{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:00:54Z","timestamp":1786118454479,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.toxlet.2026.113163","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:36:50Z","timestamp":1783985810000},"page":"113163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fenazaquin impairs liver development and metabolic homeostasis in zebrafish (Danio rerio) by disrupting glucose and lipid metabolism"],"prefix":"10.1016","volume":"423","author":[{"given":"Jingwen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-4158","authenticated-orcid":false,"given":"Tingzhang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2026.113163_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1189\/jlb.1VMR1216-535R","article-title":"Energy metabolic pathways control the fate and function of myeloid immune cells","volume":"102","author":"Al-Khami","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.toxlet.2026.113163_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114470","article-title":"Environmental stressors differentially modulate anxiety-like behaviour in male and female zebrafish","volume":"450","author":"Amar","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.toxlet.2026.113163_bib3","first-page":"976","article-title":"The Role of Mitochondrial Complexes in Liver Diseases","volume":"13","author":"An","year":"2025","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.toxlet.2026.113163_bib4","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.bbabio.2012.03.019","article-title":"Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio)","volume":"1817","author":"Artuso","year":"2012","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Bioenerg."},{"key":"10.1016\/j.toxlet.2026.113163_bib5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin. Sci."},{"key":"10.1016\/j.toxlet.2026.113163_bib6","first-page":"1512","article-title":"The effects of Spiromesifen on life history traits and demographic parameters of predatory mite Neoseiulus californicus (Acari: Phytoseiidae) and its prey Tetranychus urticae Koch (Acari: Tetranychidae)","volume":"24","author":"Bozhgani","year":"2019","journal-title":"Syst. Appl. Acarol."},{"key":"10.1016\/j.toxlet.2026.113163_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.gene.2018.05.019","article-title":"Molecular characterization of elongase of very long-chain fatty acids 6 (elovl6) genes in Misgurnus anguillicaudatus and their potential roles in adaptation to cold temperature","volume":"666","author":"Chen","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.toxlet.2026.113163_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134838","article-title":"Parental exposure to waterborne selenite induces transgenerational development toxicity in zebrafish offspring","volume":"303","author":"Cheng","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2026.113163_bib9","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.3390\/ijms20153751","article-title":"New insights about the Wnt\/\u03b2-catenin signaling pathway in primary bone tumors and their microenvironment: a promising target to develop therapeutic strategies?","volume":"20","author":"Danieau","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.toxlet.2026.113163_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/1062936X.2019.1699602","article-title":"QSPR studies on water solubility, octanol-water partition coefficient and vapour pressure of pesticides","volume":"31","author":"Duchowicz","year":"2020","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.toxlet.2026.113163_bib11","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00128-011-0318-8","article-title":"Degradation studies of fenazaquin in soil under field and laboratory conditions","volume":"87","author":"Duhan","year":"2011","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113163_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108555","article-title":"Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron","volume":"26","author":"Fisher","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.toxlet.2026.113163_bib13","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fphar.2025.1558726","article-title":"Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection","volume":"16","author":"Fonseca","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.toxlet.2026.113163_bib14","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s00128-021-03254-z","article-title":"Pesticide mixtures in the water-column versus bottom-sediments of prairie rivers","volume":"106","author":"Gamhewage","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113163_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127061","article-title":"LncHLEF promotes hepatic lipid synthesis through miR-2188-3p\/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome","volume":"253","author":"Guo","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.toxlet.2026.113163_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1042\/bst0220230","article-title":"New inhibitors of complex I of the mitochondrial electron transport chain with activity as pesticides","volume":"22","author":"Hollingworth","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.toxlet.2026.113163_bib17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1124\/dmd.123.001279","article-title":"Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress","volume":"52","author":"Jaeschke","year":"2024","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.toxlet.2026.113163_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7272808","article-title":"Toxicity assessment of herbal medicine using zebrafish embryos: A systematic review","volume":"2019","author":"Jayasinghe","year":"2019","journal-title":"Evid. -Based Complement. Altern. Med."},{"key":"10.1016\/j.toxlet.2026.113163_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111345","article-title":"G6PD facilitates axon regeneration via clathrin-mediated endocytosis","volume":"302","author":"Jiang","year":"2026","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.toxlet.2026.113163_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.cell.2013.04.041","article-title":"Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos","volume":"153","author":"Jiang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.toxlet.2026.113163_bib21","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1080\/03067319.2020.1738416","article-title":"Dissipation kinetics of fenazaquin residues in okra and soil under subtropical conditions of Punjab, India","volume":"102","author":"Kaur","year":"2022","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"10.1016\/j.toxlet.2026.113163_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.fct.2003.10.004","article-title":"Investigation in tea on fate of fenazaquin residue and its transfer in brew","volume":"42","author":"Kumar","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113163_bib23","first-page":"520","article-title":"A case of fatal fenazaquin intoxication showing severe lactic acidosis","volume":"21","author":"Lee","year":"2010","journal-title":"J. Korean Soc. Emerg. Med."},{"key":"10.1016\/j.toxlet.2026.113163_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217068","article-title":"PROX1 drives neuroendocrine plasticity and liver metastases in prostate cancer","volume":"597","author":"Liu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.toxlet.2026.113163_bib25","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/s41388-017-0070-6","article-title":"Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma","volume":"37","author":"Liu","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.toxlet.2026.113163_bib26","doi-asserted-by":"crossref","DOI":"10.1051\/rnd:19960402","article-title":"Role of glucokinase and glucose-6 phosphatase in the nutritional regulation of endogenous glucose production","author":"Mithieux","year":"1996","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.toxlet.2026.113163_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.7570\/jomes.2017.26.2.86","article-title":"The roles of the gut microbiota and toll-like receptors in obesity and nonalcoholic fatty liver disease","volume":"26","author":"Miura","year":"2017","journal-title":"J. Obes. Metab. Syndr."},{"key":"10.1016\/j.toxlet.2026.113163_bib28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cmet.2018.07.001","article-title":"Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome","volume":"28","author":"Natividad","year":"2018","journal-title":"Cell. Metab."},{"key":"10.1016\/j.toxlet.2026.113163_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2008.06.040","article-title":"Organ-specific requirements for Hdac1 in liver and pancreas formation","volume":"322","author":"No\u00ebl","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.toxlet.2026.113163_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0021859605005708","article-title":"Crop losses to pests","volume":"144","author":"Oerke","year":"2006","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.toxlet.2026.113163_bib31","doi-asserted-by":"crossref","first-page":"S374","DOI":"10.1016\/j.toxlet.2025.07.865","article-title":"P30-02 Recent developments in the assessment of neurodegenerative toxicity \u2013 an adverse outcome pathway (AOP)-based literature case study with fenazaquin","volume":"411","author":"Pieper","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.toxlet.2026.113163_bib32","article-title":"Phosphoenolpyruvate carboxykinase. I. Its ce:role in gluconeogenesis","author":"Richard","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.toxlet.2026.113163_bib33","article-title":"Impact of increasing temperatures on neuroendocrine and molecular responses of skeletal muscle and liver in fish: A comprehensive review","volume":"39","author":"S\u00e1ez-Arteaga","year":"2024","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.toxlet.2026.113163_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094482","article-title":"Pesticide residues and bees \u2013 a risk assessment","volume":"9","author":"Sanchez-Bayo","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.toxlet.2026.113163_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biocon.2019.01.020","article-title":"Worldwide decline of the entomofauna: A review of its drivers","volume":"232","author":"S\u00e1nchez-Bayo","year":"2019","journal-title":"Biol. Conserv."},{"key":"10.1016\/j.toxlet.2026.113163_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10695-011-9519-7","article-title":"Effects of Haematococcus pluvialis supplementation on antioxidant system and metabolism in rainbow trout (Oncorhynchus mykiss)","volume":"38","author":"Sheikhzadeh","year":"2012","journal-title":"Fish. Physiol. Biochem."},{"key":"10.1016\/j.toxlet.2026.113163_bib37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0261-2194(93)90043-I","article-title":"Fenazaquin, a selective acaricide for use in IPM in apple in the UK","volume":"12","author":"Solomon","year":"1993","journal-title":"Crop. Prot."},{"key":"10.1016\/j.toxlet.2026.113163_bib38","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/brv.12140","article-title":"The return of metabolism: biochemistry and physiology of the pentose phosphate pathway","volume":"90","author":"Stincone","year":"2015","journal-title":"Biol. Rev."},{"key":"10.1016\/j.toxlet.2026.113163_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106500","article-title":"Typical herbicide residues, trophic transfer, bioconcentration, and health risk of marine organisms","volume":"152","author":"Supe Tulcan","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.toxlet.2026.113163_bib40","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/ijerph18020468","article-title":"Pesticides in drinking water\u2014a review","volume":"18","author":"Syafrudin","year":"2021","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.toxlet.2026.113163_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nclimate3374","article-title":"Rapid adaptive responses to climate change in corals","volume":"7","author":"Torda","year":"2017","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.toxlet.2026.113163_bib42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1021\/acs.chemrestox.6c00030","article-title":"Drug-induced liver injury: mitochondrial mechanisms, biomarkers, and emerging therapeutic strategies","volume":"39","author":"Verma","year":"2026","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113163_bib43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fct.2009.11.036","article-title":"A high intake of conjugated linoleic acid does not affect liver and kidney function tests in healthy human subjects","volume":"48","author":"Wanders","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113163_bib44","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1038\/s41467-022-34747-y","article-title":"AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.toxlet.2026.113163_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142207","article-title":"Toxic effects of acaricide fenazaquin on development, hemolymph metabolome, and gut microbiome of honeybee (Apis mellifera) larvae","volume":"358","author":"Wu","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.toxlet.2026.113163_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119547","article-title":"The nematode perspective: Caenorhabditis elegans as a versatile biosensor for pesticide toxicity and mechanistic studies","volume":"309","author":"Xu","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2026.113163_bib47","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.fsi.2022.10.022","article-title":"Atrazine exposure induces necroptosis through the P450\/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)","volume":"131","author":"Xu","year":"2022","journal-title":"Fish. & Shellfish. Immunol."},{"key":"10.1016\/j.toxlet.2026.113163_bib48","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1242\/dev.129.9.2233","article-title":"GATA6 regulates differentiation of distal lung epithelium","volume":"129","author":"Yang","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.toxlet.2026.113163_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2021.101415","article-title":"Residual fate of fenazaquin (10EC) in apple fruit and soil","volume":"33","author":"Yaqoob","year":"2021","journal-title":"J. King Saud. Univ. -Sci."},{"key":"10.1016\/j.toxlet.2026.113163_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13527","article-title":"Suppression of SLC39A6-CREB1 axis in liver cancer causes PCK1-mediated mitochondrial dysfunction","volume":"56","author":"Yu","year":"2023","journal-title":"Cell. Prolif."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426013469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426013469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:05:00Z","timestamp":1786032300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427426013469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":50,"alternative-id":["S0378427426013469"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.113163","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenazaquin impairs liver development and metabolic homeostasis in zebrafish (Danio rerio) by disrupting glucose and lipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.113163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113163"}}