{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:38:17Z","timestamp":1787243897815,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.toxlet.2021.04.020","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T10:42:26Z","timestamp":1619865746000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells"],"prefix":"10.1016","volume":"347","author":[{"given":"Liang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyanhan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2021.04.020_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.cellbio.22.010305.104638","article-title":"Mitochondrial fusion and fission in mammals","volume":"22","author":"Chan","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0010","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1177\/0960327111407224","article-title":"Causes and prevention of herb-induced aconite poisonings in Asia","volume":"30","author":"Chan","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.forsciint.2012.02.026","article-title":"Aconitum alkaloid content and the high toxicity of aconite tincture","volume":"222","author":"Chan","year":"2012","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0020","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/nature12189","article-title":"Conserved regulatory elements in AMPK","volume":"498","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0025","series-title":"Poisonous Plants in China","first-page":"465","author":"Chen","year":"1987"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0030","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/s41401-018-0174-8","article-title":"Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade","volume":"40","author":"Deng","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0035","first-page":"21","article-title":"Activation of AMPK under hypoxia: many roads leading to Rome","author":"Dengler","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0040","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.freeradbiomed.2010.01.015","article-title":"Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species","volume":"48","author":"Dranka","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.rvsc.2003.08.010","article-title":"Effect of high intensity training on anaerobic capacity of middle gluteal muscle in Thoroughbred horses","volume":"76","author":"Eto","year":"2004","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1365-201x.1999.00607.x","article-title":"Effect of training on the activity of five muscle enzymes studied on elite cross-country skiers","volume":"167","author":"Evertsen F","year":"1999","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0055","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1242\/jcs.171017","article-title":"Mitochondrial dynamics in neuronal injury, development and plasticity","volume":"130","author":"Flippo","year":"2017","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0014-2999(97)01268-5","article-title":"Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties","volume":"337","author":"Friese","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0065","first-page":"511","article-title":"The structure and function of mitochondrial fusion protein Mfn1\/2","volume":"27","author":"Fu","year":"2007","journal-title":"Chem. Life"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0070","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1093\/jac\/dkv098","article-title":"Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines","volume":"70","author":"Funes","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0075","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0080","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0090","doi-asserted-by":"crossref","first-page":"E9863","DOI":"10.1073\/pnas.1708782114","article-title":"Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin","volume":"114","author":"Huang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/joim.12055","article-title":"The role of mitochondrial DNA mutations and free radicals in disease and ageing","volume":"273","author":"Lagouge","year":"2013","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jflm.2016.05.016","article-title":"Case reports of aconite poisoning in mainland China from 2004 to 2015: a retrospective analysis","volume":"42","author":"Li","year":"2016","journal-title":"J. Forensic Leg. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0110","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jphs.2017.01.007","article-title":"Aconitine: a potential novel treatment for systemic lupus erythematosus","volume":"133","author":"Li","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0115","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0120","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.annemergmed.2003.10.046","article-title":"Clinical features and management of herb-induced aconitine poisoning","volume":"43","author":"Lin","year":"2004","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1055\/s-0029-1240688","article-title":"Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaeli (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloids","volume":"76","author":"Lu","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbadis.2005.07.001","article-title":"The relevance of mitochondrial membrane topology to mitochondrial function","volume":"1762","author":"Mannella","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0135","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaf7478","article-title":"AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1","volume":"10","author":"Marin","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0140","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","article-title":"Metabolic regulation of mitochondrial dynamics","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jphp.12310","article-title":"A review on phytochemistry, pharmacology and toxicology studies of Aconitum","volume":"67","author":"Nyirimigabo","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0165-6147(89)90029-1","article-title":"Role of Ca2+ in toxic cell killing","volume":"10","author":"Orrenius","year":"1989","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0155","first-page":"25","article-title":"Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function","volume":"592","author":"P\u00e5hlman","year":"1990","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0160","first-page":"2551","article-title":"Research progress on neurotoxicity of Radix aconiti lateralis praeparata","volume":"12","author":"Pan","year":"2017","journal-title":"World Chin. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0165","first-page":"730","article-title":"Research progress of chinese materia medica-induced cardiotoxicity","volume":"44","author":"Pan","year":"2020","journal-title":"Progress Pharm. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.toxlet.2020.01.026","article-title":"Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury","volume":"323","author":"Pan","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0175","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mito.2018.11.002","article-title":"Mitochondrial dynamics, a key executioner in neurodegenerative diseases","volume":"47","author":"Panchal","year":"2019","journal-title":"Mitochondrion"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF03191176","article-title":"The toxicity of aconitine, emodin on ICC cell and the antagonist effect of the compatibility","volume":"34","author":"Peng","year":"2009","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0185","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s12272-009-2105-1","article-title":"Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells","volume":"32","author":"Peng","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0190","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12701","article-title":"Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFalpha-NLRP3 signalling axis","volume":"53","author":"Peng","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0195","doi-asserted-by":"crossref","first-page":"21029","DOI":"10.1038\/s41598-020-78195-4","article-title":"Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression","volume":"10","author":"Rahmel","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0200","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41467-017-00525-4","article-title":"Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster","volume":"8","author":"Rana","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0205","doi-asserted-by":"crossref","first-page":"e0175195","DOI":"10.1371\/journal.pone.0175195","article-title":"Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure","volume":"12","author":"Riba","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0210","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ebiom.2019.09.017","article-title":"Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer","volume":"48","author":"Seo","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0215","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF02439272","article-title":"Peculiarities of cardiotropic effect of aconitine","volume":"129","author":"Sheikh-Zade","year":"2000","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0220","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.11622\/smedj.2015114","article-title":"Herb-induced cardiotoxicity from accidental aconitine overdose","volume":"56","author":"Sheth","year":"2015","journal-title":"Singapore Med. J."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0225","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2009.07.031","article-title":"Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk?","volume":"126","author":"Singhuber","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056884","article-title":"Warburg and Crabtree effects in premalignant Barrett\u2019s esophagus cell lines with active mitochondria","volume":"8","author":"Suchorolski","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122124","article-title":"Melatonin: a mitochondrial targeting molecule involving mitochondrial protection and dynamics","volume":"17","author":"Tan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0240","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab4138","article-title":"AMP-activated protein kinase mediates mitochondrial fission in response to energy stress","volume":"351","author":"Toyama","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0245","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tem.2015.12.001","article-title":"Mitochondrial dynamics and metabolic regulation","volume":"27","author":"Wai","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0250","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1021\/pr200963e","volume":"11","author":"Wang","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0255","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1742-4658.2011.08010.x","article-title":"Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins","volume":"278","author":"Wu","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0260","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/bdrb.20116","article-title":"Study of aconitine toxicity in rat embryos in vitro","volume":"80","author":"Xiao","year":"2007","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2021.04.020_bib0265","first-page":"212","article-title":"Neurotoxic effect of aconitine based on the midbrain dopaminergic neurons cell culture","volume":"23","author":"Yan","year":"2013","journal-title":"J. Jiangsu Univ. (Med. Ed.)"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0270","series-title":"Practical Clinical Chinese Pharmacy","first-page":"312","author":"Zeng","year":"2001"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0275","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.neuro.2010.06.005","article-title":"Mechanism study of aconitum-induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage","volume":"31","author":"Zhao","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0280","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/B978-0-323-07307-3.10074-6","article-title":"Cellular respiration","author":"Zimmerman","year":"2011","journal-title":"Pediatr. Crit. Care"},{"key":"10.1016\/j.toxlet.2021.04.020_bib0285","first-page":"620","article-title":"Superficial analysis of Chinese materia medica processing status","volume":"36","author":"Zou","year":"2005","journal-title":"Chin. Tradit. Herbal Drugs"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421001193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421001193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:22:38Z","timestamp":1759900958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427421001193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":57,"alternative-id":["S0378427421001193"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.04.020","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.04.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}