{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:47:03Z","timestamp":1773956823618,"version":"3.50.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306918\/2021\\u20138"],"award-info":[{"award-number":["306918\/2021\\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["302986\/2021\\u20139"],"award-info":[{"award-number":["302986\/2021\\u20139"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["23\/05411\\u20130"],"award-info":[{"award-number":["23\/05411\\u20130"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["23\/17585\\u20133"],"award-info":[{"award-number":["23\/17585\\u20133"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["23\/08751\\u20137"],"award-info":[{"award-number":["23\/08751\\u20137"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["22\/06082\\u20138"],"award-info":[{"award-number":["22\/06082\\u20138"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.toxlet.2025.04.009","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T06:28:12Z","timestamp":1745648892000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Transcriptomic implications of low herbicide concentrations in hepatic cells: Insights into the individual and combined effects of 2,4-D, glyphosate, and AMPA"],"prefix":"10.1016","volume":"409","author":[{"given":"Leticia Cardoso","family":"Valente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Riechelmann-Casarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemari","family":"Otton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Karina","family":"Delella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Fernando","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-8380","authenticated-orcid":false,"given":"Guilherme Ribeiro","family":"Romualdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.fct.2012.02.016","article-title":"In vitro toxicity screening of chemical mixtures using HepG2\/C3A cells","volume":"50","author":"Bandele","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115279","article-title":"HepG2 (C3A) spheroids show higher sensitivity compared to HepaRG spheroids for drug-induced liver injury (DILI)","volume":"408","author":"Basharat","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.toxlet.2025.04.009_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/jawr.12159","article-title":"Glyphosate and its degradation product AMPA occur frequently and widely in U.S. soils, surface water, groundwater, and precipitation","volume":"50","author":"Battaglin","year":"2014","journal-title":"J. Am. Water Resour. Assoc."},{"key":"10.1016\/j.toxlet.2025.04.009_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-016-0070-0","article-title":"Trends in glyphosate herbicide use in the United States and globally","volume":"28","author":"Benbrook","year":"2016","journal-title":"Environ. Sci. Eur."},{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.tiv.2005.03.011","article-title":"Altered gene expression in human hepatoma HepG2 cells exposed to low-level 2,4-dichlorophenoxyacetic acid and potassium nitrate","volume":"19","author":"Bharadwaj","year":"2005","journal-title":"Toxicol. Vitr. Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.toxlet.2025.04.009_bib6","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.toxlet.2025.04.009_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-5793(83)80888-6","article-title":"Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate","volume":"154","author":"Boocock","year":"1983","journal-title":"FEBS Lett."},{"key":"10.1016\/j.toxlet.2025.04.009_bib8","unstructured":"Brazilian Ministry of Health (2020). Revis\u00e3o do Anexo XX da Portaria de Consolida\u00e7\u00e3o no 5 de 28 de setembro de 2017 do Minist\u00e9rio da Sa\u00fade (antiga Portaria MS N\u00ba 2914\/2011) Padr\u00e3o de Potabilidade e Planos de Amostragem Subst\u00e2ncias Qu\u00edmicas \u2013 Agrot\u00f3xicos. (accessed 23 March 2025)."},{"issue":"11","key":"10.1016\/j.toxlet.2025.04.009_bib9","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1166\/jbn.2014.1871","article-title":"Cytotoxicity and cytokine release in rat hepatocytes, C3A cells and macrophages exposed to gold nanoparticles--effect of biological dispersion media or corona","volume":"10","author":"Brown","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"issue":"9","key":"10.1016\/j.toxlet.2025.04.009_bib10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3109\/10408444.2012.710576","article-title":"Review of 2,4-dichlorophenoxyacetic acid (2,4-D) biomonitoring and epidemiology","author":"Burns","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2025.04.009_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"1","key":"10.1016\/j.toxlet.2025.04.009_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1091581813517906","article-title":"Glyphosate commercial formulation causes cytotoxicity, oxidative effects, and apoptosis on human cells: differences with its active ingredient","volume":"33","author":"Chaufan","year":"2014","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105446","article-title":"Toxicity of pesticides widely applied on soybean cultivation: synergistic effects of fipronil, glyphosate and imidacloprid in HepG2 cells","author":"Conte","year":"2022","journal-title":"Toxicol. Vitr."},{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0278-6915(83)90143-6","article-title":"Interaction of chlorophenoxyalkyl acid herbicides with rat-liver glutathione S-transferases","volume":"21","author":"Dierickx","year":"1983","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.toxlet.2025.04.009_bib15","article-title":"Conclusion on the peer review of the pesticide risk assessment of the active substance 2,4-D","volume":"12","author":"EFSA","year":"2014","journal-title":"EFSA J."},{"key":"10.1016\/j.toxlet.2025.04.009_bib16","article-title":"Guidance on the use of the benchmark dose approach in risk assessment","volume":"20","author":"EFSA","year":"2022","journal-title":"EFSA J."},{"key":"10.1016\/j.toxlet.2025.04.009_bib17","unstructured":"EPA (2017). Pesticides Industry Sales and Usage 2008 - 2012 Market Estimates \u3008https:\/\/www.epa.gov\/pesticides\/pesticides-industry-sales-and-usage-2008-2012-market-estimates\u3009 (accessed 12 February 2025)."},{"key":"10.1016\/j.toxlet.2025.04.009_bib18","unstructured":"EPA (2025). Herbicides \u3008https:\/\/www.epa.gov\/caddis\/herbicides#related\u3009 (accessed 12 February 2025)."},{"issue":"3","key":"10.1016\/j.toxlet.2025.04.009_bib19","doi-asserted-by":"crossref","first-page":"37001","DOI":"10.1289\/EHP11721","article-title":"Association of lifetime exposure to glyphosate and aminomethylphosphonic acid (AMPA) with liver inflammation and metabolic syndrome at young adulthood: findings from the CHAMACOS study","volume":"131","author":"Eskenazi","year":"2023","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.toxlet.2025.04.009_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.113937","article-title":"CEBPA facilitates LOXL2 and LOXL3 transcription to promote BCL-2 stability and thus enhances the growth and metastasis of lung carcinoma cells in vitro","volume":"435","author":"Fan","year":"2024","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.toxlet.2025.04.009_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF01060055","article-title":"In vitro binding of 14C-labeled acidic compounds to serum albumin and their tissue distribution in the rat","volume":"8","author":"Fang","year":"1980","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.toxlet.2025.04.009_bib22","unstructured":"FAO (2024). FAOSTAT \u2013 Pesticides Use \u3008https:\/\/www.fao.org\/faostat\/en\/#data\/RP\u3009 (accessed 12 February 2025)."},{"issue":"11","key":"10.1016\/j.toxlet.2025.04.009_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/toxics10110711","article-title":"Cytotoxicity mechanisms of eight major herbicide active ingredients in comparison to their commercial formulations","volume":"10","author":"Ferguson","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.toxlet.2025.04.009_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.chembiol.2016.12.013","article-title":"Mapping proteome-wide targets of glyphosate in mice","volume":"24","author":"Ford","year":"2017","journal-title":"Cell Chem. Biol."},{"issue":"6","key":"10.1016\/j.toxlet.2025.04.009_bib25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets","volume":"7","author":"Furuhashi","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.toxlet.2025.04.009_bib26","first-page":"165","article-title":"An\u00e1lise ambiental macrosc\u00f3pica e a qualidade da \u00e1gua de nascentes na bacia do Rio S\u00e3o Domingos\/SC, Brasil","volume":"11","author":"Galvan","year":"2020","journal-title":"Rev. Ibero-Am. Ci\u00eancias Ambient"},{"issue":"4","key":"10.1016\/j.toxlet.2025.04.009_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10565-017-9383-z","article-title":"A transcriptomic study suggesting human iPSC-derived hepatocytes potentially offer a better in vitro model of hepatotoxicity than most hepatoma cell lines","volume":"33","author":"Gao","year":"2017","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2025.04.009_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-6673-6-3","article-title":"Defined plant extracts can protect human cells against combined xenobiotic effects","volume":"6","author":"Gasnier","year":"2011","journal-title":"J. Occup. Med. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib29","article-title":"Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies","volume":"21","author":"Gerona","year":"2022","journal-title":"Environ. Health A Glob. Access Sci. Source"},{"issue":"1","key":"10.1016\/j.toxlet.2025.04.009_bib30","first-page":"2","article-title":"The evidence of human exposure to glyphosate: a review","volume":"18","author":"Gillezeau","year":"2019","journal-title":"Environ. Health A Glob. Access Sci. Source"},{"issue":"7","key":"10.1016\/j.toxlet.2025.04.009_bib31","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1194\/jlr.R082933","article-title":"Dynamic role of the transmembrane glycoprotein CD36 (SR-B2) in cellular fatty acid uptake and utilization","volume":"59","author":"Glatz","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.toxlet.2025.04.009_bib32","unstructured":"Government of Canada. 2,4-Dichlorophenoxyacetic Acid (2,4-D) in Drinking Water. 2020. Available from:\u3008https:\/\/www.canada.ca\/content\/dam\/hc-sc\/documents\/programs\/consultation-review-guideline-technical-document-2-4-d-drinking-water\/2-4-D-GTDConsultation-20200727-eng.pdf\u3009 (accessed 23 March 2025)."},{"issue":"14","key":"10.1016\/j.toxlet.2025.04.009_bib33","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s00018-013-1539-2","article-title":"Regulation of pyruvate metabolism and human disease","volume":"71","author":"Gray","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.toxlet.2025.04.009_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103866","article-title":"Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing","volume":"92","author":"He","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2-3","key":"10.1016\/j.toxlet.2025.04.009_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mam.2012.12.009","article-title":"The ABCs of membrane transporters in health and disease (SLC series): introduction","volume":"34","author":"Hediger","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.toxlet.2025.04.009_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.toxlet.2025.04.009_bib37","unstructured":"IBAMA (2024). Pain\u00e9is de informa\u00e7\u00f5es de agrot\u00f3xicos. \u3008https:\/\/www.gov.br\/ibama\/pt-br\/assuntos\/quimicos-e-biologicos\/agrotoxicos\/paineis-de-informacoes-de-agrotoxicos\/paineis-de-informacoes-de-agrotoxicos\u3009 (accessed 12 February 2025)."},{"key":"10.1016\/j.toxlet.2025.04.009_bib38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.envint.2017.10.020","article-title":"Potential impact of the herbicide 2,4-dichlorophenoxyacetic acid on human and ecosystems","volume":"111","author":"Islam","year":"2018","journal-title":"Environ. Int."},{"issue":"23","key":"10.1016\/j.toxlet.2025.04.009_bib39","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1007\/s11356-017-9438-y","article-title":"Effects of low doses of glyphosate on DNA damage, cell proliferation and oxidative stress in the HepG2 cell line","volume":"24","author":"Ka\u0161uba","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.toxlet.2025.04.009_bib40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biochi.2017.03.004","article-title":"ERK1 and ERK2 activation modulates diet-induced obesity in mice","volume":"137","author":"Khan","year":"2017","journal-title":"Biochimie"},{"issue":"2-4","key":"10.1016\/j.toxlet.2025.04.009_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10937404.2010.483176","article-title":"Toxicity testing in the 21st century: a vision and a strategy","volume":"13","author":"Krewski","year":"2010","journal-title":"J. Toxicol. Environ. Health Part B Crit. Rev."},{"issue":"12","key":"10.1016\/j.toxlet.2025.04.009_bib42","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.tem.2017.10.007","article-title":"Mitogen-activated protein kinase regulation in hepatic metabolism","volume":"28","author":"Lawan","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.toxlet.2025.04.009_bib43","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1002\/tox.23617","article-title":"LOXL3-promoted hepatocellular carcinoma progression via promotion of Snail1\/USP4-mediated epithelial-mesenchymal transition","volume":"37","author":"Li","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib44","doi-asserted-by":"crossref","first-page":"27030","DOI":"10.1007\/s11356-022-24167-2","article-title":"Glyphosate pollution of surface runoff, stream water, and drinking water resources in Southeast Brazil","volume":"30","author":"Lima","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.toxlet.2025.04.009_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxlet.2025.01.009","article-title":"The herbicide 2,4-dichlorophenoxyacetic acid induces pancreatic \u03b2-cell death via oxidative stress-activated AMPK\u03b1 signal downstream-regulated apoptotic pathway","volume":"405","author":"Lin","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2025.04.009_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.toxlet.2025.04.009_bib47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/07482337221149571","volume":"39","author":"Mehtiyev","year":"2023","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.toxlet.2025.04.009_bib48","article-title":"The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay","volume":"186","author":"Mesnage","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep39328","article-title":"Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide","volume":"7","author":"Mesnage","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2025.04.009_bib50","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/sj.jes.7500641","article-title":"Adult and children's exposure to 2,4-D from multiple sources and pathways","volume":"18","author":"Morgan","year":"2008","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0021859605005708","article-title":"Crop losses to pests","volume":"144","author":"Oerke","year":"2006","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.toxlet.2025.04.009_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117013","article-title":"Comparison of premix glyphosate and 2,4-D formulation and direct tank mixture for control of Conyza canadensis and Epilobium ciliatum","volume":"281","author":"Palma-Bautista","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxlet.2025.04.009_bib53","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s13762-024-05818-y","article-title":"Herbicides in modern sustainable agriculture: environmental fate, ecological implications, and human health concerns","volume":"22","author":"Parven","year":"2024","journal-title":"Int. J. Environ. Sci. Technol."},{"issue":"15","key":"10.1016\/j.toxlet.2025.04.009_bib54","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1016\/S0021-9258(18)48214-2","article-title":"Substrate specificity of acetyl coenzyme A synthetase","volume":"262","author":"Patel","year":"1987","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.toxlet.2025.04.009_bib55","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.bbamcr.2006.08.034","article-title":"Peroxisomal beta-oxidation--a metabolic pathway with multiple functions","volume":"1763","author":"Poirier","year":"2006","journal-title":"Biochim. Et. Biophys. Acta"},{"key":"10.1016\/j.toxlet.2025.04.009_bib56","article-title":"Effects of 2,4-dichlorophenoxyacetic acid (2,4-D), isolated and in a formulated product, on the functional parameters of isolated rat liver mitochondria","volume":"104","author":"Polido","year":"2024"},{"key":"10.1016\/j.toxlet.2025.04.009_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.137751","article-title":"Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver","volume":"315","author":"Qi","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2025.04.009_bib58","first-page":"1","article-title":"Sorafenib reduces steatosis-induced fibrogenesis in a human 3D co-culture model of non-alcoholic fatty liver disease","author":"Romualdo","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104286","article-title":"Effects of glyphosate exposure on western diet-induced non-alcoholic fatty liver disease in mice","volume":"104","author":"Romualdo","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115688","article-title":"Modifying effects of 2,4-D and Glyphosate exposures on gut-liver-adipose tissue axis of diet-induced non-alcoholic fatty liver disease in mice","volume":"268","author":"Romualdo","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2025.04.009_bib61","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2009.09.007","article-title":"Prevention of steatosis by hepatic JNK1","volume":"10","author":"Sabio","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.toxlet.2025.04.009_bib62","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/hep.20999","article-title":"JNK1 but not JNK2 promotes the development of steatohepatitis in mice","volume":"43","author":"Schattenberg","year":"2006","journal-title":"Hepatology"},{"issue":"15","key":"10.1016\/j.toxlet.2025.04.009_bib63","doi-asserted-by":"crossref","first-page":"8107","DOI":"10.3390\/ijms23158107","article-title":"Molecular physicochemical properties of selected pesticides as predictive factors for oxidative stress and apoptosis-dependent cell death in Caco-2 and HepG2 cells","volume":"23","author":"Silva","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2025.04.009_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110151","article-title":"SNAI1-mediated transcriptional regulation of epithelial-to-mesenchymal transition genes in breast cancer stem cells","volume":"87","author":"Singh","year":"2021","journal-title":"Cell. Signal."},{"issue":"11","key":"10.1016\/j.toxlet.2025.04.009_bib65","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.3390\/foods10112785","article-title":"Glyphosate use, toxicity and occurrence in food","volume":"10","author":"Soares","year":"2021","journal-title":"Foods"},{"issue":"2","key":"10.1016\/j.toxlet.2025.04.009_bib66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/jipb.12131","article-title":"Insight into the mode of action of 2,4-dichlorophenoxyacetic acid (2,4-D) as an herbicide","volume":"56","author":"Song","year":"2014","journal-title":"J. Integr. Plant Biol."},{"issue":"Pt 2","key":"10.1016\/j.toxlet.2025.04.009_bib67","article-title":"Hepatocellular carcinoma (HepG2\/C3A) cell-based 3D model for genotoxicity testing of chemicals","volume":"755","author":"\u0160tampar","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2025.04.009_bib68","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxlet.2025.04.009_bib69","unstructured":"https:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp214.pdf."},{"issue":"3","key":"10.1016\/j.toxlet.2025.04.009_bib70","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0278-6915(02)00238-7","article-title":"Cytotoxic effects of the herbicide 2,4-dichlorophenoxyacetic acid in HepG2 cells","volume":"41","author":"Tuschl","year":"2003","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib71","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3390\/cancers14051200","article-title":"Loxl3 promotes melanoma progression and dissemination influencing cell plasticity and survival","volume":"14","author":"V\u00e1zquez-Naharro","year":"2022","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.toxlet.2025.04.009_bib72","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/0041-008X(84)90101-7","article-title":"Differential activation and inhibition of different forms of rat liver glutathione S-transferase by the herbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T)","volume":"73","author":"Vessey","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib73","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/096368979800700505","article-title":"Comparison of porcine hepatocytes with human hepatoma (C3A) cells for use in a bioartificial liver support system","volume":"7","author":"Wang","year":"1998","journal-title":"Cell Transplant."},{"issue":"5","key":"10.1016\/j.toxlet.2025.04.009_bib74","first-page":"1960","article-title":"MYBL2 accelerates epithelial-mesenchymal transition and hepatoblastoma metastasis via the Smad\/SNAI1 pathway","volume":"12","author":"Wei","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"2 Pt 1","key":"10.1016\/j.toxlet.2025.04.009_bib75","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/rtph.1999.1371","article-title":"Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans","volume":"31","author":"Williams","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.04.009_bib76","unstructured":"World Health Organization. Glyphosate and AMPA in Drinking-water. 2005. Available from: \u3008https:\/\/cdn.who.int\/media\/docs\/default-source\/wash-documents\/wash-chemicals\/glyphosateampa-bd-290605.pdf?sfvrsn=dec35422_4\u3009 (accessed 23 March 2025)."},{"key":"10.1016\/j.toxlet.2025.04.009_bib77","series-title":"Guidelines for Drinking-water Quality","author":"World Health Organization","year":"2011"},{"key":"10.1016\/j.toxlet.2025.04.009_bib78","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-023-00426-z","article-title":"Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice","volume":"28","author":"Wu","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.toxlet.2025.04.009_bib79","series-title":"Environmental Science and Pollution Research International","article-title":"Higher urinary glyphosate exposure is associated with increased risk of liver dysfunction in adults: An analysis of NHANES, 2013-2016","author":"Xiao","year":"2023"}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425000761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425000761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:46:51Z","timestamp":1749170811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427425000761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":79,"alternative-id":["S0378427425000761"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.04.009","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic implications of low herbicide concentrations in hepatic cells: Insights into the individual and combined effects of 2,4-D, glyphosate, and AMPA","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}