{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:46:34Z","timestamp":1794008794138,"version":"4.8.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.toxlet.2019.10.016","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:40:47Z","timestamp":1571920847000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway"],"prefix":"10.1016","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2231-0179","authenticated-orcid":false,"given":"Hirofumi","family":"Hamano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Niimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Horinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Zamami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Takechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Goda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Imanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Chuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Izawa-Ishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licht","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keijo","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Ishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-7349","authenticated-orcid":false,"given":"Yasumasa","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2019.10.016_bib0005","first-page":"430","article-title":"Haematological adverse effects of histamine H2-receptor antagonists","volume":"3","author":"Aymard","year":"1988","journal-title":"Med. Toxicol. Adverse Drug Exp."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0016-5085(90)90963-2","article-title":"Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450","volume":"99","author":"Diaz","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0015","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"Ganz","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0020","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0025","series-title":"The Uremic Toxin Indoxyl Sulfate Interferes with Iron Metabolism by Regulating Hepcidin in Chronic Kidney Disease. Nephrol Dial Transplant","author":"Hamano","year":"2017"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0030","doi-asserted-by":"crossref","first-page":"e0138881","DOI":"10.1371\/journal.pone.0138881","article-title":"Dietary inulin fibers prevent proton-pump inhibitor (PPI)-Induced hypocalcemia in mice","volume":"10","author":"Hess","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jtemb.2016.01.011","article-title":"Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway","volume":"35","author":"Ikeda","year":"2016","journal-title":"J. Trace Elements Med. Biol."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11894-010-0141-0","article-title":"Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium","volume":"12","author":"Ito","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/gut.10.3.226","article-title":"Role of gastric secretion in iron absorption","volume":"10","author":"Jacobs","year":"1969","journal-title":"Gut"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0050","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0009-9236(95)90018-7","article-title":"Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human","volume":"58","author":"Kashfi","year":"1995","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0055","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1053\/j.gastro.2016.11.023","article-title":"Proton pump inhibitor and histamine-2 receptor antagonist use and Iron deficiency","volume":"152","author":"Lam","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0060","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0065","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1073\/pnas.072632499","article-title":"Severe iron deficiency anemia in transgenic mice expressing liver hepcidin","volume":"99","author":"Nicolas","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0070","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000091298","article-title":"Acid suppression therapy: where do we go from here?","volume":"24","author":"Scarpignato","year":"2006","journal-title":"Digestive Dis. (Basel, Switzerland)"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0080","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1021\/cr9001116","article-title":"Trafficking of heme and porphyrins in metazoa","volume":"109","author":"Severance","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0085","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1182\/blood-2005-10-4043","article-title":"Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System","volume":"108","author":"Tomosugi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pds.668","article-title":"A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions","volume":"11","author":"van Puijenbroek","year":"2002","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.toxlet.2019.10.016_bib0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1615\/IntJMedMushrooms.v17.i7.20","article-title":"Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice","volume":"17","author":"Wang","year":"2015","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.toxlet.2019.10.016_bib0100","series-title":"Molecular Mechanisms of Normal Iron Homeostasis. Hematology American Society of Hematology Education Program","first-page":"207","author":"Zhang","year":"2009"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427419303352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427419303352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:16:57Z","timestamp":1759900617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427419303352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":20,"alternative-id":["S0378427419303352"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2019.10.016","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2019.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}