{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:22:54Z","timestamp":1759969374977,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.toxlet.2021.09.016","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T23:24:17Z","timestamp":1633735457000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells"],"prefix":"10.1016","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-7784","authenticated-orcid":false,"given":"Kazuhiro","family":"Ogi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Ramezanpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Cooksley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shari","family":"Javadiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Fujieda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-John","family":"Wormald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Vreugde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkis James","family":"Psaltis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2021.09.016_bib0005","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/ajim.4700180604","article-title":"Cross-sectional study of platinum salts sensitization among precious metals refinery workers","volume":"18","author":"Baker","year":"1990","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0010","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1136\/oem.55.10.684","article-title":"Risk factors for sensitisation and respiratory symptoms among workers exposed to acid anhydrides: a cohort study","volume":"55","author":"Barker","year":"1998","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0015","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1034\/j.1399-3003.2000.15d14.x","article-title":"Risk factors for bronchial hyperresponsiveness in workers exposed to acid anhydrides","volume":"15","author":"Barker","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0091-6749(93)90117-X","article-title":"The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates","volume":"92","author":"Bernstein","year":"1993","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0025","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/JOM.0b013e31822cfd16","article-title":"Is trimellitic anhydride skin testing a sufficient screening tool for selectively identifying TMA-exposed workers with TMA-specific serum IgE antibodies?","volume":"53","author":"Bernstein","year":"2011","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0030","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1017\/S002221510600226X","article-title":"Defining and classifying occupational rhinitis","volume":"120","author":"Castano","year":"2006","journal-title":"J. Laryngol. Otol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0035","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00420-008-0392-3","article-title":"Persulphate challenge in female hairdressers with nasal hyperreactivity suggests immune cell, but no IgE reaction","volume":"82","author":"Diab","year":"2009","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.17.2.375","article-title":"Junctional complexes in various epithelia","volume":"17","author":"Farquhar","year":"1963","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0045","first-page":"1075","article-title":"Health effects of trimellitic anhydride occupational exposure: insights from animal models and immunosurveillance programs","volume":"73","author":"Ghosh","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.iac.2015.12.009","article-title":"Occupational rhinitis","volume":"36","author":"Grammer","year":"2016","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0055","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/00043764-200212000-00013","article-title":"Prevalence and onset of rhinitis and conjunctivitis in subjects with occupational asthma caused by trimellitic anhydride (TMA)","volume":"44","author":"Grammer","year":"2002","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2332\/allergolint.O-07-507","article-title":"Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed","volume":"57","author":"Gunawan","year":"2008","journal-title":"Allergol. Int."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0065","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1164\/rccm.201311-1982LE","article-title":"Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease","volume":"189","author":"Heijink","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0070","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/alr.21168","article-title":"House dust mite allergen Der p 1 effects on sinonasal epithelial tight junctions","volume":"3","author":"Henriquez","year":"2013","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0075","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/jcm8101617","article-title":"Sub-inhibitory clindamycin and azithromycin reduce","volume":"8","author":"Hu","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0080","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2332\/allergolint.13-OA-0621","article-title":"Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner","volume":"63","author":"Iida","year":"2014","journal-title":"Allergol. Int."},{"year":"1993","series-title":"Indoor Allergens: Assessing and Controlling Adverse Health Effects","author":"Institute of Medicine (US) Committee on the Health Effects of Indoor Allergens","key":"10.1016\/j.toxlet.2021.09.016_bib0085"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.intimp.2019.01.038","article-title":"Exacerbating effects of trimellitic anhydride in ovalbumin-induced asthmatic mice and the gene and protein expressions of TRPA1, TRPV1, TRPV2 in lung tissue","volume":"69","author":"Li","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0095","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/ajim.22390","article-title":"Asthma and respiratory symptoms among hairdressers in Denmark: results from a register based questionnaire study","volume":"57","author":"Lysdal","year":"2014","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0100","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.toxrep.2016.09.001","article-title":"Trimellitic anhydride induces low-grade mast cell degranulation without specific IgE","volume":"3","author":"Ogi","year":"2016","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0105","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/alr.22021","article-title":"In vitro safety evaluation of human nasal epithelial cell monolayers exposed to carrageenan sinus wash","volume":"7","author":"Ramezanpour","year":"2017","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4193\/Rhin16.284","article-title":"The effect of topical treatments for CRS on the sinonasal epithelial barrier","volume":"55","author":"Ramezanpour","year":"2017","journal-title":"Rhinology"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0115","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.1038\/s41598-018-29765-0","article-title":"Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production","volume":"8","author":"Ramezanpour","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0120","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1002\/cptx.69","article-title":"Inducing a mucosal barrier-sparing inflammatory response in laboratory-grown primary human nasal epithelial cells","volume":"80","author":"Ramezanpour","year":"2019","journal-title":"Curr. Protoc. Toxicol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0125","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4193\/Rhino14.005","article-title":"Nasal response in patients with diisocyanate asthma","volume":"52","author":"Sastre","year":"2014","journal-title":"Rhinology"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0130","first-page":"L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0135","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1046\/j.1365-2222.2000.00946.x","article-title":"Epidemiology of occupational rhinitis: prevalence, aetiology and determinants","volume":"30","author":"Siracusa","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0140","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.9834","article-title":"Zonula occludens and nasal epithelial barrier integrity in allergic rhinitis","volume":"8","author":"Siti Sarah","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0145","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2012.05.052","article-title":"Defective epithelial barrier in chronic rhinosinusitis: the regulation of tight junctions by IFN-\u03b3 and IL-4","volume":"130","author":"Soyka","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0150","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jaci.2015.10.050","article-title":"Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression","volume":"137","author":"Steelant","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0155","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/JLB.5MR0120-230R","article-title":"Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases","volume":"107","author":"Sugita","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0160","doi-asserted-by":"crossref","DOI":"10.1111\/all.14959","article-title":"Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis","author":"Tuli","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.toxlet.2021.09.016_bib0165","doi-asserted-by":"crossref","first-page":"109","DOI":"10.13075\/mp.5893.00317","article-title":"Papain-induced occupational rhinoconjunctivitis and asthma \u2013 a case report","volume":"67","author":"Tymoszuk","year":"2016","journal-title":"Med. Pr."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0170","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/j.jaip.2020.06.047","article-title":"Occupational rhinitis","volume":"8","author":"Vandenplas","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"Xiao","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0180","first-page":"33","article-title":"The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor","author":"Xu","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0185","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0091-6749(77)90033-1","article-title":"Trimellitic anhydride-induced airway syndromes: clinical and immunologic studies","volume":"60","author":"Zeiss","year":"1977","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.toxlet.2021.09.016_bib0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0091-6749(82)90195-6","article-title":"Clinical and immunologic evaluation of trimellitic anhydride workers in multiple industrial settings","volume":"70","author":"Zeiss","year":"1982","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742100847X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742100847X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:23:53Z","timestamp":1759901033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842742100847X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":38,"alternative-id":["S037842742100847X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.09.016","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}