{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:15:28Z","timestamp":1784578528542,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP18H02588"],"award-info":[{"award-number":["JP18H02588"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP18K06786"],"award-info":[{"award-number":["JP18K06786"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP18H02588"],"award-info":[{"award-number":["JP18H02588"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP18K06786"],"award-info":[{"award-number":["JP18K06786"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.toxlet.2021.01.020","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T18:27:28Z","timestamp":1611858448000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis"],"prefix":"10.1016","volume":"341","author":[{"given":"Rao","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shigematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tsuchimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Egashira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Ieiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-5989","authenticated-orcid":false,"given":"Satohiro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2021.01.020_bib0005","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.4049\/jimmunol.181.4.2831","article-title":"Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506","volume":"181","author":"Akool el","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00007890-199402000-00001","article-title":"Enhancement of FK506 nephrotoxicity by sodium depletion in an experimental rat model","volume":"57","author":"Andoh","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1440-1681.1995.tb02082.x","article-title":"Functional and structural characteristics of experimental FK 506 nephrotoxicity","volume":"22","author":"Andoh","year":"1995","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0020","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1681\/ASN.2015030292","article-title":"Urine injury biomarkers and risk of adverse outcomes in recipients of prevalent kidney transplants: the folic acid for vascular outcome reduction in transplantation trial","volume":"27","author":"Bansal","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0025","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1600-6143.2011.03504.x","article-title":"Chronic calcineurin inhibitor nephrotoxicity-lest we forget","volume":"11","author":"Chapman","year":"2011","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0035","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/ajt.15225","article-title":"Comparison of the effects of standard vs low-dose prolonged-release tacrolimus with or without ACEi\/ARB on the histology and function of renal allografts","volume":"19","author":"Cockfield","year":"2019","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0040","article-title":"Proximal tubular injury in medullary rays is an early sign of acute tacrolimus nephrotoxicity","volume":"2015","author":"Cosner","year":"2015","journal-title":"J. Transplant."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0045","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/00007890-199404270-00016","article-title":"The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo","volume":"57","author":"Cvetkovic","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41401-018-0070-2","article-title":"Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation","volume":"40","author":"Fu","year":"2019","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0055","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/sj.ki.5001893","article-title":"The role of heme oxygenase 1 in rapamycin-induced renal dysfunction after ischemia and reperfusion injury","volume":"70","author":"Gon\u00e7alves","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0060","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1002\/jcp.26536","article-title":"Curcumin alleviates ischemia reperfusion-induced late kidney fibrosis through the APPL1\/Akt signaling pathway","volume":"233","author":"Hongtao","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0065","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1172\/JCI45361","article-title":"Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis","volume":"123","author":"Humphreys","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.trre.2010.02.002","article-title":"Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury","volume":"24","author":"Huo","year":"2010","journal-title":"Transplant. Rev. (Orlando)"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0075","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.273.7.4135","article-title":"Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury","volume":"273","author":"Ichimura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1432-2277.1999.tb00587.x","article-title":"Tacrolimus versus cyclosporin A: a comparative study on rat renal allograft survival","volume":"12","author":"Jiang","year":"1999","journal-title":"Transpl. Int."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0085","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1046\/j.1523-1755.2002.00668.x","article-title":"Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity","volume":"62","author":"Khanna","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1159\/000339494","article-title":"Tacrolimus induces glomerular injury via endothelial dysfunction caused by reactive oxygen species and inflammatory change","volume":"35","author":"Kidokoro","year":"2012","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0095","doi-asserted-by":"crossref","first-page":"e2972","DOI":"10.1038\/cddis.2017.365","article-title":"Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K\/AKT pathway during tacrolimus-induced oxidative stress","volume":"8","author":"Lim","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0100","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/01.TP.0000081399.75231.3B","article-title":"Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression","volume":"76","author":"Maluccio","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0105","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/S0041-1345(01)01938-8","article-title":"The effect of differing immunosuppressive regimes on the functional and morphologic changes in a rat renal allograft model of chronic rejection","volume":"33","author":"McGrath","year":"2001","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12882-015-0011-y","article-title":"Kidney injury molecule-1 expression in human kidney transplants with interstitial fibrosis and tubular atrophy","volume":"16","author":"Nogare","year":"2015","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0115","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/TP.0000000000002625","article-title":"Genetic variants associated with immunosuppressant pharmacokinetics and adverse effects in the DeKAF genomics genome-wide association studies","volume":"103","author":"Oetting","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1293\/tox.26.29","article-title":"Change trends of organ weight background data in sprague dawley rats at different ages","volume":"26","author":"Piao","year":"2013","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0125","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/TP.0000000000000961","article-title":"Calcineurin-inhibition results in upregulation of local renin and subsequent vascular endothelial growth factor production in renal collecting ducts","volume":"100","author":"Prokai","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0130","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1681\/ASN.2005080891","article-title":"Molecular comparison of calcineurin inhibitor-induced fibrogenic responses in protocol renal transplant biopsies","volume":"17","author":"Roos-van Groningen","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/00007890-199002000-00041","article-title":"Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury","volume":"49","author":"Rosen","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0140","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1097\/TP.0000000000002366","article-title":"A 2018 reference guide to the banff classification of renal allograft pathology","volume":"102","author":"Roufosse","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00007890-199807150-00013","article-title":"Cholestasis and alterations of glutathione metabolism induced by tacrolimus (FK506) in the rat","volume":"66","author":"Sanchez-Campos","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0150","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.nefro.2016.11.017","article-title":"Value of urinary levels of interleukin-6, epidermal growth factor, monocyte chemoattractant protein type1 and transforming growth factor \u03b21 in predicting the extent of fibrosis lesions in kidney biopsies of patients with IgA nephropathy","volume":"37","author":"Segarra-Medrano","year":"2017","journal-title":"Nefrologia"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0155","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/00007890-199712270-00034","article-title":"Mechanism of fibrosis in experimental tacrolimus nephrotoxicity","volume":"64","author":"Shihab","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.toxlet.2021.01.020_bib0160","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00280-015-2880-y","article-title":"Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients","volume":"76","author":"Shinke","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0165","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.biocel.2010.05.010","article-title":"Aging, antagonistic pleiotropy and fibrotic disease","volume":"42","author":"Thannickal","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0170","doi-asserted-by":"crossref","first-page":"F517","DOI":"10.1152\/ajprenal.00291.2005","article-title":"Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury","volume":"290","author":"Vaidya","year":"2006","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.toxlet.2021.01.020_bib0175","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2165\/00003088-199529060-00003","article-title":"Clinical pharmacokinetics of tacrolimus","volume":"29","author":"Venkataramanan","year":"1995","journal-title":"Clin. Pharmacokinet."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421000291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421000291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:21:50Z","timestamp":1759900910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427421000291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":35,"alternative-id":["S0378427421000291"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.01.020","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of an experimental rat model of tacrolimus-induced kidney injury accompanied by interstitial fibrosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}