{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:46:06Z","timestamp":1778255166968,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.toxlet.2024.05.012","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:36:30Z","timestamp":1716046590000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Baseline physiological data from anesthetized pigs in a VX intoxication model"],"prefix":"10.1016","volume":"397","author":[{"given":"R.","family":"Goulay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"F\u00e9my","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nervo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Valentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Madi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-L.","family":"Joly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Servonnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nachon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Reymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Jaffr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2024.05.012_bib1","first-page":"149","article-title":"Organophosphorus pesticide poisoning: cases and developments","volume":"66","author":"Aardema","year":"2008","journal-title":"Neth. J. Med"},{"key":"10.1016\/j.toxlet.2024.05.012_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0041-008X(86)90399-6","article-title":"Pathophysiology of soman intoxication in primates","volume":"86","author":"Anzueto","year":"1986","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxlet.2024.05.012_bib3","first-page":"261","article-title":"Comparative analysis of cholinesterase activities in food animals using modified Ellman and Michel assays","volume":"75","author":"Askar","year":"2011","journal-title":"Can. J. Vet. Res"},{"key":"10.1016\/j.toxlet.2024.05.012_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0960327108090269","article-title":"Comparison of selected skin decontaminant products and regimens against VX in domestic swine","volume":"27","author":"Bjarnason","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib5","series-title":"in: Chemical Warfare Toxicology","first-page":"1","article-title":"Chapter 1 - Development, historical use and properties of chemical warfare agents","author":"Black","year":"2016"},{"key":"10.1016\/j.toxlet.2024.05.012_bib6","first-page":"329","article-title":"Brain cholinesterase activity in animals and birds","volume":"30","author":"Blakley","year":"1988","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00204-017-2108-5","article-title":"Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats","volume":"92","author":"Bloch-Shilderman","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib8","unstructured":"Bollen, P., 2010. The Laboratory Swine. Second ed., Laboratory Animal Pocket Reference Series. Laboratory Animal Pocket Reference Series."},{"key":"10.1016\/j.toxlet.2024.05.012_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneumeth.2012.12.027","article-title":"Intravenous recording of intracranial, broadband EEG","volume":"214","author":"Bower","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.toxlet.2024.05.012_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/cc2367","article-title":"Endotracheal tubes and imposed work of breathing: what should we do about it, if anything?","volume":"7","author":"Branson","year":"2003","journal-title":"Crit. Care"},{"key":"10.1016\/j.toxlet.2024.05.012_bib11","first-page":"665","article-title":"The effect in vitro of volatile anesthetics on the activity of cholinesterases. J Neurochem","volume":"29","author":"Braswell","year":"1977"},{"key":"10.1016\/j.toxlet.2024.05.012_bib12","unstructured":"Brazzolotto, X., 2022. 5th CBRNE Research and Innovation Conference: Self-reactivation of Swine Butyrylcholinesterase Upon V-type Nerve Agent Inhibition, A Molecular Dynamics Study (poster)."},{"key":"10.1016\/j.toxlet.2024.05.012_bib13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/00000542-199111000-00004","article-title":"Inspiratory pressure support compensates for the additional work of breathing caused by the endotracheal tube","volume":"75","author":"Brochard","year":"1991","journal-title":"Anesthesiology"},{"issue":"Suppl 2","key":"10.1016\/j.toxlet.2024.05.012_bib14","first-page":"79","article-title":"Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs","volume":"34","author":"Bures","year":"2013","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.toxlet.2024.05.012_bib15","unstructured":"Carvalho, L., 2021. Novichok(s): A Challenge to the Chemical Weapons Convention."},{"key":"10.1016\/j.toxlet.2024.05.012_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tvjl.2013.06.027","article-title":"Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures","volume":"198","author":"Chai","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.toxlet.2024.05.012_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1191\/0960327103ht359oa","article-title":"Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig","volume":"22","author":"Chilcott","year":"2003","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1191\/0960327105ht537oa","article-title":"In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig","volume":"24","author":"Chilcott","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib19","first-page":"315","article-title":"Effect of suxamethonium, pancuronium, neostigmine and halothane on serum cholinesterase activity","volume":"10","author":"Choudhury","year":"1989","journal-title":"Middle East J. Anaesthesiol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/milmed\/165.8.573","article-title":"Domestic swine model for the assessment of chemical warfare agent-anesthetic interactions: some effects of sulfur mustard","volume":"165","author":"Conley","year":"2000","journal-title":"Mil. Med"},{"key":"10.1016\/j.toxlet.2024.05.012_bib21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/acschemneuro.8b00148","article-title":"Nerve agents: what they are, how they work, how to counter them","volume":"9","author":"Costanzi","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib22","first-page":"385","article-title":"Nutritional and clinical aspects of parenteral nutrition in pigs irradiated on the abdomen with supralethal doses","volume":"25","author":"Daburon","year":"1976","journal-title":"Biomedicine"},{"key":"10.1016\/j.toxlet.2024.05.012_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2527\/jas1974.382318x","article-title":"Tissue residues, blood chemistry and physiological response of lindane-treated swine","volume":"38","author":"Davey","year":"1974","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib24","first-page":"58226","article-title":"Noninvasive EEG recordings from freely moving piglets","author":"de Camp","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.toxlet.2024.05.012_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tox.2007.05.032","article-title":"Prolonged inflammatory gene response following soman-induced seizures in mice","volume":"238","author":"Dhote","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.30802\/AALAS-JAALAS-21-000014","article-title":"Biochemical and Hematologic Reference Intervals for Anesthetized, Female, Juvenile Yorkshire Swine","volume":"61","author":"Dimitrakakis","year":"2022","journal-title":"J. Am. Assoc. Lab Anim. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tox.2008.03.013","article-title":"An unexpected plasma cholinesterase activity rebound after challenge with a high dose of the nerve agent VX","volume":"248","author":"Dorandeu","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tox.2006.09.013","article-title":"Swine models in the design of more effective medical countermeasures against organophosphorus poisoning","volume":"233","author":"Dorandeu","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib29","first-page":"528","article-title":"Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality","volume":"299","author":"Duysen","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2024.05.012_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib31","article-title":"Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method","author":"F\u00e9my","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib32","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1161\/STROKEAHA.111.620468","article-title":"Preclinical evidence toward the use of ketamine for recombinant tissue-type plasminogen activator-mediated thrombolysis under anesthesia or sedation","volume":"42","author":"Gakuba","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.toxlet.2024.05.012_bib33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0975-7406.68498","article-title":"Chemical warfare agents","volume":"2","author":"Ganesan","year":"2010","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s002040050529","article-title":"Toxicokinetics of soman in cerebrospinal fluid and blood of anaesthetized pigs","volume":"72","author":"G\u00f6ransson-Nyberg","year":"1998","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jocn.2018.01.046","article-title":"Modification of apparent intracerebral hematoma volume on T2\u2217-weighted images during normobaric oxygen therapy may contribute to false diagnosis","volume":"52","author":"Goulay","year":"2018","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib36","article-title":"Organophosphorus Compound Poisoning: Initial Data Providing Evidence of the Presence of Cholinesterase within the Cerebrospinal Fluid and Early Neurovascular Inflammation. J","volume":"2019","author":"Goulay","year":"2019","journal-title":"Toxicol. Cur Res"},{"key":"10.1016\/j.toxlet.2024.05.012_bib37","first-page":"97","article-title":"Acute and Long-Term Impact of Chemical Weapons: lessons from the Iran-Iraq War","volume":"26","author":"Haines","year":"2014","journal-title":"Forensic Sci. Rev."},{"key":"10.1016\/j.toxlet.2024.05.012_bib38","first-page":"293","article-title":"Normal physiological values for conscious pigs used in biomedical research","volume":"40","author":"Hannon","year":"1990","journal-title":"Lab Anim. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib39","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00000542-199407000-00022","article-title":"Direct negative inotropic and lusitropic effects of sevoflurane","volume":"81","author":"Harkin","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib40","first-page":"741","article-title":"A comparison of cholinesterase activity of plasma, erythrocytes, and cerebrospinal fluid of sheep, calves, dogs, swine, and rabbits","volume":"37","author":"Hazelwood","year":"1976","journal-title":"Am. J. Vet. Res"},{"key":"10.1016\/j.toxlet.2024.05.012_bib41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/0192623316639389","article-title":"Pigs in Toxicology: breed Differences in Metabolism and Background Findings","volume":"44","author":"Helke","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/cc2978","article-title":"Bench-to-bedside review: rhabdomyolysis -- an overview for clinicians","volume":"9","author":"Huerta-Alard\u00edn","year":"2005","journal-title":"Crit. Care"},{"key":"10.1016\/j.toxlet.2024.05.012_bib43","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1590\/1678-4162-10845","article-title":"Hemodynamic variables in piglets anesthetized with isoflurane or propofol, kept under spontaneous ventilation and FIO2 of 0.5","volume":"71","author":"Ido","year":"2019","journal-title":"Arq. Bras. Med. Vet. Zootec."},{"key":"10.1016\/j.toxlet.2024.05.012_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081989","article-title":"Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer\u2019s disease","volume":"8","author":"Johansson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2024.05.012_bib45","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/BF03007414","article-title":"Serum cholinesterase activity following enflurane anaesthesia","volume":"25","author":"Kaniaris","year":"1978","journal-title":"Can. Anaesth. Soc. J."},{"key":"10.1016\/j.toxlet.2024.05.012_bib46","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/bja\/85.3.440","article-title":"Effects of sevoflurane on hypoxic pulmonary vasoconstriction in anaesthetized piglets","volume":"85","author":"Kerbaul","year":"2000","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.toxlet.2024.05.012_bib47","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1001\/archneur.57.4.600","article-title":"Organophosphorus intoxication","volume":"57","author":"Khurana","year":"2000","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/01480549509014316","article-title":"Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs","volume":"18","author":"Koplovitz","year":"1995","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.14310\/horm.2002.1255","article-title":"The differential impact of volatile and intravenous anaesthetics on stress response in the swine","volume":"9","author":"Kostopanagiotou","year":"2010","journal-title":"Horm. (Athens)"},{"key":"10.1016\/j.toxlet.2024.05.012_bib50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.1365-2044.2002.02224.x","article-title":"Does sevoflurane inhibit serum cholinesterase in children?","volume":"57","author":"Lejus","year":"2002","journal-title":"Anaesthesia"},{"key":"10.1016\/j.toxlet.2024.05.012_bib51","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neubiorev.2007.02.003","article-title":"The use of pigs in neuroscience: modeling brain disorders","volume":"31","author":"Lind","year":"2007","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.toxlet.2024.05.012_bib52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2999(91)90228-I","article-title":"Comparison of pharmacodynamic effects of the non-competitive NMDA receptor antagonists MK-801 and ketamine in pigs","volume":"192","author":"L\u00f6scher","year":"1991","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.toxlet.2024.05.012_bib53","series-title":"Hayes\u2019 Handbook of Pesticide Toxicology (Third Edition)","first-page":"1543","article-title":"Chapter 72 - Clinical toxicology of anticholinesterase agents in humans","author":"Lotti","year":"2010"},{"key":"10.1016\/j.toxlet.2024.05.012_bib54","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jat.3542","article-title":"The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat\u2122 as a topical decontaminant.","volume":"38","author":"Lydon","year":"2018","journal-title":"J. Appl. Toxicol."},{"issue":"Suppl 2","key":"10.1016\/j.toxlet.2024.05.012_bib55","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jnc.14026","article-title":"Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning","volume":"142","author":"Masson","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.toxlet.2024.05.012_bib56","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfz250","article-title":"Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents","volume":"174","author":"McGarry","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib57","first-page":"117","article-title":"Thermodilution transpulmonaire: vers une approche int\u00e9gr\u00e9e du c\u0153ur et des poumons","volume":"12","author":"Michard","year":"2003","journal-title":"R. \u00e9Animat."},{"key":"10.1016\/j.toxlet.2024.05.012_bib58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxlet.2011.05.1047","article-title":"Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures","volume":"206","author":"Mikler","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2024.05.012_bib59","first-page":"1345","article-title":"Brain cholinesterases activity in healthy cattle, swine, and sheep and in cattle and sheep exposed to cholinesterase-inhibiting insecticides","volume":"42","author":"Mount","year":"1981","journal-title":"Am. J. Vet. Res"},{"key":"10.1016\/j.toxlet.2024.05.012_bib60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.rvsc.2014.04.011","article-title":"Doppler blood pressure measurement in pigs during anaesthesia","volume":"97","author":"Musk","year":"2014","journal-title":"Res Vet. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/bdd.2510160804","article-title":"Pharmacokinetics of HI-6 and atropine in anaesthetized pigs after administration by a new autoinjector.","volume":"16","author":"Nyberg","year":"1995","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.toxlet.2024.05.012_bib62","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s10646-019-02066-6","article-title":"Effect of organophosphorus pesticides in juveniles of Litopenaeus vannamei: alteration of glycogen, triglycerides, and proteins","volume":"28","author":"Osuna-Flores","year":"2019","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib63","first-page":"214","article-title":"Glycemic Status in Organophosphorus Poisoning","volume":"13","author":"Panda","year":"2015","journal-title":"J. Nepal Health Res Counc."},{"key":"10.1016\/j.toxlet.2024.05.012_bib64","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/00000542-199605000-00019","article-title":"Myocardial depressant effects of sevoflurane. Mechanical and electrophysiologic actions in vitro","volume":"84","author":"Park","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib65","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1124\/jpet.114.214932","article-title":"Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds","volume":"350","author":"Pereira","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.toxlet.2024.05.012_bib66","first-page":"371","article-title":"Hematology and biochemistry reference intervals for Ontario commercial nursing pigs close to the time of weaning","volume":"58","author":"Perri","year":"2017","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.toxlet.2024.05.012_bib67","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4103\/0972-5229.144017","article-title":"Clinical features of organophosphate poisoning: a review of different classification systems and approaches","volume":"18","author":"Peter","year":"2014","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.toxlet.2024.05.012_bib68","first-page":"481","article-title":"A technique for serial sampling of cerebrospinal fluid from conscious swine and sheep","volume":"41","author":"Prelusky","year":"1991","journal-title":"Lab Anim. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib69","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.toxlet.2014.11.010","article-title":"In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects","volume":"232","author":"Reiter","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2024.05.012_bib70","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tox.2018.09.005","article-title":"Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis)","volume":"410","author":"Reymond","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib71","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/08958370601069398","article-title":"Acute toxic effects of nerve agent VX on respiratory dynamics and functions following microinsillation inhalation exposure in guinea pigs","volume":"19","author":"Rezk","year":"2007","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib72","doi-asserted-by":"crossref","unstructured":"Richard, J.C., 2001. R\u00e9alisation et surveillance des \u00e9preuves de ventilation spontan\u00e9e. R\u00e9animation, EM Consulte 10, 738\u2013743.","DOI":"10.1016\/S1624-0693(01)00192-X"},{"key":"10.1016\/j.toxlet.2024.05.012_bib73","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-211-09469-3_21","article-title":"Management of delayed edema formation after fibrinolytic therapy for intracerebral hematomas: preliminary experimental data","volume":"105","author":"Rohde","year":"2008","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.toxlet.2024.05.012_bib74","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.physbeh.2005.02.018","article-title":"Radiotelemetry recording of electroencephalogram in piglets during rest","volume":"84","author":"Saito","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.toxlet.2024.05.012_bib75","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0021-9975(74)90016-4","article-title":"Changes in the concentrations of serum urea nitrogen, albumin, globulin, sodium and inorganic phosphorus in weaner pigs infected with Trichuris suis","volume":"84","author":"Sansom","year":"1974","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib76","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.abb.2018.06.006","article-title":"Characterization of butyrylcholinesterase from porcine milk","volume":"652","author":"Saxena","year":"2018","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.toxlet.2024.05.012_bib77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbi.2015.07.001","article-title":"Prophylaxis with human serum butyrylcholinesterase protects G\u00f6ttingen minipigs exposed to a lethal high-dose of sarin vapor","volume":"238","author":"Saxena","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.toxlet.2024.05.012_bib78","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1590\/S0100-40422012001000033","article-title":"Defesa qu\u00edmica: hist\u00f3rico, classifica\u00e7\u00e3o dos agentes de guerra e a\u00e7\u00e3o dos neurot\u00f3xicos","volume":"35","author":"Silva","year":"2012","journal-title":"Qu\u00edM. Nova"},{"key":"10.1016\/j.toxlet.2024.05.012_bib79","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(20)32644-1","article-title":"Novichok nerve agent poisoning","volume":"397","author":"Steindl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2024.05.012_bib80","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.etp.2006.03.003","article-title":"The minipig in toxicology","volume":"57","author":"Svendsen","year":"2006","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib81","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MCC.0000000000000503","article-title":"Extravascular lung water measurements in acute respiratory distress syndrome: why, how, and when?","volume":"24","author":"Tagami","year":"2018","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.toxlet.2024.05.012_bib82","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/rvsc.2001.0465","article-title":"Determination of whole blood cholinesterase in different animal species using specific substrates","volume":"70","author":"Tecles","year":"2001","journal-title":"Res Vet. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.toxlet.2010.06.012","article-title":"Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration","volume":"198","author":"Tenberken","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2024.05.012_bib84","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1080\/15563650.2018.1469759","article-title":"Novichok: a murderous nerve agent attack in the UK","volume":"56","author":"Vale","year":"2018","journal-title":"Clin. Toxicol. (Philos. )"},{"key":"10.1016\/j.toxlet.2024.05.012_bib85","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.tiv.2007.03.007","article-title":"In vitro percutaneous penetration of organophosphorus compounds using full-thickness and split-thickness pig and human skin","volume":"21","author":"Vallet","year":"2007","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.toxlet.2024.05.012_bib86","unstructured":"Wade, C.E., Waring, P.P., Gildengorin, V.L., Trail, D.S., Williams, B.F., Bonner, G.D., DeJong, R.H., 1987. Acetylcholinesterase activity of plasma and erythrocytes during hemorrhage in conscious swine (No. LAIR Institute Report No. 229)."},{"key":"10.1016\/j.toxlet.2024.05.012_bib87","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00000542-200104000-00026","article-title":"Compartment syndrome in surgical patients","volume":"94","author":"Warner","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.toxlet.2024.05.012_bib88","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0009-8981(99)00144-8","article-title":"Improved determination of acetylcholinesterase activity in human whole blood","volume":"288","author":"Worek","year":"1999","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.toxlet.2024.05.012_bib89","first-page":"21","article-title":"Baseline hemodynamics in anesthetized landrace-large white swine: reference values for research in cardiac arrest and cardiopulmonary resuscitation models","volume":"46","author":"Xanthos","year":"2007","journal-title":"J. Am. Assoc. Lab Anim. Sci."},{"key":"10.1016\/j.toxlet.2024.05.012_bib90","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s002040050187","article-title":"Acute toxicity of cyclohexylmethylphosphonofluoridate (CMPF) in rhesus monkeys: serum biochemical and hematologic changes","volume":"69","author":"Young","year":"1995","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2024.05.012_bib91","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vaa.2018.11.007","article-title":"Differential effects of sevoflurane and propofol on swine cardiac conduction system","volume":"46","author":"Zaballos","year":"2019","journal-title":"Vet. Anaesth. Analg."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424001048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424001048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T02:05:27Z","timestamp":1718244327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427424001048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":91,"alternative-id":["S0378427424001048"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.05.012","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline physiological data from anesthetized pigs in a VX intoxication model","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}