{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:19:24Z","timestamp":1792181964008,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.toxlet.2022.07.814","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T01:03:06Z","timestamp":1659142986000},"page":"76-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo"],"prefix":"10.1016","volume":"367","author":[{"given":"Lei","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2022.07.814_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.15171\/apb.2016.066","article-title":"Venlafaxine-induced cytotoxicity towards isolated rat hepatocytes involves oxidative stress and mitochondrial\/lysosomal dysfunction","volume":"6","author":"Ahmadian","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2022.07.814_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.mcb.2020.10.004","article-title":"A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy","volume":"165","author":"Alvarez-Valadez","year":"2021","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib3","first-page":"76","article-title":"Drug-induced toxic myocarditis","volume":"30","author":"Ansari","year":"2003","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.toxlet.2022.07.814_bib4","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s12011-021-02774-3","article-title":"Silica nanoparticles induce hepatotoxicity by triggering oxidative damage, apoptosis, and Bax-Bcl2 signaling pathway","volume":"200","author":"Aouey","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.toxlet.2022.07.814_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00210-009-0420-1","article-title":"Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes","volume":"380","author":"B\u00e9barov\u00e1","year":"2009","journal-title":"Naunyn-Schmiede\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib6","first-page":"1","article-title":"GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions","author":"Brun","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2022.07.814_bib7","first-page":"22","article-title":"Cathepsin B regulates mice granulosa cells\u2019 apoptosis and proliferation in vitro","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.07.814_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064557","article-title":"Gene expression in gut symbiotic organ of stinkbug affected by extracellular bacterial symbiont","volume":"8","author":"Futahashi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2022.07.814_bib9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1023\/A:1015152021192","article-title":"Evaluation of the neurotoxic activity of typical and atypical neuroleptics: relevance to iatrogenic extrapyramidal symptoms","volume":"21","author":"Gil-ad","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00210-008-0362-z","article-title":"Effect of chronic treatment of haloperidol on the rat liver: a stereological and histopathological study","volume":"379","author":"Halici","year":"2009","journal-title":"Naunyn-Schmiede\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-9966-31-41","article-title":"Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer","volume":"31","author":"Hornick","year":"2012","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"10.1016\/j.toxlet.2022.07.814_bib12","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/acs.bioconjchem.1c00405","article-title":"Critical evaluation of different lysosomal labeling methods used to analyze RNA nanocarrier trafficking in cells","volume":"32","author":"Iqbal","year":"2021","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.toxlet.2022.07.814_bib13","first-page":"21","article-title":"Leptin modulates the metastasis of canine inflammatory mammary adenocarcinoma cells through downregulation of lysosomal protective protein cathepsin A (CTSA)","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.07.814_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.phrs.2016.12.021","article-title":"Effect of lysosomotropic molecules on cellular homeostasis","volume":"117","author":"Kuzu","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.toxlet.2022.07.814_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s42003-021-02953-x","article-title":"Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins","volume":"5","author":"Luke","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2011.12.004","article-title":"Cation trapping by cellular acidic compartments: beyond the concept of lysosomotropic drugs","volume":"259","author":"Marceau","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.650055","article-title":"Nicotine causes mitochondrial dynamics imbalance and apoptosis through ROS mediated mitophagy impairment in cardiomyocytes","volume":"12","author":"Meng","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/jgh.14004","article-title":"Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse\u2019s space","volume":"33","author":"Miyata","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2022.07.814_bib20","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.3748\/wjg.v22.i22.5165","article-title":"Apoptosis induced by a low-carbohydrate and high-protein diet in rat livers","volume":"22","author":"Monteiro","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib21","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.biopha.2019.01.020","article-title":"Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line","volume":"111","author":"Morgan","year":"2019","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2022.07.814_bib22","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pnpbp.2018.01.023","article-title":"Meta regression: Relationship between antipsychotic receptor binding profiles and side-effects","volume":"84","author":"Olten","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.toxlet.2022.07.814_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173553","article-title":"Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review","volume":"887","author":"Otr\u0119ba","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.17305\/bjbms.2013.2394","article-title":"Role of D\u2081\/D\u2082 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats","volume":"13","author":"Ozdemir","year":"2013","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.toxlet.2022.07.814_bib25","first-page":"27","article-title":"Development of phenothiazine hybrids with potential medicinal interest: a review","author":"Posso","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.toxlet.2022.07.814_bib26","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1242\/jcs.196287","article-title":"Mechanisms and functions of lysosome positioning","volume":"129","author":"Pu","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.toxlet.2022.07.814_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5529518","article-title":"One-two punch therapy for the treatment of T-Cell malignancies involving p53-dependent cellular senescence","volume":"2021","author":"Qing","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.toxlet.2022.07.814_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12964-021-00764-5","article-title":"Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia","volume":"19","author":"Qing","year":"2021","journal-title":"Cell Commun. Signal.: CCS"},{"key":"10.1016\/j.toxlet.2022.07.814_bib29","article-title":"Autophagy and tumorigenesis","author":"Rangel","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.toxlet.2022.07.814_bib30","doi-asserted-by":"crossref","first-page":"23289","DOI":"10.1021\/acsomega.0c03112","article-title":"Facile cholesterol loading with a new probe ezflux allows for streamlined cholesterol efflux assays","volume":"5","author":"Ravodina","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.toxlet.2022.07.814_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.262","article-title":"Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells","volume":"8","author":"Song","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2022.07.814_bib32","first-page":"1","article-title":"LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization","author":"Tanaka","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2022.07.814_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4161\/auto.22557","article-title":"Cathepsin-mediated regulation of autophagy in saposin C deficiency","volume":"9","author":"Tatti","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2022.07.814_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2021.12.021","article-title":"Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells","volume":"357","author":"Tianji","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2022.07.814_bib35","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00204-020-02963-4","article-title":"Antidepressants- and antipsychotics-induced hepatotoxicity","volume":"95","author":"Todorovi\u0107 Vukoti\u0107","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s10495-009-0311-4","article-title":"TNFalpha-induced macrophage death via caspase-dependent and independent pathways","volume":"14","author":"Tran","year":"2009","journal-title":"Apoptosis: Int. J. Program. Cell Death"},{"key":"10.1016\/j.toxlet.2022.07.814_bib37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.15698\/cst2018.11.161","article-title":"Mechanisms and therapeutic significance of autophagy modulation by antipsychotic drugs","volume":"2","author":"Vucicevic","year":"2018","journal-title":"Cell Stress"},{"key":"10.1016\/j.toxlet.2022.07.814_bib38","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3892\/etm.2016.3155","article-title":"Preventive activity of banana peel polyphenols on CCl(4)-induced experimental hepatic injury in Kunming mice","volume":"11","author":"Wang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.toxlet.2022.07.814_bib39","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2019.1596486","article-title":"Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis","volume":"15","author":"Wang","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2022.07.814_bib40","doi-asserted-by":"crossref","DOI":"10.1097\/JCP.0000000000001576","article-title":"Drug-associated liver injury related to antipsychotics: exploratory analysis of pharmacovigilance data","author":"Zeiss","year":"2022","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.toxlet.2022.07.814_bib41","doi-asserted-by":"crossref","first-page":"75659","DOI":"10.18632\/oncotarget.12318","article-title":"Curcumin targets the TFEB-lysosome pathway for induction of autophagy","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422009699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422009699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:26:52Z","timestamp":1759901212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427422009699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":41,"alternative-id":["S0378427422009699"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.07.814","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.07.814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}