{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:44:59Z","timestamp":1762429499446,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010937","name":"St. John's University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.toxlet.2021.10.009","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T20:29:39Z","timestamp":1634848179000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Non-Smad, BMP-dependent signaling protects against the effects of acute ethanol toxicity"],"prefix":"10.1016","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-7507","authenticated-orcid":false,"given":"Naila","family":"Habeeb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheyda","family":"Najafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-6320","authenticated-orcid":false,"given":"Jeanette C.","family":"Perron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"September (1)","key":"10.1016\/j.toxlet.2021.10.009_bib0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0896-6273(00)80827-2","article-title":"BMPs as mediators of roof plate repulsion of commissural neurons","volume":"24","author":"Augsburger","year":"1999","journal-title":"Neuron"},{"issue":"March (6)","key":"10.1016\/j.toxlet.2021.10.009_bib0010","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/febs.14754","article-title":"Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN\/Akt\/GSK-3\u03b2\/\u03b2-catenin axis","volume":"286","author":"Chen","year":"2019","journal-title":"FEBS J."},{"issue":"October (8)","key":"10.1016\/j.toxlet.2021.10.009_bib0015","first-page":"515","article-title":"Fetal alcohol syndrome and fetal alcohol spectrum disorders","volume":"96","author":"Denny","year":"2017","journal-title":"Am. Fam. Phys."},{"issue":"February (570)","key":"10.1016\/j.toxlet.2021.10.009_bib0020","article-title":"Specificity, versatility, and control of TGF-\u03b2 family signaling","volume":"12","author":"Derynck","year":"2019","journal-title":"Sci. Signal."},{"issue":"March (10)","key":"10.1016\/j.toxlet.2021.10.009_bib0025","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3748\/wjg.15.1168","article-title":"In vitro and in vivo models of acute alcohol exposure","volume":"15","author":"Dolganiuc","year":"2009","journal-title":"World J. Gastroenterol."},{"issue":"May (2)","key":"10.1016\/j.toxlet.2021.10.009_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0022-1759(84)90190-X","article-title":"Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines","volume":"70","author":"Green","year":"1984","journal-title":"J. Immunol. Methods"},{"issue":"August (8)","key":"10.1016\/j.toxlet.2021.10.009_bib0035","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/acer.13135","article-title":"An update on fetal alcohol syndrome-pathogenesis, risks, and treatment","volume":"40","author":"Gupta","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"October (4)","key":"10.1016\/j.toxlet.2021.10.009_bib0040","article-title":"Neurobehavioral disorder associated with prenatal alcohol exposure workgroup; American academy of pediatrics. Neurobehavioral disorder associated with prenatal alcohol exposure","volume":"138","author":"Hagan","year":"2016","journal-title":"Pediatrics"},{"issue":"September (3)","key":"10.1016\/j.toxlet.2021.10.009_bib0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/jdb8030019","article-title":"Bone morphogenetic protein-2 in development and bone homeostasis","volume":"8","author":"Halloran","year":"2020","journal-title":"J. Dev. Biol."},{"issue":"December (6)","key":"10.1016\/j.toxlet.2021.10.009_bib0050","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.21904","article-title":"Acute ethanol exposure inhibits insulin signaling in the liver","volume":"46","author":"He","year":"2007","journal-title":"Hepatology"},{"issue":"March (12)","key":"10.1016\/j.toxlet.2021.10.009_bib0055","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1523\/JNEUROSCI.1771-18.2019","article-title":"Circuit dysfunction in SOD1-ALS model first detected in sensory feedback prior to motor neuron degeneration is alleviated by BMP signaling","volume":"39","author":"Held","year":"2019","journal-title":"J. Neurosci."},{"issue":"December (6 Pt 1)","key":"10.1016\/j.toxlet.2021.10.009_bib0060","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","article-title":"Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage","volume":"127","author":"Katagiri","year":"1994","journal-title":"J. Cell Biol."},{"issue":"February","key":"10.1016\/j.toxlet.2021.10.009_bib0065","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-physiol-022516-034303","article-title":"Spinal circuits for touch, pain, and itch","volume":"80","author":"Koch","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"January (3)","key":"10.1016\/j.toxlet.2021.10.009_bib0070","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1523\/JNEUROSCI.4478-05.2006","article-title":"Reversal of neuronal migration in a mouse model of fetal alcohol syndrome by controlling second-messenger signalings","volume":"26","author":"Kumada","year":"2006","journal-title":"J. Neurosci."},{"issue":"October (44)","key":"10.1016\/j.toxlet.2021.10.009_bib0075","doi-asserted-by":"crossref","first-page":"15243","DOI":"10.1523\/JNEUROSCI.1161-12.2012","article-title":"A longitudinal study of the long-term consequences of drinking during pregnancy: heavy in utero alcohol exposure disrupts the normal processes of brain development","volume":"32","author":"Lebel","year":"2012","journal-title":"J. Neurosci."},{"issue":"261\u201394","key":"10.1016\/j.toxlet.2021.10.009_bib0080","article-title":"The specification of dorsal cell fates in the vertebrate central nervous system","volume":"22","author":"Lee","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"issue":"February (6771)","key":"10.1016\/j.toxlet.2021.10.009_bib0085","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/35001507","article-title":"Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification","volume":"403","author":"Lee","year":"2000","journal-title":"Nature"},{"issue":"December (12)","key":"10.1016\/j.toxlet.2021.10.009_bib0090","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4161\/cbt.12.12.18442","article-title":"The Akt signaling pathway: an emerging therapeutic target in malignant melanoma","volume":"12","author":"Madhunapantula","year":"2011","journal-title":"Cancer Biol. Ther."},{"issue":"January","key":"10.1016\/j.toxlet.2021.10.009_bib0095","article-title":"White matter abnormalities in fetal alcohol spectrum disorders: focus on axon growth and guidance","author":"Mathews","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"January (1)","key":"10.1016\/j.toxlet.2021.10.009_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","article-title":"Hormesis defined","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"issue":"December (2)","key":"10.1016\/j.toxlet.2021.10.009_bib0105","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.drugalcdep.2013.07.013","article-title":"Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): quantity, frequency, and timing of drinking","volume":"133","author":"May","year":"2013","journal-title":"Drug Alcohol Depend."},{"issue":"November (11)","key":"10.1016\/j.toxlet.2021.10.009_bib0110","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1111\/jcmm.13814","article-title":"BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation","volume":"22","author":"Pardali","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"10.1016\/j.toxlet.2021.10.009_bib0115","doi-asserted-by":"crossref","first-page":"e8198","DOI":"10.1371\/journal.pone.0008198","article-title":"ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis","volume":"4","author":"Perron","year":"2009","journal-title":"PLoS One"},{"issue":"November","key":"10.1016\/j.toxlet.2021.10.009_bib0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1749-8104-6-36","article-title":"Inductive specification and axonal orientation of spinal neurons mediated by divergent bone morphogenetic protein signaling pathways","volume":"6","author":"Perron","year":"2011","journal-title":"Neural Dev."},{"issue":"May","key":"10.1016\/j.toxlet.2021.10.009_bib0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1749-8104-7-16","article-title":"Structural distinctions in BMPs underlie divergent signaling in spinal neurons","volume":"7","author":"Perron","year":"2012","journal-title":"Neural Dev."},{"issue":"July (7)","key":"10.1016\/j.toxlet.2021.10.009_bib0130","article-title":"Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA","volume":"8","author":"Perron","year":"2019","journal-title":"Biol. Open"},{"issue":"August (3)","key":"10.1016\/j.toxlet.2021.10.009_bib0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/brainsci6030031","article-title":"Ethanol-induced neurodegeneration and glial activation in the developing brain","volume":"6","author":"Saito","year":"2016","journal-title":"Brain Sci."},{"issue":"August (8)","key":"10.1016\/j.toxlet.2021.10.009_bib0140","article-title":"Embryonic ethanol exposure dysregulates BMP and notch signaling, leading to persistent atrio-ventricular valve defects in zebrafish","volume":"11","author":"Sarmah","year":"2016","journal-title":"PLoS One"},{"issue":"January (1)","key":"10.1016\/j.toxlet.2021.10.009_bib0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/acer.13273","article-title":"Alcohol exposure causes overexpression of heart development-related genes by affecting the histone H3 acetylation via BMP signaling pathway in cardiomyoblast cells","volume":"41","author":"Shi","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"year":"2020","series-title":"Table 6.20B\u2014Alcohol Use, Binge Alcohol Use, and Heavy Alcohol Use in Past Month Among Females Aged 15 to 44, by Pregnancy Status, Demographic, Socioeconomic, and Pregnancy Characteristics: Percentages, 2018 and 2019","author":"Substance Abuse and Mental Health Services Administration (SAMHSA)","key":"10.1016\/j.toxlet.2021.10.009_bib0150"},{"issue":"May\u2013June (3)","key":"10.1016\/j.toxlet.2021.10.009_bib0155","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ntt.2008.01.004","article-title":"Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain","volume":"30","author":"Tsuji","year":"2008","journal-title":"Neurotoxicol. Teratol."},{"issue":"February (2)","key":"10.1016\/j.toxlet.2021.10.009_bib0160","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1530-0277.2007.00568.x","article-title":"Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression","volume":"32","author":"Vangipuram","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"September (1)","key":"10.1016\/j.toxlet.2021.10.009_bib0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","article-title":"Bone Morphogenetic Protein (BMP) signaling in development and human diseases","volume":"1","author":"Wang","year":"2014","journal-title":"Genes Dis."},{"issue":"November (11)","key":"10.1016\/j.toxlet.2021.10.009_bib0170","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1530-0277.1999.tb04065.x","article-title":"Alcohol inhibition of cell adhesion in BMP-treated NG108-15 cells","volume":"23","author":"Wilkemeyer","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"November (5)","key":"10.1016\/j.toxlet.2021.10.009_bib0175","first-page":"e1395","article-title":"Committee on substance abuse","volume":"136","author":"Williams","year":"2015","journal-title":"Fetal Alcohol Spectrum Disord. Pediatrics"},{"issue":"November","key":"10.1016\/j.toxlet.2021.10.009_bib0180","first-page":"53","article-title":"Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development","volume":"281","author":"Zhang","year":"2017","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421008626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427421008626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:25:10Z","timestamp":1759901110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427421008626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":36,"alternative-id":["S0378427421008626"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.10.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-Smad, BMP-dependent signaling protects against the effects of acute ethanol toxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2021.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}