{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:22:14Z","timestamp":1759969334091,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"am","delay-in-days":284,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["17935522"],"award-info":[{"award-number":["17935522"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07225","20K07158"],"award-info":[{"award-number":["19K07225","20K07158"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.toxlet.2021.07.007","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T11:14:35Z","timestamp":1626088475000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An approach to evaluate metabolite-related phototoxicity with combined use of photochemical properties and skin deposition"],"prefix":"10.1016","volume":"350","author":[{"given":"Yoshiki","family":"Seto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Tonami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Iyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Onoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2021.07.007_bib0005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2006.08.032","article-title":"Blood or plasma to skin distribution of drugs: a linear free energy analysis","volume":"329","author":"Abraham","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0010","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/BF00608215","article-title":"Steady-state concentrations of imipramine and its metabolites in relation to the sparteine\/debrisoquine polymorphism","volume":"30","author":"Brosen","year":"1986","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0015","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0278-6915(01)00005-9","article-title":"Uncertainty factors for chemical risk assessment. Human variability in the pharmacokinetics of CYP1A2 probe substrates","volume":"39","author":"Dorne","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1365-2133.1985.tb02377.x","article-title":"A study of cutaneous photosensitivity induced by amiodarone","volume":"113","author":"Ferguson","year":"1985","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0025","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0022-3565(25)10527-2","article-title":"The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN\/BiRij rat","volume":"274","author":"Groen","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2009.04.005","article-title":"Can light absorption and photostability data be used to assess the photosafety risks in patients for a new drug molecule?","volume":"96","author":"Henry","year":"2009","journal-title":"J. Photochem. Photobiol. B"},{"year":"2009","series-title":"Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals M3(R2)","author":"International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)","key":"10.1016\/j.toxlet.2021.07.007_bib0035"},{"year":"2014","series-title":"ICH Guideline S10 Guidance on Photosafety Evaluation of Pharmaceuticals","author":"International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH)","key":"10.1016\/j.toxlet.2021.07.007_bib0040"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0045","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.intimp.2010.11.029","article-title":"Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy","volume":"11","author":"Ishizuka","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0050","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.xphs.2018.10.013","article-title":"Photochemical and pharmacokinetic characterization of orally administered chemicals to evaluate phototoxic risk","volume":"108","author":"Iyama","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0055","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1124\/dmd.115.065060","article-title":"New photosafety assessment strategy based on the photochemical and pharmacokinetic properties of both parent chemicals and metabolites","volume":"43","author":"Kato","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0060","first-page":"69","article-title":"Frequency distribution of CYP2C19, CYP2D6, and CYP2C9 mutant-alleles in several different populations","volume":"16","author":"Kubota","year":"2001","journal-title":"Xenobio Metabol. Dispos."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0065","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0026-895X(25)13662-6","article-title":"Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver","volume":"43","author":"Lemoine","year":"1993","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0070","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/1523-1747.ep12494582","article-title":"Phenothiazine phototoxicity: an experimental study on chlorpromazine and its metabolites","volume":"68","author":"Ljunggren","year":"1977","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2340\/0001555557325329","article-title":"Phenothiazine phototoxicity: an experimental study on chlorpromazine and related tricyclic drugs","volume":"57","author":"Ljunggren","year":"1977","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0080","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2125.1995.tb04473.x","article-title":"Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study","volume":"39","author":"Madsen","year":"1995","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1751-1097.1994.tb05018.x","article-title":"Photosensitization by fenofibrate. II. In vitro phototoxicity of the major metabolites","volume":"59","author":"Miranda","year":"1994","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2165\/00002018-200225050-00004","article-title":"Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management","volume":"25","author":"Moore","year":"2002","journal-title":"Drug Saf."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11095-005-8497-9","article-title":"Analytical studies on the prediction of photosensitive\/phototoxic potential of pharmaceutical substances","volume":"23","author":"Onoue","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpba.2007.09.003","article-title":"High-throughput reactive oxygen species (ROS) assay: an enabling technology for screening the phototoxic potential of pharmaceutical substances","volume":"46","author":"Onoue","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0105","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jpba.2008.03.026","article-title":"Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates","volume":"47","author":"Onoue","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/157488609788173044","article-title":"Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development","volume":"4","author":"Onoue","year":"2009","journal-title":"Curr. Drug Saf."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0115","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/jat.2776","article-title":"Establishment and intra-\/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation","volume":"33","author":"Onoue","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0120","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tiv.2013.11.014","article-title":"Intra-\/inter-laboratory validation study on reactive oxygen species assay for chemical photosafety evaluation using two different solar simulators","volume":"28","author":"Onoue","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/toxsci\/kft260","article-title":"Photosafety screening of phenothiazine derivatives with combined use of photochemical and cassette-dosing pharmacokinetic data","volume":"137","author":"Onoue","year":"2014","journal-title":"Toxicol. Sci."},{"year":"2014","series-title":"PCPC 2014 Safety Evaluation Guidelines; Chapter 7: Evaluation of Photoirritation and Photoallergy Potential","author":"Personal Care Products Council (PCPC)","key":"10.1016\/j.toxlet.2021.07.007_bib0130"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000247324","article-title":"Dihydroxyacetone test as a substitute for the dansyl chloride test","volume":"186","author":"Pierard","year":"1993","journal-title":"Dermatology"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0140","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1208\/s12248-011-9292-7","article-title":"Combined use of in vitro phototoxic assessments and cassette dosing pharmacokinetic study for phototoxicity characterization of fluoroquinolones","volume":"13","author":"Seto","year":"2011","journal-title":"AAPS J."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104619","article-title":"Phototoxic risk assessment of dermally-applied chemicals with structural variety based on photoreactivity and skin deposition","volume":"113","author":"Seto","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0150","doi-asserted-by":"crossref","first-page":"458","DOI":"10.2133\/dmpk.21.458","article-title":"Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments","volume":"21","author":"Takemoto","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"year":"2019","series-title":"OECD Guidelines for the Testing of Chemicals, 495, Reactive Oxygen Species (ROS) Assay","author":"The Organisation for Economic Co-operation and Development (OECD)","key":"10.1016\/j.toxlet.2021.07.007_bib0155"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-827X(99)00116-0","article-title":"In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine","volume":"55","author":"Viola","year":"2000","journal-title":"Farmaco"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0165","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0278-6915(01)00006-0","article-title":"Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates","volume":"39","author":"Walton","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2021.07.007_bib0170","first-page":"310","article-title":"Quantification of UV-induced erythema with a portable computer controlled chromameter","volume":"3","author":"Westerhof","year":"1986","journal-title":"Photodermatol"},{"key":"10.1016\/j.toxlet.2021.07.007_bib0175","first-page":"124","article-title":"Photosensitivity dermatitis from inadvertent exposure to aminolevulinic acid","volume":"80","author":"Zeltser","year":"2007","journal-title":"Cutis"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421001879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421001879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:23:36Z","timestamp":1759901016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427421001879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":35,"alternative-id":["S0378427421001879"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.07.007","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An approach to evaluate metabolite-related phototoxicity with combined use of photochemical properties and skin deposition","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}