{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:34:47Z","timestamp":1790613287007,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.toxlet.2022.08.003","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T21:40:45Z","timestamp":1660340445000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The edematogenic effect of Micrurus lemniscatus venom is dependent on venom phospholipase A2 activity and modulated by non-neurogenic factors"],"prefix":"10.1016","volume":"369","author":[{"given":"Luciana L.","family":"Casais-e-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice","family":"da Cruz-Hofling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina F.P.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/toxins9060187","article-title":"Coral snake Venomics: analyses of venom gland transcriptomes and proteomes of six Brazilian taxa","volume":"9","author":"Aird","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.toxlet.2022.08.003_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2017.08.013","article-title":"Pharmacological analysis of Poecilotheria spider venoms in mice provides clues for human treatment","volume":"138","author":"Andreev-Andrievskiy","year":"2017","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0041-0101(03)00230-7","article-title":"Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom","volume":"42","author":"Barbosa","year":"2003","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0041-0101(94)90296-8","article-title":"Local effects induced by venoms from five species of genus Micrurus sp. (coral snakes)","volume":"32","author":"Barros","year":"1994","journal-title":"Toxicon"},{"issue":"2 Pt B","key":"10.1016\/j.toxlet.2022.08.003_bib6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molimm.2015.09.023","article-title":"Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom","volume":"68","author":"Bernardes","year":"2015","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.toxlet.2022.08.003_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"Bradley","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.toxicon.2020.04.095","article-title":"Renal effects of venoms of Mexican coral snakes Micrurus browni and Micrurus laticollaris","volume":"181","author":"Braga","year":"2020","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3109\/15563650.2015.1135337","article-title":"Coral snake bites (Micrurus spp.) in Brazil: a review of literature reports","volume":"54","author":"Bucaretchi","year":"2016","journal-title":"Clin. Toxicol."},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib10","first-page":"315","article-title":"Randomized comparative trial of three antivenoms in the treatment of envenoming by lance-headed vipers (Bothrops jararaca) in S\u00e3o Paulo, Brazil","volume":"86","author":"Cardoso","year":"1993","journal-title":"Q. J. Med."},{"issue":"11","key":"10.1016\/j.toxlet.2022.08.003_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005874","article-title":"Neurogenic mediators contribute to local edema induced by Micrurus lemniscatus venom","volume":"11","author":"Casais-e-Silva","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.toxlet.2022.08.003_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxlet.2016.06.005","article-title":"the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2","volume":"257","author":"Casais-e-Silva","year":"2016","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbpb.2004.11.012","article-title":"Biological and enzymatic activities of Micrurus sp. (Coral) snake venoms","volume":"140","author":"Cecchini","year":"2005","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40409-018-0170-y","article-title":"Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom","volume":"24","author":"Cedro","year":"2018","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0041-0101(03)00007-2","article-title":"Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants","volume":"41","author":"Chacur","year":"2003","journal-title":"Toxicon"},{"issue":"8","key":"10.1016\/j.toxlet.2022.08.003_bib16","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0041-0101(00)00254-3","article-title":"Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom","volume":"39","author":"Chacur","year":"2001","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0041-0101(94)00135-U","article-title":"Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice","volume":"33","author":"Chaves","year":"1995","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41584-021-00584-4","article-title":"TNF in the era of immune checkpoint inhibitors: friend or foe?","volume":"17","author":"Chen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"9","key":"10.1016\/j.toxlet.2022.08.003_bib19","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.jprot.2011.07.011","article-title":"Venomic analysis and evaluation of antivenom cross-reactivity of South American Micrurus species","volume":"74","author":"Ciscotto","year":"2011","journal-title":"J. Proteom."},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01918.x","article-title":"Nitric oxide: a regulator of mast cell activation and mast cell-mediated inflammation","volume":"129","author":"Coleman","year":"2002","journal-title":"Clin. Exp. Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0041-0101(89)90016-0","article-title":"Effect of chlorpromazine and quinacrine on the lethality in mice of the venoms and neurotoxins from several snakes","volume":"27","author":"Crosland","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2022.08.003_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.toxlet.2020.11.010","article-title":"Anticoagulant Micrurus venoms: targets and neutralization","volume":"337","author":"Dashevsky","year":"2021","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0952-3278(95)90044-6","article-title":"Studies on the mechanism of PAF-induced vasopermeability in rat lungs","volume":"52","author":"de Lima","year":"1995","journal-title":"Prostaglandins Leukot. Ess. Fat. Acids"},{"issue":"2","key":"10.1016\/j.toxlet.2022.08.003_bib24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.toxicon.2011.11.009","article-title":"Myotoxicity and nephrotoxicity by Micrurus venoms in experimental envenomation","volume":"59","author":"de Roodt","year":"2012","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.intimp.2015.06.001","article-title":"Inflammatory mediators involved in the paw edema and hyperalgesia induced by Batroxase, a metalloproteinase isolated from Bothrops atrox snake venom","volume":"28","author":"De Toni","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.toxicon.2016.10.002","article-title":"Pharmacological analysis of hemodynamic responses to Lachesis muta (South American bushmaster) snake venom in anesthetized rats","volume":"123","author":"Dias","year":"2016","journal-title":"Toxicon"},{"issue":"2","key":"10.1016\/j.toxlet.2022.08.003_bib27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1172\/JCI103259","article-title":"A relation between non-esterified fatty acids in plasma and the metabolism of glucose","volume":"35","author":"Dole","year":"1956","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib28","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12016-019-08769-2","article-title":"Mast cell biology at molecular level: a comprehensive review","volume":"58","author":"Elieh Ali Komi","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"2","key":"10.1016\/j.toxlet.2022.08.003_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.abb.2006.09.018","article-title":"Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study","volume":"455","author":"Escalante","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.toxlet.2022.08.003_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/950273","article-title":"Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of CD36 and platelet-activating factor receptor","volume":"2013","author":"Ferracini","year":"2013","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxicon.2008.10.016","article-title":"Inflammatory oedema induced by Lachesis muta muta (Surucucu) venom and LmTX-I in the rat paw and dorsal skin","volume":"53","author":"Ferreira","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2022.08.003_bib32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/j.1476-5381.1988.tb11614.x","article-title":"Lipocortin and the mechanism of action of glucorticoids","volume":"94","author":"Flower","year":"1988","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.toxlet.2022.08.003_bib33","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0041-0101(97)00031-7","article-title":"Toxins isolated from the venom of the Brazilian coral snake (Micrurus frontalis frontalis) include hemorrhagic type phospholipases A2 and postsynaptic neurotoxins","volume":"35","author":"Francis","year":"1997","journal-title":"Toxicon"},{"issue":"2\u20133","key":"10.1016\/j.toxlet.2022.08.003_bib34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.toxicon.2009.08.009","article-title":"Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved","volume":"55","author":"Galv\u00e3o Nascimento","year":"2010","journal-title":"Toxicon"},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib35","first-page":"402","article-title":"The effects of adrenalectomy and corticosterone on vascular permeability responses in the skin of the rat","volume":"56","author":"Garcia Leme","year":"1975","journal-title":"Br. J. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0041-0101(88)90010-4","article-title":"An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica","volume":"26","author":"Guti\u00e9rrez","year":"1988","journal-title":"Toxicon"},{"issue":"5\u20136","key":"10.1016\/j.toxlet.2022.08.003_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0041-0101(80)90091-4","article-title":"Efectos locales inducidos por el veneno de la serpiente coral Micrurus nigrocinctus en rat\u00f3n blanco [Local effects induced by Micrurus nigrocinctus venom in white mice (author's transl)]","volume":"18","author":"Guti\u00e9rrez","year":"1980","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0041-0101(83)90066-1","article-title":"Local effects induced by coral snake venoms: evidence of myonecrosis after experimental inoculations of venoms from five species","volume":"21","author":"Guti\u00e9rrez","year":"1983","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.toxlet.2022.08.003_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0742-8413(86)90069-1","article-title":"Comparative study of the edema-forming activity of Costa Rican snake venoms and its neutralization by a polyvalent antivenom","volume":"85","author":"Guti\u00e9rrez","year":"1986","journal-title":"Comp. Biochem. Physiol. C"},{"issue":"10","key":"10.1016\/j.toxlet.2022.08.003_bib41","doi-asserted-by":"crossref","first-page":"F1383","DOI":"10.1152\/ajprenal.00380.2013","article-title":"The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle","volume":"305","author":"Hennenberg","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"10","key":"10.1016\/j.toxlet.2022.08.003_bib42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s000110050347","article-title":"ER-34122, a novel dual 5-lipoxygenase\/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model","volume":"47","author":"Horizoe","year":"1998","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib43","first-page":"370","article-title":"A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin-induced oedema in mice","volume":"82","author":"Ianaro","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.toxlet.2022.08.003_bib44","doi-asserted-by":"crossref","first-page":"32092","DOI":"10.1038\/srep32092","article-title":"PAFR activation of NF-\u03baB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages","volume":"6","author":"Ishizuka","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.toxlet.2022.08.003_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006503","article-title":"The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock","volume":"4","author":"Jeong","year":"2009","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.toxlet.2022.08.003_bib46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s000110050222","article-title":"Glucocorticoid modulation of human monocyte\/macrophage function: control of TNF-alpha secretion","volume":"46","author":"Joyce","year":"1997","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem. J."},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.plefa.2013.09.003","article-title":"Activation of PAF-receptor induces regulatory dendritic cells through PGE2 and IL-10","volume":"89","author":"Koga","year":"2013","journal-title":"Prostaglandins Leukot. Ess. Fat. Acids"},{"issue":"20","key":"10.1016\/j.toxlet.2022.08.003_bib49","doi-asserted-by":"crossref","first-page":"5383-193","DOI":"10.1182\/blood-2011-07-358432","article-title":"Mast cell modulation of the vascular and lymphatic endothelium","volume":"118","author":"Kunder","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2022.08.003_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.656908","article-title":"The role of tumor necrosis factor in manipulating the immunological response of tumor microenvironment","volume":"12","author":"Laha","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib51","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.toxicon.2012.07.003","article-title":"Antinociceptive properties of Micrurus lemniscatus venom","volume":"60","author":"Leite dos Santos","year":"2012","journal-title":"Toxicon"},{"issue":"8B","key":"10.1016\/j.toxlet.2022.08.003_bib52","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1111\/j.1582-4934.2008.00610.x","article-title":"Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock","volume":"13","author":"Li","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.toxlet.2022.08.003_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2016.09.008","article-title":"Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses","volume":"122","author":"Lomonte","year":"2016","journal-title":"Toxicon"},{"issue":"Pt 12","key":"10.1016\/j.toxlet.2022.08.003_bib54","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1107\/S0907444905029598","article-title":"Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity","volume":"61","author":"Magro","year":"2005","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib55","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.pharep.2016.09.005","article-title":"Hydrocortisone and dexamethasone dose-dependently stabilize mast cells derived from rat peritoneum","volume":"68","author":"Mori","year":"2016","journal-title":"Pharmacol. Rep."},{"issue":"8","key":"10.1016\/j.toxlet.2022.08.003_bib56","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1074\/jbc.M116.764464","article-title":"Platelet-activating factor mediates endotoxin tolerance by regulating indoleamine 2,3-dioxygenase-dependent expression of the suppressor of cytokine signaling 3","volume":"292","author":"Noh","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.toxlet.2022.08.003_bib57","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mce.2013.05.014","article-title":"Molecular mechanisms of glucocorticoid action in mast cells","volume":"380","author":"Oppong","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib58","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.toxicon.2006.07.006","article-title":"Mediators involved in the febrile response induced by Tityus serrulatus scorpion venom in rats","volume":"48","author":"Pessini","year":"2006","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.toxlet.2022.08.003_bib59","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1590\/S0100-879X2002001000016","article-title":"Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms","volume":"35","author":"Picolo","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.toxlet.2022.08.003_bib60","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/00003246-199910000-00019","article-title":"Human vascular endothelial cells produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation","volume":"27","author":"Ranta","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.toxlet.2022.08.003_bib61","first-page":"557","article-title":"Antivenins in Brazil: preparation","volume":"vol. 5","author":"Raw","year":"1991"},{"key":"10.1016\/j.toxlet.2022.08.003_bib62","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biochi.2017.03.008","article-title":"Primary structures and partial toxicological characterization of two phospholipases A2 from Micrurus mipartitus and Micrurus dumerilii coral snake venoms","volume":"137","author":"Rey-Su\u00e1rez","year":"2017","journal-title":"Biochimie"},{"issue":"10","key":"10.1016\/j.toxlet.2022.08.003_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076893","article-title":"Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts","volume":"8","author":"Rios","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.toxlet.2022.08.003_bib64","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0041-0101(95)00162-X","article-title":"Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice","volume":"34","author":"Rucavado","year":"1996","journal-title":"Toxicon"},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib65","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","article-title":"Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom","volume":"63","author":"Rucavado","year":"1995","journal-title":"Exp. Mol. Pathol."},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib66","first-page":"245","article-title":"Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper","volume":"79","author":"Rucavado","year":"1998","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib67","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.toxicon.2018.06.063","article-title":"Pro-inflammatory response and hemostatic disorder induced by venom of the coral snake Micrurus tener tener IN C57BL\/6 mice","volume":"150","author":"Salazar","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.toxlet.2022.08.003_bib68","doi-asserted-by":"crossref","first-page":"S258","DOI":"10.1097\/00005344-199117003-00047","article-title":"Nitric oxide \u2013 a regulatory mediator of mast cell reactivity","volume":"17","author":"Salvemini","year":"1991","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib69","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jprot.2019.03.014","article-title":"New insights into the phylogeographic distribution of the 3FTx\/PLA2 venom dichotomy across genus Micrurus in South America","volume":"200","author":"Sanz","year":"2019","journal-title":"J. Proteom."},{"issue":"2","key":"10.1016\/j.toxlet.2022.08.003_bib70","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(95)00581-5","article-title":"Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema","volume":"286","author":"Sautebin","year":"1995","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.08.003_bib71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxlet.2021.11.003","article-title":"In vivo treatment with varespladib, a phospholipase A2 inhibitor, prevents the peripheral neurotoxicity and systemic disorders induced by Micrurus corallinus (coral snake) venom in rats","volume":"356","author":"Silva-Carvalho","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2022.08.003_bib72","series-title":"As Cobras-Corais do Brasil: Biologia, Taxonomia, Venenos e Envenenamentos","first-page":"415","article-title":"As cobras-corais do Novo Mundo","author":"Silva","year":"2016"},{"key":"10.1016\/j.toxlet.2022.08.003_bib73","first-page":"855","article-title":"Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties","volume":"42","author":"Soares","year":"2003"},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib74","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1476-5381.1994.tb13137.x","article-title":"Pro-inflammatory activities in elapid snake venoms","volume":"112","author":"Tambourgi","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000622","article-title":"Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization","volume":"4","author":"Tanaka","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.toxlet.2022.08.003_bib76","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2172-13-4","article-title":"Micrurus snake venoms activate human complement system and generate anaphylatoxins","volume":"13","author":"Tanaka","year":"2012","journal-title":"BMC Immunol."},{"issue":"6","key":"10.1016\/j.toxlet.2022.08.003_bib77","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/0960327115597983","article-title":"Platelet participation in the pathogenesis of dermonecrosis induced by Loxosceles gaucho venom","volume":"35","author":"Tavares","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2022.08.003_bib78","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/MAJ.0b013e3180318fbc","article-title":"Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation","volume":"27","author":"Theodossiadis","year":"2007","journal-title":"Retina"},{"key":"10.1016\/j.toxlet.2022.08.003_bib79","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0022-3565(25)27190-7","article-title":"Some details of the inflammation caused by yeast and caragenin","volume":"150","author":"Van Arman","year":"1965","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.toxlet.2022.08.003_bib80","first-page":"659","article-title":"Endotoxin, interleukin-1, and tumor necrosis factor cause neutrophil-dependent microvascular leakage in postcapillary venules","volume":"140","author":"Yi","year":"1992","journal-title":"Am. J. Pathol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422009808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422009808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:27:04Z","timestamp":1759901224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427422009808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":80,"alternative-id":["S0378427422009808"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.003","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The edematogenic effect of Micrurus lemniscatus venom is dependent on venom phospholipase A2 activity and modulated by non-neurogenic factors","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}