{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:23:59Z","timestamp":1787865839143,"version":"build-2784847793"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0803900"],"award-info":[{"award-number":["2020YFA0803900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.toxlet.2022.12.006","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:44:17Z","timestamp":1671072257000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Developmental toxicity window of fetal testicular injury in offspring mice induced by prenatal amoxicillin exposure at different time, doses and courses"],"prefix":"10.1016","volume":"374","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2022.12.006_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/biom10101468","article-title":"Citrus sudachi peel extract suppresses cell proliferation and promotes the differentiation of Keratinocytes through inhibition of the EGFR-ERK signaling pathway","volume":"10","author":"Abe","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.toxlet.2022.12.006_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1148\/rg.2020190111","article-title":"Absent, abnormal, or reduced flow in the testis: thinking beyond torsion","volume":"40","author":"Alexander","year":"2020","journal-title":"Radiogr.: a Rev. Publ. Radiol. Soc. North Am., Inc."},{"key":"10.1016\/j.toxlet.2022.12.006_bib3","doi-asserted-by":"crossref","first-page":"972","DOI":"10.2174\/1389200219666180702104034","article-title":"Optimization of drugs pharmacotherapy during pregnancy using physiologically based pharmacokinetic models - an update","volume":"19","author":"Alsmadi","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.toxlet.2022.12.006_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2125.2004.02138.x","article-title":"First-trimester exposure to amoxycillin\/clavulanic acid: a prospective, controlled study","volume":"58","author":"Berkovitch","year":"2004","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2174\/1381612825666190319102812","article-title":"Methodological approaches to evaluate fetal drug exposure","volume":"25","author":"Bouazza","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.toxlet.2022.12.006_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115514","article-title":"In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development","volume":"419","author":"Chen","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3727\/096368910X536563","article-title":"Characterization and functionality of proliferative human Sertoli cells","volume":"20","author":"Chui","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.toxlet.2022.12.006_bib8","article-title":"Interventions for treating genital Chlamydia trachomatis infection in pregnancy","volume":"9","author":"Cluver","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.toxlet.2022.12.006_bib9","article-title":"Chlamydia (uncomplicated, genital)","volume":"2015","author":"Crofts","year":"2015","journal-title":"BMJ Clin. Evid."},{"key":"10.1016\/j.toxlet.2022.12.006_bib10","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1111\/bcp.14118","article-title":"The safety of amoxicillin and clavulanic acid use during the first trimester of pregnancy","volume":"85","author":"Daniel","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91204","article-title":"Experimentally induced testicular dysgenesis syndrome originates in the masculinization programming window","volume":"2","author":"van den Driesche","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.toxlet.2022.12.006_bib12","doi-asserted-by":"crossref","unstructured":"Eckert, R.L., Efimova, T., Dashti, S.R., et al., 2002. Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase. The journal of investigative dermatology. Symposium proceedings 7, 36\u201340. Doi:\u300810.1046\/j.1523\u20131747.2002.19634.x\u3009.","DOI":"10.1046\/j.1523-1747.2002.19634.x"},{"key":"10.1016\/j.toxlet.2022.12.006_bib13","first-page":"103","article-title":"Beta-lactam antibiotics during pregnancy: a cross-sectional comparative study Zagreb-Novi Sad","volume":"16","author":"Eric","year":"2012","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2022.12.006_bib14","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s10096-009-0805-6","article-title":"Fosfomycin in a single dose versus a 7-day course of amoxicillin-clavulanate for the treatment of asymptomatic bacteriuria during pregnancy","volume":"28","author":"Estebanez","year":"2009","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis.: Off. Publ. Eur. Soc. Clin. Microbiol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib15","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/humrep\/dew196","article-title":"Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants","volume":"31","author":"Fisher","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.toxlet.2022.12.006_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104795","article-title":"Cr(VI) induces ROS-mediated mitochondrial-dependent apoptosis in neuronal cells via the activation of Akt\/ERK\/AMPK signaling pathway","volume":"65","author":"Fu","year":"2020","journal-title":"Toxicol. Vitr.: Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.toxlet.2022.12.006_bib17","first-page":"22","article-title":"Role of constitutive StAR in Leydig cells","author":"Galano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.12.006_bib18","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4317\/medoral.18807","article-title":"Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats","volume":"19","author":"Gottberg","year":"2014","journal-title":"Med. Oral., Patol. Oral. Y. cirugia Bucal"},{"key":"10.1016\/j.toxlet.2022.12.006_bib19","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1177\/1535370215590822","article-title":"Expansion and long-term culture of human spermatogonial stem cells via the activation of SMAD3 and AKT pathways","volume":"240","author":"Guo","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.toxlet.2022.12.006_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/1008-682X.160260","article-title":"Annexin A5 regulates Leydig cell testosterone production via ERK1\/2 pathway","volume":"18","author":"He","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.toxlet.2022.12.006_bib21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/bdrb.21020","article-title":"Effects of transplacental 17-alpha-ethynyl estradiol or bisphenol A on the developmental profile of steroidogenic acute regulatory protein in the rat testis","volume":"95","author":"Horstman","year":"2012","journal-title":"Birth Defects Res. Part b-Dev. Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1155\/S1064744901000321","article-title":"A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy","volume":"9","author":"Kacmar","year":"2001","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/humupd\/dmz004","article-title":"Effect of environmental and pharmaceutical exposures on fetal testis development and function: a systematic review of human experimental data","volume":"25","author":"Kilcoyne","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.toxlet.2022.12.006_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/REP-21-0235","article-title":"Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures","volume":"163","author":"Lea","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2022.12.006_bib25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/biolre\/iox057","article-title":"Yes-associated protein and WW-containing transcription regulator 1 regulate the expression of sex-determining genes in Sertoli cells, but their inactivation does not cause sex reversal","volume":"97","author":"Levasseur","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2022.12.006_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13157","article-title":"YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"issue":"5","key":"10.1016\/j.toxlet.2022.12.006_bib27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/EDE.0b013e318258cb05","article-title":"Maternal exposure to amoxicillin and the risk of oral clefts","volume":"23","author":"Lin","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.toxlet.2022.12.006_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2018.06.005","article-title":"Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats","volume":"408","author":"Liu","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2022.12.006_bib29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/15592294.2019.1581595","article-title":"Corticosterone rather than ethanol epigenetic programmed testicular dysplasia caused by prenatal ethanol exposure in male offspring rats","volume":"14","author":"Liu","year":"2019","journal-title":"Epigenetics-Us"},{"key":"10.1016\/j.toxlet.2022.12.006_bib30","doi-asserted-by":"crossref","first-page":"E1757","DOI":"10.1210\/jc.2013-2531","article-title":"Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent","volume":"98","author":"Mazaud-Guittot","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.toxlet.2022.12.006_bib31","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/humrep\/den295","article-title":"Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human","volume":"23","author":"Mitchell","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.toxlet.2022.12.006_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125776","article-title":"Paternal cadmium exposure increases the susceptibility to diet-induced testicular injury and spermatogenic disorders in mouse offspring","volume":"246","author":"Nan","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2022.12.006_bib33","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1681\/ASN.V115874","article-title":"In utero and in vitro exposure to beta-lactams impair kidney development in the rat","volume":"11","author":"Nathanson","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41419-019-1782-z","article-title":"Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis","volume":"10","author":"Ni","year":"2019","journal-title":"Cell death Dis."},{"key":"10.1016\/j.toxlet.2022.12.006_bib35","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3201\/eid2606.191300","article-title":"Effectiveness and tolerability of oral amoxicillin in pregnant women with active syphilis, Japan, 2010-2018","volume":"26","author":"Nishijima","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.toxlet.2022.12.006_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002160","article-title":"Pregnancy-associated changes in pharmacokinetics: a systematic review","volume":"13","author":"Pariente","year":"2016","journal-title":"PLoS Med."},{"key":"10.1016\/j.toxlet.2022.12.006_bib37","doi-asserted-by":"crossref","first-page":"M17","DOI":"10.1530\/JOE-18-0684","article-title":"The GC-IGF1 axis-mediated testicular dysplasia caused by prenatal caffeine exposure","volume":"242","author":"Pei","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.toxlet.2022.12.006_bib39","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1210\/en.2016-1156","article-title":"Sertoli cells modulate testicular vascular network development, structure, and function to influence circulating testosterone concentrations in adult male mice","volume":"157","author":"Rebourcet","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2022.12.006_bib40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000342221","article-title":"Genetic control of testis development","volume":"7","author":"Sekido","year":"2013","journal-title":"Sex. Dev."},{"key":"10.1016\/j.toxlet.2022.12.006_bib41","first-page":"1529","article-title":"Effect of low-dose fenvalerate on semen quality capacitation in adult mice","volume":"124","author":"Shi","year":"2011","journal-title":"Chin. Med. J."},{"issue":"Suppl 1","key":"10.1016\/j.toxlet.2022.12.006_bib42","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1016\/j.ydbio.2018.05.023","article-title":"AKT signaling displays multifaceted functions in neural crest development","volume":"444","author":"Sittewelle","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2022.12.006_bib43","doi-asserted-by":"crossref","unstructured":"Skakkebaek NE. 2003. Testicular dysgenesis syndrome. Horm Res. 60 Suppl 3:49.","DOI":"10.1159\/000074499"},{"key":"10.1016\/j.toxlet.2022.12.006_bib44","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1002\/jcp.29208","article-title":"PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes","volume":"235","author":"Song","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"21","key":"10.1016\/j.toxlet.2022.12.006_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218377","article-title":"Exogenous oestrogen impacts cell fate decision in the developing gonads: a potential cause of declining human reproductive health","volume":"21","author":"Stewart","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2022.12.006_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13287-019-1180-6","article-title":"Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells","volume":"10","author":"Xu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.toxlet.2022.12.006_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41422-021-00539-0","article-title":"SDX on the X chromosome is required for male sex determination","volume":"32","author":"Zhan","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.toxlet.2022.12.006_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112392","article-title":"Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K\/Akt and ERK signaling","volume":"398","author":"Zhang","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.toxlet.2022.12.006_bib49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ydbio.2017.01.013","article-title":"SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice","volume":"423","author":"Zhao","year":"2017","journal-title":"Dev. Biol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422018124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427422018124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:28:34Z","timestamp":1759901314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427422018124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":49,"alternative-id":["S0378427422018124"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.12.006","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental toxicity window of fetal testicular injury in offspring mice induced by prenatal amoxicillin exposure at different time, doses and courses","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2022.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}