{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:40:52Z","timestamp":1792683652403,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.toxlet.2020.05.012","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T02:51:15Z","timestamp":1589597475000},"page":"144-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats"],"prefix":"10.1016","volume":"330","author":[{"given":"Asma","family":"Siavashpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Khalvati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Niknahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-9838","authenticated-orcid":false,"given":"Reza","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2020.05.012_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.ajkd.2016.08.023","article-title":"Bile cast nephropathy caused by obstructive cholestasis","volume":"69","author":"Aniort","year":"2017","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nutr.28.061807.155443","article-title":"Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition","volume":"28","author":"Bogan","year":"2008","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0015","first-page":"549","article-title":"Bile acids, oxidative stress, and renal function in biliary obstruction","volume":"17","author":"Bomzon","year":"1997","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0020","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/hep.30499","article-title":"Cholemic nephropathy causes acute kidney injury and is accompanied by loss of aquaporin 2 in collecting ducts","volume":"69","author":"Brasen","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0025","series-title":"Cholestatic Liver Disease","first-page":"265","author":"Carey","year":"2014"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0030","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/bmc.798","article-title":"Development of an ion\u2010pair HPLC method for investigation of energy charge changes in cerebral ischemia of mice and hypoxia of Neuro\u20102a cell line","volume":"21","author":"Chen","year":"2007","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0035","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/CCM.0b013e31822f0b08","article-title":"Nicotinamide inhibits nuclear factor-kappa B translocation after transient focal cerebral ischemia","volume":"40","author":"Chen","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molcel.2006.12.012","article-title":"DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation","volume":"25","author":"Cohen-Armon","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0272-6386(12)80446-X","article-title":"Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease","volume":"19","author":"Delmez","year":"1992","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0050","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1365-2613.2010.00730.x","article-title":"Oxidative stress in obstructive nephropathy","volume":"92","author":"Dendooven","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0055","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00018-004-4506-0","article-title":"Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation","volume":"62","author":"Erd\u00e9lyi","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0060","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1021\/jm100012m","article-title":"Evolution of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic","volume":"53","author":"Ferraris","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0065","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/ajcp\/aqx030","article-title":"Bile cast nephropathy in cirrhotic patients: effects of chronic hyperbilirubinemia","volume":"147","author":"Foshat","year":"2017","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0070","series-title":"Liver Pathophysiology","first-page":"225","article-title":"Chapter 17 - Oxidative and nitrosative stress in chronic cholestasis","author":"Grattagliano","year":"2017"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0075","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-4939-1441-8_17","article-title":"Fe(3+)-Fe(2+) transformation method: an important antioxidant assay","volume":"1208","author":"G\u00fcl\u00e7in","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.04.012","article-title":"New therapeutic aspect for carvedilol: antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage","volume":"261","author":"Hamdy","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0085","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.redox.2014.08.003","article-title":"Inputs and outputs of poly(ADP-ribosyl)ation: relevance to oxidative stress","volume":"2","author":"Heged\u0171s","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0090","first-page":"117","article-title":"The role and study of mitochondrial impairment and oxidative stress in cholestasis","volume":"vol. 1","author":"Heidari","year":"2019"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5487\/TR.2016.32.2.133","article-title":"Effect of thiol-reducing agents and antioxidants on sulfasalazine-induced hepatic injury in normotermic recirculating isolated perfused rat liver","volume":"32","author":"Heidari","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biopha.2018.10.104","article-title":"Mitochondrial dysfunction as a mechanism involved in the pathogenesis of cirrhosis-associated cholemic nephropathy","volume":"109","author":"Heidari","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12012-018-9462-2","article-title":"Poly(ADP-ribose) polymerase (PARP) and PARP inhibitors: mechanisms of action and role in cardiovascular disorders","volume":"18","author":"Henning","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1523-1755.1999.00252.x","article-title":"Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor","volume":"55","author":"Holt","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0115","article-title":"Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-\u03b2 induced Smad3 activation in vascular smooth muscle cell","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0120","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1023\/A:1022957011153","article-title":"Quantitative evaluation of DNA fragmentation","volume":"134","author":"Kalinina","year":"2002","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0125","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/jcbfm.2009.9","article-title":"Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury","volume":"29","author":"Kauppinen","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000072668","article-title":"Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function","volume":"69","author":"Klaidman","year":"2003","journal-title":"Pharmacology"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0135","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s001250051536","article-title":"Safety of high-dose nicotinamide: a review","volume":"43","author":"Knip","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.lfs.2016.02.085","article-title":"PARP inhibition attenuates neuroinflammation and oxidative stress in chronic constriction injury induced peripheral neuropathy","volume":"150","author":"Komirishetty","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0145","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ccr3.1465","article-title":"Bile cast nephropathy in a patient with cholangiocarcinoma \u2013 a case report","volume":"6","author":"Kritmetapak","year":"2018","journal-title":"Clin. Case Rep."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0150","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jhep.2017.02.019","article-title":"NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice","volume":"67","author":"Krones","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0155","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bbadis.2017.08.028","article-title":"Cholemic nephropathy \u2013 historical notes and novel perspectives","volume":"1864","author":"Krones","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0160","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","article-title":"Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis","volume":"185","author":"Leist","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0165","first-page":"870","article-title":"Efficacy and safety of nicotinamide in haemodialysis patients: the NICOREN study","volume":"32","author":"Lenglet","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0170","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0026-895X(24)23027-3","article-title":"Pyrrolidine dithiocarbamate prevents I-\u03baB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs","volume":"55","author":"Liu","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0175","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/hep.30558","article-title":"The renaissance of cholemic nephropathy: a likely underestimated cause of renal dysfunction in liver disease","volume":"69","author":"Mandorfer","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0180","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.redox.2015.12.009","article-title":"Oxidative stress influence on renal dysfunction in patients with obstructive jaundice: a case and control prospective study","volume":"8","author":"Mart\u00ednez-Cecilia","year":"2016","journal-title":"J. Redox Biol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0185","series-title":"Hepatotoxicology","first-page":"716","author":"Meeks","year":"1991"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0190","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.26763","article-title":"Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis","volume":"59","author":"Mukhopadhyay","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0195","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12640-015-9517-0","article-title":"Perinatal asphyxia leads to PARP-1 overactivity, p65 translocation, IL-1\u03b2 and TNF-\u03b1 overexpression, and apoptotic-like cell death in mesencephalon of neonatal rats: prevention by systemic neonatal nicotinamide administration","volume":"27","author":"Neira-Pe\u00f1a","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0200","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0205","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.3748\/wjg.v22.i27.6328","article-title":"Bile cast nephropathy: a case report and review of the literature","volume":"22","author":"Patel","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0210","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3748\/wjg.15.1677","article-title":"Bile-acid-induced cell injury and protection","volume":"15","author":"Perez","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1006932714982","article-title":"Newly discovered anti-inflammatory properties of the benzamides and nicotinamides","volume":"193","author":"Pero","year":"1999","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0220","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0098-2997(00)00004-2","article-title":"Pathogenesis of liver fibrosis: role of oxidative stress","volume":"21","author":"Poli","year":"2000","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0225","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cbi.2017.07.002","article-title":"Sodium thiosulfate post-conditioning protects rat hearts against ischemia reperfusion injury via reduction of apoptosis and oxidative stress","volume":"274","author":"Ravindran","year":"2017","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0230","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0235","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/exnr.1998.6969","article-title":"Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model","volume":"155","author":"Socci","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2010.06.003","article-title":"Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications","volume":"53","author":"Sodhi","year":"2010","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0245","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/jcb.22332","article-title":"Critical role of poly (ADP-ribose) polymerase-1 in modulating the mode of cell death caused by continuous oxidative stress","volume":"108","author":"Son","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0250","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11306-019-1604-4","article-title":"Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide","volume":"15","author":"Song","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0255","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1478-3231.2009.02182.x","article-title":"The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study","volume":"30","author":"Trawal\u00e9","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0260","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jhep.2010.04.025","article-title":"Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells","volume":"53","author":"Trebicka","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027093","article-title":"Nicotinamide inhibits alkylating agent-induced apoptotic neurodegeneration in the developing rat brain","volume":"6","author":"Ullah","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0270","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1365-2249.2003.02031.x","article-title":"Nicotinamide is a potent inhibitor of proinflammatory cytokines","volume":"131","author":"Ungerstedt","year":"2003","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0275","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ki.2013.78","article-title":"Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction","volume":"84","author":"van Slambrouck","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0280","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1570161054368625","article-title":"Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies","volume":"3","author":"Vir\u00e1g","year":"2005","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0285","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.54.3.375","article-title":"The therapeutic potential of poly(ADP-ribose) polymerase inhibitors","volume":"54","author":"Vir\u00e1g","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms3240","article-title":"A systematic analysis of the PARP protein family identifies new functions critical for cell physiology","volume":"4","author":"Vyas","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0295","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.3748\/wjg.v18.i36.4985","article-title":"Novel insight into mechanisms of cholestatic liver injury","volume":"18","author":"Woolbright","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0300","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00024382-200013010-00011","article-title":"Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury","volume":"13","author":"Yang","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.toxlet.2020.05.012_bib0305","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1742-7843.2004.950202.x","article-title":"Oxidative damage of biomolecules in mouse liver induced by morphine and protected by antioxidants","volume":"95","author":"Zhang","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0310","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1073\/pnas.0409786102","article-title":"A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse","volume":"102","author":"Zheng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2020.05.012_bib0315","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1111\/jcmm.14285","article-title":"Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell. Mol. Med."}],"updated-by":[{"DOI":"10.1016\/j.toxlet.2026.113186","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000}},{"DOI":"10.1016\/j.toxlet.2026.113186","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000}}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420301454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427420301454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:20:24Z","timestamp":1759900824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427420301454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":63,"alternative-id":["S0378427420301454"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.05.012","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2020.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}