{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:55:58Z","timestamp":1790362558739,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Defence UK"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.toxlet.2020.01.027","type":"journal-article","created":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T11:10:48Z","timestamp":1580555448000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["3-Quinuclidinyl-\u03b1-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning"],"prefix":"10.1016","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-8862","authenticated-orcid":false,"given":"Christopher M.","family":"Timperley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Lindsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-9374","authenticated-orcid":false,"given":"Helen","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.H.","family":"Tattersall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte L.","family":"Whitmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Christopher","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2020.01.027_bib0005","first-page":"271","article-title":"Antichounergic psychotomimetic agents","volume":"4","author":"Abood","year":"1962","journal-title":"Intern. Rev. Neurobiol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3181\/00379727-97-23782","article-title":"A new group of psychotomimetic agents","volume":"97","author":"Abood","year":"1958","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0015","first-page":"186","article-title":"Structure-activity relationships of 3-piperidyl benzilates with psychotogenic properties","volume":"120","author":"Abood","year":"1959","journal-title":"Arch. Int. Pharmacodyn."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-3806(87)90156-8","article-title":"Muscarinic receptors in human SH-SY5Y neuroblastoma cell line: regulation by phorbol ester and retinoic acid-induced differentiation","volume":"430","author":"Adem","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0025","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1476-5381.1959.tb00928.x","article-title":"Some quantitative uses of drug antagonists","volume":"14","author":"Arunlakshana","year":"1959","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0030","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/jm00222a015","article-title":"Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates","volume":"20","author":"Atkinson","year":"1977","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/oxfordjournals.bmb.a070721","article-title":"Actions of some toxic substances (psychotomimetics) on the central nervous system","volume":"25","author":"Bebbington","year":"1969","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3940(96)12488-5","article-title":"Stable functional expression of the adult subtype of human muscle acetylcholine receptor following transfection of the human rhabdomyosarcoma cell line TE671 with cDNA encoding the epsilon unit","volume":"207","author":"Beeson","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0045","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0022-3565(25)24700-0","article-title":"Ligand binding and functional characterization of muscarinic acetylcholine receptors on the TE671\/RD human cell line","volume":"257","author":"Bencherif","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1021\/jo01355a609","article-title":"p-Fluorotropic and p-fluoroatropine","volume":"22","author":"Berger","year":"1957","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-2952(71)90478-3","article-title":"Protection of animals against soman (1,2,2-trimethylpropyl methylphosphonofluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine","volume":"20","author":"Berry","year":"1971","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0060","series-title":"Anticholinergics: Progress Report, 14 February 1967","author":"Brimblecombe","year":"1967"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0028-3908(68)90050-6","article-title":"The peripheral and central actions of some anticholinergic substances","volume":"7","author":"Brimblecombe","year":"1968","journal-title":"Int. J. Neuropharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1476-5381.1970.tb09909.x","article-title":"The protective actions of some anticholinergic drugs in sarin poisoning","volume":"39","author":"Brimblecombe","year":"1970","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1476-5381.1946.tb00025.x","article-title":"Observations on the isolated phrenic nerve diaphragm preparation of the rat","volume":"1","author":"Bulbring","year":"1946","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3565(25)26415-1","article-title":"The peripheral actions of oxotremorine, a metabolite of tremorine","volume":"138","author":"Cho","year":"1962","journal-title":"J. Pharmacol. Expt. Therap."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0085","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0022-3565(24)38262-X","article-title":"Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor","volume":"289","author":"Christopoulos","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0090","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(99)00550-6","article-title":"The assessment of antagonist potency under conditions of transient response kinetics","volume":"382","author":"Christopoulos","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0095","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1139\/y62-091","article-title":"Cholinolytics in the treatment of anticholinesterase poisoning. I. The effectiveness of certain cholinolytics in combination with an oxime for treatment of sarin poisoning","volume":"40","author":"Coleman","year":"1962","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0100","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1139\/y62-092","article-title":"Cholinolytics in the treatment of anticholinesterase poisoning. II. Treatment of sarin poisoning with an oxime and various combinations of cholinolytic compounds","volume":"40","author":"Coleman","year":"1962","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0105","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1139\/y63-277","article-title":"Cholinolytics in the treatment of anticholinesterase poisoning. III. The effects of quaternization and alteration of anionic function of the potency of cholinolytics in the treatment of sarin poisoning","volume":"41","author":"Coleman","year":"1963","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0110","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1139\/y66-094","article-title":"Cholinolytics in the treatment of anticholinesterase poisoning. IV. The effectiveness of five binary combinations of cholinolytics with oximes in the treatment of organophosphorus poisoning","volume":"44","author":"Coleman","year":"1966","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1139\/y68-018","article-title":"Cholinolytics in the treatment of anticholinesterase poisoning. V. The effectiveness of Parpanit with oximes in the treatment of organophosphorus poisoning","volume":"46","author":"Coleman","year":"1968","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0120","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1039\/jr9470000952","article-title":"Substituted benzilic acids and benzophenones","volume":"0","author":"Ford-Moore","year":"1947","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/jr9470000055","article-title":"Synthetic mydriatics","volume":"0","author":"Ford-Moore","year":"1947","journal-title":"J. Chem. Soc."},{"issue":"1965","key":"10.1016\/j.toxlet.2020.01.027_bib0130","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/jm00329a014","article-title":"Stereochemical factors related to the potency of anticholinergic psychotomimetic drugs","volume":"8","author":"Gabel","year":"1965","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0135","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0143-4160(94)90079-5","article-title":"Rapid synchrony of nuclear and cytostolic Ca2+ signals activated by muscarinic stimulation in the human tumour line TE671\/RD","volume":"16","author":"Giovannardi","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3940(92)90022-Y","article-title":"Nicotinic acetylcholine receptors in human neuroblastoma (SH-SY5Y) cells","volume":"145","author":"Gould","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0145","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00374511","article-title":"Cholinergic responses in cloned human TE671\/RD tumour cells","volume":"425","author":"Grassi","year":"1993","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0150","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0155","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1081\/CLT-120015840","article-title":"Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents","volume":"40","author":"Kassa","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0160","series-title":"Isolated Skeletal Muscle Great Britain","author":"Kitchen","year":"1984"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0165","series-title":"Pharmaceutical Substances \u2013 Syntheses, Patents, Applications","author":"Kleemann","year":"2001"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0170","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0165-6147(00)01523-6","article-title":"Dynamic mechanisms of non-classical antagonism by competitive AT(1) receptor antagonists","volume":"21","author":"Lew","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mcne.1993.1001","article-title":"Characterization of nicotinic acetylcholine receptors expressed by cells of the SH-SY5Y human neuroblastoma clonal line","volume":"4","author":"Lukas","year":"1993","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-1211(99)00060-1","article-title":"Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs","volume":"38","author":"McDonough","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0185","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1021\/jm00279a030","article-title":"Absolute configuration of 3-quinuclidinyl benzilate and the behavioural effect in the dog of the optical isomers","volume":"15","author":"Meyerh\u00f6ffer","year":"1972","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0190","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nbt1228","article-title":"Global mapping of pharmacological space","volume":"24","author":"Paolini","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0195","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.toxlet.2017.11.006","article-title":"Efficacy of the antinicotinic compound MB327 against soman poisoning \u2013 importance of experimental end point","volume":"293","author":"Price","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tips.2009.11.006","article-title":"Unveiling the role of network and systems biology in drug discovery","volume":"31","author":"Pujol","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0022-3565(25)07784-5","article-title":"Spasmolytic action of bicyclic basic alcohol esters","volume":"104","author":"Randall","year":"1952","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0210","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2174\/1389557514666141128102837","article-title":"Development and structural modifications of cholinesterase reactivators against chemical warfare agents in last decade: a review","volume":"15","author":"Sharma","year":"2015","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0215","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/014107680509800307","article-title":"Nicotinic antagonists in the treatment of nerve agent intoxication","volume":"98","author":"Sheridan","year":"2005","journal-title":"J. Roy. Soc. Med."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0220","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-3057(99)00114-8","article-title":"Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment","volume":"64","author":"Shih","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0225","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s002040050670","article-title":"Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication","volume":"74","author":"Shih","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0230","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1021\/ja01129a019","article-title":"Antispasmodics. I. Bicyclic basic alcohols","volume":"74","author":"Sternbach","year":"1952","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0235","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1021\/ja01129a020","article-title":"Antispasmodics. II. Esters of bicyclic basic alcohols","volume":"74","author":"Sternbach","year":"1952","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0240","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1021\/ja01119a534","article-title":"Antispasmodics. III. Esters of bicyclic basic alcohols and their quaternary salts","volume":"75","author":"Sternbach","year":"1953","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0245","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1476-5381.1993.tb13498.x","article-title":"Ion channel blockade by oximes and recovery of diaphragm muscle from soman poisoning in vitro","volume":"108","author":"Tattersall","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0250","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cophys.2018.05.005","article-title":"Anticholinesterase toxicity","volume":"4","author":"Tattersall","year":"2018","journal-title":"Curr. Op. Physiol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0255","series-title":"Best Synthetic Methods: Organophosphorus (V) Chemistry","first-page":"46","article-title":"Treatment of organophosphate poisoning","author":"Timperley","year":"2015"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0260","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1039\/C2MD00258B","article-title":"1,1\u2019-(Propane-1,3-diyl)bis(4-tert-butylpyridinium) di(methanesulfonate) protects guinea pigs from soman poisoning when used as part of a combined therapy","volume":"3","author":"Timperley","year":"2012","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0265","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2019.01.004","article-title":"Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: part 1. On medical care and treatment of injuries from nerve agents","volume":"415","author":"Timperley","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0270","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tox.2018.11.009","volume":"413","author":"Timperley","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0275","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.toxlet.2011.05.1035","article-title":"Protection against nerve agent poisoning by a non-competitive nicotinic antagonist","volume":"206","author":"Turner","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0280","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0165-6147(02)02081-3","article-title":"Models and methods for studying insurmountable antagonism","volume":"23","author":"Vanquelin","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0285","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/cn100007x","article-title":"Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes","volume":"1","author":"Wager","year":"2010","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0290","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.taap.2008.07.005","article-title":"Therapy against organophosphate poisoning: the importance of anticholinergic drugs with antiglutamatergic properties","volume":"232","author":"Weissman","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0295","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tox.2011.09.004","article-title":"Multifunctional drugs as novel antidotes for organophosphates\u2019 poisoning","volume":"290","author":"Weissman","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2020.01.027_bib0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxlet.2019.12.010","article-title":"Assessment of false transmitters as treatments for nerve agent poisoning","volume":"321","author":"Whitmore","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0305","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1021\/jm50015a011","article-title":"Anticholinergic compounds as adjuncts to atropine in preventing lethality by sarin in the rabbit","volume":"3","author":"Wills","year":"1961","journal-title":"J. Med. Pharm. Chem."},{"key":"10.1016\/j.toxlet.2020.01.027_bib0310","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nbt1338","article-title":"Drug-target network","volume":"25","author":"Yildirim","year":"2007","journal-title":"Nat. Biotechnol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420300357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420300357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:18:38Z","timestamp":1759900718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427420300357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":62,"alternative-id":["S0378427420300357"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.01.027","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3-Quinuclidinyl-\u03b1-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}