{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:52:45Z","timestamp":1785898365372,"version":"3.56.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.toxlet.2023.07.005","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T21:39:33Z","timestamp":1689197973000},"page":"96-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Nervous system development related gene expression regulation in the zebrafish embryo after exposure to valproic acid and retinoic acid: A genome wide approach"],"prefix":"10.1016","volume":"384","author":[{"given":"Laura M.M.","family":"Samrani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Hallmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Bars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Tinwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pallardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldert H.","family":"Piersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.toxlet.2023.07.005_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/bdrc.20206","article-title":"Zebrafish embryos and larvae: a new generation of disease models and drug screens","volume":"93","author":"Ali","year":"2011","journal-title":"Birth Defects Res C. Embryo Today"},{"issue":"6","key":"10.1016\/j.toxlet.2023.07.005_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021076","article-title":"Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing","volume":"6","author":"Ali","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2023.07.005_bib3","unstructured":"Anon, Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes Text with EEA relevance. 2010; Available from: \u3008http:\/\/data.europa.eu\/eli\/dir\/2010\/63\/oj\u3009."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib4","first-page":"49","article-title":"Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use","volume":"34","author":"Aschner","year":"2017","journal-title":"ALTEX"},{"issue":"3","key":"10.1016\/j.toxlet.2023.07.005_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00204-021-03215-9","article-title":"A framework for chemical safety assessment incorporating new approach methodologies within REACH","volume":"96","author":"Ball","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.taap.2018.02.008","article-title":"Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods","volume":"354","author":"Bal-Price","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxlet.2023.07.005_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.reprotox.2014.07.082","article-title":"Zebrafish embryotoxicity test for developmental (neuro)toxicity: demo case of an integrated screening approach system using anti-epileptic drugs","volume":"49","author":"Beker van Woudenberg","year":"2014","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/(SICI)1097-0177(199809)213:1<50::AID-AJA5>3.0.CO;2-X","article-title":"Diminished growth of atrioventricular cushion tissue in stage 24 retinoic acid-treated chicken embryos","volume":"213","author":"Bouman","year":"1998","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.toxlet.2023.07.005_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2017.03.027","article-title":"Developmental neurotoxicity of different pesticides in PC-12 cells in vitro","volume":"325","author":"Christen","year":"2017","journal-title":"Toxicol. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib10","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13023-019-1064-y","article-title":"Diagnosis and management of individuals with Fetal Valproate Spectrum Disorder; a consensus statement from the European Reference Network for Congenital Malformations and Intellectual Disability","volume":"14","author":"Clayton-Smith","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10635150050207357","article-title":"Developmental variation, homology, and the pharyngula stage","volume":"49","author":"Collazo","year":"2000","journal-title":"Syst. Biol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role","volume":"3","author":"Crider","year":"2012","journal-title":"Adv. Nutr."},{"issue":"3","key":"10.1016\/j.toxlet.2023.07.005_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jsps.2013.11.002","article-title":"Alternatives to animal testing: a review","volume":"23","author":"Doke","year":"2015","journal-title":"Saudi Pharm. J."},{"issue":"22","key":"10.1016\/j.toxlet.2023.07.005_bib14","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1242\/dev.037689","article-title":"FGF signalling: diverse roles during early vertebrate embryogenesis","volume":"137","author":"Dorey","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.toxlet.2023.07.005_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.reprotox.2013.06.070","article-title":"Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies","volume":"41","author":"Ducharme","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"6","key":"10.1016\/j.toxlet.2023.07.005_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ntt.2009.04.065","article-title":"Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening","volume":"32","author":"Fan","year":"2010","journal-title":"Neurotoxicol Teratol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/tera.1420450106","article-title":"Teratogenicity of all-trans retinoic acid during early embryonic development in the cynomolgus monkey (Macaca fascicularis)","volume":"45","author":"Hendrickx","year":"1992","journal-title":"Teratology"},{"issue":"3","key":"10.1016\/j.toxlet.2023.07.005_bib19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tiv.2011.01.005","article-title":"Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies","volume":"25","author":"Hermsen","year":"2011","journal-title":"Toxicol. Vitr."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.taap.2013.05.037","article-title":"Transcriptomic analysis in the developing zebrafish embryo after compound exposure: individual gene expression and pathway regulation","volume":"272","author":"Hermsen","year":"2013","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxlet.2023.07.005_bib21","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.reprotox.2020.09.002","article-title":"An ontology for developmental processes and toxicities of neural tube closure","volume":"99","author":"Heusinkveld","year":"2021","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/toxsci\/kfp175","article-title":"mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach","volume":"113","author":"Hogberg","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2023.07.005_bib24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/ncomms1248","article-title":"Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis","volume":"2","author":"Irie","year":"2011","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.toxlet.2023.07.005_bib25","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa0907328","article-title":"Valproic acid monotherapy in pregnancy and major congenital malformations","volume":"362","author":"Jentink","year":"2010","journal-title":"N. Engl. J. Med"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfp002","article-title":"Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects","volume":"108","author":"Jergil","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.toxlet.2023.07.005_bib27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/toxsci\/kfr070","article-title":"Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells","volume":"121","author":"Jergil","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.toxlet.2023.07.005_bib28","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/abbs\/gmaa030","article-title":"Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos","volume":"52","author":"Jiang","year":"2020","journal-title":"Acta Biochim Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.toxlet.2023.07.005_bib29","first-page":"441","article-title":"Major malformations with valproic acid","volume":"52","author":"Koren","year":"2006","journal-title":"Can. Fam. Physician"},{"key":"10.1016\/j.toxlet.2023.07.005_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.euroneuro.2022.04.008","article-title":"Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells","volume":"60","author":"Kowalski","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-012-0967-3","article-title":"Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach","volume":"87","author":"Krug","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.toxlet.2023.07.005_bib32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ajhg.2011.09.015","article-title":"Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid","volume":"89","author":"Laue","year":"2011","journal-title":"Am. J. Hum. Genet"},{"issue":"7","key":"10.1016\/j.toxlet.2023.07.005_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ijdevneu.2013.03.002","article-title":"A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies","volume":"31","author":"Laurenza","year":"2013","journal-title":"Int J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3109\/19396368.2011.648302","article-title":"Alternative models in developmental toxicology","volume":"58","author":"Lee","year":"2012","journal-title":"Syst. Biol. Reprod. Med"},{"key":"10.1016\/j.toxlet.2023.07.005_bib35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.reprotox.2016.09.015","article-title":"Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling","volume":"66","author":"Li","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"12","key":"10.1016\/j.toxlet.2023.07.005_bib36","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0300-483X(00)00186-4","article-title":"In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells","volume":"147","author":"Liu","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2023.07.005_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2022.100086","article-title":"Genome-wide expression screening in the cardiac embryonic stem cell test shows additional differentiation routes that are regulated by morpholines and piperidines","volume":"3","author":"Mennen","year":"2022","journal-title":"Curr. Res Toxicol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.reprotox.2019.08.013","article-title":"Neural crest related gene transcript regulation by valproic acid analogues in the cardiac embryonic stem cell test","volume":"90","author":"Mennen","year":"2019","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.toxlet.2023.07.005_bib40","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/epi.16915","article-title":"Folic acid supplementation rescues valproic acid-induced developmental neurotoxicity and behavioral alterations in zebrafish embryos","volume":"62","author":"Muhsen","year":"2021","journal-title":"Epilepsia"},{"issue":"Pt A","key":"10.1016\/j.toxlet.2023.07.005_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ntt.2015.10.001","article-title":"Expanding the test set: Chemicals with potential to disrupt mammalian brain development","volume":"52","author":"Mundy","year":"2015","journal-title":"Neurotoxicol Teratol."},{"issue":"Suppl 1","key":"10.1016\/j.toxlet.2023.07.005_bib42","first-page":"38","article-title":"DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"ALTEX"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/cga.12142","article-title":"Using zebrafish in systems toxicology for developmental toxicity testing","volume":"56","author":"Nishimura","year":"2016","journal-title":"Congenit. Anom. (Kyoto)"},{"issue":"6","key":"10.1016\/j.toxlet.2023.07.005_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/tcm.1770120603","article-title":"Valproic acid induced abnormal development of the central nervous system of three species of amphibians: implications for neural tube defects and alternative experimental systems","volume":"12","author":"Oberemm","year":"1992","journal-title":"Teratog. Carcinog. Mutagen"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1741-4520.2003.tb01024.x","article-title":"Amelioration of sodium valproate-induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation","volume":"43","author":"Padmanabhan","year":"2003","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.toxlet.2023.07.005_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.654467","article-title":"Chromatin imbalance as the vertex between fetal valproate syndrome and chromatinopathies","volume":"9","author":"Parodi","year":"2021","journal-title":"Front Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.toxlet.2023.07.005_bib48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/bdra.20709","article-title":"The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis","volume":"88","author":"Pennimpede","year":"2010","journal-title":"Birth Defects Res A Clin. Mol. Teratol."},{"issue":"39","key":"10.1016\/j.toxlet.2023.07.005_bib49","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2023.07.005_bib50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.reprotox.2017.05.014","article-title":"Retinoic acid in developmental toxicology: teratogen, morphogen and biomarker","volume":"72","author":"Piersma","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2023.07.005_bib51","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1158\/1940-6207.CAPR-10-0143","article-title":"Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis","volume":"4","author":"Protiva","year":"2011","journal-title":"Cancer Prev. Res (Philos. )"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib52","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ydbio.2005.06.019","article-title":"The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo","volume":"285","author":"Reijntjes","year":"2005","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.toxlet.2023.07.005_bib53","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1242\/dev.065938","article-title":"Retinoic acid signalling during development","volume":"139","author":"Rhinn","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.toxlet.2023.07.005_bib54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.reprotox.2013.06.001","article-title":"Developmental outcomes at preschool age after fetal exposure to valproic acid and lamotrigine: cognitive, motor, sensory and behavioral function","volume":"41","author":"Rihtman","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.toxlet.2023.07.005_bib55","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0041-008X(70)90165-1","article-title":"Teratogenic effects of hypervitaminosis A in the hamster and the guinea pig","volume":"16","author":"Robens","year":"1970","journal-title":"Toxicol. Appl. Pharm."},{"issue":"8304","key":"10.1016\/j.toxlet.2023.07.005_bib57","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(82)90908-4","article-title":"Maternal valproic acid and congenital neural tube defects","volume":"2","author":"Robert","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2023.07.005_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2016.01.007","article-title":"A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity","volume":"60","author":"Robinson","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism--a current review of clinical and animal studies","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol Teratol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib60","series-title":"Chapter 15 - In Vitro Biomarkers of Developmental Neurotoxicity, in Reproductive and Developmental Toxicology","first-page":"255","author":"Sachana","year":"2017"},{"issue":"2","key":"10.1016\/j.toxlet.2023.07.005_bib61","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbagrm.2014.05.030","article-title":"ZebRA: An overview of retinoic acid signaling during zebrafish development","volume":"1849","author":"Samarut","year":"2015","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.toxlet.2023.07.005_bib62","article-title":"Dynamic regulation of gene expression and morphogenesis in the zebrafish embryo test after exposure to all-trans retinoic acid","author":"Samrani","year":"2022","journal-title":"Reprod. Toxicol."},{"issue":"Suppl: p","key":"10.1016\/j.toxlet.2023.07.005_bib63","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1093\/ilar.43.Suppl_1.S5","article-title":"The safety assessment process--setting the scene: an FDA perspective","volume":"43","author":"Schechtman","year":"2002","journal-title":"ILAR J."},{"issue":"6","key":"10.1016\/j.toxlet.2023.07.005_bib64","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.gde.2012.11.012","article-title":"Dynamics and precision in retinoic acid morphogen gradients","volume":"22","author":"Schilling","year":"2012","journal-title":"Curr. Opin. Genet Dev."},{"issue":"2","key":"10.1016\/j.toxlet.2023.07.005_bib65","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/toxsci\/kfx045","article-title":"The transcriptome of the zebrafish embryo after chemical exposure: a meta-analysis","volume":"157","author":"Schuttler","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.toxlet.2023.07.005_bib66","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ntt.2010.03.002","article-title":"Locomotor activity in zebrafish embryos: a new method to assess developmental neurotoxicity","volume":"32","author":"Selderslaghs","year":"2010","journal-title":"Neurotoxicol Teratol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib67","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1747-5341-4-2","article-title":"Are animal models predictive for humans?","volume":"4","author":"Shanks","year":"2009","journal-title":"Philos. Ethics Humanit Med."},{"issue":"7445","key":"10.1016\/j.toxlet.2023.07.005_bib68","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature12037","article-title":"Visualization of an endogenous retinoic acid gradient across embryonic development","volume":"496","author":"Shimozono","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.toxlet.2023.07.005_bib69","first-page":"129","article-title":"Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities","volume":"31","author":"Smirnova","year":"2014","journal-title":"ALTEX"},{"issue":"1","key":"10.1016\/j.toxlet.2023.07.005_bib70","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.tiv.2012.07.010","article-title":"Assessment of developmental delay in the zebrafish embryo teratogenicity assay","volume":"27","author":"Teixido","year":"2013","journal-title":"Toxicol. Vitr."},{"issue":"8","key":"10.1016\/j.toxlet.2023.07.005_bib71","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1517\/17425250903032681","article-title":"The role of CYP26 enzymes in retinoic acid clearance","volume":"5","author":"Thatcher","year":"2009","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"7","key":"10.1016\/j.toxlet.2023.07.005_bib72","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry","volume":"10","author":"Tomson","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.toxlet.2023.07.005_bib73","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.reprotox.2014.10.008","article-title":"An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis","volume":"55","author":"Tonk","year":"2015","journal-title":"Reprod. Toxicol."},{"issue":"6","key":"10.1016\/j.toxlet.2023.07.005_bib74","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1597\/15-170","article-title":"Dose-dependent antiteratogenic effects of folic acid on all-trans retinoic acid-induced cleft palate in fetal mice","volume":"53","author":"Wang","year":"2016","journal-title":"Cleft Palate Craniofac J."},{"key":"10.1016\/j.toxlet.2023.07.005_bib75","article-title":"MTHFD1 is critical for the negative regulation of retinoic acid receptor signalling in anencephaly","author":"Xiaolu","year":"2023","journal-title":"Brain"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423002199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423002199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:30:06Z","timestamp":1759901406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427423002199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":75,"alternative-id":["S0378427423002199"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.07.005","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nervous system development related gene expression regulation in the zebrafish embryo after exposure to valproic acid and retinoic acid: A genome wide approach","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}