{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T06:10:06Z","timestamp":1759903806775,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigacion","doi-asserted-by":"publisher","award":["PID2021-125660OB-I00","RTI2018-100903-B-I00"],"award-info":[{"award-number":["PID2021-125660OB-I00","RTI2018-100903-B-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020636","name":"Gobierno de Espana Ministerio de Educaci\u00f3n Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU18\/01559","FPU19\/04169"],"award-info":[{"award-number":["FPU18\/01559","FPU19\/04169"]}],"id":[{"id":"10.13039\/501100020636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.toxlet.2023.03.012","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T11:11:39Z","timestamp":1680347499000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["In vitro interaction of the pesticides flupyradifurone, bupirimate and its metabolite ethirimol with the ATP-binding cassette transporter G2 (ABCG2)"],"prefix":"10.1016","volume":"380","author":[{"given":"Nada","family":"Ben Halima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"\u00c1lvarez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Blanco-Paniagua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa","family":"Abid-Essefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Guedri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gracia","family":"Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2023.03.012_bib1","first-page":"779","article-title":"Dietary Intake of Pesticides Based on Vegetable Consumption in Ismailia","volume":"20","author":"Ahmed","year":"2014"},{"key":"10.1016\/j.toxlet.2023.03.012_bib2","first-page":"417","article-title":"Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C","volume":"1","author":"Allen","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.toxlet.2023.03.012_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbt.21458","article-title":"Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides","volume":"27","author":"Bircsak","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109537","article-title":"Role of the Abcg2 transporter in plasma levels and tissue accumulation of the anti-inflammatory tolfenamic acid in mice","volume":"345","author":"Blanco-Paniagua","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2023.03.012_bib5","first-page":"4423","article-title":"Setting of new maximum residue levels for flupyradifurone in strawberries, blackberries and raspberries","volume":"14","author":"EFSA","year":"2016","journal-title":"EFSA J."},{"key":"10.1016\/j.toxlet.2023.03.012_bib6","first-page":"7","article-title":"Review of the existing maximum residue levels for bupirimate according to Article 12 of Regulation (EC) No 396\/2005","volume":"17","author":"EFSA","year":"2019","journal-title":"EFSA J."},{"key":"10.1016\/j.toxlet.2023.03.012_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8812797","article-title":"Determination of the novel insecticide flupyradifurone and its two metabolites in traditional chinese herbal medicines using modified QuEChERS and high-performance liquid chromatography-tandem mass spectrometry","volume":"2020","author":"Fang","year":"2020","journal-title":"Int. J. Anal. Chem."},{"key":"10.1016\/j.toxlet.2023.03.012_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1517\/17425255.2012.637918","article-title":"Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics","volume":"8","author":"Fardel","year":"2012","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib9","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.3390\/nu11102372","article-title":"Transporters in the mammary gland\u2014contribution to presence of nutrients and drugs into milk","volume":"11","author":"Garc\u00eda-Lino","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.toxlet.2023.03.012_bib10","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1080\/19440049.2014.908261","article-title":"Novel in vitro systems for prediction of veterinary drug residues in ovine milk and dairy products","volume":"31","author":"Gonz\u00e1lez-Lobato","year":"2014","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.toxlet.2023.03.012_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2016.06.007","article-title":"Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model","volume":"305","author":"Halwachs","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/amt\/tsz071","article-title":"The effects of insecticide treatments on sugarcane aphid in forage sorghum in California, 2018","volume":"44","author":"Haviland","year":"2019","journal-title":"Arthropod Manag. Tests"},{"key":"10.1016\/j.toxlet.2023.03.012_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105268","article-title":"Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells","volume":"78","author":"Herriage","year":"2022","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.toxlet.2023.03.012_bib14","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bcp.2017.10.004","article-title":"BCRP\/ABCG2 and high-alert medications: biochemical, pharmacokinetic, pharmacogenetic, and clinical implications","volume":"147","author":"Hira","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib15","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1042\/BST20160014","article-title":"The multidrug transporter ABCG2: still more questions than answers","volume":"44","author":"Horsey","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.toxlet.2023.03.012_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113977","article-title":"Comparing the acute and chronic toxicity of flupyradifurone and imidacloprid to non-target aquatic arthropod species","volume":"243","author":"Huang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2023.03.012_bib17","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/jnci\/92.20.1651","article-title":"Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan","volume":"92","author":"Jonker","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.toxlet.2023.03.012_bib18","doi-asserted-by":"crossref","first-page":"15649","DOI":"10.1073\/pnas.202607599","article-title":"The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria","volume":"99","author":"Jonker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.toxlet.2023.03.012_bib19","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2019.02.004","article-title":"Ultra-trace level determination of neonicotinoids in honey as a tool for assessing environmental contamination","volume":"247","author":"Kammoun","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxlet.2023.03.012_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.scitotenv.2017.04.016","article-title":"Assessment of field re-entry exposure to pesticides: a dislodgeable foliar residue study","volume":"596\u2013597","author":"Kasiotis","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2023.03.012_bib21","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1038\/s41467-019-13302-2","article-title":"The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid","volume":"10","author":"Khunweeraphong","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2023.03.012_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/s12248-014-9668-6","article-title":"Role of the breast cancer resistance protein (BCRP\/ABCG2) in drug transport\u2013an update","volume":"17","author":"Mao","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.toxlet.2023.03.012_bib23","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1124\/mol.104.010439","article-title":"The breast cancer resistance protein (BCRP\/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin","volume":"67","author":"Merino","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib24","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.scitotenv.2018.08.169","article-title":"Pesticides related to land use in watersheds of the Great Lakes basin","volume":"648","author":"Metcalfe","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.toxlet.2023.03.012_bib25","first-page":"S143","article-title":"Determination of flupyradifurone and its metabolite in postmortem blood by liquid chromatography-tandem mass spectrometry","volume":"34","author":"Minji","year":"2022","journal-title":"Anal. Clin. Toxicol."},{"key":"10.1016\/j.toxlet.2023.03.012_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1124\/jpet.104.073916","article-title":"Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine","volume":"312","author":"Pavek","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2023.03.012_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2885.2010.01241.x","article-title":"Involvement of breast cancer resistance protein (BCRP\/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin","volume":"34","author":"Real","year":"2011","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2023.03.012_bib28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.trac.2004.04.001","article-title":"Trends in quality in the analytical laboratory. II. Analytical method validation and quality assurance","volume":"23","author":"Taverniers","year":"2004","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.toxlet.2023.03.012_bib29","first-page":"6447","article-title":"The breast cancer resistance protein (Bcrp1\/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine","volume":"63","author":"van Herwaarden","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.toxlet.2023.03.012_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104297","article-title":"Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)","volume":"146","author":"van Hoppe","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.toxlet.2023.03.012_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2008.08.007","article-title":"Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice","volume":"61","author":"Vlaming","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.toxlet.2023.03.012_bib32","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1038\/s41467-021-24651-2","article-title":"Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2023.03.012_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117323","article-title":"Effect of flupyradifurone on zebrafish embryonic development","volume":"285","author":"Zhong","year":"2021","journal-title":"Environ. Pollut."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423001534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423001534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:28:22Z","timestamp":1759901302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427423001534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":33,"alternative-id":["S0378427423001534"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.03.012","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro interaction of the pesticides flupyradifurone, bupirimate and its metabolite ethirimol with the ATP-binding cassette transporter G2 (ABCG2)","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}