{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:11:35Z","timestamp":1788621095186,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX24_3540"],"award-info":[{"award-number":["KYCX24_3540"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302452"],"award-info":[{"award-number":["81302452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["14B14"],"award-info":[{"award-number":["14B14"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["BK20221374"],"award-info":[{"award-number":["BK20221374"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016103","name":"Major Projects of Natural Sciences of University in Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Letters"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.toxlet.2026.113178","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T14:12:18Z","timestamp":1786889538000},"page":"113178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hijacked pathways: PFOS, the ATF2\/WT1 axis, and the mitochondrial dysfunction in Sertoli cells"],"prefix":"10.1016","volume":"424","author":[{"given":"Jinchen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianlian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianglin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxlet.2026.113178_bib1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00018-012-1079-1","article-title":"Hormonal control of Sertoli cell metabolism regulates spermatogenesis","volume":"70","author":"Alves","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.toxlet.2026.113178_bib2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00204-017-2091-x","article-title":"The effects of the obesogen tributyltin on the metabolism of Sertoli cells cultured ex vivo","volume":"92","author":"Cardoso","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","article-title":"Mitochondria as signaling organelles control mammalian stem cell fate","volume":"28","author":"Chakrabarty","year":"2021","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.toxlet.2026.113178_bib4","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.molcel.2025.03.003","article-title":"Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis","volume":"85","author":"Chen","year":"2025","journal-title":"Mol. Cell."},{"key":"10.1016\/j.toxlet.2026.113178_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/biolre\/ioac050","article-title":"The functions of Wt1 in mouse gonad development and somatic cells differentiation","volume":"107","author":"Chen","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.toxlet.2026.113178_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf018","article-title":"edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets","volume":"53","author":"Chen","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"22","key":"10.1016\/j.toxlet.2026.113178_bib7","doi-asserted-by":"crossref","first-page":"21713","DOI":"10.1007\/s11356-018-2138-4","article-title":"Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways [J]","volume":"25","author":"Chen","year":"2018","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.toxlet.2026.113178_bib8","doi-asserted-by":"crossref","first-page":"F245","DOI":"10.1152\/ajprenal.00207.2022","article-title":"WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis","volume":"324","author":"Dickinson","year":"2023","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.toxlet.2026.113178_bib9","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/cns.13435","article-title":"Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats","volume":"26","author":"Ding","year":"2020","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.toxlet.2026.113178_bib10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00204-009-0424-0","article-title":"Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL\/6 mice","volume":"83","author":"Dong","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.reprotox.2010.05.010","article-title":"Effects of PFNA exposure on expression of junction-associated molecules and secretory function in rat Sertoli cells","volume":"30","author":"Feng","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/srep38039","article-title":"Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2026.113178_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101955","article-title":"Mitochondrial dysfunction in aging","volume":"88","author":"Guo","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.toxlet.2026.113178_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104903","article-title":"Folpet induces mitochondrial dysfunction and ROS-mediated apoptosis in mouse Sertoli cells","volume":"177","author":"Ham","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.toxlet.2026.113178_bib15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0960-0760(92)90307-5","article-title":"Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis","volume":"43","author":"Hanukoglu","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.toxlet.2026.113178_bib16","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1124\/dmd.122.001186","article-title":"Drug transporters at the human blood-testis barrier","volume":"51","author":"Hau","year":"2023","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.toxlet.2026.113178_bib17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1530\/REP-07-0133","article-title":"Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis","volume":"134","author":"Hu","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.toxlet.2026.113178_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118960","article-title":"Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal\/miR-9-3p downregulating StAR expression in Leydig cells","volume":"301","author":"Huang","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxlet.2026.113178_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118960","article-title":"Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal\/miR-9-3p downregulating StAR expression in Leydig cells","volume":"301","author":"Huang","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.toxlet.2026.113178_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113822","article-title":"Nonylphenol inhibited HIF-1alpha regulated aerobic glycolysis and induced ROS mediated apoptosis in rat Sertoli cells","volume":"241","author":"Jiang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2026.113178_bib21","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxlet.2026.113178_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.854120","article-title":"WT1 in Adipose Tissue: From Development to Adult Physiology","volume":"10","author":"Kirschner","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"10.1016\/j.toxlet.2026.113178_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115231","article-title":"Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.toxlet.2026.113178_bib24","article-title":"Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.toxlet.2026.113178_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156881","article-title":"Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity","volume":"844","author":"Li","year":"2022","journal-title":"Sci. Total. Environ."},{"issue":"7","key":"10.1016\/j.toxlet.2026.113178_bib26","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/tox.22556","article-title":"Fine particle matter disrupts the blood-testis barrier by activating TGF-\u03b23\/p38 MAPK pathway and decreasing testosterone secretion in rat","volume":"33","author":"Liu","year":"2018","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.toxlet.2026.113178_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175136","article-title":"MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1\/Parkin pathway-mediated mitophagy","volume":"929","author":"Liu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.toxlet.2026.113178_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104988","article-title":"Perfluorooctane sulfonate induced toxicity in embryonic stem cell-derived cardiomyocytes via inhibiting autophagy-lysosome pathway","volume":"69","author":"Liu","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.toxlet.2026.113178_bib29","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00204-015-1492-y","article-title":"Perfluorooctanoic acid disrupts the blood\u2013testis barrier and activates the TNF\u03b1\/p38 MAPK signaling pathway in vivo and in vitro","volume":"90","author":"Lu","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib30","article-title":"Wt1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium","volume":"149","author":"Marques","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.toxlet.2026.113178_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.toxlet.2026.113178_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104673","article-title":"Technical-grade chlordane compromises rat Sertoli cells proliferation, viability and metabolic activity","volume":"63","author":"Moreira","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.toxlet.2026.113178_bib33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2021.06.016","article-title":"Sertoli cells as key drivers of testis function","volume":"121","author":"O'Donnell","year":"2022","journal-title":"Semin. Cell. Dev. Biol."},{"key":"10.1016\/j.toxlet.2026.113178_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2016.11.003","article-title":"Perfluorooctane sulfonate (PFOS) disrupts blood-testis barrier by down-regulating junction proteins via p38 MAPK\/ATF2\/MMP9 signaling pathway","volume":"373","author":"Qiu","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.toxlet.2026.113178_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/toxsci\/kft129","article-title":"Sertoli cell is a potential target for perfluorooctane sulfonate-induced reproductive dysfunction in male mice","volume":"135","author":"Qiu","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2026.113178_bib36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrurol.2012.77","article-title":"Metabolic regulation is important for spermatogenesis","volume":"9","author":"Rato","year":"2012","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.toxlet.2026.113178_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.toxlet.2026.113178_bib38","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/66.2.244","article-title":"Structural determinants of fluorochemical-induced mitochondrial dysfunction","volume":"66","author":"Starkov","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.toxlet.2026.113178_bib39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.toxlet.2026.113178_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112183","article-title":"Flurochloridone induces Sertoli cell apoptosis through ROS-dependent mitochondrial pathway","volume":"216","author":"Sun","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2026.113178_bib41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.chest.2019.08.2182","article-title":"Mitochondria and Critical Illness","volume":"157","author":"Supinski","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.toxlet.2026.113178_bib42","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.sjbs.2021.12.012","article-title":"Pachypodol attenuates Perfluorooctane sulphonate-induced testicular damage by reducing oxidative stress","volume":"29","author":"Umar Ijaz","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.toxlet.2026.113178_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114662","article-title":"Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure","volume":"253","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.toxlet.2026.113178_bib44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.reprotox.2020.05.017","article-title":"Actin binding proteins, actin cytoskeleton and spermatogenesis - Lesson from toxicant models","volume":"96","author":"Wang","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.theriogenology.2019.07.007","article-title":"Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway","volume":"138","author":"Wang","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.toxlet.2026.113178_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003645","article-title":"The Wilms tumor gene, Wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS. Genet."},{"key":"10.1016\/j.toxlet.2026.113178_bib47","doi-asserted-by":"crossref","first-page":"10030","DOI":"10.7150\/thno.66819","article-title":"hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8\/9","volume":"11","author":"Wen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.toxlet.2026.113178_bib48","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tips.2011.01.001","article-title":"Impacts of environmental toxicants on male reproductive dysfunction","volume":"32","author":"Wong","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.toxlet.2026.113178_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134994","article-title":"Mitochondrial toxicity of nanomaterials","volume":"702","author":"Wu","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.toxlet.2026.113178_bib50","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/jcb.30458","article-title":"The emerging era of lactate: A rising star in cellular signaling and its regulatory mechanisms","volume":"124","author":"Wu","year":"2023","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.toxlet.2026.113178_bib51","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biocel.2011.01.008","article-title":"c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes","volume":"43","author":"Xiao","year":"2011","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.toxlet.2026.113178_bib52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/bcpt.13306","article-title":"Reactive oxygen species, not Ca(2+), mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line","volume":"126","author":"Xiong","year":"2020","journal-title":"Basic. Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib53","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1111\/andr.13288","article-title":"TGF-\u03b23 induces lactate production in Sertoli cell through inhibiting the Notch pathway","volume":"10","author":"Xu","year":"2022","journal-title":"Andrology"},{"key":"10.1016\/j.toxlet.2026.113178_bib54","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jare.2025.06.037","article-title":"Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism","volume":"81","author":"Yang","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.toxlet.2026.113178_bib55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/14737159.2021.1924060","article-title":"Common markers of testicular Sertoli cells","volume":"21","author":"You","year":"2021","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.toxlet.2026.113178_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6625952","article-title":"ROS-Triggered Autophagy Is Involved in PFOS-Induced Apoptosis of Human Embryo Liver L-02 Cells","volume":"2021","author":"Zeng","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.toxlet.2026.113178_bib57","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/tox.20723","article-title":"PFOS and PCB 153 have direct adverse effects on neonatal testis modeled using a coculture of primary gonocyte and sertoli cells","volume":"28","author":"Zhang","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.toxlet.2026.113178_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103236","article-title":"The role of ANXA5 in DBP-induced oxidative stress through ERK\/Nrf2 pathway","volume":"72","author":"Zhang","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.toxlet.2026.113178_bib59","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.toxlet.2026.113178_bib60","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1021\/es4057467","article-title":"Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China","volume":"48","author":"Zhou","year":"2014","journal-title":"Environ. Sci. Technol."}],"container-title":["Toxicology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426013615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378427426013615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:16:49Z","timestamp":1788617809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378427426013615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":60,"alternative-id":["S0378427426013615"],"URL":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.113178","relation":{},"ISSN":["0378-4274"],"issn-type":[{"value":"0378-4274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hijacked pathways: PFOS, the ATF2\/WT1 axis, and the mitochondrial dysfunction in Sertoli cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxlet.2026.113178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113178"}}