{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:18:18Z","timestamp":1789165098449,"version":"build-2803163510"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873194"],"award-info":[{"award-number":["81873194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.toxlet.2022.05.002","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T11:40:04Z","timestamp":1652874004000},"page":"11-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity"],"prefix":"10.1016","volume":"363","author":[{"given":"Sitong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenrui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simiao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2022.05.002_bib1","first-page":"550","article-title":"Vinpocetine-based therapy is an attractive strategy against oxidative stress-induced hepatotoxicity in vitro by targeting Nrf2\/HO-1 pathway","volume":"20","author":"Abdelmageed","year":"2021","journal-title":"EXCLI J."},{"key":"10.1016\/j.toxlet.2022.05.002_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/phpp.12072","article-title":"Psoralen-narrowband UVB phototherapy for the treatment of vitiligo in comparison to narrowband UVB alone","volume":"29","author":"Bansal","year":"2013","journal-title":"Photoderm. Photoimmunol Photomed"},{"key":"10.1016\/j.toxlet.2022.05.002_bib3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00204-018-2371-0","article-title":"Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism","volume":"93","author":"Behrends","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114044","article-title":"Experimental and molecular docking studies of estrogen-like and anti-osteoporosis activity of compounds in Fructus Psoraleae","volume":"276","author":"Cai","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","article-title":"Role of oxidative stress in alcohol-induced liver injury","volume":"83","author":"Cederbaum","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib6","article-title":"Selection of suitable reference genes for qPCR gene expression analysis of HepG2 and L02 in four different liver cell injured models","volume":"2020","author":"Chen","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.toxlet.2022.05.002_bib7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00204-016-1775-y","article-title":"Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells","volume":"91","author":"Chen","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib8","first-page":"17","article-title":"Target identification with quantitative activity based protein profiling (ABPP)","author":"Chen","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/j.toxlet.2022.05.002_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41467-021-27533-9","article-title":"A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB\/CRTC2 transcriptional complex","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2022.05.002_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/15563650903059136","article-title":"Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine","volume":"47","author":"Cheung","year":"2009","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib11","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.7150\/thno.68804","article-title":"An update of label-free protein target identification methods for natural active products","volume":"12","author":"Cui","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.toxlet.2022.05.002_bib12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-biochem-062917-012837","article-title":"Horizontal cell biology: monitoring global changes of protein interaction states with the proteome-wide cellular thermal shift assay (CETSA)","volume":"88","author":"Dai","year":"2019","journal-title":"Annu Rev. Biochem"},{"key":"10.1016\/j.toxlet.2022.05.002_bib13","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1021\/acs.jnatprod.6b00627","article-title":"Drug affinity responsive target stability (DARTS) identifies laurifolioside as a new clathrin heavy chain modulator","author":"Dal Piaz","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.toxlet.2022.05.002_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103767","article-title":"Integrative proteomics-metabolomics strategy reveals the mechanism of hepatotoxicity induced by fructus psoraleae","volume":"221","author":"Duan","year":"2020","journal-title":"J. Proteom."},{"key":"10.1016\/j.toxlet.2022.05.002_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11684-019-0690-z","article-title":"New incompatible pair of TCM: epimedii folium combined with psoraleae fructus induces idiosyncratic hepatotoxicity under immunological stress conditions","volume":"14","author":"Gao","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev-anchem-071213-020024","article-title":"Energetics-based methods for protein folding and stability measurements","volume":"7","author":"Geer","year":"2014","journal-title":"Annu. Rev. Anal. Chem."},{"key":"10.1016\/j.toxlet.2022.05.002_bib17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.30213","article-title":"Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood","volume":"69","author":"Ghallab","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2022.05.002_bib18","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1177\/09603271211027947","article-title":"Modulation of NRF2\/ARE pathway- and cell death-related genes during drug-induced liver injury","volume":"40","author":"Ghanim","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib19","first-page":"11","article-title":"Relationship between oxidative stress and imatinib resistance in model chronic myeloid leukemia cells","author":"Glowacki","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.toxlet.2022.05.002_bib20","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa1114287","article-title":"Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis","volume":"367","author":"Gold","year":"2012","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nrc3563","article-title":"Role of ABL family kinases in cancer: from leukaemia to solid tumours","volume":"13","author":"Greuber","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.toxlet.2022.05.002_bib22","article-title":"Crizotinib and sunitinib induce hepatotoxicity and mitochondrial apoptosis in L02 cells via ROS and Nrf2 signaling pathway","volume":"12","author":"Guo","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.682823","article-title":"Five constituents contributed to the psoraleae fructus-induced hepatotoxicity via mitochondrial dysfunction and apoptosis","volume":"12","author":"Guo","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib24","first-page":"22","article-title":"Coordination mechanism and bio-evidence: reactive gamma-ketoenal intermediated hepatotoxicity of psoralen and isopsoralen based on computer approach and bioassay","author":"Hai","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.toxlet.2022.05.002_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4143\/crt.2019.131","article-title":"Factors influencing imatinib-induced hepatotoxicity","volume":"52","author":"Han","year":"2020","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.toxlet.2022.05.002_bib26","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41375-020-0776-2","article-title":"European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia","volume":"34","author":"Hochhaus","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.toxlet.2022.05.002_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s00204-022-03245-x","article-title":"Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study","author":"Huang","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib28","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1177\/0960327120979346","article-title":"Effects of psoralen on hepatic bile acid transporters in rats","volume":"40","author":"Huang","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-0716-0954-5_15","article-title":"Drug affinity responsive target stability (DARTS) assay to detect interaction between a purified protein and a small molecule","author":"Huang","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib30","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.apsb.2021.05.009","article-title":"Bruceine D inhibits HIF-1alpha-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT\/beta-catenin interaction","volume":"11","author":"Huang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.toxlet.2022.05.002_bib31","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.toxlet.2022.05.002_bib32","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/hep.28965","article-title":"The ascending pathophysiology of cholestatic liver disease","volume":"65","author":"Jansen","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.toxlet.2022.05.002_bib33","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1517\/17425255.2015.1065814","article-title":"Development of novel tools for the in vitro investigation of drug-induced liver injury","volume":"11","author":"Jiang","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib34","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/FTD.0b013e318292b931","article-title":"Clinical pharmacokinetics of tyrosine kinase inhibitors: implications for therapeutic drug monitoring","volume":"35","author":"Josephs","year":"2013","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.toxlet.2022.05.002_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1124\/jpet.104.070375","article-title":"Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes","volume":"311","author":"Kim","year":"2004","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.toxlet.2022.05.002_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.toxlet.2022.05.002_bib37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00204-021-02995-4","article-title":"Nrf2: a main responsive element in cells to mycotoxin-induced toxicity","volume":"95","author":"Koziel","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib38","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.05.002_bib39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib40","first-page":"123","article-title":"Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats","volume":"18","author":"Li","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib41","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/ptr.5851","article-title":"Bakuchiol contributes to the hepatotoxicity of psoralea corylifolia in rats","volume":"31","author":"Li","year":"2017","journal-title":"Phytother. Res"},{"key":"10.1016\/j.toxlet.2022.05.002_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208273","article-title":"An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions","volume":"13","author":"Lim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2022.05.002_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6716529","article-title":"Reasonable application can alleviate the liver injury for osteoarthritis treatment","volume":"2018","author":"Liu","year":"2018","journal-title":"Evid. Based Complement Altern. Med"},{"key":"10.1016\/j.toxlet.2022.05.002_bib44","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/toxsci\/kfq075","article-title":"Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity","volume":"115","author":"Liu","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2022.05.002_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/305861","article-title":"Nrf2 protection against liver injury produced by various hepatotoxicants","volume":"2013","author":"Liu","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.toxlet.2022.05.002_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1379706","article-title":"ABL1 Is a prognostic marker and associated with immune infiltration in hepatocellular carcinoma","volume":"2021","author":"Liu","year":"2021","journal-title":"J. Oncol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","article-title":"Network pharmacology in research of Chinese medicine formula: methodology, application and prospective","volume":"26","author":"Luo","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib48","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.omto.2021.12.025","article-title":"Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells","volume":"24","author":"Lv","year":"2022","journal-title":"Mol. Ther.\u00a0Oncol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","article-title":"Cellular response to oxidative stress: signaling for suicide and survival","volume":"192","author":"Martindale","year":"2002","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.toxlet.2022.05.002_bib51","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2162-3619-2-5","article-title":"The relative efficacy of imatinib, dasatinib and nilotinib for newly diagnosed chronic myeloid leukemia: a systematic review and network meta-analysis","volume":"2","author":"Mealing","year":"2013","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib52","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfx222","article-title":"Transient changes in hepatic physiology that alter bilirubin and bile acid transport may explain elevations in liver chemistries observed in clinical trials of GGF2 (Cimaglermin Alfa)","volume":"161","author":"Mosedale","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2022.05.002_bib53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fphar.2017.00367","article-title":"Hepatocellular toxicity associated with tyrosine kinase inhibitors: mitochondrial damage and inhibition of glycolysis","volume":"8","author":"Paech","year":"2017","journal-title":"Front. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib54","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-4939-2269-7_22","article-title":"Drug affinity responsive target stability (DARTS) for small-molecule target identification","author":"Pai","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/761264","article-title":"Oxidative stress, prooxidants, and antioxidants: the interplay","volume":"2014","author":"Rahal","year":"2014","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.toxlet.2022.05.002_bib56","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s41598-018-19930-w","article-title":"Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition","volume":"8","author":"Rai","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2022.05.002_bib57","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00204-017-2079-6","article-title":"Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells","volume":"92","author":"Ramirez","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.571535","article-title":"A review of the pharmacological properties of psoralen","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114798","article-title":"Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: Principles and application","author":"Ren","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib60","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.3748\/wjg.v27.i34.5682","article-title":"Liver disease and COVID-19: The link with oxidative stress, antioxidants and nutrition","volume":"27","author":"Ristic-Medic","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib61","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00204-014-1246-2","article-title":"Canonical and new generation anticancer drugs also target energy metabolism","volume":"88","author":"Rodriguez-Enriquez","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib62","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/cppb.20062","article-title":"Drug Affinity Responsive Target Stability (DARTS) to Resolve Protein-Small Molecule Interaction in Arabidopsis","author":"Rodriguez-Furlan","year":"2017","journal-title":"Curr. Protoc. Plant Biol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2020.100741","article-title":"Devilishly radical NETwork in COVID-19: oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression","volume":"77","author":"Schonrich","year":"2020","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.toxlet.2022.05.002_bib64","article-title":"Imatinib-induced hepatitis in a patient treated for gastrointestinal stromal tumor: a rare adverse effect","volume":"10","author":"Shah","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.toxlet.2022.05.002_bib65","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00204-018-2237-5","article-title":"Autophagy and acetaminophen-induced hepatotoxicity","volume":"92","author":"Shan","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib66","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.mcn.2017.10.007","article-title":"Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2\/Arg kinase","volume":"85","author":"Shapiro","year":"2017","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.toxlet.2022.05.002_bib67","first-page":"262","article-title":"Transformation of myelodysplasia to acute myeloid leukaemia during psoralen photochemotherapy (PUVA) treatment of psoriasis","volume":"69","author":"Sheehan-Dare","year":"1989","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib68","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bbrc.2019.08.125","article-title":"TMP21 regulates autophagy by modulating ROS production and mTOR activation","volume":"518","author":"Shin","year":"2019","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.toxlet.2022.05.002_bib69","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1111\/bjh.16904","article-title":"Blastic transformation of BCR-ABL1 positive chronic myeloid leukaemia through acquisition of CBFB-MYH11 and mutant KIT","volume":"190","author":"Shoumariyeh","year":"2020","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib70","doi-asserted-by":"crossref","first-page":"15640","DOI":"10.1021\/ja044286+","article-title":"Microarray platform for profiling enzyme activities in complex proteomes","volume":"126","author":"Sieber","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.toxlet.2022.05.002_bib71","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1389450121999201013152513","article-title":"Computational and biological investigations on Abl1 tyrosine kinase: a review","volume":"22","author":"Sobhia","year":"2021","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.toxlet.2022.05.002_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115852","article-title":"Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo","volume":"435","author":"Song","year":"2022","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib73","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/bcpt.13287","article-title":"The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats","volume":"125","author":"Song","year":"2019","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17512433.2018.1398644","article-title":"Pharmacology and pharmacokinetics of imatinib in pediatric patients","volume":"11","author":"Suttorp","year":"2018","journal-title":"Expert Rev. Clin. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib75","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2015.08.015","article-title":"Fluoride induces oxidative damage and SIRT1\/autophagy through ROS-mediated JNK signaling","volume":"89","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib76","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks","volume":"127","author":"Tang","year":"2015","journal-title":"Biosystems"},{"key":"10.1016\/j.toxlet.2022.05.002_bib77","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.2174\/1389557520666200429101053","article-title":"Psoralen: a biologically important coumarin with emerging applications","volume":"20","author":"Thakur","year":"2020","journal-title":"Mini Rev. Med Chem."},{"key":"10.1016\/j.toxlet.2022.05.002_bib78","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1158\/1541-7786.MCR-06-0391","article-title":"Abelson interactor protein-1 positively regulates breast cancer cell proliferation, migration, and invasion","volume":"5","author":"Wang","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.toxlet.2022.05.002_bib79","first-page":"9","article-title":"\u03b2-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS\/AMPK\/mTOR pathway","volume":"20","author":"Wang","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib80","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1128\/MCB.01454-13","article-title":"The capable ABL: what is its biological function?","volume":"34","author":"Wang","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib81","article-title":"Identifying absorbable bioactive constituents of yupingfeng powder acting on COVID-19 through integration of UPLC-Q\/TOF-MS and network pharmacology analysis","author":"Wang","year":"2022","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.toxlet.2022.05.002_bib82","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fphar.2018.00353","article-title":"Advanced activity-based protein profiling application strategies for drug development","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib83","first-page":"1","article-title":"TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches","volume":"19","author":"Wang","year":"2021","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib84","first-page":"349","article-title":"Prediction of quality markers of traditional Chinese medicines based on network pharmacology","volume":"11","author":"Wang","year":"2019","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib85","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/aps.2017.95","article-title":"Triptolide induces Sertoli cell apoptosis in mice via ROS\/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response","volume":"39","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.toxlet.2022.05.002_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107352","article-title":"Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury","volume":"92","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib87","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fct.2018.12.047","article-title":"Hepatotoxicity induced by psoralen and isopsoralen from Fructus Psoraleae: Wistar rats are more vulnerable than ICR mice","volume":"125","author":"Wang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152874","article-title":"Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats","volume":"58","author":"Wang","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.toxlet.2022.05.002_bib89","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.2147\/DDDT.S335461","article-title":"A new strategy for the rapid identification and validation of the direct targets of aconitine-Induced cardiotoxicity","volume":"15","author":"Wei","year":"2021","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.toxlet.2022.05.002_bib90","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1073\/pnas.1000148107","article-title":"Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements","volume":"107","author":"West","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.toxlet.2022.05.002_bib91","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.3389\/fphar.2018.01457","article-title":"Psoralen induces developmental toxicity in zebrafish embryos\/larvae through oxidative stress, apoptosis, and energy metabolism disorder","volume":"9","author":"Xia","year":"2018","journal-title":"Front. Pharm."},{"key":"10.1016\/j.toxlet.2022.05.002_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119367","article-title":"Estrogen cholestasis induces gut and liver injury in rats involving in activating PI3K\/Akt and MAPK signaling pathways","volume":"276","author":"Xiang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.toxlet.2022.05.002_bib93","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jpba.2017.04.026","article-title":"Studies on the metabolites difference of psoralen\/isopsoralen in human and six mammalian liver microsomes in vitro by UHPLC-MS\/MS","volume":"141","author":"Yang","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.toxlet.2022.05.002_bib94","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chembiol.2010.12.013","article-title":"Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site","volume":"18","author":"Yang","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib95","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1021\/acsomega.9b04153","article-title":"The accumulation of psoralen contributes to its hepatotoxicity revealed by pharmacokinetic and toxicokinetic study after repeated administration","volume":"5","author":"Yang","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.toxlet.2022.05.002_bib96","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1248\/bpb.b17-00672","article-title":"Bavachin induces apoptosis through mitochondrial regulated er stress pathway in HepG2 cells","volume":"41","author":"Yang","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2022.05.002_bib97","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5338182","article-title":"Network pharmacology-based strategy and molecular docking to explore the potential mechanism of jintiange capsule for treating osteoporosis","volume":"2021","author":"Yang","year":"2021","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.toxlet.2022.05.002_bib98","first-page":"1","article-title":"Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice","author":"Yu","year":"2021","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib99","first-page":"9","article-title":"Long-term exposure of psoralen and isopsoralen induced hepatotoxicity and serum metabolites profiles changes in female rats","author":"Yu","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.toxlet.2022.05.002_bib100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/15376516.2019.1650150","article-title":"Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells","volume":"30","author":"Yu","year":"2020","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.toxlet.2022.05.002_bib101","article-title":"A semi-quantitative drug affinity responsive target stability (DARTS) assay for studying Rapamycin\/mTOR interaction","author":"Zhang","year":"2019","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.toxlet.2022.05.002_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153518","article-title":"Multi-parametric cellular imaging coupled with multi-component quantitative profiling for screening of hepatotoxic equivalent markers from Psoraleae Fructus","volume":"93","author":"Zhang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.toxlet.2022.05.002_bib103","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s00204-016-1918-1","article-title":"Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria","volume":"91","author":"Zhang","year":"2017","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib104","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/acs.chemrestox.8b00082","article-title":"A study of NMR-based hepatic and serum metabolomics in a liver injury sprague-dawley rat model induced by psoralen","volume":"31","author":"Zhang","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2022.05.002_bib105","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3389\/fphar.2018.01179","article-title":"Psoralen induced liver injury by attenuating liver regenerative capability","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Pharm."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742200090X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742200090X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:25:50Z","timestamp":1759901150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842742200090X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":105,"alternative-id":["S037842742200090X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.05.002","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}