{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:07:59Z","timestamp":1773983279105,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013454","name":"Fukuyama University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K15312"],"award-info":[{"award-number":["24K15312"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K15288"],"award-info":[{"award-number":["22K15288"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K00368"],"award-info":[{"award-number":["25K00368"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.toxlet.2026.111829","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:32:56Z","timestamp":1768087976000},"page":"111829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor \u03b1-positive breast cancer cells"],"prefix":"10.1016","volume":"416","author":[{"given":"Koki","family":"Kanameda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Hirao-Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-1421","authenticated-orcid":false,"given":"Shuso","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2026.111829_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0960-0760(02)00074-2","article-title":"Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation","volume":"81","author":"Chan","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxlet.2026.111829_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023048","article-title":"Biosensors paving the way to understanding the interaction between cadmium and the estrogen receptor alpha","volume":"6","author":"Fechner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.toxlet.2026.111829_bib3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10637-014-0120-7","article-title":"Preclinical characterization of the CDK4\/6 inhibitor LY2835219: in-vivo cell cycle-dependent\/independent anti-tumor activities alone\/in combination with gemcitabine","volume":"32","author":"Gelbert","year":"2014","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.toxlet.2026.111829_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.cell.2019.06.026","article-title":"Therapeutic ligands antagonize estrogen receptor function by impairing its mobility","volume":"178","author":"Guan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2026.111829_bib5","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.3390\/cimb45090464","article-title":"2-Methoxyestradiol as an antiproliferative agent for long-term estrogen-deprived breast cancer cells","volume":"45","author":"Hirao-Suzuki","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.toxlet.2026.111829_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2020.07.043","article-title":"Fatty acid 2-hydroxylase (FA2H) as a stimulatory molecule responsible for breast cancer cell migration","volume":"531","author":"Hirao-Suzuki","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.toxlet.2026.111829_bib7","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1248\/bpb.b21-00417","article-title":"4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) targets estrogen receptor \u03b2, to evoke the resistance of human breast cancer MCF-7 cells to G-1, an agonist for G protein-coupled estrogen receptor 1","volume":"44","author":"Hirao-Suzuki","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.toxlet.2026.111829_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxlet.2019.10.018","article-title":"Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: Evidence for the involvement of constitutively activated estrogen receptor \u03b1 and very low expression of G protein-coupled estrogen receptor 1","volume":"319","author":"Hirao-Suzuki","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2026.111829_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1124\/mol.118.114124","article-title":"Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an active metabolite of bisphenol A, aggressively stimulates breast cancer cell growth in an estrogen receptor \u03b2 (ER\u03b2)-dependent manner","volume":"95","author":"Hirao-Suzuki","year":"2019","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.toxlet.2026.111829_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2023.02.008","article-title":"Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells","volume":"378","author":"Hirao-Suzuki","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2026.111829_bib11","first-page":"119","article-title":"Cadmium and cadmium compounds","volume":"58","author":"IARC","year":"1993","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.toxlet.2026.111829_bib12","first-page":"121","article-title":"Cadmium and cadmium compounds","volume":"100C","author":"IARC","year":"2012","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"10.1016\/j.toxlet.2026.111829_bib13","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.toxlet.2005.05.011","article-title":"Estimation of cumulative cadmium intake causing Itai-itai disease","volume":"159","author":"Inaba","year":"2005","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2026.111829_bib14","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1210\/endo.139.10.6229","article-title":"Estrogen receptor expression and function in long-term estrogen-deprived human breast cancer cells","volume":"139","author":"Jeng","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.toxlet.2026.111829_bib15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/jb\/mvae074","article-title":"Long-term estrogen-deprived estrogen receptor \u03b1-positive breast cancer cell migration assisted by fatty acid 2-hydroxylase","volume":"177","author":"Kanameda","year":"2025","journal-title":"J. Biochem."},{"key":"10.1016\/j.toxlet.2026.111829_bib16","first-page":"4355","article-title":"Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens","volume":"47","author":"Katzenellenbogen","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.toxlet.2026.111829_bib17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10549-013-2711-y","article-title":"Prognosis of metastatic breast cancer subtypes: the hormone receptor\/HER2-positive subtype is associated with the most favorable outcome","volume":"141","author":"Lobbezoo","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.toxlet.2026.111829_bib18","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1038\/s41467-017-01864-y","article-title":"Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance","volume":"8","author":"Martin","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2026.111829_bib19","doi-asserted-by":"crossref","first-page":"56876","DOI":"10.18632\/oncotarget.10871","article-title":"Fulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ER\u03b1 positive breast cancer by up-regulation of ER\u03b2","volume":"7","author":"Mishra","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.toxlet.2026.111829_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1158\/2159-8290.CD-16-0095","article-title":"Efficacy and safety of abemaciclib, an inhibitor of CDK4 and CDK6, for patients with breast cancer, non-small cell lung cancer, and other solid tumors","volume":"6","author":"Patnaik","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.toxlet.2026.111829_bib21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1634\/theoncologist.12-7-774","article-title":"Fulvestrant (Faslodex) - how to make a good drug better","volume":"12","author":"Robertson","year":"2007","journal-title":"Oncologist"},{"key":"10.1016\/j.toxlet.2026.111829_bib22","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1016\/S0140-6736(16)32389-3","article-title":"Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial","volume":"388","author":"Robertson","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.toxlet.2026.111829_bib23","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1200\/JCO.2016.67.1487","article-title":"Endocrine therapy for hormone receptor-positive metastatic breast cancer: American society of clinical oncology guideline","volume":"34","author":"Rugo","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.toxlet.2026.111829_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2131\/jts.47.159","article-title":"Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration","volume":"47","author":"Sakai","year":"2022","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2026.111829_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1289\/ehp.0901234","article-title":"Cadmium, environmental exposure, and health outcomes","volume":"118","author":"Satarug","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.toxlet.2026.111829_bib26","doi-asserted-by":"crossref","first-page":"21458","DOI":"10.1074\/jbc.M110621200","article-title":"The role of topoisomerase II in the excision of DNA loop domains during apoptosis","volume":"277","author":"Solovyan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2026.111829_bib27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10549-010-1007-8","article-title":"Cadmium concentration in biological media of breast cancer patients","volume":"125","author":"Strumylait\u0117","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.toxlet.2026.111829_bib28","first-page":"867","article-title":"Environmental factors and breast cancer","volume":"46","author":"Strumylait\u0117","year":"2010","journal-title":"Med. (Kaunas. )"},{"key":"10.1016\/j.toxlet.2026.111829_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2012.12.019","article-title":"(\u2013)-Xanthatin up-regulation of the GADD45\u03b3 tumor suppressor gene in MDA-MB-231 breast cancer cells: Role of topoisomerase II\u03b1 inhibition and reactive oxygen species","volume":"305","author":"Takeda","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2026.111829_bib30","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.21873\/anticanres.11087","article-title":"Bongkrekic acid as a Warburg effect modulator in long-term estradiol-deprived MCF-7 breast cancer cells","volume":"36","author":"Takeda","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1016\/j.toxlet.2026.111829_bib31","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1021\/tx4000446","article-title":"\u03949-Tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor \u03b2 (ER\u03b2)","volume":"26","author":"Takeda","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2026.111829_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114435","article-title":"Environmental exposure to cadmium in breast cancer \u2013 association with the Warburg effect and sensitivity to tamoxifen","volume":"161","author":"Tarhonska","year":"2023","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.toxlet.2026.111829_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2165\/00003088-200443070-00002","article-title":"Pharmacokinetic optimisation of treatment with oral etoposide","volume":"43","author":"Toffoli","year":"2004","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.toxlet.2026.111829_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox- and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2026.111829_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.10.003","article-title":"Dietary exposure to cadmium and risk of breast cancer in postmenopausal women: a systematic review and meta-analysis","volume":"86","author":"Van Maele-Fabry","year":"2016","journal-title":"Environ. Int."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426000123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426000123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:57:43Z","timestamp":1773979063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427426000123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"alternative-id":["S0378427426000123"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.111829","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium interferes with the antiproliferative effect of fulvestrant in endocrine therapy-resistant estrogen receptor \u03b1-positive breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.111829","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111829"}}