{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:04:02Z","timestamp":1789243442139,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973602"],"award-info":[{"award-number":["81973602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20210324111210029"],"award-info":[{"award-number":["JCYJ20210324111210029"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220531092214032"],"award-info":[{"award-number":["JCYJ20220531092214032"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.toxlet.2024.08.001","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:17:09Z","timestamp":1722644229000},"page":"24-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Identification of serum metabolites associated with aristolochic acid nephropathy severity and insights into the underlying mechanism"],"prefix":"10.1016","volume":"400","author":[{"given":"Xinhui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2024.08.001_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tox.2019.03.013","article-title":"Comparison of aristolochic acid I derived DNA adduct levels in human renal toxicity models","volume":"420","author":"Bastek","year":"2019","journal-title":"Toxicology"},{"issue":"9191","key":"10.1016\/j.toxlet.2024.08.001_bib2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/S0140-6736(05)76720-9","article-title":"Chinese-herb nephropathy","volume":"354","author":"But","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.toxlet.2024.08.001_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.aca.2006.03.008","article-title":"Differentiation of herbs linked to \u201cChinese herb nephropathy\u201d from the liquid chromatographic determination of aristolochic acids","volume":"576","author":"Chan","year":"2006","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"10.1016\/j.toxlet.2024.08.001_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/rcm.3438","article-title":"Liquid chromatography\/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: the use of information-dependent acquisition for biomarker identification","volume":"22","author":"Chan","year":"2008","journal-title":"Rapid Commun. Mass Spectrom. RCM"},{"issue":"29","key":"10.1016\/j.toxlet.2024.08.001_bib5","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1021\/acs.jafc.6b02203","article-title":"Quantitation of aristolochic acids in corn, wheat grain, and soil samples collected in serbia: identifying a novel exposure pathway in the etiology of balkan endemic nephropathy","volume":"64","author":"Chan","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.toxlet.2024.08.001_bib6","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1681\/ASN.2019020163","article-title":"Sirtuin 5 regulates proximal tubule fatty acid oxidation to protect against AKI","volume":"30","author":"Chiba","year":"2019","journal-title":"J. Am. Soc. Nephrol JASN"},{"key":"10.1016\/j.toxlet.2024.08.001_bib7","article-title":"Growing risk of aristolochic acid nephropathy in the era of COVID-19 \u2013 Correspondence","volume":"108","author":"Das","year":"2022","journal-title":"Int. J. Surg. Lond. Engl."},{"issue":"6","key":"10.1016\/j.toxlet.2024.08.001_bib8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ki.2011.428","article-title":"Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy","volume":"81","author":"De Broe","year":"2012","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.toxlet.2024.08.001_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ki.2008.129","article-title":"Aristolochic acid nephropathy: a worldwide problem","volume":"74","author":"Debelle","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.toxlet.2024.08.001_bib10","doi-asserted-by":"crossref","unstructured":"Du, X.-G., Ruan, X.-Z., Lipid Metabolism Disorder and Renal Fibrosis. Adv Exp Med Biol. 1165, 525-541. https:\/\/doi.org\/10.1007\/978-981-13-8871-2_26.","DOI":"10.1007\/978-981-13-8871-2_26"},{"issue":"3","key":"10.1016\/j.toxlet.2024.08.001_bib11","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1039\/C9RA08327H","article-title":"Recent developments in detoxication techniques for aristolochic acid-containing traditional Chinese medicines","volume":"10","author":"Fan","year":"2020","journal-title":"RSC Adv."},{"issue":"6","key":"10.1016\/j.toxlet.2024.08.001_bib12","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.cmet.2020.10.019","article-title":"Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism","volume":"32","author":"Fu","year":"2020","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.toxlet.2024.08.001_bib13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/nu11040722","article-title":"Lipid accumulation and chronic kidney disease","volume":"11","author":"Gai","year":"2019","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.toxlet.2024.08.001_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10653-017-0065-9","article-title":"Balkan endemic nephropathy and aristolochic acid I: an investigation into the role of soil and soil organic matter contamination, as a potential natural exposure pathway","volume":"40","author":"Gruia","year":"2018","journal-title":"Environ. Geochem. Health"},{"issue":"3","key":"10.1016\/j.toxlet.2024.08.001_bib15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1194\/jlr.P040501","article-title":"Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy","volume":"55","author":"Herman-Edelstein","year":"2014","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.toxlet.2024.08.001_bib16","first-page":"123","article-title":"Urinary time- or dose-dependent metabolic biomarkers of aristolochic acid-induced nephrotoxicity in rats","volume":"156","author":"Hu","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.toxlet.2024.08.001_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.7150\/ijbs.64665","article-title":"GPR43 activation-mediated lipotoxicity contributes to podocyte injury in diabetic nephropathy by modulating the ERK\/EGR1 pathway","volume":"18","author":"J","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.toxlet.2024.08.001_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/mas.21548","article-title":"Metabolomics toward personalized medicine","volume":"38","author":"Jacob","year":"2019","journal-title":"Mass Spectrom. Rev."},{"issue":"2","key":"10.1016\/j.toxlet.2024.08.001_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/ijms18020297","article-title":"An integrated view of aristolochic acid nephropathy: update of the literature","volume":"18","author":"Jadot","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2024.08.001_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmed.2020.00065","article-title":"Defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases","volume":"7","author":"Jang","year":"2020","journal-title":"Front. Med."},{"issue":"6","key":"10.1016\/j.toxlet.2024.08.001_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ki.2011.371","article-title":"Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid","volume":"81","author":"Jelakovi\u0107","year":"2012","journal-title":"Kidney Int"},{"issue":"18","key":"10.1016\/j.toxlet.2024.08.001_bib22","first-page":"2469","article-title":"Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function","volume":"134","author":"Li","year":"2020","journal-title":"Clin. Sci. Lond. Engl. 1979"},{"key":"10.1016\/j.toxlet.2024.08.001_bib23","article-title":"Lipidomics reveals the potential mechanism of honokiol against adenine-induced chronic kidney disease","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.toxlet.2024.08.001_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.toxlet.2010.12.007","article-title":"Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats","volume":"201","author":"Lou","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.toxlet.2024.08.001_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140695","article-title":"Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis","volume":"131","author":"Miguel","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.toxlet.2024.08.001_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10653-012-9477-8","article-title":"Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: links to the etiology of endemic (Balkan) nephropathy","volume":"35","author":"Pavlovi\u0107","year":"2013","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.toxlet.2024.08.001_bib27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.nutr.21.1.193","article-title":"P Eroxisomal \u03b2-O xidation and p eroxisome p roliferator \u2013a ctivated r eceptor \u03b1: an adaptive metabolic system","volume":"21","author":"Reddy","year":"2001","journal-title":"Annu. Rev. Nutr."},{"issue":"8","key":"10.1016\/j.toxlet.2024.08.001_bib28","doi-asserted-by":"crossref","first-page":"F896","DOI":"10.1152\/ajprenal.00484.2013","article-title":"Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis","volume":"306","author":"Ruggiero","year":"2014","journal-title":"Am. J. Physiol. - Ren. Physiol."},{"issue":"2","key":"10.1016\/j.toxlet.2024.08.001_bib29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1211\/0022357023051","article-title":"Acute nephrotoxicity of aristolochic acids in mice","volume":"56","author":"Sato","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"issue":"7","key":"10.1016\/j.toxlet.2024.08.001_bib30","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1124\/dmd.107.014688","article-title":"Selective toxicity of aristolochic acids I and II","volume":"35","author":"Shibutani","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"21","key":"10.1016\/j.toxlet.2024.08.001_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163161","article-title":"Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells","volume":"7","author":"Thomas","year":"2022","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.toxlet.2024.08.001_bib32","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acs.est.9b05337","article-title":"Occurrence and environmental stability of aristolochic acids in groundwater collected from serbia: links to human exposure and balkan endemic nephropathy","volume":"54","author":"Tung","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"9","key":"10.1016\/j.toxlet.2024.08.001_bib33","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/sj.ki.5001834","article-title":"Lipotoxicity","volume":"70","author":"Weinberg","year":"2006","journal-title":"Kidney Int"},{"issue":"10","key":"10.1016\/j.toxlet.2024.08.001_bib34","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.7150\/thno.56082","article-title":"Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK\/ULK1\/autophagy pathway","volume":"11","author":"Xiong","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.toxlet.2024.08.001_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.juro.2012.08.090","article-title":"Occupational exposure to herbs containing aristolochic acids increases the risk of urothelial carcinoma in chinese herbalists","volume":"189","author":"Yang","year":"2013","journal-title":"J. Urol."},{"issue":"10","key":"10.1016\/j.toxlet.2024.08.001_bib36","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2215\/CJN.11571017","article-title":"Nephrotoxicity and chinese herbal medicine","volume":"13","author":"Yang","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"9","key":"10.1016\/j.toxlet.2024.08.001_bib37","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1074\/jbc.M116.763532","article-title":"Specific inhibition of Acyl-CoA oxidase-1 by an acetylenic acid improves hepatic lipid and reactive oxygen species (ROS) metabolism in rats fed a high fat diet","volume":"292","author":"Zeng","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.toxlet.2024.08.001_bib38","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.7150\/ijbs.69618","article-title":"Dissection of targeting molecular mechanisms of aristolochic acid-induced nephrotoxicity via a combined deconvolution strategy of chemoproteomics and metabolomics","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.toxlet.2024.08.001_bib39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/jcpt.12789","article-title":"Recognition of the toxicity of aristolochic acid","volume":"44","author":"Zhang","year":"2019","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.toxlet.2024.08.001_bib40","article-title":"Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy","volume":"5","author":"Zhao","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424010701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424010701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:23:27Z","timestamp":1738941807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427424010701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":40,"alternative-id":["S0378427424010701"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.08.001","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of serum metabolites associated with aristolochic acid nephropathy severity and insights into the underlying mechanism","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}