniversary of the 1964 Report of the Advisory Committee to the US Surgeon General and updating the evidence on the health consequences of cigarette smoking","volume":"179","author":"Alberg","year":"2014","journal-title":"Am. J. Epidemiol."},{"issue":"11-12","key":"10.1016\/j.toxlet.2018.12.007_bib0015","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0278-6915(01)00084-9","article-title":"Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results","volume":"40","author":"Carmines","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2018.12.007_bib0025","doi-asserted-by":"crossref","first-page":"34424","DOI":"10.1038\/srep34424","article-title":"Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner","volume":"6","author":"Daijo","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.toxlet.2018.12.007_bib0030","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"6959","key":"10.1016\/j.toxlet.2018.12.007_bib0035","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/bmj.309.6959.901","article-title":"Mortality in relation to smoking: 40 years \u2018observations on male British doctors","volume":"309","author":"Doll","year":"1994","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.toxlet.2018.12.007_bib0040","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","article-title":"Calcium and oxidative stress: from cell signaling to cell death","volume":"38","author":"Ermak","year":"2002","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2018.12.007_bib0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1586\/14737175.2014.915745","article-title":"What is the risk of aluminium as a neurotoxin?","volume":"14","author":"Exley","year":"2014","journal-title":"Expert Rev. Neurother."},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0050","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1183\/09031936.00105110","article-title":"Effects of cigarette smoke and hypoxia on pulmonary circulation in the guinea pig","volume":"38","author":"Ferrer","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.toxlet.2018.12.007_bib0055","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0060","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"issue":"18","key":"10.1016\/j.toxlet.2018.12.007_bib0065","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1089\/ars.2017.7272","article-title":"Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress","volume":"28","author":"Garza-Lomb\u00f3","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"11","key":"10.1016\/j.toxlet.2018.12.007_bib0070","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1164\/rccm.200802-334OC","article-title":"Particulae matter in cigarette smoke alters iron homeostasis to produce a biological effect","volume":"178","author":"Ghio","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"64","key":"10.1016\/j.toxlet.2018.12.007_bib0075","doi-asserted-by":"crossref","first-page":"107730","DOI":"10.18632\/oncotarget.22594","article-title":"Autophagy flux inhibiton, G2\/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/tc.7.3.281","article-title":"Reducing the addictiveness of cigarettes. Council on scientific affairs, American Medical Association","volume":"7","author":"Henningfield","year":"1998","journal-title":"Tob. Control"},{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0085","first-page":"11","article-title":"Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases","volume":"5","author":"Hussain","year":"2018","journal-title":"Mil. Med. Res."},{"issue":"9","key":"10.1016\/j.toxlet.2018.12.007_bib0090","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/archsurg.1991.01410330093013","article-title":"Cigarette smoking decreases tissue oxygen","volume":"126","author":"Jensen","year":"1991","journal-title":"Arch Surg"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.redox.2013.01.014","article-title":"Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms","volume":"1","author":"Kalyanaraman","year":"2013","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.toxlet.2018.12.007_bib0100","doi-asserted-by":"crossref","first-page":"e89875","DOI":"10.1371\/journal.pone.0089875","article-title":"Hypoxia exerts dualistic effects on inflammatory and proliferative responses of healthy and asthmatic primary human bronchial smooth muscle cells","volume":"9","author":"Keglowich","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0105","series-title":"The Roles of NRF2 in Modulating Cellular Iron Homeostasis","author":"Kerins","year":"2017"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0110","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.redox.2013.08.002","article-title":"Nrf2 activation supports cell survival during hypoxia and hypoxia\/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species","volume":"1","author":"Kolamunne","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.toxlet.2018.12.007_bib0115","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.freeradbiomed.2013.09.001","article-title":"The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into potential of various iron therapies to induce oxidative and nitrosative stress","volume":"65","author":"Koskenkorva-Frank","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.toxlet.2018.12.007_bib0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/thx.2003.014894","article-title":"Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath","volume":"59","author":"Lane","year":"2004","journal-title":"Thorax"},{"issue":"s1","key":"10.1016\/j.toxlet.2018.12.007_bib0125","doi-asserted-by":"crossref","first-page":"S379","DOI":"10.3233\/JAD-179944","article-title":"Iron and Alzheimer\u2019s Disease: an update on emerging mechanisms","volume":"64","author":"Lane","year":"2018","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/ijerph6010209","article-title":"Smoking and chronic obstructive pulmonary disease (COPD). Parallel epidemics of the 21 century","volume":"6","author":"Laniado-Laborin","year":"2009","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2Pt 1","key":"10.1016\/j.toxlet.2018.12.007_bib0135","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/ajrccm.151.2.7842202","article-title":"Cigarette smoke, ferritin, and lipid peroxidation","volume":"151","author":"Lapenna","year":"1995","journal-title":"Am. J. Respir. Cirt. Care Med."},{"issue":"8","key":"10.1016\/j.toxlet.2018.12.007_bib0140","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.toxlet.2018.12.007_bib0145","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/15376516.2014.956909","article-title":"Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation","volume":"24","author":"Lin","year":"2014","journal-title":"Toxicol. Mech. Methods"},{"issue":"2","key":"10.1016\/j.toxlet.2018.12.007_bib0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/toxsci\/kfm112","article-title":"Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes","volume":"98","author":"Lu","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2018.12.007_bib0155","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tox.2013.03.008","article-title":"A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro","volume":"308","author":"Maertens","year":"2013","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.toxlet.2018.12.007_bib0160","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1164\/ajrccm.155.5.9154890","article-title":"Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells","volume":"155","author":"Mio","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.toxlet.2018.12.007_bib0165","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.bbadis.2011.06.002","article-title":"Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome","volume":"1812","author":"Mortaz","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0170","series-title":"The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General. Atlanta (GA)","author":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health","year":"2014"},{"issue":"9","key":"10.1016\/j.toxlet.2018.12.007_bib0175","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1172\/JCI200420945","article-title":"IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin","volume":"113","author":"Nemeth","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3164\/jcbn.2008068","article-title":"Role of oxidative stress in adaptive response in special reference to atherogenesis","volume":"43","author":"Noguchi","year":"2008","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"2-3","key":"10.1016\/j.toxlet.2018.12.007_bib0185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.resp.2011.09.013","article-title":"Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance","volume":"179","author":"Olea","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"5","key":"10.1016\/j.toxlet.2018.12.007_bib0190","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10495-007-0756-2","article-title":"Mitochondria, oxidative stress and cell death","volume":"12","author":"Ott","year":"2007","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.toxlet.2018.12.007_bib0195","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/aob\/mcv072","article-title":"The effects of induced production of reactive oxygen species in organelles on endoplasmic reticulum stress and on the unfolded protein response in Arabidopsis","volume":"116","author":"Ozgur","year":"2015","journal-title":"Ann. Bot."},{"issue":"8","key":"10.1016\/j.toxlet.2018.12.007_bib0200","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.tiv.2014.07.010","article-title":"Magnetic iron oxide nanoparticles induce autohagy preceding apoptosis through mitochondrial damage and ER stress in RAW264.7 cells","volume":"28","author":"Park","year":"2014","journal-title":"Toxicol. In Vitro 31"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0205","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tiv.2018.07.014","article-title":"Cigarette smoke condensate may disturb immune function with apoptotic cell death by impairing function of organelles in alveolar macrophages","volume":"52","author":"Park","year":"2018","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0210","series-title":"In review. Cigarette smoke extract may induce lysosomal storage disease-like adverse health effects","author":"Park","year":"2018"},{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/oxfordjournals.bmb.a011519","article-title":"Mortality from smoking worldwide","volume":"52","author":"Peto","year":"1996","journal-title":"Br. Med. Bull."},{"issue":"48","key":"10.1016\/j.toxlet.2018.12.007_bib0220","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1038\/sj.onc.1205803","article-title":"Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers","volume":"21","author":"Pfeifer","year":"2002","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.toxlet.2018.12.007_bib0225","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1046\/j.1365-2273.2003.00726.x","article-title":"Tobacco smoke and the upper airway","volume":"28","author":"Phillips","year":"2003","journal-title":"Clin. Otolaryngol. Allied Sci."},{"issue":"2","key":"10.1016\/j.toxlet.2018.12.007_bib0230","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4161\/cc.3.2.618","article-title":"Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target","volume":"3","author":"Potter","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.toxlet.2018.12.007_bib0235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1741-7007-11-71","article-title":"Mitochondrial network morphology: building an integrative, geometrical view","volume":"11","author":"Rafelski","year":"2013","journal-title":"BMC Biol."},{"issue":"9","key":"10.1016\/j.toxlet.2018.12.007_bib0240","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/00039896.1975.10666743","article-title":"The role of carbon monoxide in cigarette smoking. I. Carbon monoxide yield from cigarettes","volume":"30","author":"Robinson","year":"1975","journal-title":"Arch. Environ. Health"},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0245","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.yrtph.2014.09.008","article-title":"Somking behaviour and compensation: a review of the literature with meta-analysis","volume":"70","author":"Scherer","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.toxlet.2018.12.007_bib0250","first-page":"533","article-title":"Whole cigarette smoke promotes human gingival epithelial cell apoptosis and inhibits cell repair processes","volume":"46","author":"Semlali","year":"2011","journal-title":"J. Periodontal Res. Suppl."},{"issue":"4","key":"10.1016\/j.toxlet.2018.12.007_bib0255","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1165\/rcmb.2006-0214OC","article-title":"Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death","volume":"36","author":"Slebos","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.toxlet.2018.12.007_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175009","article-title":"Resveratrol reduces the apoptosis induced by cigarette smoke extract by upregulating MFN2","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.toxlet.2018.12.007_bib0265","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.toxlet.2018.12.007_bib0270","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1096\/fasebj.5.1.1703974","article-title":"Inhibition of macrohage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs","volume":"5","author":"Stuehr","year":"1991","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.toxlet.2018.12.007_bib0275","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/ijerph8020613","article-title":"Hazardous compounds in tobacco smoke","volume":"8","author":"Talhout","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"10","key":"10.1016\/j.toxlet.2018.12.007_bib0280","doi-asserted-by":"crossref","first-page":"e76230","DOI":"10.1371\/journal.pone.0076230","article-title":"Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance","volume":"8","author":"Tam","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.toxlet.2018.12.007_bib0285","doi-asserted-by":"crossref","first-page":"e2247","DOI":"10.1038\/cddis.2016.138","article-title":"Erianin induces G2\/M-phase arrest, apoptosis, and autophagy via the ROS\/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2018.12.007_bib0290","doi-asserted-by":"crossref","first-page":"359","DOI":"10.14694\/EdBook_AM.2013.33.359","article-title":"Tobacco and lung cancer: risks, trends, and outcomes in patients with cancer","author":"Warren","year":"2013","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"issue":"6","key":"10.1016\/j.toxlet.2018.12.007_bib0295","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.tiv.2013.06.016","article-title":"Comet assay and air-liquid interface exposure system: a new combination to evaluate genotoxic effects of cigarette whole smoke in human lung cell lines","volume":"27","author":"Weber","year":"2013","journal-title":"Toicol In Vitro"},{"issue":"17","key":"10.1016\/j.toxlet.2018.12.007_bib0300","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1128\/MCB.00437-12","article-title":"Cell death and autophagy under oxidative stress: roles of poly(ADP-Ribose) polymerases and Ca(2+)","volume":"32","author":"Wyrsch","year":"2012","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.toxlet.2018.12.007_bib0305","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.toxlet.2018.12.007_bib0310","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2017.11.001","article-title":"\u03b1-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice","volume":"14","author":"Zhang","year":"2018","journal-title":"Redox Biol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418317557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427418317557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:14:52Z","timestamp":1759900492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427418317557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":62,"alternative-id":["S0378427418317557"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.12.007","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2018.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}