{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:02:04Z","timestamp":1783184524235,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["0217\\u201300218B"],"award-info":[{"award-number":["0217\\u201300218B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030834","name":"Graduate School of Technical Sciences, Aarhus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.toxlet.2025.05.015","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:40:52Z","timestamp":1748313652000},"page":"16-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Extracellular vesicles from tomatoes upregulate CYP1A1 mRNA content in differentiated Caco-2 cells"],"prefix":"10.1016","volume":"410","author":[{"given":"Ziyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Gerbal-Chaloin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Daujat-Chavanieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-2874","authenticated-orcid":false,"given":"Martin Kr\u00f8yer","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2025.05.015_bib1","doi-asserted-by":"crossref","unstructured":"Achour B., Russell M.R., Barber J., Rostami-Hodjegan A. (2014) Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5\u2032-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics. 42(4):500-510 doi:10.1124\/dmd.113.055632%J Drug Metabolism and Disposition.","DOI":"10.1124\/dmd.113.055632"},{"key":"10.1016\/j.toxlet.2025.05.015_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.778998","article-title":"Extracellular vesicles derived from citrus sinensis modulate inflammatory genes and tight junctions in a human model of intestinal epithelium","volume":"8","author":"Bruno","year":"2021","journal-title":"Front Nutr."},{"issue":"3","key":"10.1016\/j.toxlet.2025.05.015_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1440-169X.2011.01258.x","article-title":"Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2","volume":"53","author":"Buhrke","year":"2011","journal-title":"Dev. Growth Differ."},{"issue":"3","key":"10.1016\/j.toxlet.2025.05.015_bib4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.yrtph.2015.10.009","article-title":"Adverse food-drug interactions","volume":"73","author":"de Boer","year":"2015","journal-title":"Regul. Toxicol. Pharm."},{"issue":"2","key":"10.1016\/j.toxlet.2025.05.015_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bcp.2007.09.013","article-title":"JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes","volume":"75","author":"Dvorak","year":"2008","journal-title":"Biochem Pharm."},{"issue":"7","key":"10.1016\/j.toxlet.2025.05.015_bib6","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1021\/acs.jproteome.4c00276","article-title":"Multilevel proteomic profiling of colorectal adenocarcinoma Caco-2 cell differentiation to characterize an intestinal epithelial model","volume":"23","author":"Fekete","year":"2024","journal-title":"J. Proteome Res"},{"key":"10.1016\/j.toxlet.2025.05.015_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.crtox.2021.03.002","article-title":"Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR","volume":"2","author":"Gerbal-Chaloin","year":"2021","journal-title":"Curr. Res. Toxicol."},{"issue":"23","key":"10.1016\/j.toxlet.2025.05.015_bib8","doi-asserted-by":"crossref","first-page":"12791","DOI":"10.3390\/ijms222312791","article-title":"Determination of CYP450 expression levels in the human small intestine by mass spectrometry-based targeted proteomics","volume":"22","author":"Grangeon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/tx700079z","article-title":"Cytochrome P450 and chemical toxicology","volume":"21","author":"Guengerich","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2025.05.015_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2024.106064","article-title":"Importance of isolation method on characteristics and bioactivity of extracellular vesicles from tomatoes","volume":"129","author":"Huang","year":"2024","journal-title":"J. Food Compost Anal."},{"key":"10.1016\/j.toxlet.2025.05.015_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115804","article-title":"Tomato-derived extracellular vesicles increase intestinal zinc transportation by potentially down-regulating the expression of the metallothionein family","volume":"203","author":"Huang","year":"2025","journal-title":"Food Res. Int."},{"issue":"12","key":"10.1016\/j.toxlet.2025.05.015_bib12","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1124\/dmd.107.016253","article-title":"Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines","volume":"35","author":"Haarmann-Stemmann","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.toxlet.2025.05.015_bib13","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1074\/jbc.273.5.2895","article-title":"Nuclear localization and export signals of the human aryl hydrocarbon receptor","volume":"273","author":"Ikuta","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2025.05.015_bib14","first-page":"181","article-title":"Current results on the biological and pharmacological activities of Indole-3-carbinol","volume":"17","author":"Kim","year":"2018","journal-title":"EXCLI J."},{"issue":"5","key":"10.1016\/j.toxlet.2025.05.015_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/acs.chemrestox.6b00022","article-title":"Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity","volume":"29","author":"Klaren","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2025.05.015_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2023.2214628","article-title":"Coupling in vitro food digestion with in vitro epithelial absorption; recommendations for biocompatibility","author":"Kondrashina","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"4","key":"10.1016\/j.toxlet.2025.05.015_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1101\/gad.13.1.20","article-title":"Identification of a novel mechanism of regulation of Ah (dioxin) receptor function","volume":"13","author":"Mimura","year":"1999","journal-title":"Genes Dev."},{"issue":"9340","key":"10.1016\/j.toxlet.2025.05.015_bib19","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.toxlet.2025.05.015_bib20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbrc.2016.03.012","article-title":"Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells","volume":"472","author":"Negoro","year":"2016","journal-title":"Biochem Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2025.05.015_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O'Brien","year":"2018","journal-title":"Front Endocrinol."},{"issue":"5","key":"10.1016\/j.toxlet.2025.05.015_bib22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1124\/dmd.105.008672","article-title":"The human intestinal cytochrome P450 \u201cpie","volume":"34","author":"Paine","year":"2006","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.toxlet.2025.05.015_bib23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/00498250412331285454","article-title":"Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences","volume":"34","author":"Pascussi","year":"2004","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.47.120505.105349","article-title":"The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences","volume":"48","author":"Pascussi","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.2042-7158.2003.tb02434.x","article-title":"Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines","volume":"55","author":"Pfrunder","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.05.015_bib26","first-page":"283","article-title":"Human hepatocyte culture","volume":"320","author":"Pichard","year":"2006","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.toxlet.2025.05.015_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154629","article-title":"Skatole (3-Methylindole) is a partial aryl hydrocarbon receptor agonist and induces CYP1A1\/2 and CYP1B1 expression in primary human hepatocytes","volume":"11","author":"Rasmussen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2025.05.015_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxlet.2017.10.011","article-title":"Impact of fasting followed by short-term exposure to interleukin-6 on cytochrome P450 mRNA in mice","volume":"282","author":"Rasmussen","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2025.05.015_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2017.05.029","article-title":"Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG","volume":"277","author":"Rasmussen","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2025.05.015_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.147039","article-title":"Hepatic PGC-1alpha has minor regulatory effect on the liver transcriptome and metabolome during high fat high fructose diet and exercise training","volume":"851","author":"Rasmussen","year":"2023","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.toxlet.2025.05.015_bib31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1439-0531.2010.1714.x","article-title":"Gender-related differences in cytochrome P450 in porcine liver - implication for activity, expression and inhibition by testicular steroids","volume":"46","author":"Rasmussen","year":"2011","journal-title":"Reprod. Domest. Anim."},{"issue":"2","key":"10.1016\/j.toxlet.2025.05.015_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.etap.2007.10.016","article-title":"Zinc nutritional status modulates expression of ahr-responsive p450 enzymes in vascular endothelial cells","volume":"25","author":"Shen","year":"2008","journal-title":"Environ. Toxicol. Pharm."},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/biology12010110","article-title":"Extracellular vesicles: new classification and tumor immunosuppression","volume":"12","author":"Sheta","year":"2023","journal-title":"Biology"},{"issue":"2010","key":"10.1016\/j.toxlet.2025.05.015_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.food.102308.124120","article-title":"An update on the health effects of tomato lycopene","volume":"1","author":"Story","year":"2010","journal-title":"Annu Rev. Food Sci. Technol."},{"issue":"11","key":"10.1016\/j.toxlet.2025.05.015_bib35","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1091\/mbc.e07-04-0309","article-title":"Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer","volume":"18","author":"Saaf","year":"2007","journal-title":"Mol. Biol. Cell"},{"issue":"11","key":"10.1016\/j.toxlet.2025.05.015_bib36","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1124\/dmd.114.059493","article-title":"Human small intestinal epithelial cells differentiated from adult intestinal stem cells as a novel system for predicting oral drug absorption in humans","volume":"42","author":"Takenaka","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12964-020-0523-3","article-title":"Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis","volume":"18","author":"Tian","year":"2020","journal-title":"Cell Commun. Signal"},{"issue":"15","key":"10.1016\/j.toxlet.2025.05.015_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade5041","article-title":"Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis","volume":"9","author":"Tong","year":"2023","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.toxlet.2025.05.015_bib39","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/jcb.21015","article-title":"Gene expression profiles of normal proliferating and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model","volume":"99","author":"Tremblay","year":"2006","journal-title":"J. Cell Biochem"},{"issue":"7","key":"10.1016\/j.toxlet.2025.05.015_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107041","article-title":"Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR\/Nrf2 signaling pathway","volume":"26","author":"Urzi","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.toxlet.2025.05.015_bib41","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.5186","article-title":"Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables","volume":"6","author":"Xiao","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.toxlet.2025.05.015_bib42","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3389\/fphar.2018.00927","article-title":"Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter","volume":"9","author":"Xie","year":"2018","journal-title":"Front Pharm."},{"issue":"21","key":"10.1016\/j.toxlet.2025.05.015_bib43","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1111\/febs.14956","article-title":"AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1","volume":"286","author":"Ye","year":"2019","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.toxlet.2025.05.015_bib44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharm. Ther."},{"issue":"15","key":"10.1016\/j.toxlet.2025.05.015_bib45","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1021\/acs.jafc.9b07795","article-title":"Aryl hydrocarbon receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders","volume":"68","author":"Zhao","year":"2020","journal-title":"J. Agric. Food Chem."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425001006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425001006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T14:51:30Z","timestamp":1752591090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427425001006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":45,"alternative-id":["S0378427425001006"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.05.015","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular vesicles from tomatoes upregulate CYP1A1 mRNA content in differentiated Caco-2 cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}