{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:23:46Z","timestamp":1759969426430,"version":"build-2065373602"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.toxlet.2022.08.004","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T23:01:32Z","timestamp":1660172492000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Consumption of soy isoflavones during the prepubertal phase delays puberty and causes hypergonadotropic hypogonadism with disruption of hypothalamic-pituitary gonadotropins regulation in male rats"],"prefix":"10.1016","volume":"369","author":[{"given":"Jeane Maria","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Medeiros","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Khaled","family":"Sleiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo Ogliari","family":"Dal Forno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aurelio","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Marino","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2022.08.004_bib1","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1210\/en.2007-0327","article-title":"Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular leydig cells in the adult rat","volume":"148","author":"Akingbemi","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2022.08.004_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.adolescence.2018.12.007","article-title":"Physiology of puberty in boys and girls and pathological disorders affecting its onset","author":"Alotaibi","year":"2019","journal-title":"J. Adolesc."},{"key":"10.1016\/j.toxlet.2022.08.004_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.7555\/JBR.31.20170067","article-title":"Effects of a soybean milk product on feto-neonatal development in rats","volume":"32","author":"An","year":"2018","journal-title":"J. Biomed. Res"},{"key":"10.1016\/j.toxlet.2022.08.004_bib4","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1039\/C5FO00308C","article-title":"Determination of the isoflavone composition and estrogenic activity of commercial dietary supplements based on soy or red clover","volume":"6","author":"Andres","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.toxlet.2022.08.004_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.37185\/LnS.1.1.43","article-title":"Endocrine Events Involved in Puberty: A Revisit to Existing Knowledge","volume":"1","author":"Aslam","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jsbmb.2015.09.002","article-title":"The effect of glucuronidation on isoflavone induced estrogen receptor (ER)\u03b1 and ER\u03b2 mediated coregulator interactions","volume":"154","author":"Beekmann","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib7","first-page":"1","article-title":"Regulation of Gonadotropins","author":"Bernard","year":"2019","journal-title":"Oxf. Res. Encycl. Neurosci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1095\/biolreprod.115.129320","article-title":"Cell type-specific sexual dimorphism in rat pituitary gene expression during maturation","volume":"93","author":"Bjelobaba","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.reprotox.2011.05.008","article-title":"Impact of perinatal exposure to equol enantiomers on reproductive development in rodents","volume":"32","author":"Brown","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/and.12394","article-title":"Isoflavones and their effects on the onset of puberty in male Wistar rats","volume":"47","author":"Caceres","year":"2015","journal-title":"Andrologia"},{"key":"10.1016\/j.toxlet.2022.08.004_bib11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/rda.13434","article-title":"Effects of soya milk on reproductive hormones during puberty in male Wistar rats","volume":"54","author":"Caceres","year":"2019","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.toxlet.2022.08.004_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/rda.12335","article-title":"The Effects of isoflavones on androgens and glucocorticoids during puberty on male wistar rats","volume":"49","author":"Caceres","year":"2014","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.toxlet.2022.08.004_bib13","first-page":"s12","article-title":"Pharmacokinetics of dietary isoflavones","author":"Chandrasekharan","year":"2013","journal-title":"J. Steroids Horm. Sci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib14","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/humrep\/den243","article-title":"Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic","volume":"23","author":"Chavarro","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1124\/jpet.102.046409","article-title":"Metabolism of flavonoids via enteric recycling: role of intestinal disposition","volume":"304","author":"Chen","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2022.08.004_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2014.00001","article-title":"Role of estrogen receptors and G protein-coupled estrogen receptor in regulation of hypothalamus\u2013pituitary\u2013testis axis and spermatogenesis","volume":"5","author":"Chimento","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.toxlet.2022.08.004_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2020.00563","article-title":"Skeletal effects of early-life exposure to soy isoflavones\u2014a review of evidence from rodent models","author":"Chin","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.toxlet.2022.08.004_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/1750-3841.15051","article-title":"pH-adjusted solvent extraction and reversed-phase HPLC quantification of isoflavones from soybean (Glycine max (L.) Merr.)","volume":"85","author":"Cho","year":"2020","journal-title":"J. Food Sci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.toxlet.2022.08.004_bib20","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/physrev.00018.2016","article-title":"Estrogens in male physiology","volume":"97","author":"Cooke","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.toxlet.2022.08.004_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-62703-131-8_24","article-title":"Maternal txicity","volume":"947","author":"Danielsson","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib22","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0890-6238(01)00177-0","article-title":"Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats","volume":"15","author":"Delclos","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/jat.727","article-title":"A good practice guide to the administration of substances and removal of blood, including routes and volumes","author":"Diehl","year":"2001","journal-title":"J. Appl. Toxicol. J. Appl. Toxicol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib24","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1289\/ehp.0800158","article-title":"Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility","volume":"117","author":"Eustache","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2022.08.004_bib25","first-page":"68","article-title":"Isoflavones in human breast milk and other biological fluids","author":"Franke","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.toxlet.2022.08.004_bib26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/jf0009246","article-title":"Nutritional and health benefits of soy proteins\u2020","volume":"49","author":"Friedman","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.toxlet.2022.08.004_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/B978-012373898-1.50014-0","article-title":"Anesthesia and analgesia for laboratory rodents","author":"Gaertner","year":"2008","journal-title":"Anesth. Analg. Lab. Anim."},{"key":"10.1016\/j.toxlet.2022.08.004_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.ejcn.1601495","article-title":"Dietary supplements of soya flour serum testosterone concentrations and improve markers of oxidative stress in men","volume":"57","author":"Gardner-Thorpe","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.toxlet.2022.08.004_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123853","article-title":"Scientific evidence supporting the beneficial effects of isoflavones on human health","author":"G\u00f3mez-Zorita","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.toxlet.2022.08.004_bib30","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1158\/1055-9965.EPI-06-0882","article-title":"Clinical and biological activity of soy protein powder supplementation in healthy male volunteers","volume":"16","author":"Goodin","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.toxlet.2022.08.004_bib31","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.fertnstert.2009.04.038","article-title":"Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: Results of a meta-analysis","volume":"94","author":"Hamilton-Reeves","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.toxlet.2022.08.004_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.toxlet.2008.11.005","article-title":"Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling","volume":"184","author":"Hancock","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2022.08.004_bib33","first-page":"19","article-title":"Mixture concentration-response modeling reveals antagonistic effects of estradiol and genistein in combination on brain aromatase gene (Cyp19a1b) in zebrafish","author":"Hinfray","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib34","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1210\/me.2008-0192","article-title":"Converse regulatory functions of estrogen receptor-\u03b1 and -\u03b2 subtypes expressed in hypothalamic gonadotropin-releasing hormone neurons","volume":"22","author":"Hu","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/dta.2482","article-title":"Synthetic isoflavones and doping: a novel class of aromatase inhibitors?","volume":"11","author":"Iannone","year":"2019","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.toxlet.2022.08.004_bib36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mnfr.201300390","article-title":"Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models","volume":"58","author":"Islam","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.toxlet.2022.08.004_bib37","series-title":"Knobil and Neill\u2019s Physiology of Reproduction","first-page":"1635","article-title":"- Gonadotropin-Releasing Hormone Regulation of Gonadotropin Biosynthesis and Secretion","author":"Jeong","year":"2006"},{"key":"10.1016\/j.toxlet.2022.08.004_bib38","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/endo.138.3.4968","article-title":"Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro 1","volume":"138","author":"Kaiser","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2022.08.004_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2017.11.018","article-title":"The hypothalamus-pituitary-gonad axis: Tales of mice and men","author":"Kaprara","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.toxlet.2022.08.004_bib40","first-page":"1","article-title":"Testicular Development in Male Rats Is Sensitive to a Soy-Based Diet in the Neonatal Period1","volume":"90","author":"Kemppainen","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1095\/biolreprod17.2.298","article-title":"Preputial seperation as an external sign of pubertal development in the male rat","volume":"17","author":"Korenbrot","year":"1977","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib42","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/molecules24061076","article-title":"Isoflavones","volume":"24","author":"K\u0159\u00ed\u017eov\u00e1","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.toxlet.2022.08.004_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00410","article-title":"Up-to-date review about minipuberty and overview on hypothalamic-pituitary-gonadal axis activation in fetal and neonatal life","author":"Lanciotti","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.toxlet.2022.08.004_bib44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fendo.2019.00178","article-title":"Endocrine Disrupting Chemicals: Effects on Endocrine Glands","volume":"10","author":"Lauretta","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.toxlet.2022.08.004_bib45","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1210\/endo.139.10.6253","article-title":"Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-\u03b1 knockout mice","volume":"139","author":"Lindzey","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2022.08.004_bib46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.toxlet.2022.08.004_bib47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.foodchem.2019.01.054","article-title":"Acrylamide: a review about its toxic effects in the light of Developmental Origin of Health and Disease (DOHaD) concept","volume":"283","author":"Matoso","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.toxlet.2022.08.004_bib48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/B978-0-12-397175-3.00010-7","article-title":"Gonadotropes and gonadotropin-releasing hormone signaling","volume":"1","author":"McArdle","year":"2015","journal-title":"Knobil Neill\u2019s Physiol. Reprod. Two-Vol. Set."},{"key":"10.1016\/j.toxlet.2022.08.004_bib49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.6061\/clinics\/2013(02)OA21","article-title":"Effects of the phytoestrogen genistein on the development of the reproductive system of Sprague Dawley rats","volume":"68","author":"Md Zin","year":"2013","journal-title":"Clinics"},{"key":"10.1016\/j.toxlet.2022.08.004_bib50","doi-asserted-by":"crossref","unstructured":"Messina, M., Mejia, S.B., Cassidy, A., Duncan, A., Kurzer, M., Nagato, C., Ronis, M., Rowland, I., Sievenpiper, J., Barnes, S., 2021. Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data. https:\/\/doi.org\/10.1080\/10408398.2021.1895054. https:\/\/doi.org\/10.1080\/10408398.2021.1895054.","DOI":"10.1080\/10408398.2021.1895054"},{"key":"10.1016\/j.toxlet.2022.08.004_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mce.2017.08.001","article-title":"Role of the androgen receptor in the central nervous system","volume":"465","author":"Mhaouty-Kodja","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbalip.2007.02.012","article-title":"Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter","volume":"1771","author":"Miller","year":"2007","journal-title":"Biochim. Biophys. Acta - Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.toxlet.2022.08.004_bib53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2010.04.024","article-title":"Genomics and genetics of gonadotropin beta-subunit genes: unique FSHB and duplicated LHB\/CGB loci","volume":"329","author":"Nagirnaja","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.toxlet.2022.08.004_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144812","article-title":"Molecular insights into hormone regulation via signaling pathways in Sertoli cells: With discussion on infertility and testicular tumor","volume":"753","author":"Ni","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.toxlet.2022.08.004_bib56","series-title":"Hormones","first-page":"55","article-title":"The Hypothalamus and Anterior Pituitary","author":"Norman","year":"2015"},{"key":"10.1016\/j.toxlet.2022.08.004_bib57","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-2004-831893","article-title":"Inhibins in normal male physiology","volume":"22","author":"O\u2019Connor","year":"2004","journal-title":"Semin Reprod. Med"},{"key":"10.1016\/j.toxlet.2022.08.004_bib58","series-title":"Knobil and Neill\u2019s Physiology of Reproduction","first-page":"1017","article-title":"Endocrine Regulation of Spermatogenesis A2 - Neill, Jimmy D","author":"O\u2019Donnell","year":"2006"},{"key":"10.1016\/j.toxlet.2022.08.004_bib59","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fendo.2018.00763","article-title":"Role of follicle-stimulating hormone in spermatogenesis","volume":"9","author":"Oduwole","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.toxlet.2022.08.004_bib60","first-page":"16","article-title":"Association between a soy-based infant diet and the onset of puberty: a systematic review and meta-analysis","author":"Oliveira","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2022.08.004_bib61","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1071\/RD17107","article-title":"Delayed onset of puberty in male offspring from bisphenol A-treated dams is followed by the modulation of gene expression in the hypothalamic\u2013pituitary\u2013testis axis in adulthood","volume":"29","author":"Oliveira","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.toxlet.2022.08.004_bib62","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.toxlet.2011.11.027","article-title":"Regulation of adiponectin secretion by soy isoflavones has implication for endocrine function of the testis","volume":"209","author":"Pfaehler","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2022.08.004_bib63","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1007\/s13197-020-04255-2","article-title":"Physicochemical characteristics and isoflavones content during manufacture of short-time fermented soybean product (cheonggukjang)","volume":"57","author":"Piao","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/bdr2.1133","article-title":"Comparative aspects of pre- and postnatal development of the male reproductive system","author":"Picut","year":"2018","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.toxlet.2022.08.004_bib65","doi-asserted-by":"crossref","first-page":"651","DOI":"10.33549\/physiolres.931902","article-title":"The physiological actions of isoflavone phytoestrogens","volume":"59","author":"Pilsakov\u00e1","year":"2010","journal-title":"Physiol. Res."},{"key":"10.1016\/j.toxlet.2022.08.004_bib66","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.nut.2010.03.010","article-title":"Changes in male reproductive system and mineral metabolism induced by soy isoflavones administered to rats from prenatal life until sexual maturity","volume":"27","author":"Piotrowska","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.toxlet.2022.08.004_bib67","series-title":"Knobil and Neill\u2019s Physiology of Reproduction","article-title":"Puberty in Mice and Rats","author":"Prevot","year":"2014"},{"key":"10.1016\/j.toxlet.2022.08.004_bib68","doi-asserted-by":"crossref","unstructured":"Ramasamy, R., Masterson, J.M., Lee, J.A., Huhtaniemi, I.T., Oduwole, O.O., Peltoketo, H., 2018. Role of Follicle-Stimulating Hormone in Spermatogenesis. Front. Endocrinol. | www.frontiersin.org 9, 763. https:\/\/doi.org\/10.3389\/fendo.2018.00763.","DOI":"10.3389\/fendo.2018.00763"},{"key":"10.1016\/j.toxlet.2022.08.004_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2020.12.019","article-title":"Neither soy nor isoflavone intake affects male reproductive hormones: An expanded and updated meta-analysis of clinical studies","author":"Reed","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib70","first-page":"8","article-title":"The organization and regulation of mRNA-protein complexes","author":"Rissland","year":"2017","journal-title":"Wiley Inter. Rev. RNA"},{"key":"10.1016\/j.toxlet.2022.08.004_bib71","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1385\/ENDO:13:3:281","article-title":"Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats","volume":"13","author":"Roberts","year":"2000","journal-title":"Endocrine"},{"key":"10.1016\/j.toxlet.2022.08.004_bib72","first-page":"59","article-title":"Triiodothyronine differentially modulates the LH and FSH synthesis and secretion in male rats","author":"Romano","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.toxlet.2022.08.004_bib73","first-page":"83","article-title":"Reproductive and toxicological effects of isoflavones on female offspring of rats exposed during pregnancy","volume":"5","author":"Romero","year":"2008","journal-title":"Anim. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib74","first-page":"137","article-title":"Estrogen-like endocrine disrupting chemicals affecting puberty in humans - a review","volume":"15","author":"Roy","year":"2009","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.toxlet.2022.08.004_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2019.09.008","article-title":"Epigenetics and the developmental origins of health and disease: parental environment signalling to the epigenome, critical time windows and sculpting the adult phenotype","author":"Safi-Stibler","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib76","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1007\/s00394-017-1504-1","article-title":"Soy isoflavone consumption and age at pubarche in adolescent males","volume":"57","author":"Segovia-Siapco","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.toxlet.2022.08.004_bib77","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/GME.0000000000001018","article-title":"The history and basic science development of soy isoflavones","volume":"24","author":"Setchell","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.toxlet.2022.08.004_bib78","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(96)09480-9","article-title":"Exposure of infants to phyto-oestrogens from soy-based infant formula","volume":"350","author":"Setchell","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2022.08.004_bib79","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1007\/s13197-016-2328-3","article-title":"Plant-based milk alternatives an emerging segment of functional beverages: a review","volume":"53","author":"Sethi","year":"2016","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib80","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/humrep\/17.7.1692","article-title":"Infant feeding with soy formula milk: Effects on the testis and on blood testosterone levels in marmoset monkeys during the period of neonatal testicular activity","volume":"17","author":"Sharpe","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib81","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1095\/biolreprod.109.082685","article-title":"Developmental exposures of male rats to soy isoflavones impact leydig cell differentiation","volume":"83","author":"Sherrill","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2022.08.004_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ani10030377","article-title":"Oral exposure to genistein during conception and lactation period affects the testicular development of male offspring mice","volume":"10","author":"Shi","year":"2020","journal-title":"Animals"},{"key":"10.1016\/j.toxlet.2022.08.004_bib83","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2174\/1381612826999200917154747","article-title":"Beneficiary and adverse effects of phytoestrogens: a potential constituent of plant-based diet","volume":"27","author":"Sridevi","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.toxlet.2022.08.004_bib84","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mce.2017.10.015","article-title":"Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression","volume":"463","author":"Stamatiades","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib85","doi-asserted-by":"crossref","DOI":"10.1080\/10408440091159194","article-title":"Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations","author":"Stoker","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib86","first-page":"21","article-title":"Oestrogenic endocrine disruptors in the placenta and the fetus","author":"Tang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib87","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1523\/JNEUROSCI.1006-04.2004","article-title":"Direct action of estradiol on gonadotropin-releasing hormone-1 neuronal activity via a transcription-dependent mechanism","volume":"24","author":"Temple","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.toxlet.2022.08.004_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2013.09.012","article-title":"GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression","author":"Thompson","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib89","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ijheh.2011.09.005","article-title":"Endocrine disrupting chemicals in urine of Japanese male partners of subfertile couples: a pilot study on exposure and semen quality","volume":"215","author":"Toshima","year":"2012","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.toxlet.2022.08.004_bib90","doi-asserted-by":"crossref","unstructured":"Tran, L., Hammuda, M., Wood, C., Xiao, C.W., 2013. Soy extracts suppressed iodine uptake and stimulated the production of autoimmunogen in rat thyrocytes: https:\/\/doi.org\/10.1177\/1535370213489488 238, 623\u2013630. https:\/\/doi.org\/10.1177\/1535370213489488.","DOI":"10.1177\/1535370213489488"},{"key":"10.1016\/j.toxlet.2022.08.004_bib91","unstructured":"US Environmental Protection Agency, E.P.A., 2009. EDSP Test Guidelines OPPTS 890.1500 Pubertal Development and Thyroid Function in Intact Juvenile\/Peripubertal Male Rats."},{"key":"10.1016\/j.toxlet.2022.08.004_bib92","first-page":"113","article-title":"Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials","author":"Van Die","year":"2014","journal-title":"BJU Int"},{"key":"10.1016\/j.toxlet.2022.08.004_bib93","series-title":"The Role of Functional Food Security in Global Health","article-title":"Health Effects and Safety of Soy and Isoflavones","author":"Watanabe","year":"2019"},{"key":"10.1016\/j.toxlet.2022.08.004_bib94","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1097\/01.ju.0000046780.23389.e0","article-title":"Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats","volume":"169","author":"Wisniewski","year":"2003","journal-title":"J. Urol."},{"key":"10.1016\/j.toxlet.2022.08.004_bib95","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.envint.2013.06.009","article-title":"Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men","volume":"59","author":"Xia","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2022.08.004_bib96","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.5966","article-title":"Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades","author":"Xiao","year":"2018","journal-title":"Phyther. Res."},{"key":"10.1016\/j.toxlet.2022.08.004_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-022-02320-5","article-title":"Prospective association of dietary soy and fibre intake with puberty timing: a cohort study among Chinese children","volume":"20","author":"Xiong","year":"2022","journal-title":"BMC Med"},{"key":"10.1016\/j.toxlet.2022.08.004_bib98","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/10408398.2014.989958","article-title":"An updated review of dietary isoflavones: nutrition, processing, bioavailability and impacts on human health","volume":"57","author":"Zaheer","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.toxlet.2022.08.004_bib99","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1021\/mp700077z","article-title":"Intestinal and hepatic glucuronidation of flavonoids","volume":"4","author":"Zhang","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.toxlet.2022.08.004_bib100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy059","article-title":"Leydig cells: formation, function, and regulation","volume":"99","author":"Zirkin","year":"2018","journal-title":"Biol. Reprod."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742200981X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742200981X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:26:53Z","timestamp":1759901213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842742200981X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":100,"alternative-id":["S037842742200981X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.004","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Consumption of soy isoflavones during the prepubertal phase delays puberty and causes hypergonadotropic hypogonadism with disruption of hypothalamic-pituitary gonadotropins regulation in male rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}