{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T02:16:27Z","timestamp":1778465787188,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373968"],"award-info":[{"award-number":["82373968"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.toxlet.2025.06.018","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:04:09Z","timestamp":1750849449000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Autophagy-dependent hepatocyte apoptosis mediates gilteritinib-induced hepatotoxicity"],"prefix":"10.1016","volume":"410","author":[{"given":"Yashi","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaozeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingchen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaojun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2025.06.018_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.117089","article-title":"Identification of inhibitors targeting the FLT3-ITD mutation through 4D-QSAR, in vitro, and in silico","volume":"282","author":"Chu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.toxlet.2025.06.018_bib2","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1182\/blood.2021014241","article-title":"Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1","volume":"140","author":"Janssen","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2025.06.018_bib3","doi-asserted-by":"crossref","first-page":"e1070","DOI":"10.1634\/theoncologist.2019-0976","article-title":"The European medicines agency review of gilteritinib (Xospata) for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with an FLT3 mutation","volume":"25","author":"Tzogani","year":"2020","journal-title":"Oncologist"},{"key":"10.1016\/j.toxlet.2025.06.018_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12943-019-1090-3","article-title":"AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.toxlet.2025.06.018_bib5","doi-asserted-by":"crossref","first-page":"24860","DOI":"10.1021\/acsnano.4c05081","article-title":"Multiplex profiling of miR-122 for preclinical and clinical evaluation of drug-induced liver injury by a full-scale platform","volume":"18","author":"Dong","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.toxlet.2025.06.018_bib6","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3390\/ijms18051018","article-title":"Drug-induced liver injury: cascade of events leading to cell death, apoptosis or necrosis","volume":"18","author":"Iorga","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2025.06.018_bib7","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1200\/JCO.23.01911","article-title":"Azacitidine, venetoclax, and gilteritinib in newly diagnosed and relapsed or refractory FLT3-mutated AML","volume":"42","author":"Short","year":"2024","journal-title":"J. Clin. Oncol. : Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.toxlet.2025.06.018_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/cdd.2017.145","article-title":"Viewing BCL2 and cell death control from an evolutionary perspective","volume":"25","author":"Strasser","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.toxlet.2025.06.018_bib9","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/fcp.13030","article-title":"Methylsulfonylmethane induces caspase-dependent apoptosis in acute myeloid leukemia cell lines","volume":"38","author":"Hekmatshoar","year":"2024","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.06.018_bib10","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.toxlet.2025.06.018_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-022-04748-2","article-title":"Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance","volume":"13","author":"Dong","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2025.06.018_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116869","article-title":"Downregulation of DDIT4 levels with borneol attenuates hepatotoxicity induced by gilteritinib","volume":"236","author":"Yin","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.06.018_bib13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.toxlet.2025.06.018_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.toxlet.2025.06.018_bib15","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJMoa1902688","article-title":"Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML","volume":"381","author":"Perl","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxlet.2025.06.018_bib16","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb J."},{"key":"10.1016\/j.toxlet.2025.06.018_bib17","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s40262-020-00888-w","article-title":"Pharmacokinetic profile of gilteritinib: a novel FLT-3 tyrosine kinase inhibitor","volume":"59","author":"James","year":"2020","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.toxlet.2025.06.018_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216933","article-title":"FLT3-selective PROTAC: enhanced safety and increased synergy with venetoclax in FLT3-ITD mutated acute myeloid leukemia","volume":"592","author":"Tan","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2025.06.018_bib19","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1182\/blood.2021011583","article-title":"Follow-up of patients with R\/R FLT3-mutation\u2013positive AML treated with gilteritinib in the phase 3 ADMIRAL trial","volume":"139","author":"Perl","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.toxlet.2025.06.018_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.toxlet.2025.06.018_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41420-023-01387-0","article-title":"Autophagy in hepatic ischemia-reperfusion injury","volume":"9","author":"Mao","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.toxlet.2025.06.018_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156053","article-title":"Shaoyao-Gancao Decoction, a famous Chinese medicine formula, protects against APAP-induced liver injury by promoting autophagy\/mitophagy","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.toxlet.2025.06.018_bib23","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1080\/15548627.2020.1851492","article-title":"PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)","volume":"17","author":"Luo","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2025.06.018_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12964-025-02135-w","article-title":"The inducible role of autophagy in cell death: emerging evidence and future perspectives","volume":"23","author":"Huang","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.toxlet.2025.06.018_bib25","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1242\/jcs.046250","article-title":"Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis","volume":"122","author":"Betin","year":"2009","journal-title":"J. Cell Sci."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425001250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425001250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T14:53:41Z","timestamp":1752591221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427425001250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":25,"alternative-id":["S0378427425001250"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.06.018","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy-dependent hepatocyte apoptosis mediates gilteritinib-induced hepatotoxicity","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}