{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:03:50Z","timestamp":1788458630751,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470697"],"award-info":[{"award-number":["81470697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771002"],"award-info":[{"award-number":["81771002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.toxlet.2019.05.025","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T13:42:50Z","timestamp":1560778970000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Enhancing autophagy by down-regulating GSK-3\u03b2 alleviates cisplatin-induced ototoxicity in vivo and in vitro"],"prefix":"10.1016","volume":"313","author":[{"given":"Tianyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanji","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-5435","authenticated-orcid":false,"given":"Hongjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2019.05.025_bib0005","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/onc.2014.390","article-title":"Combined regulation of mtorc1 and lysosomal acidification by gsk-3 suppresses autophagy and contributes to cancer cell growth","volume":"34","author":"Azoulay-Alfaguter","year":"2015","journal-title":"Oncogene"},{"issue":"35","key":"10.1016\/j.toxlet.2019.05.025_bib0010","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/onc.2014.390","article-title":"Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth","volume":"34","author":"Azoulay-Alfaguter","year":"2015","journal-title":"Oncogene."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2011.07.026","article-title":"Micellization of cisplatin (nc-6004) reduces its ototoxicity in guinea pigs","volume":"157","author":"Baba","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0020","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1681\/ASN.2013040350","article-title":"Delayed administration of a single dose of lithium promotes recovery from aki","volume":"25","author":"Bao","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0025","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S1470-2045(17)30566-1","article-title":"Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced met-positive gastric or gastro-oesophageal junction cancer (rilomet-1): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"18","author":"Catenacci","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/gyno.1993.1184","article-title":"Nephrotoxicity and hydration management for cisplatin, carboplatin, and ormaplatin","volume":"50","author":"Cornelison","year":"1993","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0035","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0040","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbrc.2014.04.123","article-title":"Rapamycin alleviates cisplatin-induced ototoxicity in vivo","volume":"448","author":"Fang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0045","first-page":"5","article-title":"Breast cancer cell line mcf7 escapes from g1\/s arrest induced by proteasome inhibition through a gsk-3\u03b2 dependent mechanism","author":"Gavil\u00e1n","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0050","first-page":"2742","article-title":"The western blot","author":"Hnasko","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0055","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/15548627.2015.1038016","article-title":"Identifying an essential role of nuclear lc3 for autophagy","volume":"11","author":"Huang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.heares.2016.02.019","article-title":"Hei-oc1 cells as a model for investigating drug cytotoxicity","volume":"335","author":"Kalinec","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0065","doi-asserted-by":"crossref","DOI":"10.3791\/54425","article-title":"Working with auditory hei-oc1 cells","author":"Kalinec","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.toxlet.2015.06.012","article-title":"An integrated view of cisplatin-induced nephrotoxicity and ototoxicity","volume":"237","author":"Karasawa","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0075","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.kint.2015.11.021","article-title":"Autophagy in acute kidney injury","volume":"89","author":"Kaushal","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0080","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.semcancer.2013.06.009","article-title":"Complex regulation of autophagy in cancer \u2013 integrated approaches to discover the networks that hold a double-edged sword","volume":"23","author":"Kubisch","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0085","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1217032","article-title":"Gsk3-tip60-ulk1 signaling pathway links growth factor deprivation to autophagy","volume":"336","author":"Lin","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0090","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1039\/C4MT00220B","article-title":"Fortification of blood plasma from cancer patients with human serum albumin decreases the concentration of cisplatin-derived toxic hydrolysis products in vitro","volume":"6","author":"Morris","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0095","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.heares.2009.08.001","article-title":"Selective gsk-3\u03b2 inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells","volume":"257","author":"Park","year":"2009","journal-title":"Hear. Res."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0100","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1111\/bcp.13388","article-title":"Renal toxicity and chemotherapy in children with cancer","volume":"83","author":"Ruggiero","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2018.03.009","article-title":"Cisplatin-induced gastrointestinal toxicity: an update on possible mechanisms and on available gastroprotective strategies","volume":"827","author":"Shahid","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fncel.2017.00338","article-title":"Mechanisms of cisplatin-induced ototoxicity and otoprotection","volume":"11","author":"Sheth","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.toxlet.2019.05.025_bib0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/BJ20150404","article-title":"GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling","volume":"470","author":"Stretton","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/pros.23106","article-title":"Gsk-3beta controls autophagy by modulating lkb1-ampk pathway in prostate cancer cells","volume":"76","author":"Sun","year":"2016","journal-title":"Prostate"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0125","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bcp.2013.04.022","article-title":"Activator or inhibitor? Gsk-3 as a new drug target","volume":"86","author":"Takahashi-Yanaga","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0130","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1158\/1078-0432.CCR-15-2477","article-title":"Homologous recombination deficiency (hrd) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer","volume":"22","author":"Telli","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0135","doi-asserted-by":"crossref","first-page":"17163","DOI":"10.1074\/jbc.M114.558288","article-title":"Role of autophagy in cisplatin resistance in ovarian cancer cells","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tibs.2009.10.002","article-title":"Gsk3: a multifaceted kinase in wnt signaling","volume":"35","author":"Wu","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0145","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4161\/auto.23641","article-title":"Synthesis and screening of 3-ma derivatives for autophagy inhibitors","volume":"9","author":"Wu","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0150","first-page":"5","article-title":"Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2019.05.025_bib0155","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/2211-5463.12220","article-title":"Activation of wnt\/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging","volume":"7","author":"Xia","year":"2017","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.toxlet.2019.05.025_bib0160","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000480346","article-title":"Endoplasmic reticulum stress is involved in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model","volume":"22","author":"Zong","year":"2017","journal-title":"Audiol. Neurootol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842741930164X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842741930164X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:16:37Z","timestamp":1569320197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842741930164X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":32,"alternative-id":["S037842741930164X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2019.05.025","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing autophagy by down-regulating GSK-3\u03b2 alleviates cisplatin-induced ototoxicity in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2019.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}