{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T22:32:37Z","timestamp":1768775557998,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.toxlet.2025.02.005","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T21:08:21Z","timestamp":1739567301000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Iodoacetamide triggers ovarian dysfunction in mice through TGF-\u03b2 signaling pathway and apoptosis"],"prefix":"10.1016","volume":"406","author":[{"given":"Chenyu","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongshu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suer","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.devbrainres.2005.05.008","article-title":"Fetal origin of adverse pregnancy outcome: the water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain","volume":"159","author":"Ahmed","year":"2005","journal-title":"Brain Res Dev. Brain Res"},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.rbmo.2014.03.002","article-title":"Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development","volume":"29","author":"Al-Gubory","year":"2014","journal-title":"Reprod. Biomed. Online"},{"issue":"3","key":"10.1016\/j.toxlet.2025.02.005_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.taap.2009.11.024","article-title":"Inorganic mercury causes pancreatic beta-cell death via the oxidative stress-induced apoptotic and necrotic pathways","volume":"243","author":"Chen","year":"2010","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.toxlet.2025.02.005_bib4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.chroma.2012.02.074","article-title":"Trace determination of 13 haloacetamides in drinking water using liquid chromatography triple quadrupole mass spectrometry with atmospheric pressure chemical ionization","volume":"1235","author":"Chu","year":"2012","journal-title":"J. Chromatogr. A"},{"issue":"14","key":"10.1016\/j.toxlet.2025.02.005_bib5","doi-asserted-by":"crossref","first-page":"8212","DOI":"10.1021\/es502010v","article-title":"Mice in vivo toxicity studies for monohaloacetamides emerging disinfection byproducts based on metabolomic methods","volume":"48","author":"Deng","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2025.02.005_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110037","article-title":"Developmental toxicity of disinfection by-product monohaloacetamides in embryo-larval stage of zebrafish","volume":"189","author":"Ding","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.etap.2011.11.004","article-title":"Dichloroacetonitrile induces oxidative stress and developmental apoptotic imbalance in mouse fetal brain","volume":"33","author":"Esmat","year":"2012","journal-title":"Environ. Toxicol. Pharm."},{"issue":"3","key":"10.1016\/j.toxlet.2025.02.005_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0027-5107(74)90181-X","article-title":"DNA strand breakage caused by dichlorvos, methyl methanesulphonate and iodoacetamide in Escherichia coli and cultured Chinese hamster cells","volume":"24","author":"Green","year":"1974","journal-title":"Mutat. Res"},{"key":"10.1016\/j.toxlet.2025.02.005_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jes.2017.05.008","article-title":"Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products","volume":"58","author":"Hanigan","year":"2017","journal-title":"J. Environ. Sci. (China)"},{"issue":"1-2","key":"10.1016\/j.toxlet.2025.02.005_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2004.04.018","article-title":"Ovarian granulosa cell lines","volume":"228","author":"Havelock","year":"2004","journal-title":"Mol. Cell Endocrinol."},{"issue":"7835","key":"10.1016\/j.toxlet.2025.02.005_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.toxlet.2025.02.005_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(93)80066-N","article-title":"Bcl-2 functions in an antioxidant pathway to prevent apoptosis","volume":"75","author":"Hockenbery","year":"1993","journal-title":"Cell"},{"issue":"Pt 2","key":"10.1016\/j.toxlet.2025.02.005_bib13","article-title":"Cytotoxicity of nitrogenous disinfection byproducts: A combined experimental and computational study","volume":"856","author":"Hong","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"Pt A","key":"10.1016\/j.toxlet.2025.02.005_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.envpol.2018.06.090","article-title":"Cytotoxicity induced by iodinated haloacetamides via ROS accumulation and apoptosis in HepG-2\u00a0cells","volume":"242","author":"Hong","year":"2018","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.toxlet.2025.02.005_bib15","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1021\/acs.est.1c08419","article-title":"Formation and Cytotoxicity of Halophenylacetamides: A New Group of Nitrogenous Aromatic Halogenated Disinfection Byproducts in Drinking Water","volume":"56","author":"Hu","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"7","key":"10.1016\/j.toxlet.2025.02.005_bib16","first-page":"1712","article-title":"Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac\/DIABLO release","volume":"63","author":"Kandasamy","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.toxlet.2025.02.005_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125198","article-title":"Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays","volume":"242","author":"Kim","year":"2020","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.toxlet.2025.02.005_bib18","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1002\/jcp.27501","article-title":"Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"7","key":"10.1016\/j.toxlet.2025.02.005_bib19","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1021\/acs.est.0c06856","article-title":"Occurrence and Distribution of Disinfection Byproducts in Domestic Wastewater Effluent, Tap Water, and Surface Water during the SARS-CoV-2 Pandemic in China","volume":"55","author":"Li","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2025.02.005_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ecoenv.2016.06.047","article-title":"Acute toxicity of dichloroacetonitrile (DCAN), a typical nitrogenous disinfection by-product (N-DBP), on zebrafish (Danio rerio)","volume":"133","author":"Lin","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2025.02.005_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.watres.2014.07.024","article-title":"Comparative toxicity of new halophenolic DBPs in chlorinated saline wastewater effluents against a marine alga: halophenolic DBPs are generally more toxic than haloaliphatic ones","volume":"65","author":"Liu","year":"2014","journal-title":"Water Res"},{"issue":"Pt C","key":"10.1016\/j.toxlet.2025.02.005_bib22","article-title":"Polystyrene microplastics induced female reproductive toxicity in mice","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.toxlet.2025.02.005_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.137776","article-title":"Maternal exposure to nitrosamines in drinking water during pregnancy and birth outcomes in a Chinese cohort","volume":"315","author":"Luo","year":"2023","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib24","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0967199400002409","article-title":"Sulphydryl reagent iodoacetamide inhibits progression of meiosis and sperm transformation in mouse oocytes fertilised in vitro","volume":"3","author":"Maleszewski","year":"1995","journal-title":"Zygote"},{"issue":"2","key":"10.1016\/j.toxlet.2025.02.005_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1439-0531.2008.01172.x","article-title":"Role of cell death ligand and receptor system on regulation of follicular atresia in pig ovaries","volume":"43","author":"Manabe","year":"2008","journal-title":"Reprod. Domest. Anim."},{"issue":"4","key":"10.1016\/j.toxlet.2025.02.005_bib26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/GRF.0b013e3181f96b54","article-title":"Toxicity of chemotherapy and radiation on female reproduction","volume":"53","author":"Meirow","year":"2010","journal-title":"Clin. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.toxlet.2025.02.005_bib27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/rep.1.00095","article-title":"Methods for quantifying follicular numbers within the mouse ovary","volume":"127","author":"Myers","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2025.02.005_bib28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jes.2017.04.014","article-title":"TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water","volume":"58","author":"Plewa","year":"2017","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.toxlet.2025.02.005_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhazmat.2018.07.022","article-title":"Chemical characterization and relative toxicity assessment of disinfection byproduct mixtures in a large drinking water supply network","volume":"359","author":"Postigo","year":"2018","journal-title":"J. Hazard Mater."},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.critrevonc.2013.07.006","article-title":"From old alkylating agents to new minor groove binders","volume":"89","author":"Puyo","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1-3","key":"10.1016\/j.toxlet.2025.02.005_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res"},{"key":"10.1016\/j.toxlet.2025.02.005_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.14.001.2009","article-title":"Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes","volume":"1","author":"Schmidt","year":"2009","journal-title":"Front Neuroenergetics"},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib33","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest"},{"issue":"10","key":"10.1016\/j.toxlet.2025.02.005_bib34","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1021\/acs.est.1c00078","article-title":"A New Group of Heterocyclic Nitrogenous Disinfection Byproducts (DBPs) in Drinking Water: Role of Extraction pH in Unknown DBP Exploration","volume":"55","author":"Tang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2025.02.005_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-7827-1-11","article-title":"Ovarian follicle counts--not as simple as 1, 2, 3","volume":"1","author":"Tilly","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.toxlet.2025.02.005_bib36","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.mito.2010.09.012","article-title":"Mitochondrial function in the human oocyte and embryo and their role in developmental competence","volume":"11","author":"Van Blerkom","year":"2011","journal-title":"Mitochondrion"},{"issue":"10","key":"10.1016\/j.toxlet.2025.02.005_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/tx990054q","article-title":"Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment","volume":"12","author":"van De Water","year":"1999","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.toxlet.2025.02.005_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jes.2017.04.021","article-title":"CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: An updated review","volume":"58","author":"Wagner","year":"2017","journal-title":"J. Environ. Sci. (China)"},{"issue":"24","key":"10.1016\/j.toxlet.2025.02.005_bib39","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1021\/acs.est.2c07175","article-title":"Occurrence and Cytotoxicity of Aliphatic and Aromatic Halogenated Disinfection Byproducts in Indoor Swimming Pool Water and Their Incoming Tap Water","volume":"56","author":"Wang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"30","key":"10.1016\/j.toxlet.2025.02.005_bib40","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1016\/j.biomaterials.2007.07.001","article-title":"Physical properties of alginate hydrogels and their effects on in vitro follicle development","volume":"28","author":"West","year":"2007","journal-title":"Biomaterials"},{"issue":"18","key":"10.1016\/j.toxlet.2025.02.005_bib41","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1021\/acs.est.5b02772","article-title":"Kinetic Analysis of Haloacetonitrile Stability in Drinking Waters","volume":"49","author":"Yu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.toxlet.2025.02.005_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112503","article-title":"Clinical implications of chemotherapeutic agent organ toxicity on perioperative care","volume":"146","author":"Zeien","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"7","key":"10.1016\/j.toxlet.2025.02.005_bib43","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/acs.est.1c07375","article-title":"Identification, Occurrence, and Cytotoxicity of Haloanilines: A New Class of Aromatic Nitrogenous Disinfection Byproducts in Chloraminated and Chlorinated Drinking Water","volume":"56","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.toxlet.2025.02.005_bib44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mrgentox.2010.08.014","article-title":"Assessment of the cytotoxicity and genotoxicity of haloacetic acids using microplate-based cytotoxicity test and CHO\/HGPRT gene mutation assay","volume":"703","author":"Zhang","year":"2010","journal-title":"Mutat. Res"},{"issue":"1","key":"10.1016\/j.toxlet.2025.02.005_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13048-019-0529-x","article-title":"Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes","volume":"12","author":"Zhang","year":"2019","journal-title":"J. Ovarian Res"},{"key":"10.1016\/j.toxlet.2025.02.005_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115248","article-title":"Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response","volume":"263","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.toxlet.2025.02.005_bib47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/0366-6999.198931","article-title":"Ovarian Fibrosis: A Phenomenon of Concern","volume":"130","author":"Zhou","year":"2017","journal-title":"Chin. Med J. (Engl. )"},{"key":"10.1016\/j.toxlet.2025.02.005_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2020.122191","article-title":"Determination of 10 Haloacetamides in drinking water by gas chromatography with automated solid phase extraction","volume":"1150","author":"Zhou","year":"2020","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"4","key":"10.1016\/j.toxlet.2025.02.005_bib49","first-page":"456","article-title":"Trihalomethanes and haloacetamides as disinfection by-products in different types of drinking water of Wuxi","volume":"40","author":"Zhou","year":"2023","journal-title":"J. Environ. Occup. Med."},{"key":"10.1016\/j.toxlet.2025.02.005_bib50","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.12659\/MSM.916385","article-title":"The Effect of Interleukin-6 (IL-6), Interleukin-11 (IL-11), Signal Transducer and Activator of Transcription 3 (STAT3), and AKT Signaling on Adipocyte Proliferation in a Rat Model of Polycystic Ovary Syndrome","volume":"25","author":"Zhuang","year":"2019","journal-title":"Med Sci. Monit."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425000281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425000281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T07:18:43Z","timestamp":1741591123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427425000281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"alternative-id":["S0378427425000281"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.02.005","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iodoacetamide triggers ovarian dysfunction in mice through TGF-\u03b2 signaling pathway and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}