{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:41:49Z","timestamp":1783039309056,"version":"3.54.6"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.toxlet.2024.11.011","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T07:27:10Z","timestamp":1733124430000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Investigating the relationship among zinc status, blood manganese levels, and enzymatic markers of tissue damage: an epidemiological study using NHANES 2013-2016 data"],"prefix":"10.1016","volume":"403","author":[{"given":"Afnan","family":"Alandanoosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxlet.2024.11.011_bib1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3945\/an.117.015305","article-title":"Manganese","volume":"8","author":"Aschner","year":"2017","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.toxlet.2024.11.011_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0960327112455674","article-title":"Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats","volume":"32","author":"Chtourou","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.toxlet.2024.11.011_bib3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/01913123.2020.1731638","article-title":"Induction of hepatic portal fibrosis, mitochondria damage, and extracellular vesicle formation in Sprague-Dawley rats exposed to copper, manganese, and mercury, alone and in combination","volume":"44","author":"Dhanraj","year":"2020","journal-title":"Ultra Pathol."},{"key":"10.1016\/j.toxlet.2024.11.011_bib4","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s11064-020-03059-2","article-title":"Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats","volume":"45","author":"Fan","year":"2020","journal-title":"Neurochem Res"},{"issue":"1","key":"10.1016\/j.toxlet.2024.11.011_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40001-022-00977-5","article-title":"The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017-2018","volume":"28","author":"Han","year":"2023","journal-title":"Eur. J. Med Res"},{"issue":"6","key":"10.1016\/j.toxlet.2024.11.011_bib6","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/ana.410360611","article-title":"Manganese intoxication and chronic liver failure","volume":"36","author":"Hauser","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.toxlet.2024.11.011_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-nutr-071714-034419","article-title":"Manganese is essential for neuronal health","volume":"35","author":"Horning","year":"2015","journal-title":"Annu Rev. Nutr."},{"issue":"8","key":"10.1016\/j.toxlet.2024.11.011_bib8","first-page":"2223","article-title":"Special considerations in interpreting liver function tests","volume":"59","author":"Johnston","year":"1999","journal-title":"Am. Fam. Physician"},{"issue":"6","key":"10.1016\/j.toxlet.2024.11.011_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130016","article-title":"The relationship between zinc status and inflammatory marker levels in rural Korean adults aged 40 and older","volume":"10","author":"Jung","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2024.11.011_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5346483","article-title":"Clinical and diagnostic significance of lactate dehydrogenase and its isoenzymes in animals","volume":"2020","author":"Klein","year":"2020","journal-title":"Vet. Med Int"},{"key":"10.1016\/j.toxlet.2024.11.011_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1057156","article-title":"Existing knowledge on Zn status biomarkers (1963-2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research","volume":"9","author":"Knez","year":"2023","journal-title":"Front Nutr."},{"key":"10.1016\/j.toxlet.2024.11.011_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1301319","article-title":"Associations of multiple toxic metal exposures with metabolic dysfunction-associated fatty liver disease: NHANES 2011-2018","volume":"10","author":"Li","year":"2023","journal-title":"Front Nutr."},{"key":"10.1016\/j.toxlet.2024.11.011_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10534-018-0077-7","article-title":"Effect of zinc intake on hepatic autophagy during acute alcohol intoxication","volume":"31","author":"Liuzzi","year":"2018","journal-title":"Biometals"},{"issue":"6","key":"10.1016\/j.toxlet.2024.11.011_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200283","article-title":"The impact of zinc on manganese bioavailability and cytotoxicity in HepG2 cells","volume":"67","author":"Michaelis","year":"2023","journal-title":"Mol. Nutr. Food Res"},{"issue":"1","key":"10.1016\/j.toxlet.2024.11.011_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0884533611433534","article-title":"Zinc and liver disease [published correction appears in Nutr Clin Pract. 2012 Apr;27(2):305. Mohommad, Mohammad K [corrected to Mohammad, Mohammad K]]","volume":"27","author":"Mohammad","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.toxlet.2024.11.011_bib16","series-title":"National Health and Nutrition Examination Survey. 2013-2014 data documentation, codebook, and frequencies: demographic variables and sample weights (DEMO_H)","author":"National Center for Health Statistics (NCHS)","year":"2015"},{"key":"10.1016\/j.toxlet.2024.11.011_bib17","series-title":"National Health and Nutrition Examination Survey. 2013-2014 dietary data - continuous NHANES","author":"National Center for Health Statistics (NCHS)","year":"2016"},{"key":"10.1016\/j.toxlet.2024.11.011_bib18","series-title":"National Health and Nutrition Examination Survey. 2013-2014 laboratory data - continuous NHANES","author":"National Center for Health Statistics (NCHS)","year":"2016"},{"key":"10.1016\/j.toxlet.2024.11.011_bib19","series-title":"National Health and Nutrition Examination Survey. 2015-2016 data documentation, codebook, and frequencies: demographic variables and sample weights (DEMO_I)","author":"National Center for Health Statistics (NCHS)","year":"2017"},{"key":"10.1016\/j.toxlet.2024.11.011_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s40572-015-0056-x","article-title":"Manganese toxicity upon overexposure: a decade in review","volume":"2","author":"O\u2019Neal","year":"2015","journal-title":"Curr. Environ. Health Rep."},{"issue":"6","key":"10.1016\/j.toxlet.2024.11.011_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/MCB.01298-14","article-title":"The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element","volume":"35","author":"Ogo","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2024.11.011_bib22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s40572-017-0136-1","article-title":"Relationships between essential manganese biology and manganese toxicity in neurological disease","volume":"4","author":"Pfalzer","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"issue":"1","key":"10.1016\/j.toxlet.2024.11.011_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0034-5687(89)90139-4","article-title":"The topography of particle deposition in the human lung","volume":"78","author":"Pityn","year":"1989","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.toxlet.2024.11.011_bib24","first-page":"169","article-title":"Manganese homeostasis and transport","volume":"12","author":"Roth","year":"2013","journal-title":"Met Ions Life Sci."},{"key":"10.1016\/j.toxlet.2024.11.011_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.curtheres.2024.100737","article-title":"Biomarkers of Hepatic Toxicity: An Overview","volume":"100","author":"Thakur","year":"2024","journal-title":"Curr. Ther. Res Clin. Exp."},{"key":"10.1016\/j.toxlet.2024.11.011_bib26","first-page":"hzy012","article-title":"Manganese toxicity and effects on polarized hepatocytes","volume":"13","author":"Tillman","year":"2018","journal-title":"Biosci. Horiz.: Int. J. Stud. Res."},{"issue":"5","key":"10.1016\/j.toxlet.2024.11.011_bib27","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.3390\/nu7053252","article-title":"Determination of zinc status in humans: Which indicator should we use?","volume":"7","author":"Wieringa","year":"2015","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.toxlet.2024.11.011_bib28","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.3390\/ijms21093304","article-title":"The functions of ZIP8, ZIP14, and ZnT10 in the regulation of systemic manganese homeostasis","volume":"21","author":"Winslow","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"1-2","key":"10.1016\/j.toxlet.2024.11.011_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-4274(00)00209-5","article-title":"Pattern of deposition of stainless steel welding fume particles inhaled into the respiratory systems of Sprague-Dawley rats exposed to a novel welding fume generating system","volume":"116","author":"Yu","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2024.11.011_bib30","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.3945\/jn.115.216093","article-title":"Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats","volume":"145","author":"Zhong","year":"2015","journal-title":"J. Nutr."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424020587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427424020587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:07:32Z","timestamp":1736467652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427424020587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"alternative-id":["S0378427424020587"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.11.011","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the relationship among zinc status, blood manganese levels, and enzymatic markers of tissue damage: an epidemiological study using NHANES 2013-2016 data","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2024.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}