{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:49:32Z","timestamp":1776754172909,"version":"3.51.2"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013794","name":"Shanxi Provincial Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020758","name":"Science and Technology Innovation Group of Shanxi Province","doi-asserted-by":"publisher","award":["202304051001041"],"award-info":[{"award-number":["202304051001041"]}],"id":[{"id":"10.13039\/501100020758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.toxlet.2026.111888","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:09:07Z","timestamp":1775059747000},"page":"111888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deoxynivalenol-induced hepatic and renal injury via pyroptosis under heat stress conditions"],"prefix":"10.1016","volume":"419","author":[{"given":"Jingdi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Rafique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Saqlain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-7271","authenticated-orcid":false,"given":"Zilong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2026.111888_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.701282","article-title":"Activation of NLRP3 inflammasome and onset of alzheimer's disease","volume":"12","author":"Bai","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.toxlet.2026.111888_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1286546","article-title":"Acacetin inhibits inflammation by blocking MAPK\/NF-kappaB pathways and NLRP3 inflammasome activation","volume":"15","author":"Bu","year":"2024","journal-title":"Front Pharm."},{"issue":"11","key":"10.1016\/j.toxlet.2026.111888_bib3","article-title":"Lycopene maintains mitochondrial homeostasis to counteract the enterotoxicity of deoxynivalenol","volume":"12","author":"Cai","year":"2023","journal-title":"Antioxid. (Basel)"},{"issue":"11","key":"10.1016\/j.toxlet.2026.111888_bib4","article-title":"Heat stress-mediated activation of immune-inflammatory pathways","volume":"10","author":"Cantet","year":"2021","journal-title":"Antibiot. (Basel)"},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.13323","article-title":"Changing climate, shifting mycotoxins: a comprehensive review of climate change impact on mycotoxin contamination","volume":"23","author":"Casu","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41420-024-02082-4","article-title":"Epithelial CEBPD activates fibronectin and enhances macrophage adhesion in renal ischemia-reperfusion injury","volume":"10","author":"Chang","year":"2024","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-022-00961-5","article-title":"Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis","volume":"14","author":"Chen","year":"2022","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.toxlet.2026.111888_bib8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.lfs.2018.10.058","article-title":"Testosterone mediates hyperthermic response of mice to heat exposure","volume":"214","author":"Chen","year":"2018","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.toxlet.2026.111888_bib9","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.3390\/toxins7082845","article-title":"Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent","volume":"7","author":"Clark","year":"2015","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.toxlet.2026.111888_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1173553","article-title":"Occupational heat stress, heat-related effects and the related social and economic loss: a scoping literature review","volume":"11","author":"De Sario","year":"2023","journal-title":"Front Public Health"},{"issue":"29","key":"10.1016\/j.toxlet.2026.111888_bib11","doi-asserted-by":"crossref","first-page":"10901","DOI":"10.1021\/acs.jafc.3c02020","article-title":"Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives","volume":"71","author":"Deng","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41590-021-01091-0","article-title":"Innate immunity: the first line of defense against SARS-CoV-2","volume":"23","author":"Diamond","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.toxlet.2026.111888_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5545193","article-title":"Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway","volume":"2021","author":"Ding","year":"2021","journal-title":"Evid. Based Complement Altern. Med"},{"issue":"4","key":"10.1016\/j.toxlet.2026.111888_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11040395","article-title":"Ferroptosis as a Potential Therapeutic Target of Traditional Chinese Medicine for Mycotoxicosis: A Review","volume":"11","author":"Ding","year":"2023","journal-title":"Toxics"},{"issue":"6","key":"10.1016\/j.toxlet.2026.111888_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/mnfr.200700308","article-title":"Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations","volume":"52","author":"D\u00f6ll","year":"2008","journal-title":"Mol. Nutr. Food Res"},{"issue":"10","key":"10.1016\/j.toxlet.2026.111888_bib16","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1007\/s12011-024-04058-y","article-title":"Silver Nanoparticles Loaded with Oleuropein Reduce Doxorubicin-Induced Testicular Damage by Regulating Endoplasmic Reticulum Stress, and Apoptosis","volume":"202","author":"Erbas","year":"2024","journal-title":"Biol. Trace Elem. Res"},{"issue":"7","key":"10.1016\/j.toxlet.2026.111888_bib17","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00204-019-02470-1","article-title":"Behavioural and metabolomic changes from chronic dietary exposure to low-level deoxynivalenol reveal impact on mouse well-being","volume":"93","author":"Faeste","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41597-022-01777-6","article-title":"Effects of heat stress on 16S rDNA, metagenome and metabolome in Holstein cows at different growth stages","volume":"9","author":"Feng","year":"2022","journal-title":"Sci. Data"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010124","article-title":"Answering the Cell Stress Call: Satellite Non-Coding Transcription as a Response Mechanism","volume":"14","author":"Fonseca-Carvalho","year":"2024","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0278-6915(87)90149-9","article-title":"Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse","volume":"25","author":"Forsell","year":"1987","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2026.111888_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.650292","article-title":"Immune Checkpoint Inhibitor Associated Hepatotoxicity in Primary Liver Cancer Versus Other Cancers: A Systematic Review and Meta-Analysis","volume":"11","author":"Fu","year":"2021","journal-title":"Front Oncol."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41597-024-03612-6","article-title":"A dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq","volume":"11","author":"Gan","year":"2024","journal-title":"Sci. Data"},{"issue":"3","key":"10.1016\/j.toxlet.2026.111888_bib23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/japplphysiol.00220.2018","article-title":"Sex-dependent responses to exertional heat stroke in mice","volume":"125","author":"Garcia","year":"2018","journal-title":"J. Appl. Physiol."},{"issue":"7","key":"10.1016\/j.toxlet.2026.111888_bib24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nm.4346","article-title":"Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling","volume":"23","author":"Giles","year":"2017","journal-title":"Nat. Med"},{"issue":"6","key":"10.1016\/j.toxlet.2026.111888_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph21060808","article-title":"Are Infants and Children at Risk of Adverse Health Effects from Dietary Deoxynivalenol Exposure? An Integrative Review","volume":"21","author":"Gonya","year":"2024","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.toxlet.2026.111888_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1571406","article-title":"Role of MAPKs in HSP70's Protection against Heat Stress-Induced Injury in Rat Small Intestine","volume":"2018","author":"Hao","year":"2018","journal-title":"Biomed. Res Int"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib27","doi-asserted-by":"crossref","first-page":"7020","DOI":"10.1038\/s41598-017-06017-1","article-title":"Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats","volume":"7","author":"Hou","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.toxlet.2026.111888_bib28","article-title":"Selenomethionine Alleviates Deoxynivalenol-Induced Oxidative Injury in Porcine Intestinal Epithelial Cells Independent of MAPK Pathway Regulation","volume":"13","author":"Huang","year":"2024","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib29","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1038\/s41598-022-09119-7","article-title":"vitro culture at 39 \u00b0 C during hepatic maturation of human ES cells facilitates hepatocyte-like cell functions","volume":"12","author":"Imamura","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2026.111888_bib30","first-page":"11","article-title":"Camel Whey Protein Attenuates Acute Heat Stress-Induced Kidney Injury in Rats by Up-Regulating CYP2J Activity and Activating PI3K\/AKT\/eNOS to Inhibit Oxidative Stress","volume":"11","author":"Jing","year":"2024","journal-title":"Vet. Sci."},{"issue":"4","key":"10.1016\/j.toxlet.2026.111888_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15040300","article-title":"Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells","volume":"15","author":"Kang","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"12","key":"10.1016\/j.toxlet.2026.111888_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11120727","article-title":"Co-occurrence of DON and Emerging Mycotoxins in Worldwide Finished Pig Feed and Their Combined Toxicity in Intestinal Cells","volume":"11","author":"Khoshal","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.toxlet.2026.111888_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4142\/jvs.2008.9.3.257","article-title":"Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication","volume":"9","author":"Kim","year":"2008","journal-title":"J. Vet. Sci."},{"issue":"11","key":"10.1016\/j.toxlet.2026.111888_bib34","doi-asserted-by":"crossref","first-page":"20240","DOI":"10.3390\/molecules201119692","article-title":"Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats","volume":"20","author":"Kim","year":"2015","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12550-021-00425-z","article-title":"A preliminary study on changes in heat shock protein 70 levels induced by Fusarium mycotoxins in rats: in vivo study","volume":"37","author":"K\u00f3cs\u00f3","year":"2021","journal-title":"Mycotoxin Res."},{"key":"10.1016\/j.toxlet.2026.111888_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/ijpvm.IJPVM_427_20","article-title":"Obesity and Stress: A Contingent Paralysis","volume":"13","author":"Kumar","year":"2022","journal-title":"Int J. Prev. Med"},{"issue":"5","key":"10.1016\/j.toxlet.2026.111888_bib37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1042\/EBC20220221","article-title":"Diverse mycotoxin threats to safe food and feed cereals","volume":"67","author":"Latham","year":"2023","journal-title":"Essays Biochem"},{"issue":"5","key":"10.1016\/j.toxlet.2026.111888_bib38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s12192-014-0495-6","article-title":"Upregulation of heat shock protein 32 with hemin alleviates acute heat-induced hepatic injury in mice","volume":"19","author":"Li","year":"2014","journal-title":"Cell Stress Chaperon-.-."},{"key":"10.1016\/j.toxlet.2026.111888_bib39","article-title":"A predictive model on deoxynivalenol in harvested wheat in China: Revealing the impact of the environment and agronomic practicing","author":"Li","year":"2023","journal-title":"Food Chem. 405(Pt A)"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12576-011-0183-6","article-title":"Systematical analysis of impacts of heat stress on the proliferation, apoptosis and metabolism of mouse hepatocyte","volume":"62","author":"Li","year":"2012","journal-title":"J. Physiol. Sci."},{"issue":"12","key":"10.1016\/j.toxlet.2026.111888_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33326","article-title":"Predictive value of hematocrit, serum albumin level difference, and fibrinogen-to-albumin ratio for COVID-19-associated acute respiratory failure","volume":"10","author":"Liang","year":"2024","journal-title":"Heliyon"},{"issue":"7","key":"10.1016\/j.toxlet.2026.111888_bib42","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.104143","article-title":"The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms","volume":"11","author":"Liao","year":"2024","journal-title":"Vet. Sci."},{"key":"10.1016\/j.toxlet.2026.111888_bib43","article-title":"The Role of Key Molecules of Pyroptosis in Liver Damage of Rats With Exertional Heat Stroke","volume":"2025","author":"Lin","year":"2025","journal-title":"Gastroenterol. Res Pr."},{"issue":"7","key":"10.1016\/j.toxlet.2026.111888_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107022","article-title":"Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats","volume":"26","author":"Liu","year":"2023","journal-title":"iScience"},{"issue":"22","key":"10.1016\/j.toxlet.2026.111888_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223579","article-title":"S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression","volume":"11","author":"Liu","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.toxlet.2026.111888_bib46","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/mrd.22844","article-title":"Heat stress in pregnant sows: Thermal responses and subsequent performance of sows and their offspring","volume":"84","author":"Lucy","year":"2017","journal-title":"Mol. Reprod. Dev."},{"issue":"4","key":"10.1016\/j.toxlet.2026.111888_bib47","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3892\/etm.2022.11229","article-title":"Rosiglitazone ameliorates acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome","volume":"23","author":"Ma","year":"2022","journal-title":"Exp. Ther. Med"},{"issue":"20","key":"10.1016\/j.toxlet.2026.111888_bib48","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1007\/s00216-015-8793-0","article-title":"Critical evaluation of indirect methods for the determination of deoxynivalenol and its conjugated forms in cereals","volume":"407","author":"Malachov\u00e1","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"issue":"8","key":"10.1016\/j.toxlet.2026.111888_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084244","article-title":"Implications of Sphingolipid Metabolites in Kidney Diseases","volume":"23","author":"Mallela","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.toxlet.2026.111888_bib50","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/acs.chemrestox.4c00066","article-title":"Deoxynivalenol Induces Drp-1-Mediated Mitochondrial Dysfunction via Elevating Oxidative Stress","volume":"37","author":"Mishra","year":"2024","journal-title":"Chem. Res Toxicol."},{"key":"10.1016\/j.toxlet.2026.111888_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2025.102350","article-title":"Mycotoxins: A comprehensive review of its global trends in major cereals, advancements in chromatographic detections and future prospectives","volume":"27","author":"Niaz","year":"2025","journal-title":"Food Chem. X"},{"key":"10.1016\/j.toxlet.2026.111888_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2021.103077","article-title":"Environmental stress and livestock productivity in hot-humid tropics: Alleviation and future perspectives","volume":"100","author":"Oke","year":"2021","journal-title":"J. Therm. Biol."},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14020102","article-title":"Prevalence of Fusarium fungi and Deoxynivalenol Levels in Winter Wheat Grain in Different Climatic Regions of Poland","volume":"14","author":"Okorski","year":"2022","journal-title":"Toxins (Basel)"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib54","first-page":"117","article-title":"Sex discrepancy in establishing mouse visceral obesity model induced by high-fat diet","volume":"52","author":"Peng","year":"2023","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban."},{"issue":"5","key":"10.1016\/j.toxlet.2026.111888_bib55","first-page":"623","article-title":"Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice","volume":"23","author":"Peng","year":"2020","journal-title":"Iran. J. Basic Med Sci."},{"issue":"8","key":"10.1016\/j.toxlet.2026.111888_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9080240","article-title":"Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse","volume":"9","author":"Pestka","year":"2017","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.toxlet.2026.111888_bib57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jemt.10341","article-title":"Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production","volume":"61","author":"Pignatelli","year":"2003","journal-title":"Microsc. Res Tech."},{"issue":"3","key":"10.1016\/j.toxlet.2026.111888_bib58","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12088-021-00948-0","article-title":"Effects of Heat Stress on Gut Microbiome in Rats","volume":"61","author":"Qu","year":"2021","journal-title":"Indian J. Microbiol"},{"key":"10.1016\/j.toxlet.2026.111888_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112333","article-title":"Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice","volume":"220","author":"Rajput","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.toxlet.2026.111888_bib60","doi-asserted-by":"crossref","first-page":"F1111","DOI":"10.1152\/ajprenal.00259.2019","article-title":"Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure","volume":"317","author":"Sato","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12882-019-1306-1","article-title":"Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study","volume":"20","author":"Seki","year":"2019","journal-title":"BMC Nephrol."},{"issue":"7575","key":"10.1016\/j.toxlet.2026.111888_bib62","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"7521","key":"10.1016\/j.toxlet.2026.111888_bib63","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.toxlet.2026.111888_bib64","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s00204-022-03337-8","article-title":"Toxicokinetics and metabolism of deoxynivalenol in animals and humans","volume":"96","author":"Sun","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib65","article-title":"Effect of Yeast Culture (Saccharomyces cerevisiae) on Broilers: A Preliminary Study on the Effective Components of Yeast Culture","volume":"10","author":"Sun","year":"2019","journal-title":"Anim. (Basel)"},{"issue":"4","key":"10.1016\/j.toxlet.2026.111888_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15040286","article-title":"Two-Step Epimerization of Deoxynivalenol by Quinone-Dependent Dehydrogenase and Candida parapsilosis ACCC 20221","volume":"15","author":"Tang","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"10","key":"10.1016\/j.toxlet.2026.111888_bib67","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.4251\/wjgo.v14.i10.1933","article-title":"VCAN, expressed highly in hepatitis B virus-induced hepatocellular carcinoma, is a potential biomarker for immune checkpoint inhibitors","volume":"14","author":"Wang","year":"2022","journal-title":"World J. Gastrointest. Oncol."},{"issue":"12","key":"10.1016\/j.toxlet.2026.111888_bib68","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11120733","article-title":"Deoxynivalenol Induces Inflammatory Injury in IPEC-J2 Cells via NF-kappaB Signaling Pathway","volume":"11","author":"Wang","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.toxlet.2026.111888_bib69","article-title":"Construction of diagnostic prediction model for Wilson's disease","volume":"9","author":"Wang","year":"2022","journal-title":"Front Surg."},{"issue":"8","key":"10.1016\/j.toxlet.2026.111888_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/toxins16080353","article-title":"Investigation of Deoxynivalenol Contamination in Local Area and Evaluation of Its Multiple Intestinal Toxicity","volume":"16","author":"Wang","year":"2024","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.toxlet.2026.111888_bib71","article-title":"Characteristics of menstrual cycle disorder and saliva metabolomics of young women in a high-temperature environment","volume":"13","author":"Wei","year":"2022","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib72","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s40104-024-01107-3","article-title":"The assembly and activation of the PANoptosome promote porcine granulosa cell programmed cell death during follicular atresia","volume":"15","author":"Wu","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"4","key":"10.1016\/j.toxlet.2026.111888_bib73","article-title":"Effects of Phytosterol Ester Supplementation on Egg Characteristics, Eggshell Ultrastructure, Antioxidant Capacity, Liver Function and Hepatic Metabolites of Laying Hens during Peak Laying Period","volume":"13","author":"Wu","year":"2024","journal-title":"Antioxid. (Basel)"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/toxins16010014","article-title":"Bacillus amyloliquefaciens B10 Alleviates the Immunosuppressive Effects of Deoxynivalenol and Porcine Circovirus Type 2 Infection","volume":"16","author":"Xiao","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"21","key":"10.1016\/j.toxlet.2026.111888_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/foods13213373","article-title":"Total Deoxynivalenol Contamination of Wheat Products and Coarse Grains in Shanghai, China: Occurrence and Health Risk Assessment","volume":"13","author":"Xu","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.toxlet.2026.111888_bib76","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5974157","article-title":"Comparative Transcriptome Analysis Reveals the Protective Mechanism of Glycyrrhinic Acid for Deoxynivalenol-Induced Inflammation and Apoptosis in IPEC-J2 Cells","volume":"2020","author":"Xu","year":"2020","journal-title":"Oxid. Med Cell Longev."},{"issue":"21","key":"10.1016\/j.toxlet.2026.111888_bib77","first-page":"5936","article-title":"Effects of Gukang Capsules on activity and protein expression of hepatic cytochrome P450 enzymes in rats","volume":"47","author":"Yang","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib78","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-022-00906-9","article-title":"HDAC11 promotes both NLRP3\/caspase-1\/GSDMD and caspase-3\/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells","volume":"8","author":"Yao","year":"2022","journal-title":"Cell Death Discov."},{"issue":"11","key":"10.1016\/j.toxlet.2026.111888_bib79","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.3390\/ijms9112062","article-title":"Fumonisins, trichothecenes and zearalenone in cereals","volume":"9","author":"Yazar","year":"2008","journal-title":"Int J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.toxlet.2026.111888_bib80","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911198","article-title":"Effects of Dietary Glycinin on Oxidative Damage, Apoptosis and Tight Junction in the Intestine of Juvenile Hybrid Yellow Catfish, Pelteobagrus fulvidraco female symbol x Pelteobaggrus vachelli male symbol","volume":"23","author":"Yi","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2026.111888_bib81","article-title":"Leveraging SOLOv2 model to detect heat stress of poultry in complex environments","volume":"9","author":"Yu","year":"2022","journal-title":"Front Vet. Sci."},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010054","article-title":"Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells","volume":"15","author":"Yun","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.toxlet.2026.111888_bib83","doi-asserted-by":"crossref","first-page":"84","DOI":"10.21037\/cdt-23-142","article-title":"NOX4 aggravates doxorubicin-induced cardiomyocyte pyroptosis by increasing reactive oxygen species content and activating the NLRP3 inflammasome","volume":"14","author":"Zeng","year":"2024","journal-title":"Cardiovasc Diagn. Ther."},{"key":"10.1016\/j.toxlet.2026.111888_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114655","article-title":"Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE\/TLR4-NF-\u03baB signaling pathway","volume":"253","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2026.111888_bib85","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fcell.2019.00379","article-title":"Effect and Regulation of the NLRP3 Inflammasome During Renal Fibrosis","volume":"7","author":"Zhang","year":"2019","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.toxlet.2026.111888_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.775526","article-title":"The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.toxlet.2026.111888_bib87","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jcmgh.2021.04.009","article-title":"Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis","volume":"12","author":"Zhu","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.toxlet.2026.111888_bib88","article-title":"Advances in the Effects of Heat Stress on Ovarian Granulosa Cells: Unveiling Novel Ferroptosis Pathways","volume":"11","author":"Zhu","year":"2024","journal-title":"Vet. Sci."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426000718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426000718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:20:59Z","timestamp":1776752459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427426000718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":88,"alternative-id":["S0378427426000718"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.111888","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deoxynivalenol-induced hepatic and renal injury via pyroptosis under heat stress conditions","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.111888","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111888"}}