{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:19:17Z","timestamp":1762089557958,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.toxlet.2023.06.012","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T15:34:05Z","timestamp":1688139245000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Methamphetamine increases force of contraction in isolated human atrial preparations through the release of noradrenaline"],"prefix":"10.1016","volume":"383","author":[{"given":"Joachim","family":"Neumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Hu\u00dfler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karyna","family":"Azatsian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Gergs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2023.06.012_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphar.2018.00013","article-title":"Phenotyping of mice with heart specific overexpression of A2A-adenosine receptors: evidence for cardioprotective effects of A2A-adenosine receptors","volume":"9","author":"Boknik","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.06.012_bib2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3389\/fphar.2019.01051","article-title":"Evidence for arrhythmogenic effects of A2A-adenosine receptors","volume":"10","author":"Boknik","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.06.012_bib3","series-title":"Goodman & Gilman's the pharmacological basis of therapeutics: The Pharmacological Basis of Therapeutics","first-page":"1419","author":"Brunton","year":"2018"},{"issue":"8","key":"10.1016\/j.toxlet.2023.06.012_bib4","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00204-012-0815-5","article-title":"Toxicity of amphetamines: an update","volume":"86","author":"Carvalho","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.lpm.2008.07.017","article-title":"Crystal meth: une forme de m\u00e9thamph\u00e9tamine","volume":"38","author":"Chiadmi","year":"2009","journal-title":"Presse Med."},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib6","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/jama.1975.03240160076039","article-title":"Amphetamine abuse","volume":"231","author":"Cohen","year":"1975","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0733-8627(20)30588-5","article-title":"Cardiotoxic drugs","volume":"13","author":"Derlet","year":"1995","journal-title":"Emerg. Med. Clin. North Am."},{"key":"10.1016\/j.toxlet.2023.06.012_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1146\/annurev.pharmtox.47.120505.105140","article-title":"New insights into the mechanism of action of amphetamines","volume":"47","author":"Fleckenstein","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.toxlet.2023.06.012_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00210-008-0374-8","article-title":"A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts","volume":"379","author":"Gergs","year":"2009","journal-title":"Naunyn-Schmiede 'S. Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.toxlet.2023.06.012_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1124\/jpet.121.000822","article-title":"Cardiac effects of novel histamine H2 receptor agonists","volume":"379","author":"Gergs","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/135965350000500108","article-title":"Possible fatal interaction between protease inhibitors and methamphetamine","volume":"5","author":"Hales","year":"2000","journal-title":"Antivir. Ther."},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib12","doi-asserted-by":"crossref","first-page":"C694","DOI":"10.1152\/ajpcell.00318.2020","article-title":"The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function. American journal of physiology","volume":"319","author":"Hamstra","year":"2020","journal-title":"Cell Physiol."},{"issue":"3","key":"10.1016\/j.toxlet.2023.06.012_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12028-008-9177-5","article-title":"Cerebrovascular complications of methamphetamine abuse","volume":"10","author":"Ho","year":"2009","journal-title":"Neurocritical care"},{"issue":"8","key":"10.1016\/j.toxlet.2023.06.012_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0043-118655","article-title":"Methamphetaminkonsum in mitteldeutschland: eine qualitative studie zu konsumentengruppen und -motiven aus expertensicht","volume":"68","author":"Hoffmann","year":"2018","journal-title":"Psychother., Psychosom., Med. Psychol."},{"issue":"10","key":"10.1016\/j.toxlet.2023.06.012_bib15","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.4088\/JCP.15m09872","article-title":"Risk of cardiovascular diseases and stroke events in methamphetamine users: a 10-year follow-up study","volume":"77","author":"Huang","year":"2016","journal-title":"J. Clin. Psychiatry"},{"issue":"2","key":"10.1016\/j.toxlet.2023.06.012_bib16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.npp.1300896","article-title":"Plasma drug concentrations and physiological measures in 'dance party' participants","volume":"31","author":"Irvine","year":"2006","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.toxlet.2023.06.012_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12024-014-9538-7","article-title":"Accidental death via intravaginal absorption of methamphetamine","volume":"10","author":"Jones","year":"2014","journal-title":"Forensic Sci., Med., Pathol."},{"issue":"8","key":"10.1016\/j.toxlet.2023.06.012_bib18","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/j.1360-0443.2007.01874.x","article-title":"Methamphetamine and cardiovascular pathology: a review of the evidence","volume":"102","author":"Kaye","year":"2007","journal-title":"Addict. (Abingdon, Engl. )"},{"issue":"10","key":"10.1016\/j.toxlet.2023.06.012_bib19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1161\/hh1001.091640","article-title":"Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle","volume":"88","author":"Kentish","year":"2001","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.toxlet.2023.06.012_bib20","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00213-016-4235-8","article-title":"Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways","volume":"233","author":"Krasnova","year":"2016","journal-title":"Psychopharmacology"},{"issue":"12","key":"10.1016\/j.toxlet.2023.06.012_bib21","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/jnnp-2017-316071","article-title":"Stroke and methamphetamine use in young adults: a review","volume":"88","author":"Lappin","year":"2017","journal-title":"J. Neurol., Neurosurg., Psychiatry"},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.psym.2019.09.006","article-title":"Waterlining of methamphetamine","volume":"61","author":"Lowder","year":"2020","journal-title":"Psychosomatics"},{"issue":"2","key":"10.1016\/j.toxlet.2023.06.012_bib23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jnc.12373","article-title":"Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo","volume":"127","author":"Meyer","year":"2013","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib24","first-page":"306","article-title":"Treatment of narcolepsy with methamphetamine","volume":"16","author":"Mitler","year":"1993","journal-title":"Sleep"},{"key":"10.1016\/j.toxlet.2023.06.012_bib25","first-page":"901","article-title":"Kanyaku Maou Seibun Kenkyu Seiseki (Results of the Research of the Contents of Chinese Medicine Maou)","volume":"139","author":"Nagai","year":"1893","journal-title":"Yakugaku Zasshi. J. Pharm. Soc. Jpn."},{"issue":"7","key":"10.1016\/j.toxlet.2023.06.012_bib26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/bmc.278","article-title":"Determination of methamphetamine and amphetamine in abusers' plasma and hair samples with HPLC-FL","volume":"17","author":"Nakashima","year":"2003","journal-title":"Biomed. Chromatogr.: BMC"},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2337\/diab.25.1.6","article-title":"Norepinephrine, epinephrine, and dopamine contents of the cardiovascular system in long-term diabetics","volume":"25","author":"Neubauer","year":"1976","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.toxlet.2023.06.012_bib28","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00210-021-02065-7","article-title":"Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria","volume":"394","author":"Neumann","year":"2021","journal-title":"Naunyn-Schmiede 'S. Arch. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.06.012_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.582916","article-title":"Histamine can be formed and degraded in the human and mouse heart","volume":"12","author":"Neumann","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.toxlet.2023.06.012_bib30","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00210-021-02052-y","article-title":"Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H2-histamine-receptor activation in isolated atria of transgenic mice","volume":"394","author":"Neumann","year":"2021","journal-title":"Naunyn-Schmiede 'S. Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.toxlet.2023.06.012_bib31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00213-005-0102-8","article-title":"Safety of intravenous methamphetamine administration during treatment with bupropion","volume":"182","author":"Newton","year":"2005","journal-title":"Psychopharmacology"},{"issue":"13","key":"10.1016\/j.toxlet.2023.06.012_bib32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0024-3205(91)90078-P","article-title":"Clinical effects of methamphetamine vapor inhalation","volume":"49","author":"Perez-Reyes","year":"1991","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.toxlet.2023.06.012_bib33","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1016\/j.fct.2012.08.002","article-title":"Dermal exposure to methamphetamine hydrochloride contaminated residential surfaces: surface pH values, volatility, and in vitro human skin","volume":"50","author":"Salocks","year":"2012","journal-title":"Food Chem. Toxicol.: Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0009-9236(98)90071-6","article-title":"CYP2D6 polymorphism is not crucial for the disposition of selegiline*","volume":"64","author":"Scheinin","year":"1998","journal-title":"Clin. Pharm. Ther."},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1373\/49.1.121","article-title":"Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers","volume":"49","author":"Schepers","year":"2003","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.toxlet.2023.06.012_bib36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12974-018-1385-0","article-title":"Methamphetamine neurotoxicity, microglia, and neuroinflammation","volume":"15","author":"Shaerzadeh","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.toxlet.2023.06.012_bib37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1476-5381.1962.tb01458.x","article-title":"Noradrenaline content in the heart and spleen of the mouse under normal conditions and after administration of some drugs","volume":"19","author":"SHARMAN","year":"1962","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.toxlet.2023.06.012_bib38","unstructured":"Substance Abuse and Mental Health Services Administration, 2021. Key substance use and mental health indicators in the United States: Results from the 2020 National Survey on Drug Use and Health (HHS Publication No. PEP21\u201307-01\u2013003, NSDUH Series H-56). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. \u3008https:\/\/www.samhsa.gov\/data\/\u3009. Accessed 12 December 2022."},{"issue":"4","key":"10.1016\/j.toxlet.2023.06.012_bib39","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.bbrc.2009.10.124","article-title":"Methamphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca(2+) entry via L-type Ca(2+) channel","volume":"390","author":"Sugimoto","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.toxlet.2023.06.012_bib40","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.pneurobio.2005.04.003","article-title":"Mechanisms of neurotransmitter release by amphetamines: a review","volume":"75","author":"Sulzer","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.toxlet.2023.06.012_bib41","first-page":"225","article-title":"Regulation of calcium transport in cardiac sarcoplasmic reticulum by cyclic AMP-dependent protein kinase","volume":"9","author":"Tada","year":"1976","journal-title":"Recent Adv. Stud. Card. Struct. Metab."},{"issue":"2","key":"10.1016\/j.toxlet.2023.06.012_bib42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.toxlet.2009.05.015","article-title":"Acute methamphetamine exposure inhibits cardiac contractile function","volume":"189","author":"Turdi","year":"2009","journal-title":"Toxicol. Lett."},{"issue":"1\u20133","key":"10.1016\/j.toxlet.2023.06.012_bib43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.forsciint.2012.10.005","article-title":"Methamphetamine and amphetamine concentrations in survivors of body-packer syndrome in Japan","volume":"227","author":"Uekusa","year":"2013","journal-title":"Forensic Sci. Int."},{"issue":"2","key":"10.1016\/j.toxlet.2023.06.012_bib44","first-page":"239","article-title":"Inhibitory mechanism of methamphetamine in the isolated myocardium of bullfrog","volume":"257","author":"Urabe","year":"1982","journal-title":"Arch. Int. De. Pharmacodyn. Et. De. Ther."},{"issue":"7","key":"10.1016\/j.toxlet.2023.06.012_bib45","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1081\/CLT-120026521","article-title":"Crystal methamphetamine-associated cardiomyopathy: tip of the iceberg?","volume":"41","author":"Wijetunga","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"issue":"11","key":"10.1016\/j.toxlet.2023.06.012_bib46","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0006-2952(97)00014-2","article-title":"Interactions of amphetamine analogs with human liver CYP2D6","volume":"53","author":"Wu","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.06.012_bib47","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fnmol.2018.00186","article-title":"The main molecular mechanisms underlying methamphetamine- induced neurotoxicity and implications for pharmacological treatment","volume":"11","author":"Yang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.toxlet.2023.06.012_bib48","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.201705-0943OC","article-title":"Features and outcomes of methamphetamine-associated pulmonary arterial hypertension","volume":"197","author":"Zamanian","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.toxlet.2023.06.012_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchf.2017.10.006","article-title":"Clinical characteristics and outcome of methamphetamine-associated pulmonary arterial hypertension and dilated cardiomyopathy","volume":"6","author":"Zhao","year":"2018","journal-title":"JACC Heart Fail."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423002126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423002126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:31:02Z","timestamp":1736375462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427423002126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":49,"alternative-id":["S0378427423002126"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.06.012","relation":{},"ISSN":["0378-4274"],"issn-type":[{"type":"print","value":"0378-4274"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methamphetamine increases force of contraction in isolated human atrial preparations through the release of noradrenaline","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}