{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:41:49Z","timestamp":1793014909135,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","award":["CPU2018GY33"],"award-info":[{"award-number":["CPU2018GY33"]}],"id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973562"],"award-info":[{"award-number":["81973562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074114"],"award-info":[{"award-number":["82074114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274200"],"award-info":[{"award-number":["82274200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.toxlet.2023.11.001","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T14:06:56Z","timestamp":1699366016000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP"],"prefix":"10.1016","volume":"390","author":[{"given":"Xue","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2023.11.001_bib1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"Bushati","year":"2007","journal-title":"Annu Rev. Cell Dev. Biol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153134","article-title":"Detoxification strategies of triptolide based on drug combinations and targeted delivery methods","volume":"469","author":"Cao","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2023.11.001_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110651","article-title":"Recent advances in the pharmacological applications and liver toxicity of triptolide","volume":"382","author":"Cui","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2023.11.001_bib7","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/cdd.2009.107","article-title":"Apoptosis and glutathione: beyond an antioxidant","volume":"16","author":"Franco","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.toxlet.2023.11.001_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05182-9","article-title":"Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation","volume":"9","author":"Ghini","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2023.11.001_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10565-018-9447-8","article-title":"Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity","volume":"35","author":"Hasnat","year":"2019","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137167","article-title":"MicroRNA-based diagnosis and therapy","volume":"23","author":"Ho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2023.11.001_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00087","article-title":"Sex-related differences of lipid metabolism induced by triptolide: the possible role of the LXR\u03b1\/SREBP-1 signaling pathway","volume":"7","author":"Jiang","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.toxlet.2023.11.001_bib13","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036426","article-title":"Regulation of cell death and immunity by XIAP","volume":"12","author":"Jost","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107610","article-title":"The multiple roles of the IAP super-family in cancer","volume":"214","author":"Kumar","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2023.11.001_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2019.02.053","article-title":"NAD(P)H: quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein","volume":"451","author":"Li","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2023.11.001_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/bjc.2016.379","article-title":"microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP","volume":"116","author":"Li","year":"2017","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.toxlet.2023.11.001_bib17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s11684-018-0649-5","article-title":"Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice","volume":"13","author":"Luo","year":"2019","journal-title":"Front. Med."},{"key":"10.1016\/j.toxlet.2023.11.001_bib18","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3892\/ijo.2016.3634","article-title":"XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC","volume":"49","author":"Qin","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib19","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1101\/gad.1663108","article-title":"Regulation of apoptosis by XIAP ubiquitin-ligase activity","volume":"22","author":"Schile","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.toxlet.2023.11.001_bib20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00109-022-02180-9","article-title":"EV-T synergizes with AZD5582 to overcome TRAIL resistance through concomitant suppression of cFLIP, MCL-1, and IAPs in hepatocarcinoma","volume":"100","author":"Su","year":"2022","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.toxlet.2023.11.001_bib21","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.1074\/jbc.M102415200","article-title":"X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes","volume":"276","author":"Suzuki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2023.11.001_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03749-x","article-title":"Fas\/FasL mediates NF-kappaBp65\/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis.","volume":"12","author":"Tan","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2023.11.001_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1039\/D0NP00054J","article-title":"Triptolide: reflections on two decades of research and prospects for the future","volume":"38","author":"Tong","year":"2021","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.toxlet.2023.11.001_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrm1621","article-title":"IAPs, RINGs and ubiquitylation","volume":"6","author":"Vaux","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2023.11.001_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/19396368.2017.1422046","article-title":"The role of the Fas\/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: an update","volume":"64","author":"Wang","year":"2018","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.toxlet.2023.11.001_bib26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2017.04.003","article-title":"Toxicity of triptolide and the molecular mechanisms involved","volume":"90","author":"Xi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2023.11.001_bib27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.apsb.2020.02.009","article-title":"A new perspective of triptolide-associated hepatotoxicity: the relevance of NF- kappa B and NF- kappa B-mediated cellular FLICE-inhibitory protein","volume":"10","author":"Yuan","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.toxlet.2023.11.001_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tox.2019.01.005","article-title":"A new perspective of triptolide-associated hepatotoxicity: liver hypersensitivity upon LPS stimulation","volume":"414","author":"Yuan","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2023.11.001_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4299","article-title":"Metabolic alterations in triptolide-induced acute hepatotoxicity","volume":"32","author":"Zhao","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.toxlet.2023.11.001_bib30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1039\/c2np00088a","article-title":"Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms","volume":"29","author":"Zhou","year":"2012","journal-title":"Nat. Prod. Rep."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742301086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037842742301086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:29:56Z","timestamp":1759901396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037842742301086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":30,"alternative-id":["S037842742301086X"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.11.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2023.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}