{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:47:20Z","timestamp":1791460040112,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.toxlet.2023.01.012","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:35:13Z","timestamp":1675344913000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo\/in vitro, C57BL\/6 mice, AC16 and hiPSC-CMs]"],"prefix":"10.1016","volume":"377","author":[{"given":"Xiaoran","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2023.01.012_bib1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.freeradbiomed.2021.02.016","article-title":"The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy","volume":"167","author":"Bekhite","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.toxlet.2023.01.012_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.673621","article-title":"miR-199a overexpression enhances the potency of human induced-pluripotent stem-cell-derived cardiomyocytes for myocardial repair","volume":"12","author":"Bian","year":"2021","journal-title":"Front Pharm."},{"issue":"5","key":"10.1016\/j.toxlet.2023.01.012_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nm.4087","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity","volume":"22","author":"Burridge","year":"2016","journal-title":"Nat. Med"},{"key":"10.1016\/j.toxlet.2023.01.012_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6692579","article-title":"Dihydromyricetin acts as a potential redox balance mediator in cancer chemoprevention","volume":"2021","author":"Chen","year":"2021","journal-title":"Mediat. Inflamm."},{"issue":"9","key":"10.1016\/j.toxlet.2023.01.012_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092592","article-title":"Dihydromyricetin attenuates myocardial hypertrophy induced by transverse aortic constriction via oxidative stress inhibition and SIRT3 pathway enhancement","volume":"19","author":"Chen","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.toxlet.2023.01.012_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41419-021-03614-x","article-title":"Regulated cell death pathways in doxorubicin-induced cardiotoxicity","volume":"12","author":"Christidi","year":"2021","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.toxlet.2023.01.012_bib7","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1111\/jcmm.15127","article-title":"Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury","volume":"24","author":"Davidson","year":"2020","journal-title":"J. Cell Mol. Med"},{"issue":"3","key":"10.1016\/j.toxlet.2023.01.012_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4149\/neo_2020_190716N640","article-title":"Endostar blocks the metastasis, invasion and angiogenesis of ovarian cancer cells","volume":"67","author":"Ding","year":"2020","journal-title":"Neoplasma"},{"issue":"6","key":"10.1016\/j.toxlet.2023.01.012_bib9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/iub.215","article-title":"Unraveling the mysteries of endostatin","volume":"61","author":"Fu","year":"2009","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.toxlet.2023.01.012_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.21037\/cco.2015.12.02","article-title":"Chinese guidelines on the diagnosis and treatment of melanoma (2015 Edition)","volume":"5","author":"Guo","year":"2016","journal-title":"Chin. Clin. Oncol."},{"key":"10.1016\/j.toxlet.2023.01.012_bib11","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/ncomms3308","article-title":"Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart","volume":"4","author":"Hoshino","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2023.01.012_bib12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.yjmcc.2014.09.019","article-title":"Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system","volume":"78","author":"Ikeda","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"issue":"15","key":"10.1016\/j.toxlet.2023.01.012_bib13","doi-asserted-by":"crossref","first-page":"19460","DOI":"10.18632\/aging.203357","article-title":"Pedunculoside protects against LPS-induced mastitis in mice by inhibiting inflammation and maintaining the integrity of blood-milk barrier","volume":"13","author":"Kan","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.toxlet.2023.01.012_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.650039","article-title":"Human pluripotent stem cells for modeling of anticancer therapy-induced cardiotoxicity and cardioprotective drug discovery","volume":"12","author":"Keung","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.toxlet.2023.01.012_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27041346","article-title":"Mitochondrial ROS-mediated metabolic and cytotoxic effects of isoproterenol on cardiomyocytes are p53-dependent and reversed by curcumin","volume":"27","author":"Lee","year":"2022","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.toxlet.2023.01.012_bib16","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00204-019-02448-z","article-title":"Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo","volume":"93","author":"Li","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.01.012_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40487-017-0055-1","article-title":"Current status and study progress of recombinant human endostatin in cancer treatment","volume":"6","author":"Li","year":"2018","journal-title":"Oncol. Ther."},{"key":"10.1016\/j.toxlet.2023.01.012_bib18","article-title":"Harpagoside protects against doxorubicin-induced cardiotoxicity via P53-Parkin-mediated mitophagy","volume":"10","author":"Li","year":"2022","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.toxlet.2023.01.012_bib19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.freeradbiomed.2019.06.017","article-title":"CARD9 inhibits mitochondria-dependent apoptosis of cardiomyocytes under oxidative stress via interacting with Apaf-1","volume":"141","author":"Li","year":"2019","journal-title":"Free Radic. Biol. Med"},{"issue":"4","key":"10.1016\/j.toxlet.2023.01.012_bib20","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ctrv.2013.11.009","article-title":"Antiangiogenesis beyond VEGF inhibition: a journey from antiangiogenic single-target to broad-spectrum agents","volume":"40","author":"Limaverde-Sousa","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.toxlet.2023.01.012_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2017.05.003","article-title":"Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice","volume":"262","author":"Liu","year":"2017","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.toxlet.2023.01.012_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073765","article-title":"Anti-angiogenic therapy: current challenges and future perspectives","volume":"22","author":"Lopes-Coelho","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2023.01.012_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.847012","article-title":"Cardiotoxicity of anticancer drugs: molecular mechanisms and strategies for cardioprotection","volume":"9","author":"Morelli","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.toxlet.2023.01.012_bib24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81848-6","article-title":"Endostatin: an endogenous inhibitor of angiogenesis and tumor growth","volume":"88","author":"O'Reilly","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2023.01.012_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102884","article-title":"Mitochondria in acute myocardial infarction and cardioprotection","volume":"57","author":"Ramachandra","year":"2020","journal-title":"EBioMedicine"},{"issue":"21","key":"10.1016\/j.toxlet.2023.01.012_bib26","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1111\/jcmm.15725","article-title":"Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways","volume":"24","author":"Ren","year":"2020","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.toxlet.2023.01.012_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mcp.2019.05.003","article-title":"Endostar regulates EMT, migration and invasion of lung cancer cells through the HGF-Met pathway","volume":"45","author":"Shen","year":"2019","journal-title":"Mol. Cell Probes"},{"issue":"3","key":"10.1016\/j.toxlet.2023.01.012_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.molmed.2017.01.002","article-title":"Direct effects of anti-angiogenic therapies on tumor cells: VEGF signaling","volume":"23","author":"Simon","year":"2017","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.toxlet.2023.01.012_bib29","article-title":"Mechanism of dihydromyricetin on inflammatory diseases","volume":"12","author":"Sun","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.toxlet.2023.01.012_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113888","article-title":"Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1","volume":"175","author":"Sun","year":"2020","journal-title":"Biochem Pharm."},{"issue":"9","key":"10.1016\/j.toxlet.2023.01.012_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132747","article-title":"Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity","volume":"5","author":"Tadokoro","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.toxlet.2023.01.012_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.607364","article-title":"Building multi-dimensional induced pluripotent stem cells-based model platforms to assess cardiotoxicity in cancer therapies","volume":"12","author":"Thomas","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.toxlet.2023.01.012_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118728","article-title":"LncRNA-antisense non-coding RNA in the INK4 locus promotes pyroptosis via miR-497\/thioredoxin-interacting protein axis in diabetic nephropathy","volume":"264","author":"Wang","year":"2021","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.toxlet.2023.01.012_bib34","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/sca.21339","article-title":"Dihydromyricetin suppresses inflammatory responses in vitro and in vivo through inhibition of IKKbeta activity in macrophages","volume":"38","author":"Wang","year":"2016","journal-title":"Scanning"},{"issue":"8","key":"10.1016\/j.toxlet.2023.01.012_bib35","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1111\/jcmm.14413","article-title":"Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K\/Akt pathway","volume":"23","author":"Wang","year":"2019","journal-title":"J. Cell Mol. Med"},{"key":"10.1016\/j.toxlet.2023.01.012_bib36","doi-asserted-by":"crossref","DOI":"10.1177\/15330338211064434","article-title":"Tolerance and pharmacokinetics of recombinant human endostatin administered as single-dose or multiple-dose infusions in patients with advanced solid tumors: a phase I clinical trial","volume":"20","author":"Wang","year":"2021","journal-title":"Technol. Cancer Res Treat."},{"issue":"1","key":"10.1016\/j.toxlet.2023.01.012_bib37","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202000827RR","article-title":"LncRNA TUG1 competitively binds to miR-340 to accelerate myocardial ischemia-reperfusion injury","volume":"35","author":"Wu","year":"2021","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.toxlet.2023.01.012_bib38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.canlet.2015.01.012","article-title":"Endostar attenuates melanoma tumor growth via its interruption of b-FGF mediated angiogenesis","volume":"359","author":"Xiao","year":"2015","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.toxlet.2023.01.012_bib39","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/mt.2014.53","article-title":"Multicenter randomized phase 2 clinical trial of a recombinant human endostatin adenovirus in patients with advanced head and neck carcinoma","volume":"22","author":"Ye","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.toxlet.2023.01.012_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.739095","article-title":"Advances in cardiotoxicity induced by altered mitochondrial dynamics and mitophagy","volume":"8","author":"Yin","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"24","key":"10.1016\/j.toxlet.2023.01.012_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246268","article-title":"Loss of p53 sensitizes cells to palmitic acid-induced apoptosis by reactive oxygen species accumulation","volume":"20","author":"Yu","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2023.01.012_bib42","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Pharm."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:28:05Z","timestamp":1759901285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427423000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":42,"alternative-id":["S0378427423000267"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.01.012","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanism of rh-endostatin-induced cardiotoxicity and its protection by dihydromyricetin[in vivo\/in vitro, C57BL\/6 mice, AC16 and hiPSC-CMs]","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}