{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:13:57Z","timestamp":1792725237467,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008856","name":"Department of Health of Zhejiang Province","doi-asserted-by":"publisher","award":["11-CX29"],"award-info":[{"award-number":["11-CX29"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.toxlet.2023.09.002","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T12:01:02Z","timestamp":1694088062000},"page":"20-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3\u03b2-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico molecular docking analysis"],"prefix":"10.1016","volume":"386","author":[{"given":"Yang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshuang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-shan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2023.09.002_bib1","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1210\/endo.138.4.5042","article-title":"Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy","volume":"138","author":"Abbaszade","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2023.09.002_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/jmbi.2000.4470","article-title":"The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway","volume":"307","author":"Allard","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.toxlet.2023.09.002_bib3","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/10934529.2015.1047674","article-title":"Association between urinary levels of bisphenol A and its monochlorinated derivative and obesity","volume":"50","author":"Andra","year":"2015","journal-title":"J. Environ. Sci. Health A Tox Hazard Subst. Environ. Eng."},{"key":"10.1016\/j.toxlet.2023.09.002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131842","article-title":"Bisphenol A and its alternatives in Austrian thermal paper receipts, and the migration from reusable plastic drinking bottles into water and artificial saliva using UHPLC-MS\/MS","volume":"286","author":"Banaderakhshan","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2023.09.002_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1747-0285.2010.00972.x","article-title":"Non-competitive inhibition by active site binders","volume":"75","author":"Blat","year":"2010","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.toxlet.2023.09.002_bib6","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1080\/19440049.2019.1643042","article-title":"LC-MS\/MS analysis of bisphenol S and five other bisphenols in total diet food samples","volume":"36","author":"Cao","year":"2019","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control, Expo. risk Assess."},{"key":"10.1016\/j.toxlet.2023.09.002_bib7","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1007\/s11356-012-0972-3","article-title":"Quantification of bisphenol A, 353-nonylphenol and their chlorinated derivatives in drinking water treatment plants","volume":"19","author":"Dupuis","year":"2012","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.toxlet.2023.09.002_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0045-6535(00)00507-5","article-title":"Identification and quantification of chlorinated bisphenol A in wastewater from wastepaper recycling plants","volume":"44","author":"Fukazawa","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2023.09.002_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chemosphere.2019.01.065","article-title":"Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta","volume":"221","author":"Grandin","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2023.09.002_bib10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.toxlet.2012.10.002","article-title":"Inhibition of human and rat 11beta-hydroxysteroid dehydrogenases activities by bisphenol A","volume":"215","author":"Guo","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2023.09.002_bib11","doi-asserted-by":"crossref","first-page":"9876","DOI":"10.1021\/acs.est.9b02963","article-title":"Bisphenol A, chlorinated derivatives of bisphenol A and occurrence of myocardial infarction in patients with type 2 diabetes: nested case-control studies in Two European Cohorts","volume":"53","author":"Hu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2023.09.002_bib12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.toxlet.2023.09.002_bib13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fendo.2020.00447","article-title":"Bisphenols and Leydig cell development and function","volume":"11","author":"Li","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.toxlet.2023.09.002_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0303-7207(91)90139-J","article-title":"3 beta-hydroxysteroid dehydrogenase\/delta 5-4-isomerase expression in rat and characterization of the testis isoform","volume":"80","author":"Lorence","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.toxlet.2023.09.002_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12730","article-title":"Achieving CLARITY on bisphenol A, brain and behaviour","volume":"32","author":"Patisaul","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.toxlet.2023.09.002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106547","article-title":"An overview of the literature on emerging pollutants: chlorinated derivatives of Bisphenol A (ClxBPA)","volume":"153","author":"Plattard","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2023.09.002_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1210\/er.2002-0050","article-title":"Molecular biology of the 3beta-hydroxysteroid dehydrogenase\/delta5-delta4 isomerase gene family","volume":"26","author":"Simard","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.toxlet.2023.09.002_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbrc.2019.10.035","article-title":"Structure of an antibiotic-synthesizing UDP-glucuronate 4-epimerase MoeE5 in complex with substrate","volume":"521","author":"Sun","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2023.09.002_bib19","doi-asserted-by":"crossref","first-page":"42795","DOI":"10.1074\/jbc.M208537200","article-title":"Structure\/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity","volume":"277","author":"Thomas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2023.09.002_bib20","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1507\/endocrj.K07-097","article-title":"Inhibitory effects of cholesterol sulfate on progesterone production in human granulosa-like tumor cell line, KGN","volume":"55","author":"Tsutsumi","year":"2008","journal-title":"Endocr. J."},{"key":"10.1016\/j.toxlet.2023.09.002_bib21","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxlet.2023.09.002_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","article-title":"LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng."},{"key":"10.1016\/j.toxlet.2023.09.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153334","article-title":"Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3beta-hydroxysteroid dehydrogenase activity","volume":"480","author":"Wang","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2023.09.002_bib24","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.scitotenv.2009.08.037","article-title":"Brominated flame retardants in the Arctic environment-trends and new candidates","volume":"408","author":"de Wit","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2023.09.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116406","article-title":"Aqueous photodecomposition of the emerging brominated flame retardant tetrabromobisphenol S (TBBPS)","volume":"271","author":"Xu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxlet.2023.09.002_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.toxlet.2011.09.001","article-title":"Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A","volume":"207","author":"Ye","year":"2011","journal-title":"Toxicol. Lett."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423010330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427423010330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:29:09Z","timestamp":1759901349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427423010330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":26,"alternative-id":["S0378427423010330"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.09.002","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3\u03b2-hydroxysteroid dehydrogenases: Structure-activity relationship and in silico molecular docking analysis","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}