{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:25:14Z","timestamp":1773962714339,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.toxlet.2025.111816","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:13:20Z","timestamp":1767140000000},"page":"111816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Research on the therapeutic effects of recombinant protein PON1Q\/R192 intervention on mice poisoned by different categories of organophosphorus compounds"],"prefix":"10.1016","volume":"416","author":[{"given":"Shuang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengsi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-5770","authenticated-orcid":false,"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ccc.2021.03.011","article-title":"Management of organophosphorus poisoning","volume":"37","author":"Aman","year":"2021","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.toxlet.2025.111816_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.02.017","article-title":"Targeting the glutamatergic system to counteract organophosphate poisoning: a novel therapeutic strategy","volume":"133","author":"Aroniadou-Anderjaska","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.toxlet.2025.111816_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pep.2015.05.011","article-title":"Expression and purification of biologically active recombinant human paraoxonase 1 from inclusion bodies of Escherichia coli","volume":"115","author":"Bajaj","year":"2015","journal-title":"Protein Expr. Purif."},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-020-01330-9","article-title":"Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review","volume":"9","author":"Banhela","year":"2020","journal-title":"Syst. Rev."},{"issue":"7","key":"10.1016\/j.toxlet.2025.111816_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30071615","article-title":"History of organophosphorus compounds in the context of their use as chemical warfare agents","volume":"30","author":"Boczkowski","year":"2025","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1746-6148-10-74","article-title":"Serum paraoxonase 1 (PON1) measurement: an update","volume":"10","author":"Ceron","year":"2014","journal-title":"BMC Vet. Res."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/oem.2009.052126","article-title":"\u2018Dippers' flu\u2019 and its relationship to PON1 polymorphisms","volume":"68","author":"Cherry","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.toxlet.2025.111816_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2012.07.011","article-title":"Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity","volume":"307","author":"Costa","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2025.111816_bib9","doi-asserted-by":"crossref","unstructured":"Costa, L.G., McDonald, B.E., Murphy, S.D., Omenn, G.S., Richter, R.J., Motulsky, A.G., & Furlong, C.E. Serum Paraoxonase and Its Influence on Paraoxon and Chlorpyrifos-oxon Toxicity in Rats. Toxicology and Applied Pharmacology,103(1), 66-76.","DOI":"10.1016\/0041-008X(90)90263-T"},{"key":"10.1016\/j.toxlet.2025.111816_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2020.01.017","article-title":"Differences in biological activities between recombinant human paraoxonase 1 (rhPON1) subtype isozemys R\/Q as antidotes against organophosphorus poisonings","volume":"325","author":"Cui","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2025.111816_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tox.2018.10.012","article-title":"Paraoxonase-1 genetic polymorphisms in organophosphate metabolism","volume":"411","author":"Dardiotis","year":"2019","journal-title":"Toxicology"},{"issue":"24","key":"10.1016\/j.toxlet.2025.111816_bib12","doi-asserted-by":"crossref","first-page":"24946","DOI":"10.1007\/s11356-019-05696-9","article-title":"Relationship between internal and external factors and the activity of PON1","volume":"26","author":"del Carmen Xotlanihua-Gervacio","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.pharep.2019.02.012","article-title":"The inhibition effects of some sulfonamides on human serum paraoxonase-1 (hPON1)","volume":"71","author":"Demir","year":"2019","journal-title":"Pharmacol. Rep."},{"issue":"1-3","key":"10.1016\/j.toxlet.2025.111816_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cbi.2010.02.021","article-title":"In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity","volume":"187","author":"diTargiani","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.toxlet.2025.111816_bib15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/qjmed\/hcl065","article-title":"Respiratory failure in acute organophosphorus pesticide self-poisoning","volume":"99","author":"Eddleston","year":"2006","journal-title":"QJM Int. J. Med."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.taap.2012.08.031","article-title":"PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos","volume":"265","author":"Ellison","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2165\/00139709-200322030-00004","article-title":"The role of oximes in the management of organophosphorus pesticide poisoning","volume":"22","author":"Eyer","year":"2003","journal-title":"Toxicol. Rev."},{"key":"10.1016\/j.toxlet.2025.111816_bib18","series-title":"Submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed (Third edition) [M]","year":"2016"},{"key":"10.1016\/j.toxlet.2025.111816_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/684010","article-title":"Regulation of Hepatic Paraoxonase-1 Expression","volume":"2012","author":"Fuhrman","year":"2012","journal-title":"J. Lipids"},{"key":"10.1016\/j.toxlet.2025.111816_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cbi.2016.05.036","article-title":"Paraoxonases-1, -2 and -3: What are their functions?","volume":"259","author":"Furlong","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"19","key":"10.1016\/j.toxlet.2025.111816_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17197165","article-title":"Gestational pesticide exposure and child respiratory health","volume":"17","author":"Gilden","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-7-357","article-title":"The global distribution of fatal pesticide self-poisoning: systematic review","volume":"7","author":"Gunnell","year":"2007","journal-title":"BMC Public Health"},{"issue":"10","key":"10.1016\/j.toxlet.2025.111816_bib23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/1440-1681.12275","article-title":"Preparation of paraoxonase-1 liposomes and studies on theirin vivopharmacokinetics in rats","volume":"41","author":"Han","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"2","key":"10.1016\/j.toxlet.2025.111816_bib24","first-page":"87","article-title":"Preparation and Evaluation of Long-circulating Liposomes of Paraoxonase","volume":"39","author":"Han","year":"2010","journal-title":"J. China Med. Univ."},{"issue":"9","key":"10.1016\/j.toxlet.2025.111816_bib25","article-title":"Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-\/- mouse pups and adults","volume":"15","author":"Homberg","year":"2020","journal-title":"Plos One"},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib26","doi-asserted-by":"crossref","DOI":"10.1289\/EHP3024","article-title":"Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring nonverbal IQ at age 6 years","volume":"127","author":"Jusko","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2025.111816_bib27","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.7174","article-title":"The efficacy of pralidoxime in the treatment of organophosphate poisoning in humans: a systematic review and meta-analysis of randomized trials","author":"Kharel","year":"2020","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cbi.2012.10.023","article-title":"Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents","volume":"203","author":"Kirby","year":"2013","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.toxlet.2025.111816_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/biof.1549","article-title":"Paraoxonase 1 and atherosclerosis-related diseases","volume":"46","author":"Kotur-Stevuljevi\u0107","year":"2019","journal-title":"BioFactors"},{"issue":"8","key":"10.1016\/j.toxlet.2025.111816_bib30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/00008571-200012000-00002","article-title":"Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds","volume":"10","author":"Li","year":"2000","journal-title":"Pharmacogenetics"},{"issue":"4","key":"10.1016\/j.toxlet.2025.111816_bib31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ntt.2010.03.004","article-title":"Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides","volume":"32","author":"Mackenzie Ross","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.toxlet.2025.111816_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clinbiochem.2019.01.003","article-title":"Unexpectedly higher diazoxon hydrolysis by serum paraoxonase-1 in coronary heart disease","volume":"65","author":"Mackness","year":"2019","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.toxlet.2025.111816_bib33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/tox.22253","article-title":"Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells","volume":"32","author":"Medina-D\u00edaz","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2025.111816_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jad.2017.05.002","article-title":"The global burden of fatal self-poisoning with pesticides 2006-15: systematic review","volume":"219","author":"Mew","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.etap.2015.03.001","article-title":"Allele frequencies of PON1 Q192R polymorphism in four populations of India","volume":"39","author":"Mitra","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.toxlet.2025.111816_bib36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00210-018-1473-9","article-title":"Paraoxonases: metabolic role and pharmacological projection","volume":"391","author":"Moya","year":"2018","journal-title":"NaunynSchmiede 's. Arch. Pharmacol."},{"key":"10.1016\/j.toxlet.2025.111816_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2017.02.005","article-title":"Transcriptional regulation of human Paraoxonase 1 by nuclear receptors","volume":"268","author":"Ponce-Ruiz","year":"2017","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tox.2010.02.007","article-title":"Gene\u2013environmental interactions and organophosphate toxicity","volume":"278","author":"Povey","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2025.111816_bib39","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.3390\/ijms24076658","article-title":"Organophosphorus poisoning: acute respiratory distress syndrome (ARDS) and cardiac failure as cause of death in hospitalized patients","volume":"24","author":"Ramadori","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.toxlet.2025.111816_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.taap.2011.01.014","article-title":"Paraoxonase-1 genetic polymorphisms and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides","volume":"252","author":"Singh","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"24","key":"10.1016\/j.toxlet.2025.111816_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245980","article-title":"The structure and function of paraoxonase-1 and its comparison to paraoxonase-2 and -3","volume":"25","author":"Taler-Ver\u010di\u010d","year":"2020","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.toxlet.2012.02.019","article-title":"Polyethylene glycosylation prolongs the stability of recombinant human paraoxonase-1","volume":"210","author":"Tiegang","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-019-0470-x","article-title":"Para-occupational exposure to pesticides, PON1 polymorphisms and hypothyroxinemia during the first half of pregnancy in women living in a Mexican floricultural area","volume":"18","author":"Torres-S\u00e1nchez","year":"2019","journal-title":"Environ. Health"},{"issue":"1","key":"10.1016\/j.toxlet.2025.111816_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2010.10.125","article-title":"Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1","volume":"403","author":"Valiyaveettil","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.toxlet.2025.111816_bib45","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.tiv.2011.02.012","article-title":"In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates","volume":"25","author":"Valiyaveettil","year":"2011","journal-title":"Toxicol. Vitr."},{"issue":"3","key":"10.1016\/j.toxlet.2025.111816_bib46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.toxlet.2011.02.007","article-title":"Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs","volume":"202","author":"Valiyaveettil","year":"2011","journal-title":"Toxicol. Lett."},{"issue":"8","key":"10.1016\/j.toxlet.2025.111816_bib47","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/jat.3605","article-title":"Oxidative stress in organophosphate poisoning: role of standard antidotal therapy","volume":"38","author":"Vanova","year":"2018","journal-title":"J. Appl. Toxicol."},{"issue":"4","key":"10.1016\/j.toxlet.2025.111816_bib48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/emj.2009.088500","article-title":"Effect of PON1 on dichlorvos toxicokinetics","volume":"28","author":"Wang","year":"2010","journal-title":"Emerg. Med. J."},{"issue":"2","key":"10.1016\/j.toxlet.2025.111816_bib49","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s11356-019-06740-4","article-title":"Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China","volume":"27","author":"Wang","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"9","key":"10.1016\/j.toxlet.2025.111816_bib50","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1007\/s00204-016-1772-1","article-title":"Toxicology of organophosphorus compounds in view of an increasing terrorist threat","volume":"90","author":"Worek","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2025.111816_bib51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2014.12.041","article-title":"Current status of persistent organic pesticides residues in air, water, and soil, and their possible effect on neighboring countries: a comprehensive review of India","volume":"511","author":"Yadav","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.toxlet.2025.111816_bib52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuro.2015.08.011","article-title":"Paraoxonase 1 and cytochrome P450 polymorphisms in susceptibility to acute organophosphorus poisoning in Egyptians","volume":"51","author":"Zayed","year":"2015","journal-title":"NeuroToxicology"},{"issue":"12","key":"10.1016\/j.toxlet.2025.111816_bib53","first-page":"1413","article-title":"Protective effect of recombinant human paraoxonase K\u2081\u2089\u2082 (rHuPON1 K\u2081\u2089\u2082) on lung injury induced by chlorpyrifos (CPF) poisoning","volume":"20","author":"Zhang","year":"2015","journal-title":"Chin. J. Clin. Pharmacol. Ther."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425027626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427425027626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:31:41Z","timestamp":1773952301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427425027626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S0378427425027626"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.111816","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research on the therapeutic effects of recombinant protein PON1Q\/R192 intervention on mice poisoned by different categories of organophosphorus compounds","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2025.111816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111816"}}