{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:42:55Z","timestamp":1773416575468,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology Reports"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1016\/j.toxrep.2015.05.001","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T01:00:35Z","timestamp":1431392435000},"page":"654-663","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["The teratogenic effects of imatinib mesylate on rat fetuses"],"prefix":"10.1016","volume":"2","author":[{"given":"M.M.","family":"El Gendy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Kandil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Helal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Zahou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.toxrep.2015.05.001_bib0230","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00404-007-0547-6","article-title":"Pregnancy complicated with chronic myelogeneous leukemia (cml) successfully treated with imatinib: a case report","volume":"278","author":"Buyukbayrak","year":"2008","journal-title":"Arch. Gynecol. Obstet."},{"issue":"1","key":"10.1016\/j.toxrep.2015.05.001_bib0235","first-page":"47","article-title":"A cancer disease: a review","volume":"3","author":"Nishanthi","year":"2013","journal-title":"Asian J. Pharm. Res."},{"issue":"9","key":"10.1016\/j.toxrep.2015.05.001_bib0240","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer is a preventable disease that requires major lifestyle changes","volume":"25","author":"Anand","year":"2008","journal-title":"Pharm. Res."},{"issue":"15","key":"10.1016\/j.toxrep.2015.05.001_bib0245","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra020777","article-title":"Chronic myeloid leukemia advances in biology and new approaches treatment","volume":"349","author":"Goldman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0250","first-page":"2640","volume":"105","author":"Deininger","year":"2005","journal-title":"The development of imatinib as a therapeutic agent for chronic myeloid leukemia"},{"issue":"2","key":"10.1016\/j.toxrep.2015.05.001_bib0255","first-page":"117","article-title":"A comprehensive review of imatinib mesylate (Gleevec) for dermatological diseases","volume":"5","author":"Scheinfeld","year":"2006","journal-title":"J. Drugs Dermatol."},{"issue":"22","key":"10.1016\/j.toxrep.2015.05.001_bib0260","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood.V114.22.1126.1126","article-title":"International randomized study of interferon vs sti571 (iris) 8-year follow-up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib","volume":"114","author":"Deininger","year":"2009","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.toxrep.2015.05.001_bib0265","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.toxrep.2015.05.001_bib0270","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1634\/theoncologist.9-3-271","article-title":"Indications for imatinib mesylate therapy and clinical management","volume":"9","author":"Guilhot","year":"2004","journal-title":"Oncologist"},{"issue":"2","key":"10.1016\/j.toxrep.2015.05.001_bib0275","first-page":"114","article-title":"Pregnancy outcome of two patients with chronic myelogenous leukemia treated with imatinib","volume":"33","author":"Mashhadi","year":"2008","journal-title":"Iran. J. Med. Sci."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0280","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0031-9384(84)90014-3","article-title":"Four- versus five-day estrous cycles in rats: vaginal cycling and pregnancy","volume":"33","author":"Matthews","year":"1984","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0285","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1345\/aph.1G131","article-title":"Acute renal failure secondary to imatinib mesylate treatment in prostate cancer","volume":"39","author":"Foringer","year":"2005","journal-title":"Ann. Pharmacother."},{"issue":"1","key":"10.1016\/j.toxrep.2015.05.001_bib0290","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/annonc\/mdj065","article-title":"Pregnancy on imatinib: fatal outcome with meningocele","volume":"17","author":"Choudhary","year":"2006","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.toxrep.2015.05.001_bib0295","first-page":"78","article-title":"Corticosteroids can reverse severe imatinib-induced hepatotoxicity","volume":"91","author":"Ferrero","year":"2006","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.toxrep.2015.05.001_bib0300","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3324\/haematol.10935","article-title":"Two successful pregnancies in a chronic myeloid leukemia patient treated with imatinib","volume":"92","author":"Garderet","year":"2007","journal-title":"Hematol. J."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0305","series-title":"Methods in Prenatal Toxicology","article-title":"General teratological techniques","author":"Gleich","year":"1977"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0310","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00244-006-0021-7","article-title":"Evaluation of developmental toxicity of amitraz in Sprague-Dawley rats","volume":"52","author":"Kim","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0315","series-title":"Practical Teratology","author":"Taylor","year":"1986"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0320","series-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","first-page":"1389","article-title":"Anti-neoplastic agents","author":"Chabner","year":"2001"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0325","first-page":"277","article-title":"Clinical evaluation of granisetron as an inhibitor of nausea and vomiting induced by oral anticancer drugs","volume":"9","author":"Togo","year":"2002","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.toxrep.2015.05.001_bib0330","doi-asserted-by":"crossref","first-page":"466","DOI":"10.7150\/ijbs.5.466","article-title":"Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-fu) on the liver of male albino rats","volume":"5","author":"El-Sayyad","year":"2009","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.toxrep.2015.05.001_bib0335","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1634\/theoncologist.6-2-162","article-title":"Hepatotoxicity of chemotherapy","volume":"6","author":"King","year":"2001","journal-title":"Oncologist"},{"issue":"1","key":"10.1016\/j.toxrep.2015.05.001_bib0340","first-page":"19","article-title":"Chemotherapy for acute leukemia during pregnancy. Five case reports","volume":"26","author":"Fassas","year":"1984","journal-title":"Nouv. Rev. Fr. Hematol."},{"issue":"1","key":"10.1016\/j.toxrep.2015.05.001_bib0345","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0890-6238(91)90113-T","article-title":"Effect of cyclophosphamide on mouse oocytes in vitro fertilization and cleavage: recovery","volume":"5","author":"Pdydn","year":"1991","journal-title":"Reprod. Toxicol."},{"issue":"2","key":"10.1016\/j.toxrep.2015.05.001_bib0350","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2141.1992.tb08202.x","article-title":"Interferon-\u03b1 therapy during pregnancy in chronic myelogenous leukaemia and hairy cell leukaemia","volume":"81","author":"Baer","year":"1992","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0355","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajh.2830380316","article-title":"Successful management of ph chromosome chronic myelogenous leukemia with leukapheresis during pregnancy","volume":"38","author":"Bazarbashi","year":"1991","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0360","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1034\/j.1600-0412.2000.079009803.x","article-title":"Hydroxyurea treatment for chronic myeloid leukemia during pregnancy","volume":"79","author":"Celiloglu","year":"2000","journal-title":"Acta. Obstet. Gynecol. Scand."},{"issue":"3","key":"10.1016\/j.toxrep.2015.05.001_bib0365","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00280-006-0290-x","article-title":"Reproductive toxicity evaluation of a new camptothecin anticancer agent, ckd-602, in pregnant\/lactating female rats and their offspring","volume":"59","author":"Chung","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0370","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4137\/RBI.S7663","article-title":"Reproductive toxic effects of cisplatin and its modulation by the antioxidant sodium 2-mercaptoethanesulfonate (mesna) in female rats","volume":"5","author":"Yeh","year":"2011","journal-title":"Rep. Biol. Insights"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0375","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0041-008X(86)90440-0","article-title":"Sodium 2-mercaptoethane sulfonate protection against cyclophosphamide-induced teratogenicity in rats","volume":"82","author":"Slott","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0380","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0090-8258(92)90138-9","article-title":"The effects of cisplatin on murine metaphase II oocytes","volume":"47","author":"Higdon","year":"1992","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0385","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0027-5107(98)00228-0","article-title":"Taxol-induced meiotic maturation delay, spindle defects, and aneuploidy in mouse oocytes and zygotes","volume":"423","author":"Mailhes","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0390","first-page":"1549","article-title":"Tamoxifen enhances apoptotic effect of cisplatin on primary endometrial cell cultures","volume":"23","author":"Drucker","year":"2003","journal-title":"Anticancer Res."},{"issue":"3","key":"10.1016\/j.toxrep.2015.05.001_bib0395","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0890-6238(98)00016-1","article-title":"Embryotoxic effects of ski 2053 a new potential anticancer agent, in rats","volume":"12","author":"Chung","year":"1998","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0400","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0041-008X(85)90104-8","article-title":"An analysis of factors responsible for responsible for resorption of embryos in cisplatin treated rats","volume":"80","author":"Bajt","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0405","first-page":"437","article-title":"Long-term follow-up of children exposed in utero to antineoplastic agents","volume":"16","author":"Garber","year":"1989","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0410","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1038\/leu.2009.150","article-title":"Imatinib mesylate causes growth plate closure in vivo","volume":"23","author":"Vandyke","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0415","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/0006-2952(70)90102-4","article-title":"CIS dichlorodiammineplatinum (II): persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo","volume":"19","author":"Howle","year":"1970","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0420","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/0006-2952(78)90487-2","article-title":"Nature and reactivity of platinum-pyrimidine blues with biomacromolecules","volume":"27","author":"Herrmann","year":"1978","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0425","first-page":"99","volume":"vol. 2","author":"Ritter","year":"1977"},{"issue":"7","key":"10.1016\/j.toxrep.2015.05.001_bib0430","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1200\/JCO.2005.04.6557","article-title":"Pregnancy among patients with chronic myeloid leukemia treated with imatinib","volume":"24","author":"Ault","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0435","first-page":"5505","article-title":"The effects of imatinib on pregnancy outcome","volume":"111","author":"Pye","year":"2008"},{"key":"10.1016\/j.toxrep.2015.05.001_bib0440","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00204-003-0494-3","article-title":"Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice","volume":"77","author":"Ognio","year":"2003","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0445","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0002-9378(81)90734-1","article-title":"Effects of hydroxyurea on hemodynamics of pregnant rabbits: a maternally mediated mechanism of embryotoxicity","volume":"140","author":"Millicovsky","year":"1981","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.toxrep.2015.05.001_bib0450","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cardiores.2006.05.019","article-title":"Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries","volume":"71","author":"Nystrom","year":"2006","journal-title":"Cardiovasc. Res."}],"container-title":["Toxicology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750015000529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214750015000529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T22:52:18Z","timestamp":1717887138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214750015000529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":45,"alternative-id":["S2214750015000529"],"URL":"https:\/\/doi.org\/10.1016\/j.toxrep.2015.05.001","relation":{},"ISSN":["2214-7500"],"issn-type":[{"value":"2214-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The teratogenic effects of imatinib mesylate on rat fetuses","name":"articletitle","label":"Article Title"},{"value":"Toxicology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.toxrep.2015.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}