{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:33:18Z","timestamp":1771457598134,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005932","name":"Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.toxlet.2020.01.014","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T11:30:08Z","timestamp":1579260608000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Mechanistic understanding of dendritic cell activation in skin sensitization: additional evidences to support potency classification"],"prefix":"10.1016","volume":"322","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-1501","authenticated-orcid":false,"given":"Vlentina","family":"Galbiati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-8101","authenticated-orcid":false,"given":"Marina","family":"Marinovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-5956","authenticated-orcid":false,"given":"Emanuela","family":"Corsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.toxlet.2020.01.014_bib0005","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00018-011-0846-8","article-title":"Allergic contact dermatitis: Epidemiology, molecular mechanisms, in vitro methods and regulatory aspects","volume":"69","author":"Peiser","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxlet.2020.01.014_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/175265","article-title":"Hapten-induced contact hypersensitivity, autoimmune reactions, and tumor regression: plausibility of mediating antitumor immunity","volume":"2014","author":"Erkes","year":"2014","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.toxlet.2020.01.014_bib0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.iac.2016.08.014","article-title":"Allergic contact dermatitis","volume":"37","author":"Kostner","year":"2017","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.toxlet.2020.01.014_bib0020","series-title":"The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins","author":"OECD","year":"2014"},{"issue":"6","key":"10.1016\/j.toxlet.2020.01.014_bib0025","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1034\/j.1600-0536.2000.042006344.x","article-title":"Use of the local lymph node assay for the estimation of relative contact allergenic potency","volume":"42","author":"Basketter","year":"2000","journal-title":"Contact Derm."},{"issue":"December 12","key":"10.1016\/j.toxlet.2020.01.014_bib0030","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0278-6915(03)00223-0","article-title":"Classification of contact allergens according to potency: proposals","volume":"41","author":"Kimber","year":"2003","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/toxsci\/59.2.198","article-title":"Skin sensitization testing in potency and risk assessment","volume":"59","author":"Kimber","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2020.01.014_bib0040","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3389\/fimmu.2015.00534","article-title":"Functional specialization of skin dendritic cell subsets in regulating t cell responses","volume":"6","author":"Clausen","year":"2015","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.toxlet.2020.01.014_bib0045","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/embj.201488027","article-title":"Dendritic cell maturation: Functional specialization through signaling specificity and transcriptional programming","volume":"33","author":"Dalod","year":"2014","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.toxlet.2020.01.014_bib0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2567.2007.02719.x","article-title":"Immunological decision-making: How does the immune system decide to mount a helper T-cell response?","volume":"123","author":"Kaiko","year":"2008","journal-title":"Immunology"},{"issue":"31","key":"10.1016\/j.toxlet.2020.01.014_bib0055","doi-asserted-by":"crossref","first-page":"28412","DOI":"10.1074\/jbc.M500345200","article-title":"Protein kinase C \u03b2II plays an essential role in dendritic cell differentiation and autoregulates its own expression","volume":"280","author":"Cejas","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.toxlet.2020.01.014_bib0060","doi-asserted-by":"crossref","first-page":"10697","DOI":"10.3390\/ijms130910697","article-title":"Meyer-fernandes JR. Cell signaling through protein kinase C oxidation and activation","volume":"13","author":"Cosentino-Gomes","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00204-013-1144-z","article-title":"Role of PKC-\u03b2 in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells","volume":"88","author":"Corsini","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.toxlet.2020.01.014_bib0070","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.4049\/jimmunol.162.6.3237","article-title":"Evidence for distinct intracellular signaling pathways in CD34 + progenitor to dendritic cell differentiation from a human cell line model","volume":"162","author":"Louis DC","year":"2004","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.toxlet.2020.01.014_bib0075","first-page":"157","article-title":"Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods","volume":"16","author":"Gerberick","year":"2007","journal-title":"Dermat (formerly Am J Contact Dermatitis)"},{"issue":"3","key":"10.1016\/j.toxlet.2020.01.014_bib0080","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.bbrc.2005.05.171","article-title":"A cell line model for the differentiation of human dendritic cells","volume":"333","author":"Berges","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.toxlet.2020.01.014_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2010.06.001","article-title":"Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro","volume":"24","author":"Mitjans","year":"2010","journal-title":"Toxicol. In Vitro"},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-011-0758-2","article-title":"Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin","volume":"86","author":"Galbiati","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0095","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-013-1144-z","article-title":"Role of PKC-\u03b2 in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells","volume":"88","author":"Corsini","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2020.01.014_bib0100","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yrtph.2014.06.013","article-title":"Assessment of the skin sensitising potency of the lower alkyl methacrylate esters","volume":"70","author":"Kimber","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2020.01.014_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-17787-z","article-title":"Substrate stiffness influences phenotype and function of human antigen-presenting dendritic cells","volume":"7","author":"Mennens","year":"2017","journal-title":"Sci. Rep."},{"issue":"MAY","key":"10.1016\/j.toxlet.2020.01.014_bib0110","first-page":"1","article-title":"In vitro methods for hazard assessment of industrial chemicals - Opportunities and challenges","volume":"6","author":"Wong","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2020.01.014_bib0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.atherosclerosis.2011.09.003","article-title":"The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature","volume":"221","author":"Qin","year":"2012","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.toxlet.2020.01.014_bib0120","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.tiv.2010.06.001","article-title":"Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro","volume":"24","author":"Mitjans","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2020.01.014_bib0125","first-page":"1313","article-title":"Review articles advances in immunology","author":"To","year":"2010","journal-title":"Adv. Immunol."},{"issue":"1","key":"10.1016\/j.toxlet.2020.01.014_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3892\/mmr.2015.4562","article-title":"A comparative analysis of metal allergens associated with dental alloy prostheses and the expression of HLA-DR in gingival tissue","volume":"13","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.toxlet.2020.01.014_bib0135","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/745483","article-title":"Role of TNF-alpha, IFN-gamma, and IL-10 in the development of pulmonary tuberculosis","volume":"2012","author":"Cavalcanti","year":"2012","journal-title":"Pulm. Med."},{"issue":"3","key":"10.1016\/j.toxlet.2020.01.014_bib0140","first-page":"379","volume":"5","year":"2010","journal-title":"Urban J. NIH Public Access."},{"issue":"9","key":"10.1016\/j.toxlet.2020.01.014_bib0145","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1021\/tx100043b","article-title":"Effect of a microemulsion system on hapten-peptide reactivity studies: examples of hydroxycitronellal and citral, fragrance skin sensitizers, with glutathione","volume":"23","author":"Merckel","year":"2010","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2020.01.014_bib0150","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0145-2126(95)00074-7","article-title":"Doppa induces cell death but not differentiation of U937 cells: evidence for the involvement of PKC-beta 1 in the regulation of apoptosis","volume":"20","author":"Pongracz","year":"1996","journal-title":"Leuk. Res."},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0155","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.tiv.2007.10.005","article-title":"Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells","volume":"22","author":"Mitjans","year":"2008","journal-title":"Toxicol. In Vitro"},{"issue":"2","key":"10.1016\/j.toxlet.2020.01.014_bib0160","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tiv.2008.12.010","article-title":"Potential method to determine irritant potency in vitro - Comparison of two reconstructed epidermal culture models with different barrier competency","volume":"23","author":"Spiekstra","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2020.01.014_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2014.01.002","article-title":"Corticosteroids modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1 cells","volume":"81","author":"Corsini","year":"2014","journal-title":"Pharmacol. Res."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420300229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420300229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:17:45Z","timestamp":1759900665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427420300229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":33,"alternative-id":["S0378427420300229"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.01.014","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic understanding of dendritic cell activation in skin sensitization: additional evidences to support potency classification","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}