{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:08:44Z","timestamp":1765994924261,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.toxlet.2021.10.004","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T14:20:29Z","timestamp":1634134829000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Role of scavenger receptors in silica nanoparticle-induced cytokine responses in bronchial epithelial cells"],"prefix":"10.1016","volume":"353","author":[{"given":"Magne","family":"Refsnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonje","family":"Skuland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"\u00d8vrevik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marit","family":"L\u00e5g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.toxlet.2021.10.004_bib0005","doi-asserted-by":"crossref","first-page":"15547","DOI":"10.1039\/C4CP05882H","article-title":"Native silica nanoparticles are powerful membrane disruptors","volume":"17","author":"Alkhammash","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.toxlet.2021.10.004_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1743-8977-5-14","article-title":"Optimized dispersion of nanoparticles for biological in vitro and in vivo studies","volume":"5","author":"Bihari","year":"2008","journal-title":"Part. Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1165\/rcmb.2006-0197OC","article-title":"Silica-directed mast cell activation is enhanced by scavenger receptors","volume":"36","author":"Brown","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"9","key":"10.1016\/j.toxlet.2021.10.004_bib0020","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nri3515","article-title":"Scavenger receptors in homeostasis and immunity","volume":"13","author":"Canton","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.toxlet.2021.10.004_bib0025","doi-asserted-by":"crossref","first-page":"e41952","DOI":"10.1371\/journal.pone.0041952","article-title":"Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA","volume":"7","author":"Dieudonn\u00e9","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0030","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"issue":"5876","key":"10.1016\/j.toxlet.2021.10.004_bib0035","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.toxlet.2021.10.004_bib0040","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2217\/nnm.11.41","article-title":"Macrophage scavenger receptor A mediates the uptake of gold colloids by macrophages in vitro","volume":"6","author":"Fran\u00e7a","year":"2011","journal-title":"Nanomedicine (Lond.)"},{"issue":"8","key":"10.1016\/j.toxlet.2021.10.004_bib0045","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/1753425917738331","article-title":"Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells","volume":"23","author":"G\u00f3mez","year":"2017","journal-title":"Innate Immun."},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0050","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/mi.2014.88","article-title":"Key role for scavenger receptor B-I in the integrative physiology of host defense during bacterial pneumonia","volume":"8","author":"Gowdy","year":"2015","journal-title":"Mucosal Immunol."},{"issue":"45","key":"10.1016\/j.toxlet.2021.10.004_bib0055","doi-asserted-by":"crossref","first-page":"34218","DOI":"10.1074\/jbc.M605229200","article-title":"MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL\/6 mice","volume":"281","author":"Hamilton","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.toxlet.2021.10.004_bib0060","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.tiv.2009.06.031","article-title":"Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures","volume":"23","author":"Herseth","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.toxlet.2021.10.004_bib0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.atherosclerosis.2017.01.034","article-title":"SR-BI as target in atherosclerosis and cardiovascular disease - a comprehensive appraisal of the cellular functions of SR-BI in physiology and disease","volume":"258","author":"Hoekstra","year":"2017","journal-title":"Atherosclerosis"},{"issue":"47","key":"10.1016\/j.toxlet.2021.10.004_bib0070","first-page":"5916","article-title":"Scavenger receptor BI: a multi-purpose player in cholesterol and steroid metabolism","volume":"16","author":"Hoekstra","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.toxlet.2021.10.004_bib0075","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0080","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/toxsci\/kfm050","article-title":"A murine scavenger receptor MARCO recognizes polystyrene nanoparticles","volume":"97","author":"Kanno","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.toxlet.2021.10.004_bib0085","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.bbamem.2016.06.023","article-title":"Interactions between silica nanoparticles and phospholipid membranes","volume":"1858","author":"Kettiger","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092634","article-title":"Effect of silica particle size on macrophage inflammatory responses","volume":"9","author":"Kusaka","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.toxlet.2021.10.004_bib0095","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/bcpt.12963","article-title":"Silica nanoparticle-induced cytokine responses in BEAS-2B and HBEC3-KT cells: significance of particle size and signalling pathways in different lung cell cultures","volume":"122","author":"L\u00e5g","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.taap.2006.10.004","article-title":"In vitro toxicity of silica nanoparticles in human lung cancer cells","volume":"217","author":"Lin","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.toxlet.2021.10.004_bib0105","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00204-017-1993-y","article-title":"Toxicology of silica nanoparticles: an update","volume":"91","author":"Murugadoss","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2021.10.004_bib0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fimmu.2018.00103","article-title":"Macrophage recognition of crystals and nanoparticles","volume":"9","author":"Nakayama","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.toxlet.2021.10.004_bib0115","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/smll.200800461","article-title":"Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells","volume":"5","author":"Napierska","year":"2009","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1743-8977-7-39","article-title":"The nanosilica hazard: another variable entity","volume":"7","author":"Napierska","year":"2010","journal-title":"Part. Fibre Toxicol."},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0125","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.toxlet.2012.03.002","article-title":"Cytokine production by co-cultures exposed to monodisperse amorphous silica nanoparticles: the role of size and surface area","volume":"211","author":"Napierska","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0130","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1021\/ar300022h","article-title":"Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening","volume":"46","author":"Nel","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0135","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/17435390.2010.513836","article-title":"Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A","volume":"5","author":"Orr","year":"2011","journal-title":"Nanotoxicology"},{"issue":"1-2","key":"10.1016\/j.toxlet.2021.10.004_bib0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2006.07.029","article-title":"Mechanisms of silica-induced IL-8 release from A549 cells: initial kinase-activation does not require EGFR activation or particle uptake","volume":"227","author":"Ovrevik","year":"2006","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0145","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acs.chemrestox.6b00409","article-title":"Unveiling the variability of \"Quartz hazard\" in light of recent toxicological findings","volume":"30","author":"Pavan","year":"2017","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12989-019-0315-3","article-title":"The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?","volume":"16","author":"Pavan","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.toxlet.2021.10.004_bib0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1743-8977-10-3","article-title":"Silica induces NLRP3 inflammasome activation in human lung epithelial cells","volume":"10","author":"Peeters","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.toxlet.2021.10.004_bib0160","doi-asserted-by":"crossref","DOI":"10.1111\/bcpt.13221","article-title":"Concentration-dependent cytokine responses of silica nanoparticles and role of ROS in human lung epithelial cells","author":"Refsnes","year":"2019","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-8977-9-32","article-title":"Comparison of non-crystalline silica nanoparticles in IL-1ss release from macrophages","volume":"9","author":"Sandberg","year":"2012","journal-title":"Part. Fibre Toxicol."},{"issue":"6","key":"10.1016\/j.toxlet.2021.10.004_bib0170","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.toxlet.2021.10.004_bib0175","first-page":"e811","article-title":"Implications of scavenger receptors in the safe development of nanotherapeutics","volume":"2","author":"Shannahan","year":"2015","journal-title":"Receptors Clin. Investig."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/toxsci\/kfu217","article-title":"Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors","volume":"143","author":"Shannahan","year":"2015","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.toxlet.2021.10.004_bib0185","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1194\/jlr.M056150","article-title":"Lipoprotein (a) upregulates ABCA1 in liver cells via scavenger receptor-B1 through its oxidized phospholipids","volume":"56","author":"Sharma","year":"2015","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0190","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tiv.2013.10.018","article-title":"Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions","volume":"28","author":"Skuland","year":"2014","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0195","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.taap.2014.05.006","article-title":"Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38\/TACE\/TGF-alpha\/EGFR-pathway and NF-kappaBeta signalling","volume":"279","author":"Skuland","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-020-00345-3","article-title":"Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model","volume":"17","author":"Skuland","year":"2020","journal-title":"Part. Fibre Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2021.10.004_bib0205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/bcpt.13341","article-title":"Synthetic hydrosilicate nanotubes induce low pro-inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures","volume":"126","author":"Skuland","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2021.10.004_bib0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1465-9921-9-59","article-title":"Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry","volume":"9","author":"Sulahian","year":"2008","journal-title":"Respir. Res."},{"issue":"5","key":"10.1016\/j.toxlet.2021.10.004_bib0215","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.celrep.2017.01.004","article-title":"SR-B1 is a silica receptor that mediates canonical inflammasome activation","volume":"18","author":"Tsugita","year":"2017","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0220","doi-asserted-by":"crossref","first-page":"158554","DOI":"10.1016\/j.bbalip.2019.158554","article-title":"Scavenger receptor class B, type 1 facilitates cellular fatty acid uptake","volume":"1865","author":"Wang","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"2","key":"10.1016\/j.toxlet.2021.10.004_bib0225","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/cells4020178","article-title":"Scavenger receptor structure and function in health and disease","volume":"4","author":"Zani","year":"2015","journal-title":"Cells"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421008511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421008511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:25:04Z","timestamp":1759901104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427421008511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":45,"alternative-id":["S0378427421008511"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.10.004","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of scavenger receptors in silica nanoparticle-induced cytokine responses in bronchial epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}